{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:11:59Z","timestamp":1772619119013,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T00:00:00Z","timestamp":1344556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/pr.2012.107","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T16:03:37Z","timestamp":1344614617000},"page":"479-489","source":"Crossref","is-referenced-by-count":32,"title":["Sodium pyruvate reduces hypoxic\u2013ischemic injury to neonatal rat brain"],"prefix":"10.1038","volume":"72","author":[{"given":"Rui","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"She","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Hua","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,10]]},"reference":[{"key":"BFpr2012107_CR1","doi-asserted-by":"publisher","first-page":"587-95","DOI":"10.1016\/j.ajog.2008.06.094","volume":"199","author":"EM Graham","year":"2008","unstructured":"Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE . A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 2008;199:587-95.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr2012107_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/01.JPN.0000346221.48202.7e","volume":"23","author":"MT Verklan","year":"2009","unstructured":"Verklan MT . The chilling details: hypoxic-ischemic encephalopathy. J Perinat Neonatal Nurs 2009;23:59\u201368; quiz 69\u201370.","journal-title":"J Perinat Neonatal Nurs"},{"key":"BFpr2012107_CR3","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.clinthera.2006.09.005","volume":"28","author":"JM Perlman","year":"2006","unstructured":"Perlman JM . Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin Ther 2006;28:1353\u201365.","journal-title":"Clin Ther"},{"key":"BFpr2012107_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000046140","volume":"23","author":"R Geddes","year":"2001","unstructured":"Geddes R, Vannucci RC, Vannucci SJ . Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat. Dev Neurosci 2001;23:180\u20135.","journal-title":"Dev Neurosci"},{"key":"BFpr2012107_CR5","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ana.22419","volume":"69","author":"FJ Northington","year":"2011","unstructured":"Northington FJ, Chavez-Valdez R, Martin LJ . Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol 2011;69:743\u201358.","journal-title":"Ann Neurol"},{"key":"BFpr2012107_CR6","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1177\/0883073809338212","volume":"24","author":"H Hagberg","year":"2009","unstructured":"Hagberg H, Mallard C, Rousset CI, Xiaoyang Wang . Apoptotic mechanisms in the immature brain: involvement of mitochondria. J Child Neurol 2009;24:1141\u20136.","journal-title":"J Child Neurol"},{"key":"BFpr2012107_CR7","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1056\/NEJMra041996","volume":"351","author":"DM Ferriero","year":"2004","unstructured":"Ferriero DM . Neonatal brain injury. N Engl J Med 2004;351:1985\u201395.","journal-title":"N Engl J Med"},{"key":"BFpr2012107_CR8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.freeradbiomed.2005.08.040","volume":"40","author":"K Blomgren","year":"2006","unstructured":"Blomgren K, Hagberg H . Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med 2006;40:388\u201397.","journal-title":"Free Radic Biol Med"},{"key":"BFpr2012107_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainres.2009.03.056","volume":"1272","author":"A Mart\u00edn","year":"2009","unstructured":"Mart\u00edn A, Rojas S, P\u00e9rez-Asensio F, Planas AM . Transient benefits but lack of protection by sodium pyruvate after 2-hour middle cerebral artery occlusion in the rat. Brain Res 2009;1272:45\u201351.","journal-title":"Brain Res"},{"key":"BFpr2012107_CR10","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.expneurol.2010.07.013","volume":"225","author":"N Moro","year":"2010","unstructured":"Moro N, Sutton RL . Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat. Exp Neurol 2010;225:391\u2013401.","journal-title":"Exp Neurol"},{"key":"BFpr2012107_CR11","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1089\/neu.2008.0771","volume":"26","author":"M Fukushima","year":"2009","unstructured":"Fukushima M, Lee SM, Moro N, Hovda DA, Sutton RL . Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury. J Neurotrauma 2009;26:1095\u2013110.","journal-title":"J Neurotrauma"},{"key":"BFpr2012107_CR12","doi-asserted-by":"publisher","first-page":"RC171","DOI":"10.1523\/JNEUROSCI.21-20-j0002.2001","volume":"21","author":"JY Lee","year":"2001","unstructured":"Lee JY, Kim YH, Koh JY . Protection by pyruvate against transient forebrain ischemia in rats. J Neurosci 2001;21:RC171.","journal-title":"J Neurosci"},{"key":"BFpr2012107_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neulet.2011.01.029","volume":"491","author":"N Moro","year":"2011","unstructured":"Moro N, Ghavim SS, Hovda DA, Sutton RL . Delayed sodium pyruvate treatment improves working memory following experimental traumatic brain injury. Neurosci Lett 2011;491:158\u201362.","journal-title":"Neurosci Lett"},{"key":"BFpr2012107_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00431-011-1489-3","volume":"17","author":"D Zhou","year":"2012","unstructured":"Zhou D, Qian J, Chang H, Xi B, Sun RP . Pyruvate administered to newborn rats with insulin-induced hypoglycemic brain injury reduces neuronal death and cognitive impairment. Eur J Pediatr 2012; 17:103\u20139.","journal-title":"Eur J Pediatr"},{"key":"BFpr2012107_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.nbd.2006.12.007","volume":"26","author":"JS Yi","year":"2007","unstructured":"Yi JS, Kim TY, Kyu Kim D, Koh JY . Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia. Neurobiol Dis 2007;26:94\u2013104.","journal-title":"Neurobiol Dis"},{"key":"BFpr2012107_CR16","doi-asserted-by":"publisher","first-page":"9060","DOI":"10.1523\/JNEUROSCI.17-23-09060.1997","volume":"17","author":"S Desagher","year":"1997","unstructured":"Desagher S, Glowinski J, Pr\u00e9mont J . Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J Neurosci 1997;17:9060\u20137.","journal-title":"J Neurosci"},{"key":"BFpr2012107_CR17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0304-3940(02)01327-7","volume":"337","author":"E Mazzio","year":"2003","unstructured":"Mazzio E, Soliman KF . Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. Neurosci Lett 2003;337:77\u201380.","journal-title":"Neurosci Lett"},{"key":"BFpr2012107_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0026-2862(03)00052-9","volume":"66","author":"YJ Lee","year":"2003","unstructured":"Lee YJ, Kang IJ, B\u00fcnger R, Kang YH . Mechanisms of pyruvate inhibition of oxidant-induced apoptosis in human endothelial cells. Microvasc Res 2003;66:91\u2013101.","journal-title":"Microvasc Res"},{"key":"BFpr2012107_CR19","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.nbd.2009.12.010","volume":"37","author":"H Shen","year":"2010","unstructured":"Shen H, Hu X, Liu C, et al. Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiol Dis 2010;37:711\u201322.","journal-title":"Neurobiol Dis"},{"key":"BFpr2012107_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice","year":"1981","unstructured":"Rice JE 3rd, Vannucci RC, Brierley JB . The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131\u201341.","journal-title":"Ann Neurol"},{"key":"BFpr2012107_CR21","doi-asserted-by":"publisher","first-page":"9287","DOI":"10.1523\/JNEUROSCI.22-21-09287.2002","volume":"22","author":"DA Linseman","year":"2002","unstructured":"Linseman DA, Phelps RA, Bouchard RJ, et al. Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J Neurosci 2002;22:9287\u201397.","journal-title":"J Neurosci"},{"key":"BFpr2012107_CR22","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1046\/j.1471-4159.1999.02037.x","volume":"73","author":"H Matsuzaki","year":"1999","unstructured":"Matsuzaki H, Tamatani M, Mitsuda N, et al. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. J Neurochem 1999;73:2037\u201346.","journal-title":"J Neurochem"},{"key":"BFpr2012107_CR23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0891-0618(03)00037-1","volume":"26","author":"JC Jagtap","year":"2003","unstructured":"Jagtap JC, Chandele A, Chopde BA, Shastry P . Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC. J Chem Neuroanat 2003;26:109\u201318.","journal-title":"J Chem Neuroanat"},{"key":"BFpr2012107_CR24","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.brainres.2005.08.029","volume":"1060","author":"JB Kim","year":"2005","unstructured":"Kim JB, Yu YM, Kim SW, Lee JK . Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res 2005;1060:188\u201392.","journal-title":"Brain Res"},{"key":"BFpr2012107_CR25","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1177\/153537020322800304","volume":"228","author":"JB Redell","year":"2003","unstructured":"Redell JB, Moore AN, Dash PK . Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunction. Exp Biol Med (Maywood) 2003;228:261\u20139.","journal-title":"Exp Biol Med (Maywood)"},{"key":"BFpr2012107_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.brainres.2009.05.071","volume":"1282","author":"C Liu","year":"2009","unstructured":"Liu C, Lin N, Wu B, Qiu Y . Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury. Brain Res 2009;1282:173\u201382.","journal-title":"Brain Res"},{"key":"BFpr2012107_CR27","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/hipo.450030302","volume":"3","author":"A Amsel","year":"1993","unstructured":"Amsel A . Hippocampal function in the rat: cognitive mapping or vicarious trial and error? Hippocampus 1993;3:251\u20136.","journal-title":"Hippocampus"},{"key":"BFpr2012107_CR28","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1161\/STROKEAHA.110.599118","volume":"42","author":"W Chen","year":"2011","unstructured":"Chen W, Ma Q, Suzuki H, Hartman R, Tang J, Zhang JH . Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke 2011;42:764\u20139.","journal-title":"Stroke"},{"key":"BFpr2012107_CR29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bbr.2003.11.002","volume":"153","author":"A Kumral","year":"2004","unstructured":"Kumral A, Uysal N, Tugyan K, et al. Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats. Behav Brain Res 2004;153:77\u201386.","journal-title":"Behav Brain Res"},{"key":"BFpr2012107_CR30","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"CV Vorhees","year":"2006","unstructured":"Vorhees CV, Williams MT . Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1:848\u201358.","journal-title":"Nat Protoc"},{"key":"BFpr2012107_CR31","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","volume":"10","author":"S Desagher","year":"2000","unstructured":"Desagher S, Martinou JC . Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000;10:369\u201377.","journal-title":"Trends Cell Biol"},{"key":"BFpr2012107_CR32","doi-asserted-by":"publisher","first-page":"7770","DOI":"10.1074\/jbc.273.13.7770","volume":"273","author":"JG Pastorino","year":"1998","unstructured":"Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL . The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 1998;273:7770\u20135.","journal-title":"J Biol Chem"},{"key":"BFpr2012107_CR33","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1073\/pnas.95.9.4997","volume":"95","author":"JM J\u00fcrgensmeier","year":"1998","unstructured":"J\u00fcrgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC . Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 1998;95:4997\u20135002.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr2012107_CR34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1083\/jcb.143.1.217","volume":"143","author":"R Eskes","year":"1998","unstructured":"Eskes R, Antonsson B, Osen-Sand A, et al. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J Cell Biol 1998;143:217\u201324.","journal-title":"J Cell Biol"},{"key":"BFpr2012107_CR35","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/00004647-200104000-00001","volume":"21","author":"G Cao","year":"2001","unstructured":"Cao G, Minami M, Pei W, et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab 2001;21:321\u201333.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFpr2012107_CR36","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1179\/174313208X338133","volume":"31","author":"J Zhong","year":"2009","unstructured":"Zhong J, Zhao L, Du Y, Wei G, Yao WG, Lee WH . Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats. Neurol Res 2009;31:483\u20139.","journal-title":"Neurol Res"},{"key":"BFpr2012107_CR37","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/jnr.20024","volume":"75","author":"J Zhong","year":"2004","unstructured":"Zhong J, Deng J, Huang S, Yang X, Lee WH . High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. J Neurosci Res 2004;75:794\u2013806.","journal-title":"J Neurosci Res"},{"key":"BFpr2012107_CR38","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1634\/stemcells.2008-0333","volume":"27","author":"X Wei","year":"2009","unstructured":"Wei X, Du Z, Zhao L, et al. IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 2009;27:478\u201388.","journal-title":"Stem Cells"},{"key":"BFpr2012107_CR39","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.neulet.2009.08.049","volume":"465","author":"Q Shi","year":"2009","unstructured":"Shi Q, Zhang P, Zhang J, et al. Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci Lett 2009;465:220\u20135.","journal-title":"Neurosci Lett"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2012107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012107","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T09:40:24Z","timestamp":1714297224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2012107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,10]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["BFpr2012107"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.107","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,10]]}}}