{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:40:08Z","timestamp":1787002808081,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"32","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2017,8,10]]},"DOI":"10.1038\/onc.2017.95","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T16:15:33Z","timestamp":1491236133000},"page":"4653-4661","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition"],"prefix":"10.1038","volume":"36","author":[{"given":"T K","family":"Moyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Eischen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"BFonc201795_CR1","first-page":"788","volume":"6","author":"X Xu","year":"2013","unstructured":"Xu X, Zhang L, Wang Y, Zhang Q, Zhang L, Sun B et al. Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review. Int J Clin Exp Pathol 2013; 6: 788\u2013794.","journal-title":"Int J Clin Exp Pathol"},{"key":"BFonc201795_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1309\/NKK3FEX2BE5L7EKB","volume":"129","author":"KH Young","year":"2008","unstructured":"Young KH, Xie Q, Zhou G, Eickhoff JC, Sanger WG, Aoun P et al. Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event. Am J Clin Pathol 2008; 129: 157\u2013166.","journal-title":"Am J Clin Pathol"},{"key":"BFonc201795_CR3","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/10428190701836845","volume":"49","author":"L Christie","year":"2008","unstructured":"Christie L, Kernohan N, Levison D, Sales M, Cunningham J, Gillespie K et al. C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: an adverse prognostic indicator? Leuk Lymphoma 2008; 49: 470\u2013476.","journal-title":"Leuk Lymphoma"},{"key":"BFonc201795_CR4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1365-2141.2008.07152.x","volume":"142","author":"YO Huh","year":"2008","unstructured":"Huh YO, Lin KI, Vega F, Schlette E, Yin CC, Keating MJ et al. MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis. Br J Haematol 2008; 142: 36\u201344.","journal-title":"Br J Haematol"},{"key":"BFonc201795_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/318533a0","volume":"318","author":"JM Adams","year":"1985","unstructured":"Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985; 318: 533\u2013538.","journal-title":"Nature"},{"key":"BFonc201795_CR6","doi-asserted-by":"publisher","first-page":"9762","DOI":"10.1158\/0008-5472.CAN-07-2462","volume":"67","author":"VB Sampson","year":"2007","unstructured":"Sampson VB, Rong NH, Han J, Yang Q, Aris V, Soteropoulos P et al. MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 2007; 67: 9762\u20139770.","journal-title":"Cancer Res"},{"key":"BFonc201795_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1097-2765(00)80367-6","volume":"4","author":"DW Felsher","year":"1999","unstructured":"Felsher DW, Bishop JM . Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 1999; 4: 199\u2013207.","journal-title":"Mol Cell"},{"key":"BFonc201795_CR8","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.cell.2004.05.014","volume":"117","author":"M Kraus","year":"2004","unstructured":"Kraus M, Alimzhanov MB, Rajewsky N, Rajewsky K . Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha\/beta heterodimer. Cell 2004; 117: 787\u2013800.","journal-title":"Cell"},{"key":"BFonc201795_CR9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0092-8674(00)80373-6","volume":"90","author":"KP Lam","year":"1997","unstructured":"Lam KP, Kuhn R, Rajewsky K . In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997; 90: 1073\u20131083.","journal-title":"Cell"},{"key":"BFonc201795_CR10","doi-asserted-by":"publisher","first-page":"e60275","DOI":"10.1371\/journal.pone.0060275","volume":"8","author":"V Pede","year":"2013","unstructured":"Pede V, Rombout A, Vermeire J, Naessens E, Mestdagh P, Robberecht N et al. CLL cells respond to B-Cell receptor stimulation with a microRNA\/mRNA signature associated with MYC activation and cell cycle progression. PLoS One 2013; 8: e60275.","journal-title":"PLoS One"},{"key":"BFonc201795_CR11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1182\/blood-2015-07-660969","volume":"127","author":"A Yeomans","year":"2016","unstructured":"Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS et al. Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation. Blood 2016; 127: 449\u2013457.","journal-title":"Blood"},{"key":"BFonc201795_CR12","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1182\/blood-2012-02-362624","volume":"120","author":"JA Woyach","year":"2012","unstructured":"Woyach JA, Johnson AJ, Byrd JC . The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood 2012; 120: 1175\u20131184.","journal-title":"Blood"},{"key":"BFonc201795_CR13","doi-asserted-by":"publisher","first-page":"32662","DOI":"10.1074\/jbc.274.46.32662","volume":"274","author":"LO Beitz","year":"1999","unstructured":"Beitz LO, Fruman DA, Kurosaki T, Cantley LC, Scharenberg AM . SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J Biol Chem 1999; 274: 32662\u201332666.","journal-title":"J Biol Chem"},{"key":"BFonc201795_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","volume":"463","author":"RE Davis","year":"2010","unstructured":"Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010; 463: 88\u201392.","journal-title":"Nature"},{"key":"BFonc201795_CR15","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev-immunol-020711-075027","volume":"30","author":"AL Shaffer 3rd","year":"2012","unstructured":"Shaffer AL 3rd, Young RM, Staudt LM . Pathogenesis of human B cell lymphomas. Annu Rev Immunol 2012; 30: 565\u2013610.","journal-title":"Annu Rev Immunol"},{"key":"BFonc201795_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nature11378","volume":"490","author":"R Schmitz","year":"2012","unstructured":"Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature 2012; 490: 116\u2013120.","journal-title":"Nature"},{"key":"BFonc201795_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1200\/JCO.2012.42.7906","volume":"31","author":"RH Advani","year":"2013","unstructured":"Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed\/refractory B-cell malignancies. J Clin Oncol 2013; 31: 88\u201394.","journal-title":"J Clin Oncol"},{"key":"BFonc201795_CR18","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1056\/NEJMoa1306220","volume":"369","author":"ML Wang","year":"2013","unstructured":"Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med 2013; 369: 507\u2013516.","journal-title":"N Engl J Med"},{"key":"BFonc201795_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1056\/NEJMoa1215637","volume":"369","author":"JC Byrd","year":"2013","unstructured":"Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013; 369: 32\u201342.","journal-title":"N Engl J Med"},{"key":"BFonc201795_CR20","doi-asserted-by":"publisher","first-page":"8164","DOI":"10.1073\/pnas.1332764100","volume":"100","author":"Z Li","year":"2003","unstructured":"Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B . A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci USA 2003; 100: 8164\u20138169.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc201795_CR21","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1182\/blood-2012-12-473090","volume":"122","author":"JN Psathas","year":"2013","unstructured":"Psathas JN, Doonan PJ, Raman P, Freedman BD, Minn AJ, Thomas-Tikhonenko A . The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop. Blood 2013; 122: 4220\u20134229.","journal-title":"Blood"},{"key":"BFonc201795_CR22","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.molimm.2004.04.008","volume":"41","author":"JM Dal Porto","year":"2004","unstructured":"Dal Porto JM, Gauld SB, Merrell KT, Mills D, Pugh-Bernard AE, Cambier J . B cell antigen receptor signaling 101. Mol Immunol 2004; 41: 599\u2013613.","journal-title":"Mol Immunol"},{"key":"BFonc201795_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S1097-2765(02)00445-8","volume":"9","author":"TC Meng","year":"2002","unstructured":"Meng TC, Fukada T, Tonks NK . Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 2002; 9: 387\u2013399.","journal-title":"Mol Cell"},{"key":"BFonc201795_CR24","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1073\/pnas.051626198","volume":"98","author":"Y Baba","year":"2001","unstructured":"Baba Y, Hashimoto S, Matsushita M, Watanabe D, Kishimoto T, Kurosaki T et al. BLNK mediates Syk-dependent Btk activation. Proc Natl Acad Sci USA 2001; 98: 2582\u20132586.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc201795_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/cmdc.200600221","volume":"2","author":"Z Pan","year":"2007","unstructured":"Pan Z, Scheerens H, Li SJ, Schultz BE, Sprengeler PA, Burrill LC et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem 2007; 2: 58\u201361.","journal-title":"ChemMedChem"},{"key":"BFonc201795_CR26","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/1074-7613(95)90114-0","volume":"3","author":"WN Khan","year":"1995","unstructured":"Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G et al. Defective B cell development and function in Btk-deficient mice. Immunity 1995; 3: 283\u2013299.","journal-title":"Immunity"},{"key":"BFonc201795_CR27","doi-asserted-by":"publisher","first-page":"13152","DOI":"10.1073\/pnas.94.24.13152","volume":"94","author":"AB Satterthwaite","year":"1997","unstructured":"Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, Witte ON . Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proc Natl Acad Sci USA 1997; 94: 13152\u201313157.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc201795_CR28","doi-asserted-by":"publisher","first-page":"30873","DOI":"10.1074\/jbc.M004813200","volume":"275","author":"J Ding","year":"2000","unstructured":"Ding J, Takano T, Gao S, Han W, Noda C, Yanagi S et al. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress. J Biol Chem 2000; 275: 30873\u201330877.","journal-title":"J Biol Chem"},{"key":"BFonc201795_CR29","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1371\/journal.pbio.0060152","volume":"6","author":"Y Refaeli","year":"2008","unstructured":"Refaeli Y, Young RM, Turner BC, Duda J, Field KA, Bishop JM . The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas. PLoS Biol 2008; 6: e152.","journal-title":"PLoS Biol"},{"key":"BFonc201795_CR30","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1038\/cdd.2012.1","volume":"19","author":"MW Gramling","year":"2012","unstructured":"Gramling MW, Eischen CM . Suppression of Ras\/Mapk pathway signaling inhibits Myc-induced lymphomagenesis. Cell Death Differ 2012; 19: 1220\u20131227.","journal-title":"Cell Death Differ"},{"key":"BFonc201795_CR31","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/ng.2468","volume":"44","author":"C Love","year":"2012","unstructured":"Love C, Sun Z, Jima D, Li G, Zhang J, Miles R et al. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet 2012; 44: 1321\u20131325.","journal-title":"Nat Genet"},{"key":"BFonc201795_CR32","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/ng.2469","volume":"44","author":"J Richter","year":"2012","unstructured":"Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B et al. Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet 2012; 44: 1316\u20131320.","journal-title":"Nat Genet"},{"key":"BFonc201795_CR33","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1182\/blood-2011-10-386417","volume":"119","author":"S Ponader","year":"2012","unstructured":"Ponader S, Chen SS, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 2012; 119: 1182\u20131189.","journal-title":"Blood"},{"key":"BFonc201795_CR34","doi-asserted-by":"publisher","first-page":"13075","DOI":"10.1073\/pnas.1004594107","volume":"107","author":"LA Honigberg","year":"2010","unstructured":"Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA 2010; 107: 13075\u201313080.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFonc201795_CR35","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1056\/NEJMoa1509981","volume":"374","author":"JC Byrd","year":"2016","unstructured":"Byrd JC, Harrington B, O'Brien S, Jones JA, Schuh A, Devereux S et al. Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia. N Engl J Med 2016; 374: 323\u2013332.","journal-title":"N Engl J Med"},{"key":"BFonc201795_CR36","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1084\/jem.182.6.1815","volume":"182","author":"T Kurosaki","year":"1995","unstructured":"Kurosaki T, Johnson SA, Pao L, Sada K, Yamamura H, Cambier JC . Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med 1995; 182: 1815\u20131823.","journal-title":"J Exp Med"},{"key":"BFonc201795_CR37","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.bbamcr.2009.03.004","volume":"1793","author":"RL Geahlen","year":"2009","unstructured":"Geahlen RL . Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta 2009; 1793: 1115\u20131127.","journal-title":"Biochim Biophys Acta"},{"key":"BFonc201795_CR38","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1182\/blood-2007-07-100115","volume":"111","author":"L Chen","year":"2008","unstructured":"Chen L, Monti S, Juszczynski P, Daley J, Chen W, Witzig TE et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood 2008; 111: 2230\u20132237.","journal-title":"Blood"},{"key":"BFonc201795_CR39","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1161\/ATVBAHA.115.306130","volume":"35","author":"AP Bye","year":"2015","unstructured":"Bye AP, Unsworth AJ, Vaiyapuri S, Stainer AR, Fry MJ, Gibbins JM . Ibrutinib inhibits platelet integrin alphaIIbbeta3 outside-in signaling and thrombus stability but not adhesion to collagen. Arterioscler Thromb Vasc Biol 2015; 35: 2326\u20132335.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFonc201795_CR40","doi-asserted-by":"publisher","first-page":"11557","DOI":"10.1074\/jbc.M114.629527","volume":"290","author":"BK Manne","year":"2015","unstructured":"Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M et al. Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets. J Biol Chem 2015; 290: 11557\u201311568.","journal-title":"J Biol Chem"},{"key":"BFonc201795_CR41","doi-asserted-by":"publisher","first-page":"C1045","DOI":"10.1152\/ajpcell.90644.2007","volume":"295","author":"HE Speich","year":"2008","unstructured":"Speich HE, Grgurevich S, Kueter TJ, Earhart AD, Slack SM, Jennings LK . Platelets undergo phosphorylation of Syk at Y525\/526 and Y352 in response to pathophysiological shear stress. Am J Physiol Cell Physiol 2008; 295: C1045\u2013C1054.","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFonc201795_CR42","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.4049\/jimmunol.177.3.1581","volume":"177","author":"JM Irish","year":"2006","unstructured":"Irish JM, Czerwinski DK, Nolan GP, Levy R . Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J Immunol 2006; 177: 1581\u20131589.","journal-title":"J Immunol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/onc201795.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/onc201795","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/onc.2017.95","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/onc201795.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T17:05:25Z","timestamp":1647882325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/onc201795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,3]]},"references-count":42,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2017,8,10]]}},"alternative-id":["BFonc201795"],"URL":"https:\/\/doi.org\/10.1038\/onc.2017.95","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,3]]},"assertion":[{"value":"29 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}