{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:32:40Z","timestamp":1775482360316,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1038\/pr.2012.23","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T16:59:23Z","timestamp":1329325163000},"page":"653-660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups"],"prefix":"10.1038","volume":"71","author":[{"given":"Silvia","family":"Gazzin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Zelenka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Zdrahalova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Konickova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Coda","family":"Zabetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo J.","family":"Giraudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L.","family":"Berengeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Raseni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libor","family":"Vitek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Tiribelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"BFpr201223_CR1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/0140-6736(91)90074-Y","volume":"338","author":"DA Benaron","year":"1991","unstructured":"Benaron DA, Bowen FW . Variation of initial serum bilirubin rise in newborn infants with type of illness. Lancet 1991;338:78\u201381.","journal-title":"Lancet"},{"key":"BFpr201223_CR2","first-page":"12","volume":"2","author":"VK Bhutani","year":"2005","unstructured":"Bhutani VK, Johnson L . 2005 Kernicterus: a preventable neonatal brain injury. J Arab Neonatal Forum 2005;2:12\u201324.","journal-title":"J Arab Neonatal Forum"},{"key":"BFpr201223_CR3","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1203\/PDR.0b013e3181568c94","volume":"62","author":"SD Calligaris","year":"2007","unstructured":"Calligaris SD, Bellarosa C, Giraudi P, Wennberg RP, Ostrow JD, Tiribelli C . Cytotoxicity is predicted by unbound and not total bilirubin concentration. Pediatr Res 2007;62:576\u201380.","journal-title":"Pediatr Res"},{"key":"BFpr201223_CR4","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1093\/oxfordjournals.jbchem.a135003","volume":"96","author":"M Takahashi","year":"1984","unstructured":"Takahashi M, Sugiyama K, Shumiya S, Nagase S . Penetration of bilirubin into the brain in albumin-deficient and jaundiced rats (AJR) and Nagase analbuminemic rats (NAR). J Biochem 1984;96:1705\u201312.","journal-title":"J Biochem"},{"key":"BFpr201223_CR5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1053\/j.semperi.2004.09.002","volume":"28","author":"CE Ahlfors","year":"2004","unstructured":"Ahlfors CE, Wennberg RP . Bilirubin-albumin binding and neonatal jaundice. Semin Perinatol 2004;28:334\u20139.","journal-title":"Semin Perinatol"},{"key":"BFpr201223_CR6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000091843","volume":"90","author":"C Cannon","year":"2006","unstructured":"Cannon C, Daood MJ, O\u2019Day TL, Watchko JF . Sex-specific regional brain bilirubin content in hyperbilirubinemic Gunn rat pups. Biol Neonate 2006;90:40\u20135.","journal-title":"Biol Neonate"},{"key":"BFpr201223_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000242905","volume":"55","author":"S Aono","year":"1989","unstructured":"Aono S, Semba R, Sato H, Kashiwamata S . Mode of bilirubin deposition in the cerebellum of developing jaundiced Gunn rats. Biol Neonate 1989;55:119\u201323.","journal-title":"Biol Neonate"},{"key":"BFpr201223_CR8","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1203\/01.pdr.0000219561.07550.04","volume":"60","author":"MJ Daood","year":"2006","unstructured":"Daood MJ, Watchko JF . Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups. Pediatr Res 2006;60:44\u20139.","journal-title":"Pediatr Res"},{"key":"BFpr201223_CR9","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.1542\/peds.106.2.e15","volume":"106","author":"TW Hansen","year":"2000","unstructured":"Hansen TW . Pioneers in the scientific study of neonatal jaundice and kernicterus. Pediatrics 2000;106:E15.","journal-title":"Pediatrics"},{"key":"BFpr201223_CR10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jchromb.2008.03.005","volume":"867","author":"J Zelenka","year":"2008","unstructured":"Zelenka J, Len\u00edcek M, Muchov\u00e1 L,et al. Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues. J Chromatogr B Analyt Technol Biomed Life Sci 2008;867:37\u201342.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"BFpr201223_CR11","first-page":"722","volume":"43","author":"J Kapitulnik","year":"1993","unstructured":"Kapitulnik J, Gonzalez FJ . Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol Pharmacol 1993;43:722\u20135.","journal-title":"Mol Pharmacol"},{"key":"BFpr201223_CR12","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1002\/rcm.2431","volume":"20","author":"F De Matteis","year":"2006","unstructured":"De Matteis F, Lord GA, Kee Lim C, Pons N . Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high-performance liquid chromatography\/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2006;20:1209\u201317.","journal-title":"Rapid Commun Mass Spectrom"},{"key":"BFpr201223_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0006-2952(03)00284-3","volume":"66","author":"N Pons","year":"2003","unstructured":"Pons N, Pipino S, De Matteis F . Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. Biochem Pharmacol 2003;66:405\u201314.","journal-title":"Biochem Pharmacol"},{"key":"BFpr201223_CR14","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.bcp.2005.08.009","volume":"70","author":"A Abu-Bakar","year":"2005","unstructured":"Abu-Bakar A, Moore MR, Lang MA . Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochem Pharmacol 2005;70:1527\u201335.","journal-title":"Biochem Pharmacol"},{"key":"BFpr201223_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1203\/01.PDR.0000085169.87948.B6","volume":"54","author":"E Hank\u00f8","year":"2003","unstructured":"Hank\u00f8 E, Tommarello S, Watchko JF, Hansen TW . Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain. Pediatr Res 2003;54:441\u20135.","journal-title":"Pediatr Res"},{"issue":"Suppl 1","key":"BFpr201223_CR16","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1038\/sj.jp.7210633","volume":"21","author":"JF Watchko","year":"2001","unstructured":"Watchko JF, Daood MJ, Mahmood B, Vats K, Hart C, Ahdab-Barmada M . P-glycoprotein and bilirubin disposition. J Perinatol 2001;21:Suppl 1:S43\u20137; discussion S59\u201362.","journal-title":"J Perinatol"},{"key":"BFpr201223_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1042\/BJ20080918","volume":"417","author":"L Corich","year":"2009","unstructured":"Corich L, Aranda A, Carrassa L, Bellarosa C, Ostrow JD, Tiribelli C . The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1. Biochem J 2009;417:305\u201312.","journal-title":"Biochem J"},{"key":"BFpr201223_CR18","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/j.febslet.2006.01.056","volume":"580","author":"S Calligaris","year":"2006","unstructured":"Calligaris S, Cekic D, Roca-Burgos L,et al. Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity. FEBS Lett 2006;580:1355\u20139.","journal-title":"FEBS Lett"},{"key":"BFpr201223_CR19","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.neuroscience.2006.10.026","volume":"144","author":"AS Falc\u00e3o","year":"2007","unstructured":"Falc\u00e3o AS, Bellarosa C, Fernandes A,et al. Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Neuroscience 2007;144:878\u201388.","journal-title":"Neuroscience"},{"key":"BFpr201223_CR20","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s00431-005-0055-2","volume":"165","author":"KA Strauss","year":"2006","unstructured":"Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH . Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006;165:306\u201319.","journal-title":"Eur J Pediatr"},{"key":"BFpr201223_CR21","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1046\/j.1365-2362.2003.01261.x","volume":"33","author":"JD Ostrow","year":"2003","unstructured":"Ostrow JD, Pascolo L, Shapiro SM, Tiribelli C . New concepts in bilirubin encephalopathy. Eur J Clin Invest 2003;33:988\u201397.","journal-title":"Eur J Clin Invest"},{"key":"BFpr201223_CR22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1385\/NMM:8:4:513","volume":"8","author":"JF Watchko","year":"2006","unstructured":"Watchko JF . Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular Med 2006;8:513\u201329.","journal-title":"Neuromolecular Med"},{"key":"BFpr201223_CR23","first-page":"149","volume":"37","author":"JR Chowdhury","year":"1993","unstructured":"Chowdhury JR, Kondapalli R, Chowdhury NR . Gunn rat: a model for inherited deficiency of bilirubin glucuronidation. Adv Vet Sci Comp Med 1993;37:149\u201373.","journal-title":"Adv Vet Sci Comp Med"},{"key":"BFpr201223_CR24","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s004010050639","volume":"93","author":"JW Conlee","year":"1997","unstructured":"Conlee JW, Shapiro SM . Development of cerebellar hypoplasia in jaundiced Gunn rats: a quantitative light microscopic analysis. Acta Neuropathol 1997;93:450\u201360.","journal-title":"Acta Neuropathol"},{"key":"BFpr201223_CR25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000120237","volume":"12","author":"H Keino","year":"1985","unstructured":"Keino H, Sato H, Semba R, Aono S, Aoki E, Kashiwamata S . Mode of prevention by phototherapy of cerebellar hypoplasia in a new Sprague-Dawley strain of jaundiced Gunn rats. Pediatr Neurosci 1985;12:145\u201350.","journal-title":"Pediatr Neurosci"},{"key":"BFpr201223_CR26","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1172\/JCI104858","volume":"42","author":"R Schmid","year":"1963","unstructured":"Schmid R, Hammaker L . Metabolism and disposition of c14-bilirubin in congenital nonhemolytic jaundice. J Clin Invest 1963;42:1720\u201334.","journal-title":"J Clin Invest"},{"key":"BFpr201223_CR27","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1073\/pnas.75.2.682","volume":"75","author":"J Kapitulnik","year":"1978","unstructured":"Kapitulnik J, Ostrow JD . Stimulation of bilirubin catabolism in jaundiced Gunn rats by an induced of microsomal mixed-function monooxygenases. Proc Natl Acad Sci USA 1978;75:682\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr201223_CR28","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S0006-2952(01)00568-8","volume":"61","author":"C Zaccaro","year":"2001","unstructured":"Zaccaro C, Sweitzer S, Pipino S,et al. Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-\/-) mutant mice. Biochem Pharmacol 2001;61:843\u20139.","journal-title":"Biochem Pharmacol"},{"key":"BFpr201223_CR29","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000047136","volume":"80","author":"CE Ahlfors","year":"2001","unstructured":"Ahlfors CE, Shapiro SM . Auditory brainstem response and unbound bilirubin in jaundiced (jj) Gunn rat pups. Biol Neonate 2001;80:158\u201362.","journal-title":"Biol Neonate"},{"key":"BFpr201223_CR30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/oxfordjournals.jhered.a104478","volume":"29","author":"CH Gunn","year":"1938","unstructured":"Gunn CH . Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 1938;29:137\u20139.","journal-title":"J Hered"},{"key":"BFpr201223_CR31","unstructured":"Zarattini P, Gazzin S, Stebel M. Improvement of a historical animal model for Crigler Najjar Type I syndrome: development of the normobilirubinemic JJ genotype as a true control for the Gunn jaundiced rat, 2011. Experimental Models: 110-114. (\n                    http:\/\/www.felasa.eu\/media\/uploads\/Proceedings_FELASA-ScandLAS-2010_small_SEC.pdf\n                    \n                  )."},{"key":"BFpr201223_CR32","doi-asserted-by":"publisher","first-page":"e16165","DOI":"10.1371\/journal.pone.0016165","volume":"6","author":"S Gazzin","year":"2011","unstructured":"Gazzin S, Berengeno AL, Strazielle N,et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS ONE 2011;6:e16165.","journal-title":"PLoS ONE"},{"key":"BFpr201223_CR33","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.21808","volume":"510","author":"S Gazzin","year":"2008","unstructured":"Gazzin S, Strazielle N, Schmitt C,et al. Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol 2008;510:497\u2013507.","journal-title":"J Comp Neurol"}],"updated-by":[{"DOI":"10.1038\/pr.2012.44","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T00:00:00Z","timestamp":1337212800000}}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201223","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:56:51Z","timestamp":1684472211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["BFpr201223"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.23","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/pr.2012.44","asserted-by":"object"}]},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,15]]},"assertion":[{"value":"6 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}