{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:40:06Z","timestamp":1762980006393},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Prostate Cancer Prostatic Dis"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/pcan.2013.43","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T10:14:27Z","timestamp":1381832067000},"page":"40-46","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Performance of multiparametric MRI in men at risk of prostate cancer before the first biopsy: a paired validating cohort study using template prostate mapping biopsies as the reference standard"],"prefix":"10.1038","volume":"17","author":[{"given":"M","family":"Abd-Alazeez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H U","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Arya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Anastasiadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Charman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Emberton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"BFpcan201343_CR1","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1056\/NEJMoa0810084","volume":"360","author":"FH Schroder","year":"2009","unstructured":"Schroder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 2009; 360: 1320\u20131328.","journal-title":"N Engl J Med"},{"key":"BFpcan201343_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S1470-2045(10)70146-7","volume":"11","author":"J Hugosson","year":"2010","unstructured":"Hugosson J, Carlsson S, Aus G, Bergdahl S, Khatami A, Lodding P et al. Mortality results from the Goteborg randomised population-based prostate-cancer screening trial. Lancet Oncol 2010; 11: 725\u2013732.","journal-title":"Lancet Oncol"},{"key":"BFpcan201343_CR3","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/S0090-4295(02)01878-2","volume":"60","author":"JA Taylor","year":"2002","unstructured":"Taylor JA, Gancarczyk KJ, Fant GV, McLeod DG . Increasing the number of core samples taken at prostate needle biopsy enhances the detection of clinically significant prostate cancer. Urology 2002; 60: 841\u2013845.","journal-title":"Urology"},{"key":"BFpcan201343_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrclinonc.2009.18","volume":"6","author":"HU Ahmed","year":"2009","unstructured":"Ahmed HU, Kirkham A, Arya M, Illing R, Freeman A, Allen C et al. Is it time to consider a role for MRI before prostate biopsy? Nat Rev Clin Oncol 2009; 6: 197\u2013206.","journal-title":"Nat Rev Clin Oncol"},{"key":"BFpcan201343_CR5","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/pros.22622","volume":"73","author":"ED Crawford","year":"2013","unstructured":"Crawford ED, Rove KO, Barqawi AB, Maroni PD, Werahera PN, Baer CA et al. Clinical-pathologic correlation between transperineal mapping biopsies of the prostate and three-dimensional reconstruction of prostatectomy specimens. Prostate 2013; 73: 778\u2013787.","journal-title":"Prostate"},{"key":"BFpcan201343_CR6","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/j.1464-410X.2012.10933.x","volume":"110","author":"Y Hu","year":"2012","unstructured":"Hu Y, Ahmed HU, Carter T, Arumainayagam N, Lecornet E, Barzell W et al. A biopsy simulation study to assess the accuracy of several transrectal ultrasonography (TRUS)-biopsy strategies compared with template prostate mapping biopsies in patients who have undergone radical prostatectomy. BJU Int 2012; 110: 812\u2013820.","journal-title":"BJU Int"},{"key":"BFpcan201343_CR7","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1007\/s00330-011-2377-y","volume":"22","author":"JO Barentsz","year":"2012","unstructured":"Barentsz JO, Richenberg J, Clements R, Choyke P, Verma S, Villeirs G et al. ESUR prostate MR guidelines 2012. Eur Radiol 2012; 22: 746\u2013757.","journal-title":"Eur Radiol"},{"key":"BFpcan201343_CR8","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.eururo.2012.06.044","volume":"62","author":"D Portalez","year":"2012","unstructured":"Portalez D, Mozer P, Cornud F, Renard-Penna R, Misrai V, Thoulouzan M et al. Validation of the European Society of Urogenital Radiology scoring system for prostate cancer diagnosis on multiparametric magnetic resonance imaging in a cohort of repeat biopsy patients. Eur Urol 2012; 62: 986\u2013996.","journal-title":"Eur Urol"},{"key":"BFpcan201343_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.urology.2007.06.1126","volume":"70","author":"WE Barzell","year":"2007","unstructured":"Barzell WE, Melamed MR . Appropriate patient selection in the focal treatment of prostate cancer: the role of transperineal 3-Dimensional pathologic mapping of the prostate\u2014a 4-year experience. Urology 2007; 70: 27\u201335.","journal-title":"Urology"},{"key":"BFpcan201343_CR10","unstructured":"Simmons L, Ahmed HU, Moore CM, Emberton M . Imaging for Significant Prostate Cancer Risk Evaluation (PICTURE). ClinicalTrials.gov.; 2011."},{"key":"BFpcan201343_CR11","doi-asserted-by":"crossref","unstructured":"Emberton M . PROMIS\u2014Prostate MRI Imaging Study\u2014Evaluation of Multi-Parametric Magnetic Resonance Imaging in the Diagnosis and Characterization of Prostate Cancer. ClinicalTrials.gov,; 2011.","DOI":"10.1186\/ISRCTN16082556"},{"key":"BFpcan201343_CR12","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1097\/01.pas.0000173646.99337.b1","volume":"29","author":"JI Epstein","year":"2005","unstructured":"Epstein JI, Allsbrook WC, Amin MB, Egevad LL . The 2005 international society of urological pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma. Am J Surg Pathol 2005; 29: 1228\u20131242.","journal-title":"Am J Surg Pathol"},{"key":"BFpcan201343_CR13","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1097\/PAS.0b013e3182217b79","volume":"35","author":"S Karram","year":"2011","unstructured":"Karram S, Trock BJ, Netto GJ, Epstein JI . Should intervening benign tissue be included in the measurement of discontinuous foci of cancer on prostate needle biopsy? Correlation with radical prostatectomy findings. Am J Surg Pathol 2011; 35: 1351\u20131355.","journal-title":"Am J Surg Pathol"},{"key":"BFpcan201343_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.juro.2011.03.147","volume":"186","author":"HU Ahmed","year":"2011","unstructured":"Ahmed HU, Hu Y, Carter T, Arumainayagam N, Lecornet E, Freeman A et al. Characterizing clinically significant prostate cancer using template prostate mapping biopsy. J Urol 2011; 186: 458\u2013464.","journal-title":"J Urol"},{"key":"BFpcan201343_CR15","doi-asserted-by":"crossref","unstructured":"Efron B, Tibshirani RJ Monographs on Statistics & Applied Probability: An Introduction to the Bootstrap. Chapman & Hall\/CRC, 1994.","DOI":"10.1201\/9780429246593"},{"key":"BFpcan201343_CR16","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.urology.2009.04.102","volume":"74","author":"P Puech","year":"2009","unstructured":"Puech P, Potiron E, Lemaitre L, Leroy X, Haber GP, Crouzet S et al. Dynamic contrast-enhanced-magnetic resonance imaging evaluation of intraprostatic prostate cancer: correlation with radical prostatectomy specimens. Urology 2009; 74: 1094\u20131099.","journal-title":"Urology"},{"key":"BFpcan201343_CR17","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ejrad.2009.08.007","volume":"77","author":"GM Villeirs","year":"2011","unstructured":"Villeirs GM, De Meerleer GO, De Visschere PJ, Fonteyne VH, Verbaeys AC, Oosterlinck W . Combined magnetic resonance imaging and spectroscopy in the assessment of high grade prostate carcinoma in patients with elevated PSA: a single-institution experience of 356 patients. Eur J Radiol 2011; 77: 340\u2013345.","journal-title":"Eur J Radiol"},{"key":"BFpcan201343_CR18","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/j.juro.2011.07.013","volume":"186","author":"B Turkbey","year":"2011","unstructured":"Turkbey B, Mani H, Shah V, Rastinehad AR, Bernardo M, Pohida T et al. Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds. J Urol 2011; 186: 1818\u20131824.","journal-title":"J Urol"},{"key":"BFpcan201343_CR19","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/jmri.20793","volume":"25","author":"A Tanimoto","year":"2007","unstructured":"Tanimoto A, Nakashima J, Kohno H, Shinmoto H, Kuribayashi S . Prostate cancer screening: the clinical value of diffusion-weighted imaging and dynamic MR imaging in combination with T2-weighted imaging. J Magn Reson Imaging 2007; 25: 146\u2013152.","journal-title":"J Magn Reson Imaging"},{"key":"BFpcan201343_CR20","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/jmri.23938","volume":"37","author":"S Isebaert","year":"2013","unstructured":"Isebaert S, Van den Bergh L, Haustermans K, Joniau S, Lerut E, De Wever L et al. Multiparametric MRI for prostate cancer localization in correlation to whole-mount histopathology. J Magn Reson Imaging 2013; 37: 1392\u20131401.","journal-title":"J Magn Reson Imaging"},{"key":"BFpcan201343_CR21","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1007\/s00330-011-2130-6","volume":"21","author":"O Akin","year":"2011","unstructured":"Akin O, Gultekin DH, Vargas HA, Zheng J, Moskowitz C, Pei X et al. Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: preliminary results. Eur Radiol 2011; 21: 1970\u20131978.","journal-title":"Eur Radiol"},{"key":"BFpcan201343_CR22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/pcan.2011.9","volume":"14","author":"NB Delongchamps","year":"2011","unstructured":"Delongchamps NB, Beuvon F, Eiss D, Flam T, Muradyan N, Zerbib M et al. Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer. Prostate Cancer Prostatic Dis 2011; 14: 232\u2013237.","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"BFpcan201343_CR23","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.eururo.2006.06.025","volume":"50","author":"A Kirkham","year":"2006","unstructured":"Kirkham A, Emberton M, Allen C . How good is MRI at detecting and characterising cancer within the prostate? Eur Urol 2006; 50: 1163\u20131175.","journal-title":"Eur Urol"},{"key":"BFpcan201343_CR24","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S1470-2045(12)70121-3","volume":"13","author":"HU Ahmed","year":"2012","unstructured":"Ahmed HU, Hindley RG, Dickinson L, Freeman A, Kirkham AP, Sahu M et al. Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study. Lancet Oncol 2012; 13: 622\u2013632.","journal-title":"Lancet Oncol"},{"key":"BFpcan201343_CR25","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1016\/j.juro.2012.08.025","volume":"188","author":"S Vourganti","year":"2012","unstructured":"Vourganti S, Rastinehad A, Yerram NK, Nix J, Volkin D, Hoang A et al. Multiparametric magnetic resonance imaging and ultrasound fusion biopsy detect prostate cancer in patients with prior negative transrectal ultrasound biopsies. J Urol 2012; 188: 2152\u20132157.","journal-title":"J Urol"},{"issue":"8 Pt 2","key":"BFpcan201343_CR26","doi-asserted-by":"publisher","first-page":"E171","DOI":"10.1111\/j.1464-410X.2011.10112.x","volume":"108","author":"J Haffner","year":"2011","unstructured":"Haffner J, Lemaitre L, Puech P, Haber GP, Leroy X, Jones JS et al. Role of magnetic resonance imaging before initial biopsy: comparison of magnetic resonance imaging-targeted and systematic biopsy for significant prostate cancer detection. BJU Int 2011; 108 (8 Pt 2): E171\u2013E178.","journal-title":"BJU Int"},{"key":"BFpcan201343_CR27","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.juro.2012.10.009","volume":"189","author":"V Kasivisvanathan","year":"2013","unstructured":"Kasivisvanathan V, Dufour R, Moore CM, Ahmed HU, Abd-Alazeez M, Charman SC et al. Transperineal magnetic resonance image targeted prostate biopsy versus transperineal template prostate biopsy in the detection of clinically significant prostate cancer. J Urol 2013; 189: 860\u2013866.","journal-title":"J Urol"},{"key":"BFpcan201343_CR28","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.juro.2012.08.195","volume":"189","author":"NB Delongchamps","year":"2013","unstructured":"Delongchamps NB, Peyromaure M, Schull A, Beuvon F, Bouazza N, Flam T et al. Prebiopsy magnetic resonance imaging and prostate cancer detection: comparison of random and targeted biopsies. J Urol 2013; 189: 493\u2013499.","journal-title":"J Urol"},{"key":"BFpcan201343_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000325880","volume":"87","author":"P Rouse","year":"2011","unstructured":"Rouse P, Shaw G, Ahmed HU, Freeman A, Allen C, Emberton M . Multi-parametric magnetic resonance imaging to rule-in and rule-out clinically important prostate cancer in men at risk: a cohort study. Urol Int 2011; 87: 49\u201353.","journal-title":"Urol Int"},{"key":"BFpcan201343_CR30","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.juro.2013.02.021","volume":"190","author":"N Bittner","year":"2013","unstructured":"Bittner N, Merrick GS, Butler WM, Bennett A, Galbreath RW . Incidence and pathologic features of prostate cancer detected on transperineal template-guided mapping biopsy following negative transrectal ultrasound-guided biopsy. J Urol 2013; 190: 509\u2013514.","journal-title":"J Urol"},{"key":"BFpcan201343_CR31","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1056\/NEJMcibr0905562","volume":"361","author":"HU Ahmed","year":"2009","unstructured":"Ahmed HU . The index lesion and the origin of prostate cancer. N Engl J Med 2009; 361: 1704\u20131706.","journal-title":"N Engl J Med"},{"key":"BFpcan201343_CR32","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.eururo.2011.05.006","volume":"60","author":"G Ploussard","year":"2011","unstructured":"Ploussard G, Epstein JI, Montironi R, Carroll PR, Wirth M, Grimm M-O et al. The contemporary concept of significant versus insignificant prostate cancer. Eur Urol 2011; 60: 291\u2013303.","journal-title":"Eur Urol"},{"key":"BFpcan201343_CR33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.juro.2010.08.082","volume":"185","author":"T Wolters","year":"2011","unstructured":"Wolters T, Roobol MJ, PJv Leeuwen, RCNvd Bergh, Hoedemaeker RF, Leenders GJLHv et al. A critical analysis of the tumor volume threshold for clinically insignificant prostate cancer using a data set of a randomized screening trial. J Urol 2011; 185: 121\u2013125.","journal-title":"J Urol"}],"container-title":["Prostate Cancer and Prostatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/pcan201343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/pcan201343","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/pcan201343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:05:12Z","timestamp":1648674312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pcan201343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["BFpcan201343"],"URL":"https:\/\/doi.org\/10.1038\/pcan.2013.43","relation":{},"ISSN":["1365-7852","1476-5608"],"issn-type":[{"value":"1365-7852","type":"print"},{"value":"1476-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]},"assertion":[{"value":"16 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None of the funding sources had any role in the data acquisition, analyses and production of this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}