{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:13:48Z","timestamp":1769836428968,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1038\/pr.2012.89","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T15:59:35Z","timestamp":1342195175000},"page":"370-374","source":"Crossref","is-referenced-by-count":25,"title":["TNF-\u03b1\/IL-2 ratio discriminates latent from active tuberculosis in immunocompetent children: a pilot study"],"prefix":"10.1038","volume":"72","author":[{"given":"Nad\u00e8ge","family":"Gourgouillon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"de Lauzanne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles-Henry","family":"Cottart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Curis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Debord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Gu\u00e9rin-El Khourouj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"P\u00e9dron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Faye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghislaine","family":"Sterkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"BFpr201289_CR1","unstructured":"WHO report. Global tuberculosis control 2011. WHO, 2011. ( http:\/\/www.who.int\/tb\/publications\/global_report\/2011\/gtbr11_full.pdf .)"},{"key":"BFpr201289_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ccm.2005.02.010","volume":"26","author":"K Feja","year":"2005","unstructured":"Feja K, Saiman L . Tuberculosis in children. Clin Chest Med 2005;26:295\u2013312, vii.","journal-title":"Clin Chest Med"},{"issue":"Suppl","key":"BFpr201289_CR3","doi-asserted-by":"crossref","first-page":"iv24","DOI":"10.1136\/ard.2005.042531","volume":"64","author":"S Stenger","year":"2005","unstructured":"Stenger S . Immunological control of tuberculosis: role of tumour necrosis factor and more. Ann Rheum Dis 2005;64:Suppl 4:iv24\u20138.","journal-title":"Ann Rheum Dis"},{"key":"BFpr201289_CR4","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/S0140-6736(06)68579-6","volume":"367","author":"G Ferrara","year":"2006","unstructured":"Ferrara G, Losi M, D\u2019Amico R, et al. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 2006;367:1328\u201334.","journal-title":"Lancet"},{"key":"BFpr201289_CR5","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S1473-3099(04)01203-4","volume":"4","author":"E van de Vosse","year":"2004","unstructured":"van de Vosse E, Hoeve MA, Ottenhoff TH . Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae. Lancet Infect Dis 2004;4:739\u201349.","journal-title":"Lancet Infect Dis"},{"key":"BFpr201289_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2174\/156652407780598557","volume":"7","author":"GA Rook","year":"2007","unstructured":"Rook GA . Th2 cytokines in susceptibility to tuberculosis. Curr Mol Med 2007;7:327\u201337.","journal-title":"Curr Mol Med"},{"key":"BFpr201289_CR7","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.vaccine.2009.11.004","volume":"28","author":"MK Lalor","year":"2010","unstructured":"Lalor MK, Smith SG, Floyd S, et al. Complex cytokine profiles induced by BCG vaccination in UK infants. Vaccine 2010;28:1635\u201341.","journal-title":"Vaccine"},{"key":"BFpr201289_CR8","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1002\/eji.201040731","volume":"40","author":"KA Wilkinson","year":"2010","unstructured":"Wilkinson KA, Wilkinson RJ . Polyfunctional T cells in human tuberculosis. Eur J Immunol 2010;40:2139\u201342.","journal-title":"Eur J Immunol"},{"key":"BFpr201289_CR9","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nm.2299","volume":"17","author":"A Harari","year":"2011","unstructured":"Harari A, Rozot V, Enders FB, et al. Dominant TNF-a+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat Med 2011;17:372\u20136.","journal-title":"Nat Med"},{"key":"BFpr201289_CR10","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.4049\/jimmunol.180.5.3569","volume":"180","author":"AP Soares","year":"2008","unstructured":"Soares AP, Scriba TJ, Joseph S, et al. Bacillus Calmette-Gu\u00e9rin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J Immunol 2008;180:3569\u201377.","journal-title":"J Immunol"},{"key":"BFpr201289_CR11","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1056\/NEJMcp021045","volume":"347","author":"RM Jasmer","year":"2002","unstructured":"Jasmer RM, Nahid P, Hopewell PC . Clinical practice. Latent tuberculosis infection. N Engl J Med 2002;347:1860\u20136.","journal-title":"N Engl J Med"},{"key":"BFpr201289_CR12","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1097\/INF.0b013e3182272227","volume":"30","author":"C Debord","year":"2011","unstructured":"Debord C, De Lauzanne A, Gourgouillon N, et al. Interferon-gamma release assay performance for diagnosing tuberculosis disease in 0- to 5-year-old children. Pediatr Infect Dis J 2011;30:995\u20137.","journal-title":"Pediatr Infect Dis J"},{"key":"BFpr201289_CR13","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1574-695X.2006.00110.x","volume":"47","author":"R Al-Attiyah","year":"2006","unstructured":"Al-Attiyah R, Madi N, El-Shamy AS, Wiker H, Andersen P, Mustafa A . Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis. FEMS Immunol Med Microbiol 2006;47:254\u201361.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"BFpr201289_CR14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.tube.2004.09.011","volume":"85","author":"TH Ottenhoff","year":"2005","unstructured":"Ottenhoff TH, Verreck FA, Hoeve MA, van de Vosse E . Control of human host immunity to mycobacteria. Tuberculosis (Edinb) 2005;85:53\u201364.","journal-title":"Tuberculosis (Edinb)"},{"key":"BFpr201289_CR15","doi-asserted-by":"publisher","first-page":"6343","DOI":"10.4049\/jimmunol.169.11.6343","volume":"169","author":"J Turner","year":"2002","unstructured":"Turner J, Gonzalez-Juarrero M, Ellis DL, et al. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL\/6 mice. J Immunol 2002;169:6343\u201351.","journal-title":"J Immunol"},{"key":"BFpr201289_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4049\/jimmunol.0903856","volume":"185","author":"PL Lin","year":"2010","unstructured":"Lin PL, Flynn JL . Understanding latent tuberculosis: a moving target. J Immunol 2010;185:15\u201322.","journal-title":"J Immunol"},{"key":"BFpr201289_CR17","first-page":"1548","volume":"14","author":"J Lighter-Fisher","year":"2010","unstructured":"Lighter-Fisher J, Peng CH, Tse DB . Cytokine responses to QuantiFERON\u00ae peptides, purified protein derivative and recombinant ESAT-6 in children with tuberculosis. Int J Tuberc Lung Dis 2010;14:1548\u201355.","journal-title":"Int J Tuberc Lung Dis"},{"key":"BFpr201289_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2466-9-21","volume":"9","author":"NN Chegou","year":"2009","unstructured":"Chegou NN, Black GF, Kidd M, van Helden PD, Walzl G . Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report. BMC Pulm Med 2009;9:21.","journal-title":"BMC Pulm Med"},{"key":"BFpr201289_CR19","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/eji.200838693","volume":"39","author":"JS Sutherland","year":"2009","unstructured":"Sutherland JS, Adetifa IM, Hill PC, Adegbola RA, Ota MO . Pattern and diversity of cytokine production differentiates between Myco-bacterium tuberculosis infection and disease. Eur J Immunol 2009;39:723\u20139.","journal-title":"Eur J Immunol"},{"key":"BFpr201289_CR20","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1111\/j.1469-0691.2009.03104.x","volume":"16","author":"R Biselli","year":"2010","unstructured":"Biselli R, Mariotti S, Sargentini V, et al. Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls. Clin Microbiol Infect 2010;16:1282\u20134.","journal-title":"Clin Microbiol Infect"},{"key":"BFpr201289_CR21","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nri1840","volume":"6","author":"G Pantaleo","year":"2006","unstructured":"Pantaleo G, Harari A . Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat Rev Immunol 2006;6:417\u201323.","journal-title":"Nat Rev Immunol"},{"key":"BFpr201289_CR22","unstructured":"Team RDC . A Language and Environment for Statistical Computing. R Fundation for Statistical Computing, Vienna, Austria, 2011. ( http:\/\/www.r-project.org\/links.html )."},{"key":"BFpr201289_CR23","unstructured":"Tobias J, Sander O, Beerenwinkel N, Lengauer RT. 2009. ROCR: Visualizing the performance of scoring classifiers. R package version 0.0-4. ( http:\/\/CRAN.R-project.org\/package=ROCR .)."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201289","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:34:26Z","timestamp":1743726866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,13]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["BFpr201289"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.89","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,13]]}}}