{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:26:37Z","timestamp":1788981997831,"version":"build-2803163510"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T00:00:00Z","timestamp":1383609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/pr.2013.195","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T17:00:43Z","timestamp":1383670843000},"page":"241-250","source":"Crossref","is-referenced-by-count":57,"title":["Gene\u2013environment interactions in severe intraventricular hemorrhage of preterm neonates"],"prefix":"10.1038","volume":"75","author":[{"name":"; for the Gene Targets for IVH Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura R.","family":"Ment","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"\u00c5d\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hyun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murim","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Lifton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,5]]},"reference":[{"key":"BFpr2013195_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"LA Papile","year":"1978","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H . Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529\u201334.","journal-title":"J Pediatr"},{"key":"BFpr2013195_CR2","doi-asserted-by":"publisher","first-page":"F388","DOI":"10.1136\/adc.2009.168997","volume":"95","author":"P Nongena","year":"2010","unstructured":"Nongena P, Ederies A, Azzopardi DV, Edwards AD . Confidence in the prediction of neurodevelopmental outcome by cranial ultrasound and MRI in preterm infants. Arch Dis Child Fetal Neonatal Ed 2010;95:F388\u201390.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr2013195_CR3","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1111\/j.1469-8749.2010.03612.x","volume":"52","author":"G Beaino","year":"2010","unstructured":"Beaino G, Khoshnood B, Kaminski M, et al.; EPIPAGE Study Group. Predictors of cerebral palsy in very preterm infants: the EPIPAGE prospective population-based cohort study. Dev Med Child Neurol 2010;52:e119\u201325.","journal-title":"Dev Med Child Neurol"},{"key":"BFpr2013195_CR4","doi-asserted-by":"publisher","first-page":"e639","DOI":"10.1542\/peds.2010-1421","volume":"127","author":"TM Luu","year":"2011","unstructured":"Luu TM, Ment L, Allan W, Schneider K, Vohr BR . Executive and memory function in adolescents born very preterm. Pediatrics 2011;127:e639\u201346.","journal-title":"Pediatrics"},{"key":"BFpr2013195_CR5","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1001\/archgenpsychiatry.2011.62","volume":"68","author":"AH Whitaker","year":"2011","unstructured":"Whitaker AH, Feldman JF, Lorenz JM, et al. Neonatal head ultrasound abnormalities in preterm infants and adolescent psychiatric disorders. Arch Gen Psychiatry 2011;68:742\u201352.","journal-title":"Arch Gen Psychiatry"},{"issue":"Suppl 1","key":"BFpr2013195_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/14767058.2012.667600","volume":"25","author":"M Hallman","year":"2012","unstructured":"Hallman M . Premature birth and diseases in premature infants: common genetic background? J Matern Fetal Neonatal Med 2012;25(Suppl 1):21\u20134.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFpr2013195_CR7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1203\/PDR.0b013e31818d1dbd","volume":"65","author":"S Mohamed","year":"2009","unstructured":"Mohamed S, Schaa K, Cooper ME, et al. Genetic contributions to the development of retinopathy of prematurity. Pediatr Res 2009;65:193\u20137.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","volume":"126","author":"BJ Stoll","year":"2010","unstructured":"Stoll BJ, Hansen NI, Bell EF, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010;126:443\u201356.","journal-title":"Pediatrics"},{"key":"BFpr2013195_CR9","doi-asserted-by":"publisher","first-page":"F403","DOI":"10.1136\/adc.2010.183236","volume":"95","author":"MA Mohamed","year":"2010","unstructured":"Mohamed MA, Aly H . Transport of premature infants is associated with increased risk for intraventricular haemorrhage. Arch Dis Child Fetal Neonatal Ed 2010;95:F403\u20137.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"Suppl 2","key":"BFpr2013195_CR10","doi-asserted-by":"publisher","first-page":"S516","DOI":"10.1161\/CIRCULATIONAHA.110.971127","volume":"122","author":"JM Perlman","year":"2010","unstructured":"Perlman JM, Wyllie J, Kattwinkel J, et al.; Neonatal Resuscitation Chapter Collaborators. Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2010;122(Suppl 2):S516\u201338.","journal-title":"Circulation"},{"key":"BFpr2013195_CR11","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1159\/000297773","volume":"97","author":"DG Sweet","year":"2010","unstructured":"Sweet DG, Carnielli V, Greisen G, et al.; European Association of Perinatal Medicine. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants - 2010 update. Neonatology 2010;97:402\u201317.","journal-title":"Neonatology"},{"issue":"2 Pt 1","key":"BFpr2013195_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0002-9378(95)90557-X","volume":"172","author":"M Hack","year":"1995","unstructured":"Hack M, Wright LL, Shankaran S, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Network, November 1989 to October 1990. Am J Obstet Gynecol 1995;172(2 Pt 1):457\u201364.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr2013195_CR13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","volume":"8","author":"JJ Volpe","year":"2009","unstructured":"Volpe JJ . Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol 2009;8:110\u201324.","journal-title":"Lancet Neurol"},{"key":"BFpr2013195_CR14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S0095-5108(02)00048-9","volume":"29","author":"L Shalak","year":"2002","unstructured":"Shalak L, Perlman JM . Hemorrhagic-ischemic cerebral injury in the preterm infant: current concepts. Clin Perinatol 2002;29:745\u201363.","journal-title":"Clin Perinatol"},{"key":"BFpr2013195_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1542\/peds.2011-1578","volume":"129","author":"AL Kent","year":"2012","unstructured":"Kent AL, Wright IM, Abdel-Latif ME ; New South Wales and Australian Capital Territory Neonatal Intensive Care Units Audit Group. Mortality and adverse neurologic outcomes are greater in preterm male infants. Pediatrics 2012;129:124\u201331.","journal-title":"Pediatrics"},{"key":"BFpr2013195_CR16","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1542\/peds.2005-1414","volume":"117","author":"V Bhandari","year":"2006","unstructured":"Bhandari V, Bizzarro MJ, Shetty A, et al.; Neonatal Genetics Study Group. Familial and genetic susceptibility to major neonatal morbidities in preterm twins. Pediatrics 2006;117:1901\u20136.","journal-title":"Pediatrics"},{"key":"BFpr2013195_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1469-8749.2011.04135.x","volume":"54","author":"JC Harteman","year":"2012","unstructured":"Harteman JC, Groenendaal F, van Haastert IC, et al. Atypical timing and presentation of periventricular haemorrhagic infarction in preterm infants: the role of thrombophilia. Dev Med Child Neurol 2012;54:140\u20137.","journal-title":"Dev Med Child Neurol"},{"key":"BFpr2013195_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1203\/PDR.0b013e31821ceb63","volume":"70","author":"KK Ryckman","year":"2011","unstructured":"Ryckman KK, Dagle JM, Kelsey K, Momany AM, Murray JC . Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates. Pediatr Res 2011;70:90\u20135.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR19","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2741\/1890","volume":"11","author":"RJ Baier","year":"2006","unstructured":"Baier RJ . Genetics of perinatal brain injury in the preterm infant. Front Biosci 2006;11:1371\u201387.","journal-title":"Front Biosci"},{"key":"BFpr2013195_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1203\/PDR.0b013e3181c1b176","volume":"67","author":"P Ballabh","year":"2010","unstructured":"Ballabh P . Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr Res 2010;67:1\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR21","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature05913","volume":"447","author":"A Bird","year":"2007","unstructured":"Bird A . Perceptions of epigenetics. Nature 2007;447:396\u20138.","journal-title":"Nature"},{"key":"BFpr2013195_CR22","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1136\/adc.51.9.651","volume":"51","author":"G Hambleton","year":"1976","unstructured":"Hambleton G, Wigglesworth JS . Origin of intraventricular haemorrhage in the preterm infant. Arch Dis Child 1976;51:651\u20139.","journal-title":"Arch Dis Child"},{"key":"BFpr2013195_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1042\/CS20110627","volume":"123","author":"EF Davis","year":"2012","unstructured":"Davis EF, Newton L, Lewandowski AJ, et al. Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies. Clin Sci 2012;123:53\u201372.","journal-title":"Clin Sci"},{"key":"BFpr2013195_CR24","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/01.HYP.0000215580.43711.d1","volume":"47","author":"C Torrens","year":"2006","unstructured":"Torrens C, Brawley L, Anthony FW, et al. Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 2006;47:982\u20137.","journal-title":"Hypertension"},{"key":"BFpr2013195_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/HCO.0b013e328345986e","volume":"26","author":"AV Shirodkar","year":"2011","unstructured":"Shirodkar AV, Marsden PA . Epigenetics in cardiovascular disease. Curr Opin Cardiol 2011;26:209\u201315.","journal-title":"Curr Opin Cardiol"},{"key":"BFpr2013195_CR26","doi-asserted-by":"publisher","first-page":"H247","DOI":"10.1152\/ajpheart.01309.2010","volume":"301","author":"E Rexhaj","year":"2011","unstructured":"Rexhaj E, Bloch J, Jayet PY, et al. Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms. Am J Physiol Heart Circ Physiol 2011;301:H247\u201352.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFpr2013195_CR27","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1186\/1471-2164-13-636","volume":"13","author":"KR van Eijk","year":"2012","unstructured":"van Eijk KR, de Jong S, Boks MP, et al. Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects. BMC Genomics 2012;13:636.","journal-title":"BMC Genomics"},{"key":"BFpr2013195_CR28","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.braindev.2009.03.007","volume":"31","author":"R Trollmann","year":"2009","unstructured":"Trollmann R, Gassmann M . The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain. Brain Dev 2009;31:503\u20139.","journal-title":"Brain Dev"},{"key":"BFpr2013195_CR29","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0165-3806(01)00220-6","volume":"130","author":"J Chow","year":"2001","unstructured":"Chow J, Ogunshola O, Fan SY, Li Y, Ment LR, Madri JA . Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. Brain Res Dev Brain Res 2001;130:123\u201332.","journal-title":"Brain Res Dev Brain Res"},{"key":"BFpr2013195_CR30","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1074\/jbc.M109.067868","volume":"285","author":"JE Fish","year":"2010","unstructured":"Fish JE, Yan MS, Matouk CC, et al. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem 2010;285:810\u201326.","journal-title":"J Biol Chem"},{"key":"BFpr2013195_CR31","doi-asserted-by":"publisher","first-page":"L1001","DOI":"10.1152\/ajplung.00092.2012","volume":"303","author":"Q Yang","year":"2012","unstructured":"Yang Q, Lu Z, Ramchandran R, Longo LD, Raj JU . Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. Am J Physiol Lung Cell Mol Physiol 2012;303:L1001\u201310.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2013195_CR32","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/S1734-1140(12)70943-X","volume":"64","author":"A Gadek-Michalska","year":"2012","unstructured":"Gadek-Michalska A, Tadeusz J, Rachwalska P, Spyrka J, Bugajski J . Brain nitric oxide synthases in the interleukin-1\u00df-induced activation of hypothalamic-pituitary-adrenal axis. Pharmacol Rep 2012;64:1455\u201365.","journal-title":"Pharmacol Rep"},{"key":"BFpr2013195_CR33","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1001\/archpsyc.1997.01830160040006","volume":"54","author":"RA Mach\u00f3n","year":"1997","unstructured":"Mach\u00f3n RA, Mednick SA, Huttunen MO . Adult major affective disorder after prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1997;54:322\u20138.","journal-title":"Arch Gen Psychiatry"},{"key":"BFpr2013195_CR34","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1440-1681.2009.05212.x","volume":"36","author":"LD Vieira-Filho","year":"2009","unstructured":"Vieira-Filho LD, Lara LS, Silva PA, et al. Placental oxidative stress in malnourished rats and changes in kidney proximal tubule sodium ATPases in offspring. Clin Exp Pharmacol Physiol 2009;36:1157\u201363.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFpr2013195_CR35","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1056\/NEJMoa053727","volume":"354","author":"DB Gould","year":"2006","unstructured":"Gould DB, Phalan FC, van Mil SE, et al. Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med 2006;354:1489\u201396.","journal-title":"N Engl J Med"},{"key":"BFpr2013195_CR36","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1038\/labinvest.2011.124","volume":"91","author":"HL Nguyen","year":"2011","unstructured":"Nguyen HL, Lee YJ, Shin J, et al. TGF-\u00df signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest 2011;91:1554\u201363.","journal-title":"Lab Invest"},{"key":"BFpr2013195_CR37","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dev.01551","volume":"132","author":"JH McCarty","year":"2005","unstructured":"McCarty JH, Lacy-Hulbert A, Charest A, et al. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 2005;132:165\u201376.","journal-title":"Development"},{"key":"BFpr2013195_CR38","doi-asserted-by":"publisher","first-page":"13783","DOI":"10.1073\/pnas.96.24.13783","volume":"96","author":"M Srivastava","year":"1999","unstructured":"Srivastava M, Atwater I, Glasman M, et al. Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+\/-) knockout mouse. Proc Natl Acad Sci USA 1999;96:13783\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr2013195_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0925-4773(00)00360-9","volume":"95","author":"Y Tanaka","year":"2000","unstructured":"Tanaka Y, Naruse I, Hongo T, et al. Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein. Mech Dev 2000;95:133\u201345.","journal-title":"Mech Dev"},{"key":"BFpr2013195_CR40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.devcel.2011.11.018","volume":"22","author":"SJ Tam","year":"2012","unstructured":"Tam SJ, Richmond DL, Kaminker JS, et al. Death receptors DR6 and TROY regulate brain vascular development. Dev Cell 2012;22:403\u201317.","journal-title":"Dev Cell"},{"key":"BFpr2013195_CR41","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/44334","volume":"401","author":"D Lyden","year":"1999","unstructured":"Lyden D, Young AZ, Zagzag D, et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 1999;401:670\u20137.","journal-title":"Nature"},{"key":"BFpr2013195_CR42","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1242\/dev.129.12.2891","volume":"129","author":"J Zhu","year":"2002","unstructured":"Zhu J, Motejlek K, Wang D, Zang K, Schmidt A, Reichardt LF . beta8 integrins are required for vascular morphogenesis in mouse embryos. Development 2002;129:2891\u2013903.","journal-title":"Development"},{"key":"BFpr2013195_CR43","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1136\/jmg.2008.062844","volume":"46","author":"V Tran-Fadulu","year":"2009","unstructured":"Tran-Fadulu V, Pannu H, Kim DH, et al. Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations. J Med Genet 2009;46:607\u201313.","journal-title":"J Med Genet"},{"key":"BFpr2013195_CR44","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1128\/MCB.20.15.5643-5652.2000","volume":"20","author":"DD Spyropoulos","year":"2000","unstructured":"Spyropoulos DD, Pharr PN, Lavenburg KR, et al. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol 2000;20:5643\u201352.","journal-title":"Mol Cell Biol"},{"key":"BFpr2013195_CR45","doi-asserted-by":"publisher","first-page":"8334","DOI":"10.1038\/sj.onc.1205160","volume":"20","author":"R Benezra","year":"2001","unstructured":"Benezra R, Rafii S, Lyden D . The Id proteins and angiogenesis. Oncogene 2001;20:8334\u201341.","journal-title":"Oncogene"},{"key":"BFpr2013195_CR46","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.2353\/ajpath.2010.090593","volume":"176","author":"Y Asano","year":"2010","unstructured":"Asano Y, Stawski L, Hant F, et al. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 2010;176:1983\u201398.","journal-title":"Am J Pathol"},{"key":"BFpr2013195_CR47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.thromres.2010.10.003","volume":"127","author":"S Chabrier","year":"2011","unstructured":"Chabrier S, Husson B, Dinomais M, Landrieu P, Nguyen The Tich S . New insights (and new interrogations) in perinatal arterial ischemic stroke. Thromb Res 2011;127:13\u201322.","journal-title":"Thromb Res"},{"key":"BFpr2013195_CR48","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/j.1651-2227.2001.tb01358.x","volume":"90","author":"W G\u00f6pel","year":"2001","unstructured":"G\u00f6pel W, Gortner L, Kohlmann T, Schultz C, M\u00f6ller J . Low prevalence of large intraventricular haemorrhage in very low birthweight infants carrying the factor V Leiden or prothrombin G20210A mutation. Acta Paediatr 2001;90:1021\u20134.","journal-title":"Acta Paediatr"},{"key":"BFpr2013195_CR49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.thromres.2011.10.026","volume":"130","author":"V Oli\u00e9","year":"2012","unstructured":"Oli\u00e9 V, Zhu T, Martinez I, Scarabin PY, Emmerich J . Sex-specific risk factors for recurrent venous thromboembolism. Thromb Res 2012;130:16\u201320.","journal-title":"Thromb Res"},{"key":"BFpr2013195_CR50","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.atherosclerosis.2011.02.027","volume":"216","author":"RP Kloppenborg","year":"2011","unstructured":"Kloppenborg RP, Nederkoorn PJ, van der Graaf Y, Geerlings MI . Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study. Atherosclerosis 2011;216:461\u20136.","journal-title":"Atherosclerosis"},{"key":"BFpr2013195_CR51","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1526-4610.2012.02106.x","volume":"52","author":"S Stuart","year":"2012","unstructured":"Stuart S, Cox HC, Lea RA, Griffiths LR . The role of the MTHFR gene in migraine. Headache 2012;52:515\u201320.","journal-title":"Headache"},{"key":"BFpr2013195_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1399-0004.2004.00373.x","volume":"67","author":"R Dodelson de Kremer","year":"2005","unstructured":"Dodelson de Kremer R, Grosso C . Maternal mutation 677C &gt; T in the methylenetetrahydrofolate reductase gene associated with severe brain injury in offspring. Clin Genet 2005;67:69\u201380.","journal-title":"Clin Genet"},{"key":"BFpr2013195_CR53","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/pr.2012.150","volume":"73","author":"JC Harteman","year":"2013","unstructured":"Harteman JC, Groenendaal F, Benders MJ, Huisman A, Blom HJ, de Vries LS . Role of thrombophilic factors in full-term infants with neonatal encephalopathy. Pediatr Res 2013;73:80\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR54","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1373\/clinchem.2004.036194","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Grindflek AW, Ueland PM, et al. Screening for serum total homocysteine in newborn children. Clin Chem 2004;50:1769\u201384.","journal-title":"Clin Chem"},{"key":"BFpr2013195_CR55","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1067\/mob.2002.121105","volume":"186","author":"AM Molloy","year":"2002","unstructured":"Molloy AM, Mills JL, McPartlin J, Kirke PN, Scott JM, Daly S . Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C\u2013&gt;T variant. Am J Obstet Gynecol 2002;186:499\u2013503.","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl","key":"BFpr2013195_CR56","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1016\/j.jpeds.2010.11.011","volume":"158","author":"ME Bauman","year":"2011","unstructured":"Bauman ME, Cheung PY, Massicotte MP . Hemostasis and platelet dysfunction in asphyxiated neonates. J Pediatr 2011;158(Suppl):e35\u20139.","journal-title":"J Pediatr"},{"key":"BFpr2013195_CR57","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/(SICI)1097-4644(19960401)61:1<72::AID-JCB9>3.0.CO;2-#","volume":"61","author":"RK Chawla","year":"1996","unstructured":"Chawla RK, Watson WH, Jones DP . Effect of hypoxia on hepatic DNA methylation and tRNA methyltransferase in rat: similarities to effects of methyl-deficient diets. J Cell Biochem 1996;61:72\u201380.","journal-title":"J Cell Biochem"},{"key":"BFpr2013195_CR58","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/PL00010035","volume":"29","author":"K Ito","year":"1999","unstructured":"Ito K, Miwa N, Hagiwara K, et al. Regulation of methionine adenosyltransferase activity by the glutathione level in rat liver during ischemia-reperfusion. Surg Today 1999;29:1053\u20138.","journal-title":"Surg Today"},{"key":"BFpr2013195_CR59","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1203\/01.PDR.0000161406.19231.98","volume":"57","author":"S Blaise","year":"2005","unstructured":"Blaise S, Alberto JM, N\u00e9d\u00e9lec E, et al. Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats. Pediatr Res 2005;57:777\u201382.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR60","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.jpeds.2013.06.025","volume":"163","author":"U Ad\u00e9n","year":"2013","unstructured":"Ad\u00e9n U, Lin A, Carlo W, et al.; Gene Targets for Intraventricular Hemorrhage Study Group. Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates. J Pediatr 2013;163:1503\u20131506.e1.","journal-title":"J Pediatr"},{"key":"BFpr2013195_CR61","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/B978-1-4160-3995-2.10011-1","volume-title":"Neurology of the Newborn","author":"JJ Volpe","year":"2008","unstructured":"Volpe JJ . Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage of the premature infant. In: Neurology of the Newborn, 5 edn. Philadelphia, PA: Saunders Elsevier; 2008:517\u201388."},{"key":"BFpr2013195_CR62","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neuroscience.2012.08.043","volume":"226","author":"X Chen","year":"2012","unstructured":"Chen X, Threlkeld SW, Cummings EE, et al. Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus. Neuroscience 2012;226:89\u2013100.","journal-title":"Neuroscience"},{"key":"BFpr2013195_CR63","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.pharmthera.2011.01.014","volume":"130","author":"L Capuron","year":"2011","unstructured":"Capuron L, Miller AH . Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 2011;130:226\u201338.","journal-title":"Pharmacol Ther"},{"key":"BFpr2013195_CR64","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.bbi.2009.10.010","volume":"24","author":"U Ad\u00e9n","year":"2010","unstructured":"Ad\u00e9n U, Favrais G, Plaisant F, et al. Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-\/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept. Brain Behav Immun 2010;24:747\u201358.","journal-title":"Brain Behav Immun"},{"key":"BFpr2013195_CR65","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.ijdevneu.2012.06.001","volume":"30","author":"GB Sadowska","year":"2012","unstructured":"Sadowska GB, Threlkeld SW, Flangini A, Sharma S, Stonestreet BS . Ontogeny and the effects of in utero brain ischemia on interleukin-1\u00df and interleukin-6 protein expression in ovine cerebral cortex and white matter. Int J Dev Neurosci 2012;30:457\u201363.","journal-title":"Int J Dev Neurosci"},{"key":"BFpr2013195_CR66","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuroscience.2010.03.024","volume":"168","author":"LW Fan","year":"2010","unstructured":"Fan LW, Tien LT, Zheng B, Pang Y, Rhodes PG, Cai Z . Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone. Neuroscience 2010;168:240\u201352.","journal-title":"Neuroscience"},{"key":"BFpr2013195_CR67","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.brainres.2013.02.042","volume":"1508","author":"Y Ma","year":"2013","unstructured":"Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M . Cyclooxygenase-2-related signaling in the hypothalamus plays differential roles in response to various acute stresses. Brain Res 2013;1508:23\u201333.","journal-title":"Brain Res"},{"key":"BFpr2013195_CR68","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1203\/00006450-200001000-00013","volume":"47","author":"Z Cai","year":"2000","unstructured":"Cai Z, Pan ZL, Pang Y, Evans OB, Rhodes PG . Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res 2000;47:64\u201372.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR69","doi-asserted-by":"publisher","first-page":"8000","DOI":"10.1523\/JNEUROSCI.1748-05.2005","volume":"25","author":"SD Bilbo","year":"2005","unstructured":"Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF . Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci 2005;25:8000\u20139.","journal-title":"J Neurosci"},{"key":"BFpr2013195_CR70","unstructured":"Leviton A, Allred EN, Dammann O, et al. Systemic inflammation, intraventricular hemorrhage, and white matter injury. J Child Neurol 2012; e-pub ahead of print 30 October 2012."},{"key":"BFpr2013195_CR71","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1053\/gast.2002.37043","volume":"123","author":"IR Hwang","year":"2002","unstructured":"Hwang IR, Kodama T, Kikuchi S, et al. Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection. Gastroenterology 2002;123:1793\u2013803.","journal-title":"Gastroenterology"},{"key":"BFpr2013195_CR72","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/ana.21766","volume":"66","author":"YW Wu","year":"2009","unstructured":"Wu YW, Croen LA, Torres AR, Van De Water J, Grether JK, Hsu NN . Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants. Ann Neurol 2009;66:663\u201370.","journal-title":"Ann Neurol"},{"key":"BFpr2013195_CR73","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.psyneuen.2012.11.004","volume":"38","author":"M Girotti","year":"2013","unstructured":"Girotti M, Donegan JJ, Morilak DA . Influence of hypothalamic IL-6\/gp130 receptor signaling on the HPA axis response to chronic stress. Psychoneuroendocrinology 2013;38:1158\u201369.","journal-title":"Psychoneuroendocrinology"},{"key":"BFpr2013195_CR74","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1203\/01.PDR.0000163523.49021.53","volume":"58","author":"D Harding","year":"2005","unstructured":"Harding D, Brull D, Humphries SE, Whitelaw A, Montgomery H, Marlow N . Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study. Pediatr Res 2005;58:117\u201320.","journal-title":"Pediatr Res"},{"key":"BFpr2013195_CR75","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/sj.gene.6363986","volume":"4","author":"K Adcock","year":"2003","unstructured":"Adcock K, Hedberg C, Loggins J, Kruger TE, Baier RJ . The TNF-alpha -308, MCP-1 -2518 and TGF-beta1 +915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants. Genes Immun 2003;4:420\u20136.","journal-title":"Genes Immun"},{"key":"BFpr2013195_CR76","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/ana.21525","volume":"65","author":"LS de Vries","year":"2009","unstructured":"de Vries LS, Koopman C, Groenendaal F, et al. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Ann Neurol 2009;65:12\u20138.","journal-title":"Ann Neurol"},{"key":"BFpr2013195_CR77","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/ana.23544","volume":"71","author":"LS de Vries","year":"2012","unstructured":"de Vries LS, Mancini GM . Intracerebral hemorrhage and COL4A1 and COL4A2 mutations, from fetal life into adulthood. Ann Neurol 2012;71:439\u201341.","journal-title":"Ann Neurol"},{"key":"BFpr2013195_CR78","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/ana.22682","volume":"71","author":"YC Weng","year":"2012","unstructured":"Weng YC, Sonni A, Labelle-Dumais C, et al. COL4A1 mutations in patients with sporadic late-onset intracerebral hemorrhage. Ann Neurol 2012;71:470\u20137.","journal-title":"Ann Neurol"},{"key":"BFpr2013195_CR79","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jpeds.2009.04.014","volume":"155","author":"K Bilguvar","year":"2009","unstructured":"Bilguvar K, DiLuna ML, Bizzarro MJ, et al.; Pacifier and Breastfeeding Trial Group. COL4A1 mutation in preterm intraventricular hemorrhage. J Pediatr 2009;155:743\u20135.","journal-title":"J Pediatr"},{"key":"BFpr2013195_CR80","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1161\/STROKEAHA.107.496596","volume":"39","author":"NU Ko","year":"2008","unstructured":"Ko NU, Rajendran P, Kim H, et al. Endothelial nitric oxide synthase polymorphism (-786T-&gt;C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2008;39:1103\u20138.","journal-title":"Stroke"},{"key":"BFpr2013195_CR81","doi-asserted-by":"publisher","first-page":"E11","DOI":"10.3171\/2009.10.FOCUS09143","volume":"28","author":"P Vannemreddy","year":"2010","unstructured":"Vannemreddy P, Notarianni C, Yanamandra K, Napper D, Bocchini J . Is an endothelial nitric oxide synthase gene mutation a risk factor in the origin of intraventricular hemorrhage? Neurosurg Focus 2010;28:E11.","journal-title":"Neurosurg Focus"},{"issue":"Suppl 4","key":"BFpr2013195_CR82","first-page":"131","volume":"25(","author":"C Poggi","year":"2012","unstructured":"Poggi C, Giusti B, Vestri A, Pasquini E, Abbate R, Dani C . Genetic polymorphisms of antioxidant enzymes in preterm infants. J Matern Fetal Neonatal Med 2012;25( Suppl 4 ):131\u20134.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFpr2013195_CR83","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0140-6736(12)61134-9","volume":"381","author":"DN Franz","year":"2013","unstructured":"Franz DN, Belousova E, Sparagana S, et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet 2013;381:125\u201332.","journal-title":"Lancet"},{"key":"BFpr2013195_CR84","doi-asserted-by":"publisher","first-page":"3415","DOI":"10.1093\/hmg\/ddt191","volume":"22","author":"F Farooq","year":"2013","unstructured":"Farooq F, Abad\u00eda-Molina F, MacKenzie D, et al. Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation. Hum Mol Genet 2013;22:3415\u201324.","journal-title":"Hum Mol Genet"},{"key":"BFpr2013195_CR85","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1756285612472386","volume":"6","author":"WK Liew","year":"2013","unstructured":"Liew WK, Kang PB . Recent developments in the treatment of Duchenne muscular dystrophy and spinal muscular atrophy. Ther Adv Neurol Disord 2013;6:147\u201360.","journal-title":"Ther Adv Neurol Disord"},{"key":"BFpr2013195_CR86","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/gim.2012.157","volume":"15","author":"TA Manolio","year":"2013","unstructured":"Manolio TA, Chisholm RL, Ozenberger B, et al. Implementing genomic medicine in the clinic: the future is here. Genet Med 2013;15:258\u201367.","journal-title":"Genet Med"},{"key":"BFpr2013195_CR87","first-page":"485","volume":"62","author":"SC Bauer","year":"2010","unstructured":"Bauer SC, Msall ME . Optimizing neurodevelopmental outcomes after prematurity: lessons in neuroprotection and early intervention. Minerva Pediatr 2010;62:485\u201397.","journal-title":"Minerva Pediatr"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2013195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2013195","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2013195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:58:52Z","timestamp":1684472332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2013195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,5]]},"references-count":87,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["BFpr2013195"],"URL":"https:\/\/doi.org\/10.1038\/pr.2013.195","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,5]]}}}