{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:58:58Z","timestamp":1768773538178,"version":"3.49.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/pr.2012.167","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T17:07:09Z","timestamp":1353431229000},"page":"163-170","source":"Crossref","is-referenced-by-count":35,"title":["Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system"],"prefix":"10.1038","volume":"73","author":[{"given":"Ingrid","family":"Dannevig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Lee","family":"Solev\u00e5g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonje","family":"Sonerud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola Didrik","family":"Saugstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Nakstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"BFpr2012167_CR1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.brainres.2010.09.080","volume":"1363","author":"ML Dalen","year":"2010","unstructured":"Dalen ML, Alme TN, Bj\u00f8r\u00e5s M, Munkeby BH, Rootwelt T, Saugstad OD . Reduced expression of DNA glycosylases in post-hypoxic newborn pigs undergoing therapeutic hypothermia. Brain Res 2010;1363:198\u2013205.","journal-title":"Brain Res"},{"key":"BFpr2012167_CR2","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.clinthera.2006.09.005","volume":"28","author":"JM Perlman","year":"2006","unstructured":"Perlman JM . Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin Ther 2006;28:1353\u201365.","journal-title":"Clin Ther"},{"key":"BFpr2012167_CR3","doi-asserted-by":"crossref","unstructured":"Stevenson DK . Fetal and Neonatal Brain Injury, 4th edn. Cambridge, UK: Cambridge University Press, 2009.","DOI":"10.1017\/CBO9780511581281"},{"key":"BFpr2012167_CR4","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.resuscitation.2010.08.018","volume":"81","author":"S Richmond","year":"2010","unstructured":"Richmond S, Wyllie J . European Resuscitation Council Guidelines for Resuscitation 2010 Section 7. Resuscitation of babies at birth. Resuscitation 2010;81:1389\u201399.","journal-title":"Resuscitation"},{"issue":"16 Suppl 2","key":"BFpr2012167_CR5","doi-asserted-by":"publisher","first-page":"S516","DOI":"10.1161\/CIRCULATIONAHA.110.971127","volume":"122","author":"JM Perlman","year":"2010","unstructured":"Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010;122:16 Suppl 2:S516\u201338.","journal-title":"Circulation"},{"key":"BFpr2012167_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1001\/archpedi.1995.02170130022005","volume":"149","author":"JM Perlman","year":"1995","unstructured":"Perlman JM, Risser R . Cardiopulmonary resuscitation in the delivery room. Associated clinical events. Arch Pediatr Adolesc Med 1995;149:20\u20135.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"BFpr2012167_CR7","doi-asserted-by":"publisher","first-page":"F413","DOI":"10.1136\/adc.2007.124503","volume":"93","author":"M Woldesenbet","year":"2008","unstructured":"Woldesenbet M, Rosenfeld CR, Ramilo O, Johnson-Welch S, Perlman JM . Severe neonatal hypoxic respiratory failure correlates with histological chorioamnionitis and raised concentrations of interleukin 6 (IL6), IL8 and C-reactive protein. Arch Dis Child Fetal Neonatal Ed 2008;93:F413\u20137.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr2012167_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1001\/archsurg.135.3.291","volume":"135","author":"F Gebhard","year":"2000","unstructured":"Gebhard F, Pfetsch H, Steinbach G, Strecker W, Kinzl L, Br\u00fcckner UB . Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg 2000;135:291\u20135.","journal-title":"Arch Surg"},{"key":"BFpr2012167_CR9","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/S0020-1383(03)00022-6","volume":"34","author":"W Strecker","year":"2003","unstructured":"Strecker W, Gebhard F, Perl M, et al. Biochemical characterization of individual injury pattern and injury severity. Injury 2003;34:879\u201387.","journal-title":"Injury"},{"key":"BFpr2012167_CR10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1046\/j.1471-4159.1995.64010292.x","volume":"64","author":"CC Huang","year":"1995","unstructured":"Huang CC, Yonetani M, Lajevardi N, Delivoria-Papadopoulos M, Wilson DF, Pastuszko A . Comparison of postasphyxial resuscitation with 100% and 21% oxygen on cortical oxygen pressure and striatal dopamine metabolism in newborn piglets. J Neurochem 1995;64:292\u20138.","journal-title":"J Neurochem"},{"key":"BFpr2012167_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.siny.2010.05.007","volume":"15","author":"L Bennet","year":"2010","unstructured":"Bennet L, Booth L, Gunn AJ . Potential biomarkers for hypoxic-ischemic encephalopathy. Semin Fetal Neonatal Med 2010;15:253\u201360.","journal-title":"Semin Fetal Neonatal Med"},{"key":"BFpr2012167_CR12","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1212\/WNL.0b013e3181fd62d2","volume":"75","author":"PE Vos","year":"2010","unstructured":"Vos PE, Jacobs B, Andriessen TM, et al. GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study. Neurology 2010;75:1786\u201393.","journal-title":"Neurology"},{"key":"BFpr2012167_CR13","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1203\/01.PDR.0000179407.46810.2D","volume":"58","author":"BH Munkeby","year":"2005","unstructured":"Munkeby BH, B\u00f8rke WB, Bj\u00f8rnland K, et al. Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8. Pediatr Res 2005;58:542\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2012167_CR14","doi-asserted-by":"publisher","first-page":"e14261","DOI":"10.1371\/journal.pone.0014261","volume":"5","author":"R Solberg","year":"2010","unstructured":"Solberg R, L\u00f8berg EM, Andresen JH, et al. Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF. PLoS ONE 2010;5:e14261.","journal-title":"PLoS ONE"},{"key":"BFpr2012167_CR15","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1186\/cc8879","volume":"14","author":"P Meybohm","year":"2010","unstructured":"Meybohm P, Gruenewald M, Zacharowski KD, et al. Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation. Crit Care 2010;14:R21.","journal-title":"Crit Care"},{"key":"BFpr2012167_CR16","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1528-1167.2007.01047.x","volume":"48","author":"L Librizzi","year":"2007","unstructured":"Librizzi L, Regondi MC, Pastori C, Frigerio S, Frassoni C, de Curtis M . Expression of adhesion factors induced by epileptiform activity in the endothelium of the isolated guinea pig brain in vitro. Epilepsia 2007; 48:743\u201351.","journal-title":"Epilepsia"},{"key":"BFpr2012167_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.resuscitation.2012.01.001","volume":"83","author":"H Zhao","year":"2012","unstructured":"Zhao H, Li CS, Gong P, et al. Molecular mechanisms of therapeutic hypothermia on neurological function in a swine model of cardiopulmonary resuscitation. Resuscitation 2012;83:913\u201320.","journal-title":"Resuscitation"},{"key":"BFpr2012167_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000275560","volume":"98","author":"AL Solev\u00e5g","year":"2010","unstructured":"Solev\u00e5g AL, Dannevig I, Nakstad B, Saugstad OD . Resuscitation of severely asphyctic newborn pigs with cardiac arrest by using 21% or 100% oxygen. Neonatology 2010;98:64\u201372.","journal-title":"Neonatology"},{"key":"BFpr2012167_CR19","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.resuscitation.2010.06.007","volume":"81","author":"AL Solev\u00e5g","year":"2010","unstructured":"Solev\u00e5g AL, Dannevig I, Wyckoff M, Saugstad OD, Nakstad B . Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia. Resuscitation 2010;81:1571\u20136.","journal-title":"Resuscitation"},{"key":"BFpr2012167_CR20","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000302718","volume":"99","author":"I Dannevig","year":"2011","unstructured":"Dannevig I, Solev\u00e5g AL, Wyckoff M, Saugstad OD, Nakstad B . Delayed onset of cardiac compressions in cardiopulmonary resuscitation of newborn pigs with asphyctic cardiac arrest. Neonatology 2011;99:153\u201362.","journal-title":"Neonatology"},{"key":"BFpr2012167_CR21","doi-asserted-by":"publisher","first-page":"F417","DOI":"10.1136\/adc.2010.200386","volume":"96","author":"AL Solev\u00e5g","year":"2011","unstructured":"Solev\u00e5g AL, Dannevig I, Wyckoff M, Saugstad OD, Nakstad B . Return of spontaneous circulation with a compression:ventilation ratio of 15:2 versus 3:1 in newborn pigs with cardiac arrest due to asphyxia. Arch Dis Child Fetal Neonatal Ed 2011;96:F417\u201321.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr2012167_CR22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/01.shk.0000070739.34700.f6","volume":"19","author":"MW Kn\u00f6ferl","year":"2003","unstructured":"Kn\u00f6ferl MW, Liener UC, Seitz DH, et al. Cardiopulmonary, histological, and inflammatory alterations after lung contusion in a novel mouse model of blunt chest trauma. Shock 2003;19:519\u201325.","journal-title":"Shock"},{"key":"BFpr2012167_CR23","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1515\/jpm.2010.081","volume":"38","author":"ML Dalen","year":"2010","unstructured":"Dalen ML, Alme TN, Munkeby BH, et al. Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation. J Perinat Med 2010;38:545\u201356.","journal-title":"J Perinat Med"},{"key":"BFpr2012167_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/pr.2011.43","volume":"71","author":"ML Dalen","year":"2012","unstructured":"Dalen ML, Liu X, Elstad M, et al. Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat. Pediatr Res 2012;71:247\u201352.","journal-title":"Pediatr Res"},{"key":"BFpr2012167_CR25","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/RLI.0b013e3182266431","volume":"46","author":"C de Lange","year":"2011","unstructured":"de Lange C, Brabrand K, Emblem KE, et al. Cerebral perfusion in perinatal hypoxia and resuscitation assessed by transcranial contrast-enhanced ultrasound and 3 T MRI in newborn pigs. Invest Radiol 2011;46:686\u201396.","journal-title":"Invest Radiol"},{"key":"BFpr2012167_CR26","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1203\/01.PDR.0000141988.89820.E3","volume":"56","author":"BH Munkeby","year":"2004","unstructured":"Munkeby BH, B\u00f8rke WB, Bj\u00f8rnland K, et al. Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets. Pediatr Res 2004;56:783\u201390.","journal-title":"Pediatr Res"},{"key":"BFpr2012167_CR27","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.braindev.2008.09.001","volume":"31","author":"S Sunagawa","year":"2009","unstructured":"Sunagawa S, Ichiyama T, Honda R, Fukunaga S, Maeba S, Furukawa S . Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in perinatal asphyxia. Brain Dev 2009;31:588\u201393.","journal-title":"Brain Dev"},{"key":"BFpr2012167_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/pr.2011.3","volume":"71","author":"N Bednarek","year":"2012","unstructured":"Bednarek N, Svedin P, Garnotel R, et al. Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia: a potential marker of neonatal encephalopathy. Pediatr Res 2012;71:63\u201370.","journal-title":"Pediatr Res"},{"key":"BFpr2012167_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1742-2094-8-51","volume":"8","author":"C Wewer","year":"2011","unstructured":"Wewer C, Seibt A, Wolburg H, et al. Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis. J Neuroinflammation 2011;8:51.","journal-title":"J Neuroinflammation"},{"key":"BFpr2012167_CR30","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.resuscitation.2012.01.001","volume":"83","author":"H Zhao","year":"2012","unstructured":"Zhao H, Li CS, Gong P, et al. Molecular mechanisms of therapeutic hypothermia on neurological function in a swine model of cardiopulmonary resuscitation. Resuscitation 2012;83:913\u201320.","journal-title":"Resuscitation"},{"key":"BFpr2012167_CR31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1046\/j.1440-1789.2002.00438.x","volume":"22","author":"P Rezaie","year":"2002","unstructured":"Rezaie P, Dean A . Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 2002;22:106\u201332.","journal-title":"Neuropathology"},{"key":"BFpr2012167_CR32","first-page":"293","volume":"40","author":"JP Hannon","year":"1990","unstructured":"Hannon JP, Bossone CA, Wade CE . Normal physiological values for conscious pigs used in biomedical research. Lab Anim Sci 1990;40:293\u20138.","journal-title":"Lab Anim Sci"},{"key":"BFpr2012167_CR33","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1046\/j.1525-1373.2000.22314.x","volume":"223","author":"WG Pond","year":"2000","unstructured":"Pond WG, Boleman SL, Fiorotto ML, et al. Perinatal ontogeny of brain growth in the domestic pig. Proc Soc Exp Biol Med 2000;223:102\u20138.","journal-title":"Proc Soc Exp Biol Med"},{"key":"BFpr2012167_CR34","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0022-3476(82)80595-7","volume":"100","author":"A Laptook","year":"1982","unstructured":"Laptook A, Stonestreet BS, Oh W . The effects of different rates of plasmanate infusions upon brain blood flow after asphyxia and hypotension in newborn piglets. J Pediatr 1982;100:791\u20136.","journal-title":"J Pediatr"},{"key":"BFpr2012167_CR35","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","volume":"40","author":"M Thoresen","year":"1996","unstructured":"Thoresen M, Haaland K, L\u00f8berg EM, et al. A piglet survival model of posthypoxic encephalopathy. Pediatr Res 1996;40:738\u201348.","journal-title":"Pediatr Res"},{"key":"BFpr2012167_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402\u20138.","journal-title":"Methods"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2012167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012167","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:56:29Z","timestamp":1684472189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2012167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFpr2012167"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.167","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}