{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:57:00Z","timestamp":1792493820560,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T00:00:00Z","timestamp":1342742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1038\/pr.2012.96","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T15:55:17Z","timestamp":1342799717000},"page":"375-383","source":"Crossref","is-referenced-by-count":21,"title":["Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS"],"prefix":"10.1038","volume":"72","author":[{"given":"Marla R.","family":"Wolfson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence L.","family":"Hubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mazela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,20]]},"reference":[{"key":"BFpr201296_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/00008480-200104000-00006","volume":"13","author":"AH Jobe","year":"2001","unstructured":"Jobe AH, Ikegami M . Prevention of bronchopulmonary dysplasia. Curr Opin Pediatr 2001;13:124\u20139.","journal-title":"Curr Opin Pediatr"},{"key":"BFpr201296_CR2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1651-2227.2009.01600.x","volume":"99","author":"A Lodha","year":"2010","unstructured":"Lodha A, Asztalos E, Moore AM . Cytokine levels in neonatal necrotizing enterocolitis and long-term growth and neurodevelopment. Acta Paediatr 2010;99:338\u201343.","journal-title":"Acta Paediatr"},{"key":"BFpr201296_CR3","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1542\/peds.109.2.330","volume":"109","author":"American Academy of Pediatrics \u2013 Committee on fetus and newborn and Canadian Paediatric Society \u2013 Fetus and newborn committee","year":"2002","unstructured":"American Academy of Pediatrics \u2013 Committee on fetus and newborn and Canadian Paediatric Society \u2013 Fetus and newborn committee. Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 2002;109:330\u20138.","journal-title":"Pediatrics"},{"key":"BFpr201296_CR4","doi-asserted-by":"publisher","first-page":"L721","DOI":"10.1152\/ajplung.00076.2011","volume":"301","author":"R Sakurai","year":"2011","unstructured":"Sakurai R, Li Y, Torday JS, Rehan VK . Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-\u00df signaling. Am J Physiol Lung Cell Mol Physiol 2011;301:L721\u201330.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr201296_CR5","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1128\/IAI.01043-07","volume":"76","author":"CL George","year":"2008","unstructured":"George CL, Goss KL, Meyerholz DK, Lamb FS, Snyder JM . Surfactant-associated protein A provides critical immunoprotection in neonatal mice. Infect Immun 2008;76:380\u201390.","journal-title":"Infect Immun"},{"key":"BFpr201296_CR6","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1164\/rccm.200912-1818OC","volume":"181","author":"A Sato","year":"2010","unstructured":"Sato A, Whitsett JA, Scheule RK, Ikegami M . Surfactant protein-d inhibits lung inflammation caused by ventilation in premature newborn lambs. Am J Respir Crit Care Med 2010;181:1098\u2013105.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201296_CR7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1164\/rccm.201012-2010OC","volume":"184","author":"A Hilgendorff","year":"2011","unstructured":"Hilgendorff A, Parai K, Ertsey R, et al. Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. Am J Respir Crit Care Med 2011;184:537\u201346.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201296_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1465-9921-10-19","volume":"10","author":"MJ Wallace","year":"2009","unstructured":"Wallace MJ, Probyn ME, Zahra VA, et al. Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs. Respir Res 2009;10:19.","journal-title":"Respir Res"},{"key":"BFpr201296_CR9","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1164\/ajrccm.159.3.9804027","volume":"159","author":"KH Albertine","year":"1999","unstructured":"Albertine KH, Jones GP, Starcher BC, et al. Chronic lung injury in preterm lambs. Disordered respiratory tract development. Am J Respir Crit Care Med 1999;159:945\u201358.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201296_CR10","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1164\/ajrccm.160.4.9810071","volume":"160","author":"JJ Coalson","year":"1999","unstructured":"Coalson JJ, Winter VT, Siler-Khodr T, Yoder BA . Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med 1999;160:1333\u201346.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201296_CR11","doi-asserted-by":"publisher","first-page":"F1","DOI":"10.1136\/fn.73.1.F1","volume":"73","author":"P Groneck","year":"1995","unstructured":"Groneck P, Speer CP . Inflammatory mediators and bronchopulmonary dysplasia. Arch Dis Child Fetal Neonatal Ed 1995;73:F1\u20133.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr201296_CR12","doi-asserted-by":"publisher","first-page":"F455","DOI":"10.1136\/adc.2007.121327","volume":"93","author":"CL Bose","year":"2008","unstructured":"Bose CL, Dammann CE, Laughon MM . Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. Arch Dis Child Fetal Neonatal Ed 2008;93:F455\u201361.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr201296_CR13","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1097\/01.CCM.0000114578.48244.21","volume":"32","author":"AH van Kaam","year":"2004","unstructured":"van Kaam AH, Haitsma JJ, Dik WA, et al. Response to exogenous surfactant is different during open lung and conventional ventilation. Crit Care Med 2004;32:774\u201380.","journal-title":"Crit Care Med"},{"key":"BFpr201296_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1006\/pupt.2002.0383","volume":"15","author":"C Stamme","year":"2002","unstructured":"Stamme C, Brasch F, von Bethmann A, Uhlig S . Effect of surfactant on ventilation-induced mediator release in isolated perfused mouse lungs. Pulm Pharmacol Ther 2002;15:455\u201361.","journal-title":"Pulm Pharmacol Ther"},{"key":"BFpr201296_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1165\/ajrcmb.24.4.4239","volume":"24","author":"JF van Iwaarden","year":"2001","unstructured":"van Iwaarden JF, Claassen E, Jeurissen SH, Haagsman HP, Kraal G . Alveolar macrophages, surfactant lipids, and surfactant protein B regulate the induction of immune responses via the airways. Am J Respir Cell Mol Biol 2001;24:452\u20138.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr201296_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1126\/science.1948032","volume":"254","author":"CG Cochrane","year":"1991","unstructured":"Cochrane CG, Revak SD . Pulmonary surfactant protein B (SP-B): structure-function relationships. Science 1991;254:566\u20138.","journal-title":"Science"},{"key":"BFpr201296_CR17","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1203\/PDR.0b013e318175dd14","volume":"64","author":"Y Zhu","year":"2008","unstructured":"Zhu Y, Miller TL, Chidekel A, Shaffer TH . KL4-surfactant (Lucinactant) protects human airway epithelium from hyperoxia. Pediatr Res 2008;64:154\u20138.","journal-title":"Pediatr Res"},{"issue":"4 Pt 1","key":"BFpr201296_CR18","first-page":"L875","volume":"273","author":"K Tokieda","year":"1997","unstructured":"Tokieda K, Whitsett JA, Clark JC, et al. Pulmonary dysfunction in neonatal SP-B-deficient mice. Am J Physiol 1997;273(4 Pt 1):L875\u201382.","journal-title":"Am J Physiol"},{"key":"BFpr201296_CR19","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1165\/rcmb.2008-0359OC","volume":"41","author":"M Ikegami","year":"2009","unstructured":"Ikegami M, Weaver TE, Grant SN, Whitsett JA . Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation. Am J Respir Cell Mol Biol 2009;41:433\u20139.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr201296_CR20","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1056\/NEJMra022387","volume":"347","author":"JA Whitsett","year":"2002","unstructured":"Whitsett JA, Weaver TE . Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 2002;347:2141\u20138.","journal-title":"N Engl J Med"},{"key":"BFpr201296_CR21","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1056\/NEJM199302113280606","volume":"328","author":"LM Nogee","year":"1993","unstructured":"Nogee LM, de Mello DE, Dehner LP, Colten HR . Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis. N Engl J Med 1993;328:406\u201310.","journal-title":"N Engl J Med"},{"key":"BFpr201296_CR22","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S0022-3476(05)83276-7","volume":"125","author":"A Hamvas","year":"1994","unstructured":"Hamvas A, Cole FS, deMello DE, et al. Surfactant protein B deficiency: antenatal diagnosis and prospective treatment with surfactant replacement. J Pediatr 1994;125:356\u201361.","journal-title":"J Pediatr"},{"key":"BFpr201296_CR23","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/ppul.20468","volume":"41","author":"P Kinniry","year":"2006","unstructured":"Kinniry P, Pick J, Stephens S, et al. KL4-surfactant prevents hyperoxic and LPS-induced lung injury in mice. Pediatr Pulmonol 2006;41:916\u201328.","journal-title":"Pediatr Pulmonol"},{"key":"BFpr201296_CR24","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1164\/ajrccm\/141.3.743","volume":"141","author":"N Gilliard","year":"1990","unstructured":"Gilliard N, Richman PM, Merritt TA, Spragg RG . Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury. Am Rev Respir Dis 1990;141:743\u20137.","journal-title":"Am Rev Respir Dis"},{"key":"BFpr201296_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1203\/PDR.0b013e3181eaff66","volume":"68","author":"MH Terry","year":"2010","unstructured":"Terry MH, Merritt TA, Harding B, et al. Pulmonary distribution of lucinactant and poractant alfa and their peridosing hemodynamic effects in a preterm lamb model of respiratory distress syndrome. Pediatr Res 2010;68:193\u20138.","journal-title":"Pediatr Res"},{"issue":"6 Pt 1","key":"BFpr201296_CR26","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1364","volume":"147","author":"JF Lewis","year":"1993","unstructured":"Lewis JF, Ikegami M, Jobe AH, Absolom D . Physiologic responses and distribution of aerosolized surfactant (Survanta) in a nonuniform pattern of lung injury. Am Rev Respir Dis 1993;147(6 Pt 1):1364\u201370.","journal-title":"Am Rev Respir Dis"},{"key":"BFpr201296_CR27","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1203\/00006450-199606000-00004","volume":"39","author":"E Manalo","year":"1996","unstructured":"Manalo E, Merritt TA, Kheiter A, Amirkhanian J, Cochrane C . Comparative effects of some serum components and proteolytic products of fibrinogen on surface tension-lowering abilities of beractant and a synthetic peptide containing surfactant KL4. Pediatr Res 1996;39:947\u201352.","journal-title":"Pediatr Res"},{"key":"BFpr201296_CR28","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1203\/00006450-200206000-00005","volume":"51","author":"M Ikegami","year":"2002","unstructured":"Ikegami M, Jobe AH . Injury responses to different surfactants in ventilated premature lamb lungs. Pediatr Res 2002;51:689\u201395.","journal-title":"Pediatr Res"},{"key":"BFpr201296_CR29","doi-asserted-by":"publisher","first-page":"7794","DOI":"10.1073\/pnas.92.17.7794","volume":"92","author":"JC Clark","year":"1995","unstructured":"Clark JC, Wert SE, Bachurski CJ, et al. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA 1995;92:7794\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr201296_CR30","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1165\/ajrcmb.22.3.3645","volume":"22","author":"MF Beers","year":"2000","unstructured":"Beers MF, Hamvas A, Moxley MA, et al. Pulmonary surfactant metabolism in infants lacking surfactant protein B. Am J Respir Cell Mol Biol 2000;22:380\u201391.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr201296_CR31","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1164\/ajrccm.153.1.8542150","volume":"153","author":"CG Cochrane","year":"1996","unstructured":"Cochrane CG, Revak SD, Merritt TA, et al. The efficacy and safety of KL4-surfactant in preterm infants with respiratory distress syndrome. Am J Respir Crit Care Med 1996;153:404\u201310.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201296_CR32","doi-asserted-by":"publisher","first-page":"L897","DOI":"10.1152\/ajplung.00431.2001","volume":"283","author":"Z Wang","year":"2002","unstructured":"Wang Z, Baatz JE, Holm BA, Notter RH . Content-dependent activity of lung surfactant protein B in mixtures with lipids. Am J Physiol Lung Cell Mol Physiol 2002;283:L897\u2013906.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr201296_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0009-3084(01)00197-9","volume":"114","author":"RH Notter","year":"2002","unstructured":"Notter RH, Wang Z, Egan EA, Holm BA . Component-specific surface and physiological activity in bovine-derived lung surfactants. Chem Phys Lipids 2002;114:21\u201334.","journal-title":"Chem Phys Lipids"},{"key":"BFpr201296_CR34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1006\/abio.1995.0012","volume":"232","author":"M van Eijk","year":"1995","unstructured":"van Eijk M, De Haas CG, Haagsman HP . Quantitative analysis of pulmonary surfactant proteins B and C. Anal Biochem 1995;232:231\u20137.","journal-title":"Anal Biochem"},{"key":"BFpr201296_CR35","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1016\/j.bpj.2008.12.3966","volume":"96","author":"VC Antharam","year":"2009","unstructured":"Antharam VC, Elliott DW, Mills FD, Farver RS, Sternin E, Long JR . Penetration depth of surfactant peptide KL4 into membranes is determined by fatty acid saturation. Biophys J 2009;96:4085\u201398.","journal-title":"Biophys J"},{"key":"BFpr201296_CR36","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.bbamem.2009.08.020","volume":"1798","author":"JR Long","year":"2010","unstructured":"Long JR, Mills FD, Ganesh OK, Antharam VC, Farver RS . Partitioning, dynamics, and orientation of lung surfactant peptide KL(4) in phospholipid bilayers. Biochim Biophys Acta 2010;1798:216\u201322.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr201296_CR37","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1073\/pnas.0909361107","volume":"107","author":"M Numata","year":"2010","unstructured":"Numata M, Chu HW, Dakhama A, Voelker DR . Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection. Proc Natl Acad Sci USA 2010;107:320\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr201296_CR38","first-page":"221","volume":"12","author":"TA Merritt","year":"1988","unstructured":"Merritt TA, Strayer DS, Hallman M, Spragg RD, Wozniak P . Immunologic consequences of exogenous surfactant administration. Semin Perinatol 1988;12:221\u201330.","journal-title":"Semin Perinatol"},{"key":"BFpr201296_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1365-2249.1991.tb05585.x","volume":"83","author":"DS Strayer","year":"1991","unstructured":"Strayer DS, Hallman M, Merritt TA . Immunogenicity of surfactant. II. Porcine and bovine surfactants. Clin Exp Immunol 1991;83:41\u20136.","journal-title":"Clin Exp Immunol"},{"key":"BFpr201296_CR40","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1542\/peds.2004-2183","volume":"115","author":"FR Moya","year":"2005","unstructured":"Moya FR, Gadzinowski J, Bancalari E, et al.; International Surfaxin Collaborative Study Group. A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants. Pediatrics 2005;115:1018\u201329.","journal-title":"Pediatrics"},{"key":"BFpr201296_CR41","doi-asserted-by":"publisher","first-page":"e1361","DOI":"10.1542\/peds.2006-0149","volume":"119","author":"F Moya","year":"2007","unstructured":"Moya F, Sinha S, Gadzinowski J, et al.; SELECT and STAR Study Investigators. One-year follow-up of very preterm infants who received lucinactant for prevention of respiratory distress syndrome: results from 2 multicenter randomized, controlled trials. Pediatrics 2007;119:e1361\u201370.","journal-title":"Pediatrics"},{"key":"BFpr201296_CR42","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1542\/peds.2004-2231","volume":"115","author":"SK Sinha","year":"2005","unstructured":"Sinha SK, Lacaze-Masmonteil T, Valls i Soler A, et al.; Surfaxin Therapy Against Respiratory Distress Syndrome Collaborative Group. A multicenter, randomized, controlled trial of lucinactant versus poractant alfa among very premature infants at high risk for respiratory distress syndrome. Pediatrics 2005;115:1030\u20138.","journal-title":"Pediatrics"},{"key":"BFpr201296_CR43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/NPM-2011-2736","volume":"4","author":"CG Guardia","year":"2011","unstructured":"Guardia CG, Moya FR, Sinha S, et al. Reintubation and risk of morbidity and mortality in preterm infants after surfactant replacement therapy. J Neonatal Perinatal Med 2011;4:101\u20139.","journal-title":"J Neonatal Perinatal Med"},{"key":"BFpr201296_CR44","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1203\/00006450-198506000-00014","volume":"19","author":"RH Notter","year":"1985","unstructured":"Notter RH, Egan EA, Kwong MS, Holm BA, Shapiro DL . Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique, and gestational age. Pediatr Res 1985;19:569\u201377.","journal-title":"Pediatr Res"},{"key":"BFpr201296_CR45","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1097\/MAT.0b013e318168fef0","volume":"54","author":"MR Wolfson","year":"2008","unstructured":"Wolfson MR, Hirschl RB, Jackson JC, et al. Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep. ASAIO J 2008;54:256\u201369.","journal-title":"ASAIO J"},{"key":"BFpr201296_CR46","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","volume":"181","author":"CC Hsia","year":"2010","unstructured":"Hsia CC, Hyde DM, Ochs M, Weibel ER; ATS\/ERS Joint Task Force on Quantitative Assessment of Lung Structure. An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 2010;181:394\u2013418.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201296_CR47","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1152\/jappl.1992.72.3.1024","volume":"72","author":"MR Wolfson","year":"1992","unstructured":"Wolfson MR, Greenspan JS, Deoras KS, Rubenstein SD, Shaffer TH . Comparison of gas and liquid ventilation: clinical, physiological, and histological correlates. J Appl Physiol 1992;72:1024\u201331.","journal-title":"J Appl Physiol"},{"key":"BFpr201296_CR48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/ppul.1950090208","volume":"9","author":"KS Deoras","year":"1990","unstructured":"Deoras KS, Wolfson MR, Searls RL, Hilfer SR, Sheffield JB, Shaffer TH . Use of a touch sensitive screen and computer assisted image analysis for quantitation of developmental changes in pulmonary structure. Pediatr Pulmonol 1990;9:109\u201318.","journal-title":"Pediatr Pulmonol"},{"key":"BFpr201296_CR49","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1152\/japplphysiol.00246.2005","volume":"99","author":"BN Shashikant","year":"2005","unstructured":"Shashikant BN, Miller TL, Welch RW, Pilon AL, Shaffer TH, Wolfson MR . Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles. J Appl Physiol 2005;99:2204\u201311.","journal-title":"J Appl Physiol"},{"key":"BFpr201296_CR50","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0160-5402(90)90061-O","volume":"23","author":"C Schierwagen","year":"1990","unstructured":"Schierwagen C, Bylund-Fellenius AC, Lundberg C . Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity. J Pharmacol Methods 1990;23:179\u201386.","journal-title":"J Pharmacol Methods"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201296.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201296","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201296.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:57:35Z","timestamp":1684472255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,20]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["BFpr201296"],"URL":"https:\/\/doi.org\/10.1038\/pr.2012.96","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,20]]}}}