{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:21:44Z","timestamp":1788916904696,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T00:00:00Z","timestamp":1352937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T00:00:00Z","timestamp":1352937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/pr.2012.156","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T17:00:06Z","timestamp":1352998806000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth\u2013restricted fetal sheep"],"prefix":"10.1038","volume":"73","author":[{"given":"Reuben Blair","family":"Dodson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Rozance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S.","family":"Fleenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson C.","family":"Petrash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G.","family":"Shoemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall S.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia L.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,15]]},"reference":[{"key":"BFpr2012156_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10237-006-0018-1","volume":"5","author":"RW Kobs","year":"2006","unstructured":"Kobs RW, Chesler NC . The mechanobiology of pulmonary vascular remodeling in the congenital absence of eNOS. Biomech Model Mechanobiol 2006;5:217\u201325.","journal-title":"Biomech Model Mechanobiol"},{"key":"BFpr2012156_CR2","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1161\/01.CIR.0000069826.36125.B4","volume":"107","author":"ME Safar","year":"2003","unstructured":"Safar ME, Levy BI, Struijker-Boudier H . Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 2003;107:2864\u20139.","journal-title":"Circulation"},{"issue":"Pt 23","key":"BFpr2012156_CR3","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1242\/jeb.202.23.3305","volume":"202","author":"RE Shadwick","year":"1999","unstructured":"Shadwick RE . Mechanical design in arteries. J Exp Biol 1999;202(Pt 23):3305\u201313.","journal-title":"J Exp Biol"},{"key":"BFpr2012156_CR4","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0369-8114(01)00147-X","volume":"49","author":"G Faury","year":"2001","unstructured":"Faury G . Function-structure relationship of elastic arteries in evolution: from microfibrils to elastin and elastic fibres. Pathol Biol 2001;49:310\u201325.","journal-title":"Pathol Biol"},{"key":"BFpr2012156_CR5","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.placenta.2008.11.005","volume":"30","author":"T Burkhardt","year":"2009","unstructured":"Burkhardt T, Matter CM, Lohmann C, et al. Decreased umbilical artery compliance and IGF-I plasma levels in infants with intrauterine growth restriction \u2013 implications for fetal programming of hypertension. Placenta 2009;30:136\u201341.","journal-title":"Placenta"},{"key":"BFpr2012156_CR6","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1152\/physrev.00041.2008","volume":"89","author":"JE Wagenseil","year":"2009","unstructured":"Wagenseil JE, Mecham RP . Vascular extracellular matrix and arterial mechanics. Physiol Rev 2009;89:957\u201389.","journal-title":"Physiol Rev"},{"issue":"4 Pt 2","key":"BFpr2012156_CR7","first-page":"H1385","volume":"277","author":"SM Wells","year":"1999","unstructured":"Wells SM, Langille BL, Lee JM, Adamson SL . Determinants of mechanical properties in the developing ovine thoracic aorta. Am J Physiol 1999;277(4 Pt 2):H1385\u201391.","journal-title":"Am J Physiol"},{"key":"BFpr2012156_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1053\/j.semperi.2007.11.004","volume":"32","author":"JS Barry","year":"2008","unstructured":"Barry JS, Rozance PJ, Anthony RV . An animal model of placental insufficiency-induced intrauterine growth restriction. Semin Perinatol 2008;32:225\u201330.","journal-title":"Semin Perinatol"},{"key":"BFpr2012156_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ajog.2004.05.088","volume":"192","author":"HL Galan","year":"2005","unstructured":"Galan HL, Anthony RV, Rigano S, et al. Fetal hypertension and abnormal Doppler velocimetry in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol 2005;192:272\u20139.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr2012156_CR10","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S1357-4310(95)90793-9","volume":"1","author":"DJ Barker","year":"1995","unstructured":"Barker DJ . Intrauterine programming of adult disease. Mol Med Today 1995;1:418\u201323.","journal-title":"Mol Med Today"},{"key":"BFpr2012156_CR11","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1136\/hrt.2004.047407","volume":"91","author":"KL Thornburg","year":"2005","unstructured":"Thornburg KL, Louey S . Fetal roots of cardiac disease. Heart 2005;91:867\u20138.","journal-title":"Heart"},{"key":"BFpr2012156_CR12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.theriogenology.2007.09.021","volume":"69","author":"JS Barry","year":"2008","unstructured":"Barry JS, Anthony RV . The pregnant sheep as a model for human pregnancy. Theriogenology 2008;69:55\u201367.","journal-title":"Theriogenology"},{"key":"BFpr2012156_CR13","unstructured":"Boer RD . Trends in Continuum Mechanics of Porous Media. Springer: Norwell, MA, 2005."},{"key":"BFpr2012156_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1139\/y03-022","volume":"81","author":"K Et-Taouil","year":"2003","unstructured":"Et-Taouil K, Safar M, Plante GE . Mechanisms and consequences of large artery rigidity. Can J Physiol Pharmacol 2003;81:205\u201311.","journal-title":"Can J Physiol Pharmacol"},{"key":"BFpr2012156_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3317\/jraas.2004.025","volume":"5","author":"A Mahmud","year":"2004","unstructured":"Mahmud A, Feely J . Arterial stiffness and the renin-angiotensin-aldosterone system. J Renin Angiotensin Aldosterone Syst 2004;5:102\u20138.","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"BFpr2012156_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/MNH.0b013e328335eec9","volume":"19","author":"AM Briones","year":"2010","unstructured":"Briones AM, Arribas SM, Salaices M . Role of extracellular matrix in vascular remodeling of hypertension. Curr Opin Nephrol Hypertens 2010;19:187\u201394.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"BFpr2012156_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0070-2153(04)62006-0","volume":"62","author":"CM Kelleher","year":"2004","unstructured":"Kelleher CM, McLean SE, Mecham RP . Vascular extracellular matrix and aortic development. Curr Top Dev Biol 2004;62:153\u201388.","journal-title":"Curr Top Dev Biol"},{"key":"BFpr2012156_CR18","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.matbio.2007.10.008","volume":"27","author":"MK O\u2019Connell","year":"2008","unstructured":"O\u2019Connell MK, Murthy S, Phan S, et al. The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging. Matrix Biol 2008;27:171\u201381.","journal-title":"Matrix Biol"},{"key":"BFpr2012156_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1010835316564","volume":"61","author":"G Holzapfel","year":"2000","unstructured":"Holzapfel G, Gasser T, Ogden R . A new constitutive framework for arterial wall mechanics and a comparative study of material models. J Elasticity 2000;61:1\u201348.","journal-title":"J Elasticity"},{"key":"BFpr2012156_CR20","doi-asserted-by":"publisher","first-page":"H1875","DOI":"10.1152\/ajpheart.00872.2009","volume":"299","author":"JF Eberth","year":"2010","unstructured":"Eberth JF, Popovic N, Gresham VC, Wilson E, Humphrey JD . Time course of carotid artery growth and remodeling in response to altered pulsatility. Am J Physiol Heart Circ Physiol 2010;299:H1875\u201383.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFpr2012156_CR21","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/CIRCRESAHA.108.192054","volume":"104","author":"JE Wagenseil","year":"2009","unstructured":"Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP . Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circ Res 2009;104:1217\u201324.","journal-title":"Circ Res"},{"issue":"Pt 13","key":"BFpr2012156_CR22","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.1113\/jphysiol.2011.210625","volume":"589","author":"JA Thompson","year":"2011","unstructured":"Thompson JA, Richardson BS, Gagnon R, Regnault TR . Chronic intrauterine hypoxia interferes with aortic development in the late gestation ovine fetus. J Physiol (Lond) 2011;589(Pt 13):3319\u201332.","journal-title":"J Physiol (Lond)"},{"key":"BFpr2012156_CR23","doi-asserted-by":"publisher","first-page":"R1731","DOI":"10.1152\/ajpregu.00274.2011","volume":"301","author":"JA Thompson","year":"2011","unstructured":"Thompson JA, Gros R, Richardson BS, Piorkowska K, Regnault TR . Central stiffening in adulthood linked to aberrant aortic remodeling under suboptimal intrauterine conditions. Am J Physiol Regul Integr Comp Physiol 2011;301:R1731\u20137.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFpr2012156_CR24","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1046\/j.1440-1681.2001.03555.x","volume":"28","author":"CN Martyn","year":"2001","unstructured":"Martyn CN, Greenwald SE . A hypothesis about a mechanism for the programming of blood pressure and vascular disease in early life. Clin Exp Pharmacol Physiol 2001;28:948\u201351.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFpr2012156_CR25","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1097\/HJH.0b013e3282f82c3e","volume":"26","author":"PM Nilsson","year":"2008","unstructured":"Nilsson PM, Lurbe E, Laurent S . The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome. J Hypertens 2008;26:1049\u201357.","journal-title":"J Hypertens"},{"key":"BFpr2012156_CR26","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/j.1651-2227.2008.00904.x","volume":"97","author":"M Norman","year":"2008","unstructured":"Norman M . Low birth weight and the developing vascular tree: a systematic review. Acta Paediatr 2008;97:1165\u201372.","journal-title":"Acta Paediatr"},{"key":"BFpr2012156_CR27","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1042\/CS20070420","volume":"115","author":"PH Rond\u00f3","year":"2008","unstructured":"Rond\u00f3 PH, Lemos JO, Pereira JA, Oliveira JM, Innocente LR . Relationship between birthweight and arterial elasticity in childhood. Clin Sci 2008;115:317\u201326.","journal-title":"Clin Sci"},{"key":"BFpr2012156_CR28","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1161\/01.HYP.37.5.1236","volume":"37","author":"S Laurent","year":"2001","unstructured":"Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236\u201341.","journal-title":"Hypertension"},{"key":"BFpr2012156_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1159\/000096722","volume":"44","author":"J D\u00edez","year":"2007","unstructured":"D\u00edez J . Arterial stiffness and extracellular matrix. Adv Cardiol 2007;44:76\u201395.","journal-title":"Adv Cardiol"},{"key":"BFpr2012156_CR30","first-page":"225","volume":"98","author":"MJ Domanski","year":"1998","unstructured":"Domanski MJ, Mitchell GF, Norman J, Exner D, Pitt B, Pfeffer MA . Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction. Circulation 1998 98:225.","journal-title":"Circulation"},{"key":"BFpr2012156_CR31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1053\/euhj.1999.1756","volume":"21","author":"C Stefanadis","year":"2000","unstructured":"Stefanadis C, Dernellis J, Tsiamis E, et al. Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease. Eur Heart J 2000;21:390\u20136.","journal-title":"Eur Heart J"},{"key":"BFpr2012156_CR32","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1136\/bmj.318.7181.427","volume":"318","author":"JG Eriksson","year":"1999","unstructured":"Eriksson JG, Fors\u00e9n T, Tuomilehto J, Winter PD, Osmond C, Barker DJ . Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ 1999;318:427\u201331.","journal-title":"BMJ"},{"key":"BFpr2012156_CR33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1177\/1933719107302324","volume":"14","author":"K Meyer","year":"2007","unstructured":"Meyer K, Lubo Zhang. Fetal programming of cardiac function and disease. Reprod Sci 2007;14:209\u201316.","journal-title":"Reprod Sci"},{"key":"BFpr2012156_CR34","doi-asserted-by":"publisher","first-page":"E638","DOI":"10.1152\/ajpendo.00192.2009","volume":"297","author":"PJ Rozance","year":"2009","unstructured":"Rozance PJ, Crispo MM, Barry JS, et al. Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation. Am J Physiol Endocrinol Metab 2009;297:E638\u201346.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFpr2012156_CR35","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1203\/PDR.0b013e318189358c","volume":"65","author":"PJ Rozance","year":"2009","unstructured":"Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW Jr . Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Pediatr Res 2009;65:72\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2012156_CR36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0378-4347(92)80301-6","volume":"582","author":"TJ Sims","year":"1992","unstructured":"Sims TJ, Bailey AJ . Quantitative analysis of collagen and elastin cross-links using a single-column system. J Chromatogr 1992;582:49\u201355.","journal-title":"J Chromatogr"},{"key":"BFpr2012156_CR37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3109\/03008209509028401","volume":"31","author":"B Starcher","year":"1995","unstructured":"Starcher B, Conrad M . A role for neutrophil elastase in the progression of solar elastosis. Connect Tissue Res 1995;31:133\u201340.","journal-title":"Connect Tissue Res"},{"key":"BFpr2012156_CR38","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/03008208209160269","volume":"9","author":"RW Farndale","year":"1982","unstructured":"Farndale RW, Sayers CA, Barrett AJ . A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 1982;9:247\u20138.","journal-title":"Connect Tissue Res"},{"key":"BFpr2012156_CR39","doi-asserted-by":"publisher","first-page":"H1451","DOI":"10.1152\/ajpheart.00127.2008","volume":"295","author":"SR Lammers","year":"2008","unstructured":"Lammers SR, Kao PH, Qi HJ, et al. Changes in the structure\u2013function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves. Am J Physiol Heart Circ Physiol 2008;295:H1451\u20139.","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2012156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012156","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:56:21Z","timestamp":1684472181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2012156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,15]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFpr2012156"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.156","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,15]]},"assertion":[{"value":"21 May 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}