{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:15:43Z","timestamp":1783768543317,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1038\/pr.2013.98","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T15:56:15Z","timestamp":1371225375000},"page":"290-298","source":"Crossref","is-referenced-by-count":52,"title":["Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia"],"prefix":"10.1038","volume":"74","author":[{"given":"Shannon","family":"Fleck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoanna","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Hae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta L.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita J.","family":"Moon-Grady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Miniati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tippi C.","family":"MacKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"BFpr201398_CR1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.clp.2009.03.004","volume":"36","author":"JA Deprest","year":"2009","unstructured":"Deprest JA, Gratacos E, Nicolaides K, et al. Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe. Clin Perinatol 2009;36:329\u201347, ix.","journal-title":"Clin Perinatol"},{"key":"BFpr201398_CR2","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.clp.2009.03.011","volume":"36","author":"E Jelin","year":"2009","unstructured":"Jelin E, Lee H . Tracheal occlusion for fetal congenital diaphragmatic hernia: the US experience. Clin Perinatol 2009;36:349\u201361, ix.","journal-title":"Clin Perinatol"},{"key":"BFpr201398_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000311944","volume":"29","author":"R Ruano","year":"2011","unstructured":"Ruano R, Duarte SA, Pimenta EJ, et al. Comparison between fetal endoscopic tracheal occlusion using a 1.0-mm fetoscope and prenatal expectant management in severe congenital diaphragmatic hernia. Fetal Diagn Ther 2011;29:64\u201370.","journal-title":"Fetal Diagn Ther"},{"key":"BFpr201398_CR4","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/j.jpedsurg.2010.04.006","volume":"45","author":"T Jancelewicz","year":"2010","unstructured":"Jancelewicz T, Vu LT, Keller RL, et al. Outcomes of multigestational pregnancies affected by congenital diaphragmatic hernia. J Pediatr Surg 2010;45:1753\u20138.","journal-title":"J Pediatr Surg"},{"key":"BFpr201398_CR5","doi-asserted-by":"publisher","first-page":"422.e1","DOI":"10.1016\/j.ajog.2007.07.001","volume":"197","author":"HL Hedrick","year":"2007","unstructured":"Hedrick HL, Danzer E, Merchant A, et al. Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia. Am J Obstet Gynecol 2007;197:422.e1\u20134.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201398_CR6","first-page":"307","volume-title":"J Pediatr Surg","author":"PW Dillon","year":"2004","unstructured":"Dillon PW, Cilley RE, Mauger D, Zachary C, Meier A . The relationship of pulmonary artery pressure and survival in congenital diaphragmatic hernia. J Pediatr Surg 2004;39:307\u201312; discussion 307\u201312."},{"key":"BFpr201398_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1164\/rccm.200907-1126OC","volume":"182","author":"RL Keller","year":"2010","unstructured":"Keller RL, Tacy TA, Hendricks-Munoz K, et al. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med 2010;182:555\u201361.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201398_CR8","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1067\/mob.2003.69","volume":"188","author":"S Fuke","year":"2003","unstructured":"Fuke S, Kanzaki T, Mu J, et al. Antenatal prediction of pulmonary hypoplasia by acceleration time\/ejection time ratio of fetal pulmonary arteries by Doppler blood flow velocimetry. Am J Obstet Gynecol 2003;188:228\u201333.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201398_CR9","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1067\/mob.2002.127130","volume":"187","author":"RE Broth","year":"2002","unstructured":"Broth RE, Wood DC, Rasanen J, et al. Prenatal prediction of lethal pulmonary hypoplasia: the hyperoxygenation test for pulmonary artery reactivity. Am J Obstet Gynecol 2002;187:940\u20135.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201398_CR10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nrcardio.2011.87","volume":"8","author":"RT Schermuly","year":"2011","unstructured":"Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger F . Mechanisms of disease: pulmonary arterial hypertension. Nat Rev Cardiol 2011;8:443\u201355.","journal-title":"Nat Rev Cardiol"},{"issue":"Suppl 1","key":"BFpr201398_CR11","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","volume":"54","author":"PM Hassoun","year":"2009","unstructured":"Hassoun PM, Mouthon L, Barber\u00e0 JA, et al. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol 2009;54:Suppl 1:S10\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"BFpr201398_CR12","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/S0022-3468(97)90381-X","volume":"32","author":"GB Mychaliska","year":"1997","unstructured":"Mychaliska GB, Rice HE, Tarantal AF, et al. In utero hematopoietic stem cell transplants prolong survival of postnatal kidney transplantation in monkeys. J Pediatr Surg 1997;32:976\u201381.","journal-title":"J Pediatr Surg"},{"key":"BFpr201398_CR13","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1182\/blood.V86.7.2829.2829","volume":"86","author":"JM Hall","year":"1995","unstructured":"Hall JM, Lingenfelter P, Adams SL, Lasser D, Hansen JA, Bean MA . Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood 1995;86:2829\u201332.","journal-title":"Blood"},{"key":"BFpr201398_CR14","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1161\/CIRCULATIONAHA.105.540542","volume":"112","author":"SL Merklinger","year":"2005","unstructured":"Merklinger SL, Jones PL, Martinez EC, Rabinovitch M . Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation 2005;112:423\u201331.","journal-title":"Circulation"},{"key":"BFpr201398_CR15","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1172\/JCI24838","volume":"115","author":"RT Schermuly","year":"2005","unstructured":"Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005;115:2811\u201321.","journal-title":"J Clin Invest"},{"key":"BFpr201398_CR16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/978-1-60761-500-2_28","volume":"661","author":"F Grimminger","year":"2010","unstructured":"Grimminger F, Schermuly RT . PDGF receptor and its antagonists: role in treatment of PAH. Adv Exp Med Biol 2010;661:435\u201346.","journal-title":"Adv Exp Med Biol"},{"key":"BFpr201398_CR17","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s10620-010-1220-7","volume":"55","author":"S Dhillon","year":"2010","unstructured":"Dhillon S, Kaker A, Dosanjh A, Japra D, Vanthiel DH . Irreversible pulmonary hypertension associated with the use of interferon alpha for chronic hepatitis C. Dig Dis Sci 2010;55:1785\u201390.","journal-title":"Dig Dis Sci"},{"key":"BFpr201398_CR18","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1164\/ajrccm.151.5.7735624","volume":"151","author":"M Humbert","year":"1995","unstructured":"Humbert M, Monti G, Brenot F, et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 1995;151:1628\u201331.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201398_CR19","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.109.933762","volume":"122","author":"E Soon","year":"2010","unstructured":"Soon E, Holmes AM, Treacy CM, et al. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation 2010;122:920\u20137.","journal-title":"Circulation"},{"key":"BFpr201398_CR20","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1164\/rccm.2106007","volume":"165","author":"K Balabanian","year":"2002","unstructured":"Balabanian K, Foussat A, Dorfm\u00fcller P, et al. CX(3)C chemokine fractalkine in pulmonary arterial hypertension. Am J Respir Crit Care Med 2002;165:1419\u201325.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr201398_CR21","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1172\/JCI35070","volume":"119","author":"M Izikki","year":"2009","unstructured":"Izikki M, Guignabert C, Fadel E, et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest 2009;119:512\u201323.","journal-title":"J Clin Invest"},{"key":"BFpr201398_CR22","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1055\/s-0031-1295436","volume":"223","author":"T Schaible","year":"2011","unstructured":"Schaible T, Veit M, Tautz J, et al. Serum cytokine levels in neonates with congenital diaphragmatic hernia. Klin Padiatr 2011;223:414\u20138.","journal-title":"Klin Padiatr"},{"key":"BFpr201398_CR23","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1073\/pnas.93.2.705","volume":"93","author":"DW Bianchi","year":"1996","unstructured":"Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA . Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA 1996;93:705\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr201398_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1172\/JCI6611","volume":"104","author":"S Maloney","year":"1999","unstructured":"Maloney S, Smith A, Furst DE, et al. Microchimerism of maternal origin persists into adult life. J Clin Invest 1999;104:41\u20137.","journal-title":"J Clin Invest"},{"key":"BFpr201398_CR25","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1126\/science.1164511","volume":"322","author":"JE Mold","year":"2008","unstructured":"Mold JE, Micha\u00eblsson J, Burt TD, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008;322:1562\u20135.","journal-title":"Science"},{"key":"BFpr201398_CR26","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1378\/chest.127.5.1793","volume":"127","author":"K Hayashida","year":"2005","unstructured":"Hayashida K, Fujita J, Miyake Y, et al. Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension. Chest 2005;127:1793\u20138.","journal-title":"Chest"},{"key":"BFpr201398_CR27","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1172\/JCI44907","volume":"121","author":"A Nijagal","year":"2011","unstructured":"Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC . Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest 2011;121:582\u201392.","journal-title":"J Clin Invest"},{"key":"BFpr201398_CR28","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.jpedsurg.2012.03.012","volume":"47","author":"P Saadai","year":"2012","unstructured":"Saadai P, Lee TH, Bautista G, et al. Alterations in maternal-fetal cellular trafficking after fetal surgery. J Pediatr Surg 2012;47:1089\u201394.","journal-title":"J Pediatr Surg"},{"key":"BFpr201398_CR29","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1016\/j.jpedsurg.2008.04.033","volume":"43","author":"E Danzer","year":"2008","unstructured":"Danzer E, Davey MG, Kreiger PA, et al. Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles. J Pediatr Surg 2008;43:1767\u201375.","journal-title":"J Pediatr Surg"},{"key":"BFpr201398_CR30","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nrcardio.2011.104","volume":"8","author":"DS O\u2019Callaghan","year":"2011","unstructured":"O\u2019Callaghan DS, Savale L, Montani D, et al. Treatment of pulmonary arterial hypertension with targeted therapies. Nat Rev Cardiol 2011;8:526\u201338.","journal-title":"Nat Rev Cardiol"},{"key":"BFpr201398_CR31","doi-asserted-by":"publisher","first-page":"381.e1","DOI":"10.1016\/j.ajog.2007.06.061","volume":"197","author":"M Davey","year":"2007","unstructured":"Davey M, Shegu S, Danzer E, et al. Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion\/glucocorticoid therapy. Am J Obstet Gynecol 2007;197:381.e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201398_CR32","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1161\/CIRCULATIONAHA.108.845909","volume":"123","author":"C Luong","year":"2011","unstructured":"Luong C, Rey-Perra J, Vadivel A, et al. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation 2011;123:2120\u201331.","journal-title":"Circulation"},{"key":"BFpr201398_CR33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00383-003-1052-z","volume":"19","author":"N Guarino","year":"2004","unstructured":"Guarino N, Solari V, Shima H, Puri P . Upregulated expression of EGF and TGF-alpha in the proximal respiratory epithelium in the human hypoplastic lung in congenital diaphragmatic hernia. Pediatr Surg Int 2004;19:755\u20139.","journal-title":"Pediatr Surg Int"},{"key":"BFpr201398_CR34","doi-asserted-by":"publisher","first-page":"L1159","DOI":"10.1152\/ajplung.00325.2010","volume":"302","author":"YT Chang","year":"2012","unstructured":"Chang YT, Ringman Uggla A, Osterholm C, et al. Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 2012;302:L1159\u201366.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr201398_CR35","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1016\/j.jpedsurg.2008.07.022","volume":"43","author":"B Frenckner","year":"2008","unstructured":"Frenckner B, Broom\u00e9 M, Lindstr\u00f6m M, Radell P . Platelet-derived growth factor inhibition\u2013a new treatment of pulmonary hypertension in congenital diaphragmatic hernia? J Pediatr Surg 2008;43:1928\u201331.","journal-title":"J Pediatr Surg"},{"key":"BFpr201398_CR36","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1097\/QAD.0b013e3283489d1f","volume":"25","author":"SM Keating","year":"2011","unstructured":"Keating SM, Golub ET, Nowicki M, et al.; Women\u2019s Interagency HIV Study. The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women. AIDS 2011;25:1823\u201332.","journal-title":"AIDS"},{"key":"BFpr201398_CR37","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1111\/j.1537-2995.2006.00992.x","volume":"46","author":"TH Lee","year":"2006","unstructured":"Lee TH, Chafets DM, Reed W, et al. Enhanced ascertainment of microchimerism with real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphisms. Transfusion 2006;46:1870\u20138.","journal-title":"Transfusion"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201398.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201398","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201398.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:00:50Z","timestamp":1684472450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,14]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["BFpr201398"],"URL":"https:\/\/doi.org\/10.1038\/pr.2013.98","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,14]]}}}