{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:44:51Z","timestamp":1791265491764,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/pr.2012.184","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T17:01:18Z","timestamp":1354899678000},"page":"337-343","source":"Crossref","is-referenced-by-count":23,"title":["Hyperglycemia increases the risk of death in extremely preterm baboons"],"prefix":"10.1038","volume":"73","author":[{"given":"Cynthia L.","family":"Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"McGill-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"McCurnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,7]]},"reference":[{"key":"BFpr2012184_CR1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/sj.jp.7210879","volume":"23","author":"R Garg","year":"2003","unstructured":"Garg R, Agthe AG, Donohue PK, Lehmann CU . Hyperglycemia and retinopathy of prematurity in very low birth weight infants. J Perinatol 2003;23:186\u201394.","journal-title":"J Perinatol"},{"key":"BFpr2012184_CR2","doi-asserted-by":"publisher","first-page":"e584","DOI":"10.1542\/peds.2009-0449","volume":"125","author":"G Alexandrou","year":"2010","unstructured":"Alexandrou G, Ski\u00f6ld B, Karl\u00e9n J, et al. Early hyperglycemia is a risk factor for death and white matter reduction in preterm infants. Pediatrics 2010;125:e584\u201391.","journal-title":"Pediatrics"},{"key":"BFpr2012184_CR3","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/sj.jp.7211594","volume":"26","author":"CL Blanco","year":"2006","unstructured":"Blanco CL, Baillargeon JG, Morrison RL, Gong AK . Hyperglycemia in extremely low birth weight infants in a predominantly Hispanic population and related morbidities. J Perinatol 2006;26:737\u201341.","journal-title":"J Perinatol"},{"key":"BFpr2012184_CR4","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.jpedsurg.2004.02.005","volume":"39","author":"NJ Hall","year":"2004","unstructured":"Hall NJ, Peters M, Eaton S, Pierro A . Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis. J Pediatr Surg 2004;39:898\u2013901; discussion 898\u2013901.","journal-title":"J Pediatr Surg"},{"key":"BFpr2012184_CR5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.jpeds.2010.05.028","volume":"157","author":"EA Liechty","year":"2010","unstructured":"Liechty EA . The resistant premie: documenting the prevalence of hyperglycemia in the extremely low birth weight infant. J Pediatr 2010;157:699\u2013700.","journal-title":"J Pediatr"},{"key":"BFpr2012184_CR6","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1542\/peds.2006-0628","volume":"118","author":"SP Hays","year":"2006","unstructured":"Hays SP, Smith EO, Sunehag AL . Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants. Pediatrics 2006;118:1811\u20138.","journal-title":"Pediatrics"},{"key":"BFpr2012184_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/jp.2010.152","volume":"31","author":"JW Kaempf","year":"2011","unstructured":"Kaempf JW, Kaempf AJ, Wu Y, Stawarz M, Niemeyer J, Grunkemeier G . Hyperglycemia, insulin and slower growth velocity may increase the risk of retinopathy of prematurity. J Perinatol 2011;31:251\u20137.","journal-title":"J Perinatol"},{"key":"BFpr2012184_CR8","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/sj.jp.7211593","volume":"26","author":"LS Kao","year":"2006","unstructured":"Kao LS, Morris BH, Lally KP, Stewart CD, Huseby V, Kennedy KA . Hyperglycemia and morbidity and mortality in extremely low birth weight infants. J Perinatol 2006;26:730\u20136.","journal-title":"J Perinatol"},{"issue":"3 Pt 1","key":"BFpr2012184_CR9","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1542\/peds.113.3.537","volume":"113","author":"D Mitanchez-Mokhtari","year":"2004","unstructured":"Mitanchez-Mokhtari D, Lahlou N, Kieffer F, Magny JF, Roger M, Voyer M . Both relative insulin resistance and defective islet beta-cell processing of proinsulin are responsible for transient hyperglycemia in extremely preterm infants. Pediatrics 2004;113(3 Pt 1):537\u201341.","journal-title":"Pediatrics"},{"key":"BFpr2012184_CR10","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.jpeds.2010.12.040","volume":"158","author":"SK Chacko","year":"2011","unstructured":"Chacko SK, Ordonez J, Sauer PJ, Sunehag AL . Gluconeogenesis is not regulated by either glucose or insulin in extremely low birth weight infants receiving total parenteral nutrition. J Pediatr 2011;158:891\u20136.","journal-title":"J Pediatr"},{"key":"BFpr2012184_CR11","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1210\/en.2009-0777","volume":"151","author":"CL Blanco","year":"2010","unstructured":"Blanco CL, Liang H, Joya-Galeana J, DeFronzo RA, McCurnin D, Musi N . The ontogeny of insulin signaling in the preterm baboon model. Endocrinology 2010;151:1990\u20137.","journal-title":"Endocrinology"},{"key":"BFpr2012184_CR12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0014-4800(82)90045-4","volume":"37","author":"MB Escobedo","year":"1982","unstructured":"Escobedo MB, Hilliard JL, Smith F, et al. A baboon model of bronchopulmonary dysplasia. I. Clinical features. Exp Mol Pathol 1982;37:323\u201334.","journal-title":"Exp Mol Pathol"},{"key":"BFpr2012184_CR13","doi-asserted-by":"publisher","first-page":"e1262","DOI":"10.1542\/peds.2008-2045","volume":"122","author":"D McCurnin","year":"2008","unstructured":"McCurnin D, Clyman RI . Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons. Pediatrics 2008;122:e1262\u20137.","journal-title":"Pediatrics"},{"key":"BFpr2012184_CR14","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2337\/db07-0790","volume":"57","author":"AO Chavez","year":"2008","unstructured":"Chavez AO, Lopez-Alvarenga JC, Tejero ME, et al. Physiological and molecular determinants of insulin action in the baboon. Diabetes 2008;57:899\u2013908.","journal-title":"Diabetes"},{"key":"BFpr2012184_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1600-0684.2009.00384.x","volume":"38","author":"R Guardado-Mendoza","year":"2009","unstructured":"Guardado-Mendoza R, Dick EJ Jr, Jimenez-Ceja LM, et al. Spontaneous pathology of the baboon endocrine system. J Med Primatol 2009;38:383\u20139.","journal-title":"J Med Primatol"},{"key":"BFpr2012184_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-2431-10-52","volume":"10","author":"NM van der Lugt","year":"2010","unstructured":"van der Lugt NM, Smits-Wintjens VE, van Zwieten PH, Walther FJ . Short and long term outcome of neonatal hyperglycemia in very preterm infants: a retrospective follow-up study. BMC Pediatr 2010;10:52.","journal-title":"BMC Pediatr"},{"key":"BFpr2012184_CR17","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1161\/01.CIR.96.6.1750","volume":"96","author":"M Muggeo","year":"1997","unstructured":"Muggeo M, Verlato G, Bonora E, Zoppini G, Corbellini M, de Marco R . Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study. Circulation 1997;96:1750\u20134.","journal-title":"Circulation"},{"key":"BFpr2012184_CR18","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1007\/BF00401838","volume":"38","author":"M Muggeo","year":"1995","unstructured":"Muggeo M, Verlato G, Bonora E, et al. Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: the Verona Diabetes Study. Diabetologia 1995;38:672\u20139.","journal-title":"Diabetologia"},{"key":"BFpr2012184_CR19","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/PCC.0b013e3181e88b1f","volume":"11","author":"AJ Rake","year":"2010","unstructured":"Rake AJ, Srinivasan V, Nadkarni V, Kaptan R, Newth CJ . Glucose variability and survival in critically ill children: allostasis or harm? Pediatr Crit Care Med 2010;11:707\u201312.","journal-title":"Pediatr Crit Care Med"},{"key":"BFpr2012184_CR20","first-page":"527","volume":"12","author":"K Shiroyama","year":"1998","unstructured":"Shiroyama K, Moriwaki K, Yuge O . The direct effect of dopamine on glucose release from primary cultured rat hepatocytes.\nIn Vivo 1998;12:527\u20139.","journal-title":"In Vivo"},{"issue":"2 Pt 1","key":"BFpr2012184_CR21","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1542\/peds.110.2.285","volume":"110","author":"BJ Stoll","year":"2002","unstructured":"Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110(2 Pt 1):285\u201391.","journal-title":"Pediatrics"},{"key":"BFpr2012184_CR22","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jpeds.2010.04.032","volume":"157","author":"K Beardsall","year":"2010","unstructured":"Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, et al. Prevalence and determinants of hyperglycemia in very low birth weight infants: cohort analyses of the NIRTURE study. J Pediatr 2010;157:715\u20139.e1\u20133.","journal-title":"J Pediatr"},{"key":"BFpr2012184_CR23","doi-asserted-by":"crossref","unstructured":"Halliday HL, Ehrenkranz RA, Doyle LW . Early (<8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 2010;1:CD001146.","DOI":"10.1002\/14651858.CD001146.pub3"},{"key":"BFpr2012184_CR24","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1056\/NEJMoa052521","volume":"354","author":"G Van den Berghe","year":"2006","unstructured":"Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354:449\u201361.","journal-title":"N Engl J Med"},{"key":"BFpr2012184_CR25","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1056\/NEJMoa0810625","volume":"360","author":"S Finfer","year":"2009","unstructured":"Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283\u201397.","journal-title":"N Engl J Med"},{"key":"BFpr2012184_CR26","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s00246-009-9512-4","volume":"30","author":"CM Preissig","year":"2009","unstructured":"Preissig CM, Rigby MR, Maher KO . Glycemic control for postoperative pediatric cardiac patients. Pediatr Cardiol 2009;30:1098\u2013104.","journal-title":"Pediatr Cardiol"},{"issue":"Suppl 5","key":"BFpr2012184_CR27","first-page":"S128","volume":"83","author":"R Garcia Branco","year":"2007","unstructured":"Garcia Branco R, Tasker RC, Ramos Garcia PC, Piva JP, Dias Xavier L . Glycemic control and insulin therapy in sepsis and critical illness. J Pediatr (Rio J) 2007;83:Suppl 5:S128\u201336.","journal-title":"J Pediatr (Rio J)"},{"key":"BFpr2012184_CR28","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/01.TA.0000162141.26392.07","volume":"58","author":"GV Bochicchio","year":"2005","unstructured":"Bochicchio GV, Sung J, Joshi M, et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005;58:921\u20134.","journal-title":"J Trauma"},{"key":"BFpr2012184_CR29","first-page":"540","volume":"51","author":"DC Gore","year":"2001","unstructured":"Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M . Association of hyperglycemia with increased mortality after severe burn injury. J Trauma 2001;51:540\u20134.","journal-title":"J Trauma"},{"key":"BFpr2012184_CR30","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000083863","volume":"87","author":"SM Ng","year":"2005","unstructured":"Ng SM, May JE, Emmerson AJ . Continuous insulin infusion in hyperglycaemic extremely-low- birth-weight neonates. Biol Neonate 2005;87:269\u201372.","journal-title":"Biol Neonate"},{"key":"BFpr2012184_CR31","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.earlhumdev.2008.09.013","volume":"84","author":"K Beardsall","year":"2008","unstructured":"Beardsall K, Dunger D . Insulin therapy in preterm newborns. Early Hum Dev 2008;84:839\u201342.","journal-title":"Early Hum Dev"},{"key":"BFpr2012184_CR32","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1001\/jama.2008.886","volume":"300","author":"PH Whincup","year":"2008","unstructured":"Whincup PH, Kaye SJ, Owen CG, et al. Birth weight and risk of type 2 diabetes: a systematic review. JAMA 2008;300:2886\u201397.","journal-title":"JAMA"},{"issue":"5 Suppl 2","key":"BFpr2012184_CR33","doi-asserted-by":"publisher","first-page":"1674S","DOI":"10.1093\/jn\/133.5.1674S","volume":"133","author":"PM Catalano","year":"2003","unstructured":"Catalano PM, Kirwan JP, Haugel-de Mouzon S, King J . Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus. J Nutr 2003;133:5 Suppl 2:1674S\u201383S.","journal-title":"J Nutr"},{"key":"BFpr2012184_CR34","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1056\/NEJMoa042275","volume":"351","author":"PL Hofman","year":"2004","unstructured":"Hofman PL, Regan F, Jackson WE, et al. Premature birth and later insulin resistance. N Engl J Med 2004;351:2179\u201386.","journal-title":"N Engl J Med"},{"key":"BFpr2012184_CR35","doi-asserted-by":"publisher","first-page":"E226","DOI":"10.1152\/ajpendo.00046.2002","volume":"283","author":"MM Chi","year":"2002","unstructured":"Chi MM, Hoehn A, Moley KH . Metabolic changes in the glucose-induced apoptotic blastocyst suggest alterations in mitochondrial physiology. Am J Physiol Endocrinol Metab 2002;283:E226\u201332.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFpr2012184_CR36","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1067\/mpd.2002.128891","volume":"141","author":"R Wang","year":"2002","unstructured":"Wang R, Mart\u00ednez-Fr\u00edas ML, Graham JM Jr . Infants of diabetic mothers are at increased risk for the oculo-auriculo-vertebral sequence: a case-based and case-control approach. J Pediatr 2002;141:611\u20137.","journal-title":"J Pediatr"},{"key":"BFpr2012184_CR37","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1164\/rccm.200502-230OC","volume":"172","author":"DC McCurnin","year":"2005","unstructured":"McCurnin DC, Yoder BA, Coalson J, et al. Effect of ductus ligation on cardiopulmonary function in premature baboons. Am J Respir Crit Care Med 2005;172:1569\u201374.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr2012184_CR38","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1084-2756(03)00113-1","volume":"9","author":"RM Cowett","year":"2004","unstructured":"Cowett RM, Farrag HM . Selected principles of perinatal-neonatal glucose metabolism. Semin Neonatol 2004;9:37\u201347.","journal-title":"Semin Neonatol"},{"key":"BFpr2012184_CR39","unstructured":"Denne SC, Poindexter BB, Leitch CA, Ernst JA, Lemons PK, Lemons JA . Nutrition and metabolism in the high risk neonate. In: Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine. Diseases of the Fetus and Infant. Philadelphia, PA: Mosby-Elsevier, 2006:661\u201391."},{"key":"BFpr2012184_CR40","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1530\/JOE-12-0070","volume":"214","author":"AR Quinn","year":"2012","unstructured":"Quinn AR, Blanco CL, Perego C, et al. The ontogeny of the endocrine pancreas in the fetal\/newborn baboon. J Endocrinol 2012;214:289\u201399.","journal-title":"J Endocrinol"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2012184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012184","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2012184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:56:39Z","timestamp":1684472199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2012184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,7]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["BFpr2012184"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.184","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,7]]}}}