{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:37:52Z","timestamp":1778924272802,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2-4","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1038\/pr.2013.19","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T17:04:50Z","timestamp":1359651890000},"page":"508-513","source":"Crossref","is-referenced-by-count":8,"title":["Pediatric systems medicine: evaluating needs and opportunities using congenital heart block as a case study"],"prefix":"10.1038","volume":"73","author":[{"given":"Jesper","family":"Tegn\u00e9r","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad","family":"Abugessaisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,1,31]]},"reference":[{"key":"BFpr201319_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrg1272","volume":"5","author":"AL Barab\u00e1si","year":"2004","unstructured":"Barab\u00e1si AL, Oltvai ZN . Network biology: understanding the cell\u2019s functional organization. Nat Rev Genet 2004;5:101\u201313.","journal-title":"Nat Rev Genet"},{"key":"BFpr201319_CR2","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","volume":"144","author":"M Vidal","year":"2011","unstructured":"Vidal M, Cusick ME, Barab\u00e1si AL . Interactome networks and human disease. Cell 2011;144:986\u201398.","journal-title":"Cell"},{"key":"BFpr201319_CR3","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1098\/rsta.2010.0048","volume":"368","author":"P Hunter","year":"2010","unstructured":"Hunter P, Coveney PV, de Bono B, et al. A vision and strategy for the virtual physiological human in 2010 and beyond. Philos Transact A Math Phys Eng Sci 2010;368:2595\u2013614.","journal-title":"Philos Transact A Math Phys Eng Sci"},{"key":"BFpr201319_CR4","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.nbt.2012.03.004","volume":"29","author":"L Hood","year":"2012","unstructured":"Hood L, Flores M . A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. N Biotechnol 2012;29:613\u201324.","journal-title":"N Biotechnol"},{"key":"BFpr201319_CR5","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.cell.2012.02.009","volume":"148","author":"R Chen","year":"2012","unstructured":"Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012;148:1293\u2013307.","journal-title":"Cell"},{"key":"BFpr201319_CR6","first-page":"139","volume":"5","author":"JP Buyon","year":"2009","unstructured":"Buyon JP, Clancy RM, Friedman DM . Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside. Nat Clin Pract Rheumatol 2009;5:139\u201348.","journal-title":"Nat Clin Pract Rheumatol"},{"key":"BFpr201319_CR7","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1651-2227.2011.02563.x","volume":"101","author":"G Bergman","year":"2012","unstructured":"Bergman G, Eliasson H, Mohlkert LA, Wahren-Herlenius M, Sonesson SE . Progression to first-degree heart block in preschool children exposed in utero to maternal anti-SSA\/Ro52 autoantibodies. Acta Paediatr 2012;101:488\u201393.","journal-title":"Acta Paediatr"},{"key":"BFpr201319_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/apa.12049","volume":"102","author":"A Skog","year":"2013","unstructured":"Skog A, Tingstr\u00f6m J, Salomonsson S, Sonesson SE, Wahren-Herlenius M . Neurodevelopment in children with and without congenital heart block born to anti-Ro\/SSA-positive mothers. Acta Paediatr 2013;102:40\u20136.","journal-title":"Acta Paediatr"},{"key":"BFpr201319_CR9","doi-asserted-by":"publisher","first-page":"D19","DOI":"10.1093\/nar\/gkq1019","volume":"39(Database iss","author":"R Leinonen","year":"2011","unstructured":"Leinonen R, Sugawara H, Shumway M ; International Nucleotide Sequence Database Collaboration. The sequence read archive. Nucleic Acids Res 2011;39(Database issue):D19\u201321.","journal-title":"Nucleic Acids Res"},{"key":"BFpr201319_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature11247","volume":"489","author":"I Dunham","year":"2012","unstructured":"Dunham I, Kundaje A, Aldred SF, et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489:57\u201374.","journal-title":"Nature"},{"key":"BFpr201319_CR11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrg2857","volume":"11","author":"EE Schadt","year":"2010","unstructured":"Schadt EE, Linderman MD, Sorenson J, Lee L, Nolan GP . Computational solutions to large-scale data management and analysis. Nat Rev Genet 2010;11:647\u201357.","journal-title":"Nat Rev Genet"},{"issue":"Suppl 1","key":"BFpr201319_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1365-2052.2006.01476.x","volume":"37","author":"J Quackenbush","year":"2006","unstructured":"Quackenbush J . From \u2018omes to biology. Anim Genet 2006;37:Suppl 1:48\u201356.","journal-title":"Anim Genet"},{"key":"BFpr201319_CR13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nmeth.1226","volume":"5","author":"A Mortazavi","year":"2008","unstructured":"Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B . Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008;5:621\u20138.","journal-title":"Nat Methods"},{"key":"BFpr201319_CR14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nrg3305","volume":"13","author":"A Nekrutenko","year":"2012","unstructured":"Nekrutenko A, Taylor J . Next-generation sequencing data interpretation: enhancing reproducibility and accessibility. Nat Rev Genet 2012;13:667\u201372.","journal-title":"Nat Rev Genet"},{"key":"BFpr201319_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrg3000","volume":"12","author":"VK Rakyan","year":"2011","unstructured":"Rakyan VK, Down TA, Balding DJ, Beck S . Epigenome-wide association studies for common human diseases. Nat Rev Genet 2011;12:529\u201341.","journal-title":"Nat Rev Genet"},{"key":"BFpr201319_CR16","doi-asserted-by":"publisher","first-page":"D1","DOI":"10.1093\/nar\/gkr1196","volume":"40(Database iss","author":"MY Galperin","year":"2012","unstructured":"Galperin MY, Fern\u00e1ndez-Su\u00e1rez XM . The 2012 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection. Nucleic Acids Res 2012;40(Database issue):D1\u20138.","journal-title":"Nucleic Acids Res"},{"key":"BFpr201319_CR17","doi-asserted-by":"publisher","first-page":"e1002375","DOI":"10.1371\/journal.pcbi.1002375","volume":"8","author":"P Khatri","year":"2012","unstructured":"Khatri P, Sirota M, Butte AJ . Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol 2012;8:e1002375.","journal-title":"PLoS Comput Biol"},{"key":"BFpr201319_CR18","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.1002\/art.34663","volume":"64","author":"PS Ramos","year":"2012","unstructured":"Ramos PS, Marion MC, Langefeld CD, Buyon JP, Clancy RM ; International Consortium on Systemic Lupus Erythematosus Genetics. Brief report: enrichment of associations in genes with fibrosis, apoptosis, and innate immunity functions with cardiac manifestations of neonatal lupus. Arthritis Rheum 2012;64:4060\u20135.","journal-title":"Arthritis Rheum"},{"key":"BFpr201319_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/pr.2011.61","volume":"71(4 Pt 2)","author":"HS Bernstein","year":"2012","unstructured":"Bernstein HS, Srivastava D . Stem cell therapy for cardiac disease. Pediatr Res 2012;71(4 Pt 2):491\u20139.","journal-title":"Pediatr Res"},{"key":"BFpr201319_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/msc.189","volume":"8","author":"J Tingstr\u00f6m","year":"2010","unstructured":"Tingstr\u00f6m J, Barimani M, Sonesson SE, Wahren-Herlenius M, Henriksson EW . The experiences of pregnancy in women with SSA\/Ro52 autoantibodies. Musculoskeletal Care 2010;8:215\u201323.","journal-title":"Musculoskeletal Care"},{"key":"BFpr201319_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.midw.2011.10.008","volume":"29","author":"J Tingstr\u00f6m","year":"2013","unstructured":"Tingstr\u00f6m J, Welin Henriksson E, Sonesson SE, Wahren-Herlenius M . Ro52 autoantibody-positive women\u2019s experience of being pregnant and giving birth to a child with congenital heart block. Midwifery 2013;29:18\u201323.","journal-title":"Midwifery"},{"key":"BFpr201319_CR22","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/jamia.2009.000893","volume":"17","author":"SN Murphy","year":"2010","unstructured":"Murphy SN, Weber G, Mendis M, et al. Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc 2010;17:124\u201330.","journal-title":"J Am Med Inform Assoc"},{"key":"BFpr201319_CR23","first-page":"391","volume":"2009","author":"HJ Lowe","year":"2009","unstructured":"Lowe HJ, Ferris TA, Hernandez PM, Weber SC . STRIDE \u2013 an integrated standards-based translational research informatics platform. AMIA Annu Symp Proc 2009;2009:391\u20135.","journal-title":"AMIA Annu Symp Proc"},{"key":"BFpr201319_CR24","unstructured":"Fujibuchi W, Goto S, Migimatsu H, et al. DBGET\/LinkDB: an integrated database retrieval system. Pac Symp Biocomput 1998;683\u201394."},{"key":"BFpr201319_CR25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S . KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000;28:27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"BFpr201319_CR26","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1479-5876-8-68","volume":"8","author":"S Szalma","year":"2010","unstructured":"Szalma S, Koka V, Khasanova T, Perakslis ED . Effective knowledge management in translational medicine. J Transl Med 2010;8:68.","journal-title":"J Transl Med"},{"key":"BFpr201319_CR27","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nrg3208","volume":"13","author":"PB Jensen","year":"2012","unstructured":"Jensen PB, Jensen LJ, Brunak S . Mining electronic health records: towards better research applications and clinical care. Nat Rev Genet 2012;13:395\u2013405.","journal-title":"Nat Rev Genet"},{"key":"BFpr201319_CR28","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1109\/TBME.2011.2170986","volume":"59","author":"J Mattila","year":"2012","unstructured":"Mattila J, Koikkalainen J, Virkki A, van Gils M, L\u00f6tj\u00f6nen J ; Alzheimer\u2019s Disease Neuroimaging Initiative. Design and application of a generic clinical decision support system for multiscale data. IEEE Trans Biomed Eng 2012;59:234\u201340.","journal-title":"IEEE Trans Biomed Eng"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201319","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:58:47Z","timestamp":1684472327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,31]]},"references-count":28,"journal-issue":{"issue":"2-4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["BFpr201319"],"URL":"https:\/\/doi.org\/10.1038\/pr.2013.19","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,31]]}}}