{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:25Z","timestamp":1790713405867,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1038\/pr.2012.26","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T16:59:23Z","timestamp":1329325163000},"page":"645-652","source":"Crossref","is-referenced-by-count":33,"title":["Intracerebral lipopolysaccharide induces neuroinflammatory change and augmented brain injury in growth-restricted neonatal rats"],"prefix":"10.1038","volume":"71","author":[{"given":"Leigh R.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma B.","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara T.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"BFpr201226_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1042\/cs0950115","volume":"95","author":"DJ Barker","year":"1998","unstructured":"Barker DJ . In utero programming of chronic disease. Clin Sci 1998; 95:115\u201328.","journal-title":"Clin Sci"},{"key":"BFpr201226_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1034\/j.1600-0412.2002.810204.x","volume":"81","author":"T Henriksen","year":"2002","unstructured":"Henriksen T, Clausen T . The fetal origins hypothesis: placental insufficiency and inheritance versus maternal malnutrition in well-nourished populations. Acta Obstet Gynecol Scand 2002;81:112\u20134.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"BFpr201226_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3109\/00016349409006268","volume":"73","author":"R Laurini","year":"1994","unstructured":"Laurini R, Laurin J, Mars\u00e1l K . Placental histology and fetal blood flow in intrauterine growth retardation. Acta Obstet Gynecol Scand 1994; 73:529\u201334.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"BFpr201226_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1542\/peds.2005-2343","volume":"118","author":"R Geva","year":"2006","unstructured":"Geva R, Eshel R, Leitner Y, Valevski AF, Harel S . Neuropsychological outcome of children with intrauterine growth restriction: a 9-year prospective study. Pediatrics 2006;118:91\u2013100.","journal-title":"Pediatrics"},{"key":"BFpr201226_CR5","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/S0140-6736(03)14466-2","volume":"362","author":"S Jarvis","year":"2003","unstructured":"Jarvis S, Glinianaia SV, Torrioli MG, et al. Cerebral palsy and intrauterine growth in single births: European collaborative study. Lancet 2003; 362:1106\u201311.","journal-title":"Lancet"},{"key":"BFpr201226_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ijdevneu.2007.08.020","volume":"26","author":"S Rees","year":"2008","unstructured":"Rees S, Harding R, Walker D . An adverse intrauterine environment: implications for injury and altered development of the brain. Int J Dev Neurosci 2008;26:3\u201311.","journal-title":"Int J Dev Neurosci"},{"key":"BFpr201226_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.nbd.2007.01.001","volume":"26","author":"P Olivier","year":"2007","unstructured":"Olivier P, Baud O, Bouslama M, Evrard P, Gressens P, Verney C . Moderate growth restriction: deleterious and protective effects on white matter damage. Neurobiol Dis 2007;26:253\u201363.","journal-title":"Neurobiol Dis"},{"key":"BFpr201226_CR8","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1203\/00006450-200111000-00003","volume":"50","author":"JJ Volpe","year":"2001","unstructured":"Volpe JJ . Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 2001;50:553\u201362.","journal-title":"Pediatr Res"},{"key":"BFpr201226_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0006-8993(03)02545-9","volume":"975","author":"Z Cai","year":"2003","unstructured":"Cai Z, Pang Y, Lin S, Rhodes PG . Differential roles of tumor necrosis factor-\u03b1 and interleukin-1\u03b2 in lipopolysaccharide-induced brain injury in the neonatal rat. Brain Res 2003;975:37\u201347.","journal-title":"Brain Res"},{"key":"BFpr201226_CR10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0165-3806(02)00606-5","volume":"140","author":"Y Pang","year":"2003","unstructured":"Pang Y, Cai Z, Rhodes PG . Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide. Brain Res Dev Brain Res 2003;140:205\u201314.","journal-title":"Brain Res Dev Brain Res"},{"key":"BFpr201226_CR11","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1203\/PDR.0b013e3181dc240f","volume":"67","author":"Y Pang","year":"2010","unstructured":"Pang Y, Zheng B, Campbell LR, Fan LW, Cai Z, Rhodes PG . IGF-1 can either protect against or increase LPS-induced damage in the developing rat brain. Pediatr Res 2010;67:579\u201384.","journal-title":"Pediatr Res"},{"key":"BFpr201226_CR12","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.150.7.2659","volume":"150","author":"SC Lee","year":"1993","unstructured":"Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW . Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1\u03b2. J Immunol 1993;150:2659\u201367.","journal-title":"J Immunol"},{"key":"BFpr201226_CR13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1203\/00006450-200001000-00013","volume":"47","author":"Z Cai","year":"2000","unstructured":"Cai Z, Pan ZL, Pang Y, Evans OB, Rhodes PG . Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res 2000;47:64\u201372.","journal-title":"Pediatr Res"},{"key":"BFpr201226_CR14","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1212\/WNL.56.10.1278","volume":"56","author":"H Kadhim","year":"2001","unstructured":"Kadhim H, Tabarki B, Verellen G, De Prez C, Rona AM, S\u00e9bire G . Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology 2001;56:1278\u201384.","journal-title":"Neurology"},{"key":"BFpr201226_CR15","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/jlb.65.6.744","volume":"65","author":"S Yamagami","year":"1999","unstructured":"Yamagami S, Tamura M, Hayashi M, et al. Differential production of MCP-1 and cytokine-induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats. J Leukoc Biol 1999;65:744\u201349.","journal-title":"J Leukoc Biol"},{"key":"BFpr201226_CR16","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1254\/jphs.08298FP","volume":"109","author":"T Katayama","year":"2009","unstructured":"Katayama T, Tanaka H, Yoshida T, Uehara T, Minami M . Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes. J Pharmacol Sci 2009;109:88\u201393.","journal-title":"J Pharmacol Sci"},{"key":"BFpr201226_CR17","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1523\/JNEUROSCI.22-07-02478.2002","volume":"22","author":"S Lehnardt","year":"2002","unstructured":"Lehnardt S, Lachance C, Patrizi S, et al. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 2002;22:2478\u201386.","journal-title":"J Neurosci"},{"key":"BFpr201226_CR18","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.bbi.2009.11.005","volume":"24","author":"GA Lodygensky","year":"2010","unstructured":"Lodygensky GA, West T, Stump M, Holtzman DM, Inder TE, Neil JJ . In vivo MRI analysis of an inflammatory injury in the developing brain. Brain Behav Immun 2010;24:759\u201367.","journal-title":"Brain Behav Immun"},{"key":"BFpr201226_CR19","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S0887-8994(97)00041-6","volume":"16","author":"K Deguchi","year":"1997","unstructured":"Deguchi K, Oguchi K, Takashima S . Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol 1997;16:296\u2013300.","journal-title":"Pediatr Neurol"},{"key":"BFpr201226_CR20","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1089\/ars.2006.8.911","volume":"8","author":"G Guo","year":"2006","unstructured":"Guo G, Bhat NR . Hypoxia\/reoxygenation differentially modulates NF-\u03baB activation and iNOS expression in astrocytes and microglia. Antioxid Redox Signal 2006;8:911\u20138.","journal-title":"Antioxid Redox Signal"},{"key":"BFpr201226_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.brainres.2006.04.129","volume":"1098","author":"C Burke","year":"2006","unstructured":"Burke C, Sinclair K, Cowin G, et al. Intrauterine growth restriction due to uteroplacental vascular insufficiency leads to increased hypoxia-induced cerebral apoptosis in newborn piglets. Brain Res 2006;1098:19\u201325.","journal-title":"Brain Res"},{"key":"BFpr201226_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0920-9964(99)00041-9","volume":"40","author":"EC Mallard","year":"1999","unstructured":"Mallard EC, Rehn A, Rees S, Tolcos M, Copolov D . Ventriculomegaly and reduced hippocampal volume following intrauterine growth-restriction: implications for the aetiology of schizophrenia. Schizophr Res 1999;40:11\u201321.","journal-title":"Schizophr Res"},{"key":"BFpr201226_CR23","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/S0006-8993(01)02074-1","volume":"895","author":"RH Lane","year":"2001","unstructured":"Lane RH, Ramirez RJ, Tsirka AE, et al. Uteroplacental insufficiency lowers the threshold towards hypoxia-induced cerebral apoptosis in growth-retarded fetal rats. Brain Res 2001;895:186\u201393.","journal-title":"Brain Res"},{"key":"BFpr201226_CR24","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1111\/j.1651-2227.2007.00496.x","volume":"96","author":"NF Padilla-Gomes","year":"2007","unstructured":"Padilla-Gomes NF, Enr\u00edquez G, Acosta-Rojas R, Perapoch J, Hernandez-Andrade E, Gratacos E . Prevalence of neonatal ultrasound brain lesions in premature infants with and without intrauterine growth restriction. Acta Paediatr 2007;96:1582\u20137.","journal-title":"Acta Paediatr"},{"key":"BFpr201226_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0014-4886(03)00032-3","volume":"181","author":"A Craig","year":"2003","unstructured":"Craig A, Ling Luo N, Beardsley DJ, et al. Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human. Exp Neurol 2003;181:231\u201340.","journal-title":"Exp Neurol"},{"key":"BFpr201226_CR26","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1148\/radiology.168.3.3406411","volume":"168","author":"LL Baker","year":"1988","unstructured":"Baker LL, Stevenson DK, Enzmann DR . End-stage periventricular leukomalacia: MR evaluation. Radiology 1988;168:809\u201315.","journal-title":"Radiology"},{"key":"BFpr201226_CR27","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1148\/radiology.214.1.r00dc35199","volume":"214","author":"ER Melhem","year":"2000","unstructured":"Melhem ER, Hoon AH Jr, Ferrucci JT Jr, et al. Periventricular leukomalacia: relationship between lateral ventricular volume on brain MR images and severity of cognitive and motor impairment. Radiology 2000;214:199\u2013204.","journal-title":"Radiology"},{"key":"BFpr201226_CR28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1447-0756.2003.00174.x","volume":"30","author":"L Yang","year":"2004","unstructured":"Yang L, Sameshima H, Ikeda T, Ikenoue T . Lipopolysaccharide administration enhances hypoxic-ischemic brain damage in newborn rats. J Obstet Gynaecol Res 2004;30:142\u20137.","journal-title":"J Obstet Gynaecol Res"},{"key":"BFpr201226_CR29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1203\/01.PDR.0000163513.03619.8D","volume":"58","author":"S Eklind","year":"2005","unstructured":"Eklind S, Mallard C, Arvidsson P, Hagberg H . Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain. Pediatr Res 2005;58:112\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr201226_CR30","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1203\/01.pdr.0000191140.87314.ce","volume":"59","author":"T Ikeda","year":"2006","unstructured":"Ikeda T, Yang L, Ikenoue T, Mallard C, Hagberg H . Endotoxin-induced hypoxic-ischemic tolerance is mediated by up-regulation of corticosterone in neonatal rat. Pediatr Res 2006;59:56\u201360.","journal-title":"Pediatr Res"},{"key":"BFpr201226_CR31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1055\/s-2000-9423","volume":"17","author":"MJ Simchen","year":"2000","unstructured":"Simchen MJ, Beiner ME, Strauss-Liviathan N, et al. Neonatal outcome in growth-restricted versus appropriately grown preterm infants. Am J Perinatol 2000;17:187\u201392.","journal-title":"Am J Perinatol"},{"key":"BFpr201226_CR32","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.ajog.2004.01.036","volume":"191","author":"TJ Garite","year":"2004","unstructured":"Garite TJ, Clark R, Thorp JA . Intrauterine growth restriction increases morbidity and mortality among premature neonates. Am J Obstet Gynecol 2004;191:481\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201226_CR33","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1161\/01.HYP.0000053448.95913.3D","volume":"41","author":"BT Alexander","year":"2003","unstructured":"Alexander BT . Placental insufficiency leads to development of hypertension in growth-restricted offspring. Hypertension 2003;41:457\u201362.","journal-title":"Hypertension"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201226","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T18:47:31Z","timestamp":1686768451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["BFpr201226"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.26","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,15]]}}}