{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:55:37Z","timestamp":1772895337584,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T00:00:00Z","timestamp":1383868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1038\/pr.2013.199","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T16:52:49Z","timestamp":1383929569000},"page":"51-61","source":"Crossref","is-referenced-by-count":36,"title":["Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism"],"prefix":"10.1038","volume":"75","author":[{"given":"Emmanuel","family":"Somm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Larvaron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"van de Looij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Toulotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Chatagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Faure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylviane","family":"M\u00e9tairon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Mansourian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Gruetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane V.","family":"Sizonenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra S.","family":"H\u00fcppi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,8]]},"reference":[{"key":"BFpr2013199_CR1","unstructured":"World health statistics report 2012. \n                    http:\/\/www.who.int\/gho\/publications\/world_health_statistics\/EN_WHS2012_Fullpdf\n                    \n                  ."},{"key":"BFpr2013199_CR2","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1093\/ije\/31.6.1235","volume":"31","author":"DJ Barker","year":"2002","unstructured":"Barker DJ, Eriksson JG, Fors\u00e9n T, Osmond C . Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 2002;31:1235\u20139.","journal-title":"Int J Epidemiol"},{"key":"BFpr2013199_CR3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1067\/S0022-3476(03)00243-9","volume":"143","author":"B Latal-Hajnal","year":"2003","unstructured":"Latal-Hajnal B, von Siebenthal K, Kovari H, Bucher HU, Largo RH . Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome. J Pediatr 2003;143:163\u201370.","journal-title":"J Pediatr"},{"key":"BFpr2013199_CR4","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0306-4522(00)00271-2","volume":"100","author":"C Mallard","year":"2000","unstructured":"Mallard C, Loeliger M, Copolov D, Rees S . Reduced number of neurons in the hippocampus and the cerebellum in the postnatal guinea-pig following intrauterine growth-restriction. Neuroscience 2000;100:327\u201333.","journal-title":"Neuroscience"},{"key":"BFpr2013199_CR5","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1203\/PDR.0b013e318165c005","volume":"63","author":"GA Lodygensky","year":"2008","unstructured":"Lodygensky GA, Seghier ML, Warfield SK, et al. Intrauterine growth restriction affects the preterm infant\u2019s hippocampus. Pediatr Res 2008;63:438\u201343.","journal-title":"Pediatr Res"},{"key":"BFpr2013199_CR6","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1203\/00006450-200111000-00008","volume":"50","author":"N Modi","year":"2001","unstructured":"Modi N, Lewis H, Al-Naqeeb N, Ajayi-Obe M, Dor\u00e9 CJ, Rutherford M . The effects of repeated antenatal glucocorticoid therapy on the developing brain. Pediatr Res 2001;50:581\u20135.","journal-title":"Pediatr Res"},{"key":"BFpr2013199_CR7","doi-asserted-by":"publisher","first-page":"e50131","DOI":"10.1371\/journal.pone.0050131","volume":"7","author":"E Somm","year":"2012","unstructured":"Somm E, Vauthay DM, Gu\u00e9rardel A, et al. Early metabolic defects in dexamethasone-exposed and undernourished intrauterine growth restricted rats. PLoS ONE 2012;7:e50131.","journal-title":"PLoS ONE"},{"key":"BFpr2013199_CR8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/dneu.20583","volume":"68","author":"CW Noorlander","year":"2008","unstructured":"Noorlander CW, Visser GH, Ramakers GM, Nikkels PG, de Graan PN . Prenatal corticosteroid exposure affects hippocampal plasticity and reduces lifespan. Dev Neurobiol 2008;68:237\u201346.","journal-title":"Dev Neurobiol"},{"key":"BFpr2013199_CR9","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.3168\/jds.S0022-0302(72)85741-2","volume":"55","author":"T Nagasawa","year":"1972","unstructured":"Nagasawa T, Kiyosawa I, Kuwahara K . Amounts of lactoferrin in human colostrum and milk. J Dairy Sci 1972;55:1651\u20139.","journal-title":"J Dairy Sci"},{"key":"BFpr2013199_CR10","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bbagen.2011.06.018","volume":"1820","author":"IA Garc\u00eda-Montoya","year":"2012","unstructured":"Garc\u00eda-Montoya IA, Cend\u00f3n TS, Ar\u00e9valo-Gallegos S, Rasc\u00f3n-Cruz Q . Lactoferrin a multiple bioactive protein: an overview. Biochim Biophys Acta 2012;1820:226\u201336.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2013199_CR11","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1001\/jama.2009.1403","volume":"302","author":"P Manzoni","year":"2009","unstructured":"Manzoni P, Rinaldi M, Cattani S, et al.; Italian Task Force for the Study and Prevention of Neonatal Fungal Infections, Italian Society of Neonatology. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA 2009;302:1421\u20138.","journal-title":"JAMA"},{"key":"BFpr2013199_CR12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/978-1-4757-9068-9_36","volume":"443","author":"C Fillebeen","year":"1998","unstructured":"Fillebeen C, Dexter D, Mitchell V, et al. Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment. Adv Exp Med Biol 1998;443:293\u2013300.","journal-title":"Adv Exp Med Biol"},{"key":"BFpr2013199_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.neulet.2009.01.071","volume":"452","author":"L An","year":"2009","unstructured":"An L, Sato H, Konishi Y, et al. Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer\u2019s disease. Neurosci Lett 2009;452:277\u201380.","journal-title":"Neurosci Lett"},{"key":"BFpr2013199_CR14","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.lfs.2005.05.085","volume":"78","author":"B Ji","year":"2006","unstructured":"Ji B, Maeda J, Higuchi M, et al. Pharmacokinetics and brain uptake of lactoferrin in rats. Life Sci 2006;78:851\u20135.","journal-title":"Life Sci"},{"key":"BFpr2013199_CR15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0165-3806(90)90002-G","volume":"53","author":"H Uno","year":"1990","unstructured":"Uno H, Lohmiller L, Thieme C, et al. Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus. Brain Res Dev Brain Res 1990;53:157\u201367.","journal-title":"Brain Res Dev Brain Res"},{"key":"BFpr2013199_CR16","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.1021\/jf063759o","volume":"55","author":"SC Wu","year":"2007","unstructured":"Wu SC, Chen HL, Yen CC, et al. Recombinant porcine lactoferrin expressed in the milk of transgenic mice enhances offspring growth performance. J Agric Food Chem 2007;55:4670\u20137.","journal-title":"J Agric Food Chem"},{"key":"BFpr2013199_CR17","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1203\/00006450-199607000-00013","volume":"40","author":"DG Burrin","year":"1996","unstructured":"Burrin DG, Wang H, Heath J, Dudley MA . Orally administered lactoferrin increases hepatic protein synthesis in formula-fed newborn pigs. Pediatr Res 1996;40:72\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr2013199_CR18","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1139\/o11-075","volume":"90","author":"Y Liao","year":"2012","unstructured":"Liao Y, Jiang R, L\u00f6nnerdal B . Biochemical and molecular impacts of lactoferrin on small intestinal growth and development during early life. Biochem Cell Biol 2012;90:476\u201384.","journal-title":"Biochem Cell Biol"},{"key":"BFpr2013199_CR19","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1080\/07315724.2000.10718933","volume":"19","author":"PA Ronayne de Ferrer","year":"2000","unstructured":"Ronayne de Ferrer PA, Baroni A, Sambucetti ME, Lopez NE, Ceriani Cernadas JM . Lactoferrin levels in term and preterm milk. J Am Coll Nutr 2000;19:370\u20133.","journal-title":"J Am Coll Nutr"},{"key":"BFpr2013199_CR20","doi-asserted-by":"publisher","first-page":"4366","DOI":"10.1210\/en.2003-1307","volume":"145","author":"J Cornish","year":"2004","unstructured":"Cornish J, Callon KE, Naot D, et al. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 2004;145:4366\u201374.","journal-title":"Endocrinology"},{"key":"BFpr2013199_CR21","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1042\/CBI20090358","volume":"34","author":"I Antonio","year":"2010","unstructured":"Antonio I, Valeria B, Maddalena G, Giovanni T . Immunohistochemical evidence of lactoferrin in human embryo-fetal bone and cartilage tissues. Cell Biol Int 2010;34:845\u20139.","journal-title":"Cell Biol Int"},{"key":"BFpr2013199_CR22","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ijo.2009.143","volume":"33","author":"JM Moreno-Navarrete","year":"2009","unstructured":"Moreno-Navarrete JM, Ortega FJ, Ricart W, Fernandez-Real JM . Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation. Int J Obes (Lond) 2009;33:991\u20131000.","journal-title":"Int J Obes (Lond)"},{"key":"BFpr2013199_CR23","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.jnutbio.2010.09.015","volume":"22","author":"JM Moreno-Navarrete","year":"2011","unstructured":"Moreno-Navarrete JM, Ortega F, Sabater M, Ricart W, Fern\u00e1ndez-Real JM . Proadipogenic effects of lactoferrin in human subcutaneous and visceral preadipocytes. J Nutr Biochem 2011;22:1143\u20139.","journal-title":"J Nutr Biochem"},{"issue":"5 Pt 1","key":"BFpr2013199_CR24","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1542\/peds.111.5.969","volume":"111","author":"S Saigal","year":"2003","unstructured":"Saigal S, Pinelli J, Hoult L, Kim MM, Boyle M . Psychopathology and social competencies of adolescents who were extremely low birth weight. Pediatrics 2003;111(5 Pt 1):969\u201375.","journal-title":"Pediatrics"},{"key":"BFpr2013199_CR25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1006\/mcne.1994.1048","volume":"5","author":"SJ Yi","year":"1994","unstructured":"Yi SJ, Masters JN, Baram TZ . Glucocorticoid receptor mRNA ontogeny in the fetal and postnatal rat forebrain. Mol Cell Neurosci 1994;5:385\u201393.","journal-title":"Mol Cell Neurosci"},{"key":"BFpr2013199_CR26","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1460-9568.1992.tb00888.x","volume":"4","author":"G Barbany","year":"1992","unstructured":"Barbany G, Persson H . Regulation of Neurotrophin mRNA Expression in the Rat Brain by Glucocorticoids. Eur J Neurosci 1992;4:396\u2013403.","journal-title":"Eur J Neurosci"},{"key":"BFpr2013199_CR27","doi-asserted-by":"publisher","first-page":"6356","DOI":"10.1210\/en.2008-0388","volume":"149","author":"A Hossain","year":"2008","unstructured":"Hossain A, Hajman K, Charitidi K, et al. Prenatal dexamethasone impairs behavior and the activation of the BDNF exon IV promoter in the paraventricular nucleus in adult offspring. Endocrinology 2008;149:6356\u201365.","journal-title":"Endocrinology"},{"key":"BFpr2013199_CR28","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1097\/00001756-199305000-00016","volume":"4","author":"C Cosi","year":"1993","unstructured":"Cosi C, Spoerri PE, Comelli MC, Guidolin D, Skaper SD . Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones. Neuroreport 1993;4:527\u201330.","journal-title":"Neuroreport"},{"key":"BFpr2013199_CR29","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1210\/me.2007-0264","volume":"22","author":"E Kumamaru","year":"2008","unstructured":"Kumamaru E, Numakawa T, Adachi N, et al. Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 2008;22:546\u201358.","journal-title":"Mol Endocrinol"},{"key":"BFpr2013199_CR30","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1073\/pnas.0800888106","volume":"106","author":"T Numakawa","year":"2009","unstructured":"Numakawa T, Kumamaru E, Adachi N, Yagasaki Y, Izumi A, Kunugi H . Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Proc Natl Acad Sci USA 2009;106:647\u201352.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr2013199_CR31","first-page":"340","volume":"13","author":"J Zhao","year":"2001","unstructured":"Zhao J, Ramadan E, Cappiello M, Wroblewska B, Bzdega T, Neale JH . NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance. Eur J Neurosci 2001;13:340\u20136.","journal-title":"Eur J Neurosci"},{"key":"BFpr2013199_CR32","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1523\/JNEUROSCI.06-11-03385.1986","volume":"6","author":"GL Westbrook","year":"1986","unstructured":"Westbrook GL, Mayer ML, Namboodiri MA, Neale JH . High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture. J Neurosci 1986;6:3385\u201392.","journal-title":"J Neurosci"},{"key":"BFpr2013199_CR33","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1471-4159.2006.04253.x","volume":"100","author":"R Bergeron","year":"2007","unstructured":"Bergeron R, Imamura Y, Frangioni JV, Greene RW, Coyle JT . Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus. J Neurochem 2007;100:346\u201357.","journal-title":"J Neurochem"},{"key":"BFpr2013199_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"TV Bliss","year":"1993","unstructured":"Bliss TV, Collingridge GL . A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993;361:31\u20139.","journal-title":"Nature"},{"key":"BFpr2013199_CR35","doi-asserted-by":"publisher","first-page":"R681","DOI":"10.1152\/ajpregu.90396.2008","volume":"296","author":"ME Schober","year":"2009","unstructured":"Schober ME, McKnight RA, Yu X, Callaway CW, Ke X, Lane RH . Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Am J Physiol Regul Integr Comp Physiol 2009;296:R681\u201392.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFpr2013199_CR36","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.physbeh.2011.02.032","volume":"104","author":"EW Neeley","year":"2011","unstructured":"Neeley EW, Berger R, Koenig JI, Leonard S . Strain dependent effects of prenatal stress on gene expression in the rat hippocampus. Physiol Behav 2011;104:334\u20139.","journal-title":"Physiol Behav"},{"key":"BFpr2013199_CR37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2164-6-59","volume":"6","author":"PB Dallas","year":"2005","unstructured":"Dallas PB, Gottardo NG, Firth MJ, et al. Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR \u2013 how well do they correlate? BMC Genomics 2005;6:59.","journal-title":"BMC Genomics"},{"key":"BFpr2013199_CR38","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/jcbfm.2008.152","volume":"29","author":"DW Schelshorn","year":"2009","unstructured":"Schelshorn DW, Schneider A, Kuschinsky W, et al. Expression of hemoglobin in rodent neurons. J Cereb Blood Flow Metab 2009;29:585\u201395.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFpr2013199_CR39","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1097\/01.wnr.0000223391.74575.c9","volume":"17","author":"DL Van den Hove","year":"2006","unstructured":"Van den Hove DL, Steinbusch HW, Bruschettini M, et al. Prenatal stress reduces S100B in the neonatal rat hippocampus. Neuroreport 2006;17:1077\u201380.","journal-title":"Neuroreport"},{"key":"BFpr2013199_CR40","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0278-6915(00)00036-3","volume":"38","author":"K Yamauchi","year":"2000","unstructured":"Yamauchi K, Toida T, Nishimura S, et al. 13-Week oral repeated administration toxicity study of bovine lactoferrin in rats. Food Chem Toxicol 2000;38:503\u201312.","journal-title":"Food Chem Toxicol"},{"key":"BFpr2013199_CR41","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.yrtph.2008.07.003","volume":"52","author":"D Cerven","year":"2008","unstructured":"Cerven D, DeGeorge G, Bethell D . 28-day repeated dose oral toxicity of recombinant human holo-lactoferrin in rats. Regul Toxicol Pharmacol 2008;52:174\u20139.","journal-title":"Regul Toxicol Pharmacol"},{"key":"BFpr2013199_CR42","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1139\/o06-040","volume":"84","author":"R Paesano","year":"2006","unstructured":"Paesano R, Torcia F, Berlutti F, et al. Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women. Biochem Cell Biol 2006;84:377\u201380.","journal-title":"Biochem Cell Biol"},{"key":"BFpr2013199_CR43","first-page":"563","volume":"46","author":"K Williams","year":"2000","unstructured":"Williams K, Wilson MA, Bressler J . Regulation and developmental expression of the divalent metal-ion transporter in the rat brain. Cell Mol Biol (Noisy-le-grand) 2000;46:563\u201371.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"BFpr2013199_CR44","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3945\/jn.108.096354","volume":"139","author":"ES Carlson","year":"2009","unstructured":"Carlson ES, Tkac I, Magid R, et al. Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr 2009;139:672\u20139.","journal-title":"J Nutr"},{"issue":"Pt 6","key":"BFpr2013199_CR45","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1042\/BST0361267","volume":"36","author":"MK Georgieff","year":"2008","unstructured":"Georgieff MK . The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus. Biochem Soc Trans 2008;36(Pt 6):1267\u201371.","journal-title":"Biochem Soc Trans"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2013199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2013199","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2013199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:58:56Z","timestamp":1684472336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2013199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,8]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["BFpr2013199"],"URL":"https:\/\/doi.org\/10.1038\/pr.2013.199","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,8]]}}}