{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:40:22Z","timestamp":1787002822568,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1038\/pr.2014.181","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T11:55:40Z","timestamp":1416398140000},"page":"310-315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The expression of epithelial\u2013mesenchymal transition\u2013related proteins in biliary epithelial cells is associated with liver fibrosis in biliary atresia"],"prefix":"10.1038","volume":"77","author":[{"given":"Yongtao","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"BFpr2014181_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/hep.21701","volume":"46","author":"B Narayanaswamy","year":"2007","unstructured":"Narayanaswamy B, Gonde C, Tredger JM, Hussain M, Vergani D, Davenport M . Serial circulating markers of inflammation in biliary atresia\u2013evolution of the post-operative inflammatory process. Hepatology 2007;46:180\u20137.","journal-title":"Hepatology"},{"key":"BFpr2014181_CR2","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1002\/hep.23196","volume":"50","author":"SS Choi","year":"2009","unstructured":"Choi SS, Diehl AM . Epithelial-to-mesenchymal transitions in the liver. Hepatology 2009;50:2007\u201313.","journal-title":"Hepatology"},{"key":"BFpr2014181_CR3","doi-asserted-by":"publisher","first-page":"G575","DOI":"10.1152\/ajpgi.00102.2006","volume":"291","author":"JK Sicklick","year":"2006","unstructured":"Sicklick JK, Choi SS, Bustamante M, et al. Evidence for epithelial-3mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol 2006;291:G575\u201383.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFpr2014181_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1172\/JCI0215518","volume":"110","author":"M Iwano","year":"2002","unstructured":"Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG . Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002;110:341\u201350.","journal-title":"J Clin Invest"},{"key":"BFpr2014181_CR5","doi-asserted-by":"publisher","first-page":"23337","DOI":"10.1074\/jbc.M700194200","volume":"282","author":"M Zeisberg","year":"2007","unstructured":"Zeisberg M, Yang C, Martino M, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007;282:23337\u201347.","journal-title":"J Biol Chem"},{"key":"BFpr2014181_CR6","first-page":"3331","volume":"118","author":"A Omenetti","year":"2008","unstructured":"Omenetti A, Porrello A, Jung Y, et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 2008;118:3331\u201342.","journal-title":"J Clin Invest"},{"key":"BFpr2014181_CR7","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1091\/mbc.e11-02-0103","volume":"22","author":"PA Gregory","year":"2011","unstructured":"Gregory PA, Bracken CP, Smith E, et al. An autocrine TGF-beta\/ZEB\/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 2011;22:1686\u201398.","journal-title":"Mol Biol Cell"},{"key":"BFpr2014181_CR8","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/ncb1722","volume":"10","author":"PA Gregory","year":"2008","unstructured":"Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008;10:593\u2013601.","journal-title":"Nat Cell Biol"},{"key":"BFpr2014181_CR9","doi-asserted-by":"publisher","first-page":"14910","DOI":"10.1074\/jbc.C800074200","volume":"283","author":"M Korpal","year":"2008","unstructured":"Korpal M, Lee ES, Hu G, Kang Y . The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008;283:14910\u20134.","journal-title":"J Biol Chem"},{"key":"BFpr2014181_CR10","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1101\/gad.1640608","volume":"22","author":"SM Park","year":"2008","unstructured":"Park SM, Gaur AB, Lengyel E, Peter ME . The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008;22:894\u2013907.","journal-title":"Genes Dev"},{"key":"BFpr2014181_CR11","doi-asserted-by":"publisher","first-page":"5764","DOI":"10.1038\/sj.onc.1208927","volume":"24","author":"J Zavadil","year":"2005","unstructured":"Zavadil J, B\u00f6ttinger EP . TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005;24:5764\u201374.","journal-title":"Oncogene"},{"key":"BFpr2014181_CR12","doi-asserted-by":"publisher","first-page":"e541","DOI":"10.1038\/cddis.2013.22","volume":"4","author":"Y Chen","year":"2013","unstructured":"Chen Y, Xiao Y, Ge W, et al. miR-200b inhibits TGF-\u00df1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells. Cell Death Dis 2013;4:e541.","journal-title":"Cell Death Dis"},{"key":"BFpr2014181_CR13","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s10620-010-1347-6","volume":"56","author":"YH Deng","year":"2011","unstructured":"Deng YH, Pu CL, Li YC, et al. Analysis of biliary epithelial-mesenchymal transition in portal tract fibrogenesis in biliary atresia. Dig Dis Sci 2011;56:731\u201340.","journal-title":"Dig Dis Sci"},{"key":"BFpr2014181_CR14","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/path.2488","volume":"217","author":"K Harada","year":"2009","unstructured":"Harada K, Sato Y, Ikeda H, et al. Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J Pathol 2009;217:654\u201364.","journal-title":"J Pathol"},{"key":"BFpr2014181_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.humpath.2007.05.021","volume":"39","author":"R D\u00edaz","year":"2008","unstructured":"D\u00edaz R, Kim JW, Hui JJ, et al. Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis. Hum Pathol 2008;39:102\u201315.","journal-title":"Hum Pathol"},{"key":"BFpr2014181_CR16","doi-asserted-by":"publisher","first-page":"20202","DOI":"10.1074\/jbc.M110.102012","volume":"285","author":"SN Flier","year":"2010","unstructured":"Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R . Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010;285:20202\u201312.","journal-title":"J Biol Chem"},{"key":"BFpr2014181_CR17","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/0022-3468(94)90730-7","volume":"29","author":"I Shirahase","year":"1994","unstructured":"Shirahase I, Ooshima A, Tanaka K, Yamabe H, Inomata Y, Ozawa K . Immunohistochemical demonstration of collagen types III and IV and myofibroblasts in the liver of patients with biliary atresia. J Pediatr Surg 1994;29:639\u201344.","journal-title":"J Pediatr Surg"},{"key":"BFpr2014181_CR18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0002-9440(10)65595-2","volume":"153","author":"GA Ramm","year":"1998","unstructured":"Ramm GA, Nair VG, Bridle KR, Shepherd RW, Crawford DH . Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. Am J Pathol 1998;153:527\u201335.","journal-title":"Am J Pathol"},{"key":"BFpr2014181_CR19","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/hep.24156","volume":"53","author":"A Omenetti","year":"2011","unstructured":"Omenetti A, Bass LM, Anders RA, et al. Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. Hepatology 2011;53:1246\u201358.","journal-title":"Hepatology"},{"key":"BFpr2014181_CR20","first-page":"1221","volume":"139","author":"S Milani","year":"1991","unstructured":"Milani S, Herbst H, Schuppan D, Stein H, Surrenti C . Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991;139:1221\u20139.","journal-title":"Am J Pathol"},{"key":"BFpr2014181_CR21","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0168-8278(99)80221-9","volume":"31","author":"T Lamireau","year":"1999","unstructured":"Lamireau T, Le Bail B, Boussarie L, et al. Expression of collagens type I and IV, osteonectin and transforming growth factor beta-1 (TGFbeta1) in biliary atresia and paucity of intrahepatic bile ducts during infancy. J Hepatol 1999;31:248\u201355.","journal-title":"J Hepatol"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2014181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2014181","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2014181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T01:01:39Z","timestamp":1684458099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2014181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,19]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["BFpr2014181"],"URL":"https:\/\/doi.org\/10.1038\/pr.2014.181","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,19]]},"assertion":[{"value":"2 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}