{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:19:19Z","timestamp":1772781559671,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1038\/pr.2014.187","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T19:44:57Z","timestamp":1416858297000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Proteomic analysis of pediatric sinonasal secretions shows increased MUC5B mucin in CRS"],"prefix":"10.1038","volume":"77","author":[{"given":"Amarel","family":"Saieg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Pena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary C.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Preciado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"BFpr2014187_CR1","first-page":"1","volume":"10","author":"V Benson","year":"1994","unstructured":"Benson V, Marano MA . Current estimates from the National Health Interview Survey, 1992. Vital Health Stat 1994;10:1\u2013269.","journal-title":"Vital Health Stat"},{"key":"BFpr2014187_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S0194-5998(95)70152-4","volume":"113","author":"RE Gliklich","year":"1995","unstructured":"Gliklich RE, Metson R . The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 1995;113:104\u20139.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"BFpr2014187_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00010.2005","volume":"86","author":"MC Rose","year":"2006","unstructured":"Rose MC, Voynow JA . Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 2006;86:245\u201378.","journal-title":"Physiol Rev"},{"key":"BFpr2014187_CR4","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1177\/000348940511401212","volume":"114","author":"MT Pe\u00f1a","year":"2005","unstructured":"Pe\u00f1a MT, Aujla PK, Patel KM, Zalzal GH, Rose MC . Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls. Ann Otol Rhinol Laryngol 2005;114:958\u201365.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BFpr2014187_CR5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/000348940711600513","volume":"116","author":"MT Pe\u00f1ia","year":"2007","unstructured":"Pe\u00f1ia MT, Aujla PK, Zudaire E, et al. Localization and expression of MUC5B and MUC7 mucins in pediatric sinus mucosa. Ann Otol Rhinol Laryngol 2007;116:389\u201397.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BFpr2014187_CR6","doi-asserted-by":"publisher","first-page":"554","DOI":"10.2500\/ajr.2006.20.2935","volume":"20","author":"H Viswanathan","year":"2006","unstructured":"Viswanathan H, Brownlee IA, Pearson JP, Carrie S . MUC5B secretion is up-regulated in sinusitis compared with controls. Am J Rhinol 2006;20:554\u20137.","journal-title":"Am J Rhinol"},{"key":"BFpr2014187_CR7","first-page":"1975","volume":"89","author":"HR Zang","year":"2009","unstructured":"Zang HR, Wang T, Li YC, et al. [A histopathological study: chronic rhinosinusitis in adolescents versus adults]. Zhonghua Yi Xue Za Zhi 2009;89:1975\u20138.","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"BFpr2014187_CR8","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/elps.200305862","volume":"25","author":"B Casado","year":"2004","unstructured":"Casado B, Pannell LK, Viglio S, Iadarola P, Baraniuk JN . Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry. Electrophoresis 2004;25:1386\u201393.","journal-title":"Electrophoresis"},{"key":"BFpr2014187_CR9","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1002\/pmic.200401172","volume":"5","author":"B Casado","year":"2005","unstructured":"Casado B, Pannell LK, Iadarola P, Baraniuk JN . Identification of human nasal mucous proteins using proteomics. Proteomics 2005;5:2949\u201359.","journal-title":"Proteomics"},{"key":"BFpr2014187_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/1615-9861(200201)2:1<112::AID-PROT112>3.0.CO;2-N","volume":"2","author":"B Ghafouri","year":"2002","unstructured":"Ghafouri B, St\u00e5hlbom B, Tagesson C, Lindahl M . Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics 2002;2:112\u201320.","journal-title":"Proteomics"},{"key":"BFpr2014187_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/jssc.200800474","volume":"32","author":"LM Benson","year":"2009","unstructured":"Benson LM, Mason CJ, Friedman O, Kita H, Bergen HR 3rd, Plager DA . Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients. J Sep Sci 2009;32:44\u201356.","journal-title":"J Sep Sci"},{"key":"BFpr2014187_CR12","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1074\/mcp.M800203-MCP200","volume":"7","author":"H Choi","year":"2008","unstructured":"Choi H, Fermin D, Nesvizhskii AI . Significance analysis of spectral count data in label-free shotgun proteomics. Mol Cell Proteomics 2008;7:2373\u201385.","journal-title":"Mol Cell Proteomics"},{"key":"BFpr2014187_CR13","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1021\/pr300058z","volume":"11","author":"R Cao","year":"2012","unstructured":"Cao R, Wang TT, DeMaria G, Sheehan JK, Kesimer M . Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study. J Proteome Res 2012;11:4013\u201323.","journal-title":"J Proteome Res"},{"key":"BFpr2014187_CR14","doi-asserted-by":"publisher","first-page":"L92","DOI":"10.1152\/ajplung.90388.2008","volume":"296","author":"M Kesimer","year":"2009","unstructured":"Kesimer M, Kirkham S, Pickles RJ, et al. Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways? Am J Physiol Lung Cell Mol Physiol 2009;296:L92\u2013L100.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2014187_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1477-5956-9-4","volume":"9","author":"M Ali","year":"2011","unstructured":"Ali M, Lillehoj EP, Park Y, Kyo Y, Kim KC . Analysis of the proteome of human airway epithelial secretions. Proteome Sci 2011;9:4.","journal-title":"Proteome Sci"},{"key":"BFpr2014187_CR16","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.otohns.2009.04.022","volume":"141","author":"W Min-man","year":"2009","unstructured":"Min-man W, Hong S, Zhi-qiang X, Xue-ping F, Chang-qi L, Dan L . Differential proteomic analysis of nasal polyps, chronic sinusitis, and normal nasal mucosa tissues. Otolaryngol Head Neck Surg 2009;141:364\u20138.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"BFpr2014187_CR17","doi-asserted-by":"publisher","first-page":"L879","DOI":"10.1152\/ajplung.00156.2006","volume":"292","author":"JK Kim","year":"2007","unstructured":"Kim JK, Kim SS, Rha KW, et al. Expression and localization of surfactant proteins in human nasal epithelium. Am J Physiol Lung Cell Mol Physiol 2007;292:L879\u201384.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2014187_CR18","doi-asserted-by":"publisher","first-page":"17036","DOI":"10.1074\/jbc.M210429200","volume":"278","author":"Y Chen","year":"2003","unstructured":"Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R . Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine\/autocrine loop. J Biol Chem 2003;278:17036\u201343.","journal-title":"J Biol Chem"},{"key":"BFpr2014187_CR19","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s11882-004-0030-4","volume":"4","author":"B Casado","year":"2004","unstructured":"Casado B . Proteomics for nasal secretion analysis. Curr Allergy Asthma Rep 2004;4:224\u20139.","journal-title":"Curr Allergy Asthma Rep"},{"key":"BFpr2014187_CR20","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/hmg\/11.8.937","volume":"11","author":"CD Bingle","year":"2002","unstructured":"Bingle CD, Craven CJ . PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 2002;11:937\u201343.","journal-title":"Hum Mol Genet"},{"key":"BFpr2014187_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1165\/rcmb.2003-0142OC","volume":"30","author":"MA Campos","year":"2004","unstructured":"Campos MA, Abreu AR, Nlend MC, Cobas MA, Conner GE, Whitney PL . Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol 2004;30:184\u201392.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2014187_CR22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/path.1726","volume":"205","author":"L Bingle","year":"2005","unstructured":"Bingle L, Cross SS, High AS, et al. SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype. J Pathol 2005;205:491\u20137.","journal-title":"J Pathol"},{"key":"BFpr2014187_CR23","doi-asserted-by":"publisher","first-page":"L1066","DOI":"10.1152\/ajplung.00057.2003","volume":"285","author":"KL Hartshorn","year":"2003","unstructured":"Hartshorn KL, White MR, Mogues T, Ligtenberg T, Crouch E, Holmskov U . Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Am J Physiol Lung Cell Mol Physiol 2003;285:L1066\u201376.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2014187_CR24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0014-5793(03)00217-5","volume":"540","author":"W Kang","year":"2003","unstructured":"Kang W, Reid KB . DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration? FEBS Lett 2003;540:21\u20135.","journal-title":"FEBS Lett"},{"key":"BFpr2014187_CR25","doi-asserted-by":"publisher","first-page":"32109","DOI":"10.1074\/jbc.M203788200","volume":"277","author":"FJ Bikker","year":"2002","unstructured":"Bikker FJ, Ligtenberg AJ, Nazmi K, et al. Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340\/DMBT1), a member of the scavenger receptor cysteine-rich superfamily. J Biol Chem 2002;277:32109\u201315.","journal-title":"J Biol Chem"},{"key":"BFpr2014187_CR26","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10719-006-9020-1","volume":"24","author":"C Eriksson","year":"2007","unstructured":"Eriksson C, Fr\u00e4ngsmyr L, Danielsson Niemi L, et al. Variant size- and glycoforms of the scavenger receptor cysteine-rich protein gp-340 with differential bacterial aggregation. Glycoconj J 2007;24:131\u201342.","journal-title":"Glycoconj J"},{"key":"BFpr2014187_CR27","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/glycob\/11.11.969","volume":"11","author":"DJ Thornton","year":"2001","unstructured":"Thornton DJ, Davies JR, Kirkham S, et al. Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin. Glycobiology 2001;11:969\u201377.","journal-title":"Glycobiology"},{"key":"BFpr2014187_CR28","first-page":"381","volume":"38","author":"Y Al Badaai","year":"2009","unstructured":"Al Badaai Y, DiFalco MR, Tewfik MA, Samaha M . Quantitative proteomics of nasal mucus in chronic sinusitis with nasal polyposis. J Otolaryngol Head Neck Surg 2009;38:381\u20139.","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"BFpr2014187_CR29","doi-asserted-by":"publisher","first-page":"680","DOI":"10.2500\/ajr.2007.21.3103","volume":"21","author":"MA Tewfik","year":"2007","unstructured":"Tewfik MA, Latterich M, DiFalco MR, Samaha M . Proteomics of nasal mucus in chronic rhinosinusitis. Am J Rhinol 2007;21:680\u20135.","journal-title":"Am J Rhinol"},{"key":"BFpr2014187_CR30","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1177\/000348941112001203","volume":"120","author":"DC Upton","year":"2011","unstructured":"Upton DC, Welham NV, Kuo JS, Walker JW, Pasic TR . Chronic rhinosinusitis with nasal polyps: a proteomic analysis. Ann Otol Rhinol Laryngol 2011;120:780\u20136.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"BFpr2014187_CR31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/archoto.2008.505","volume":"135","author":"X Wu","year":"2009","unstructured":"Wu X, Ghimbovschi S, Aujla PK, Rose MC, Pe\u00f1a MT . Expression profiling of inflammatory mediators in pediatric sinus mucosa. Arch Otolaryngol Head Neck Surg 2009;135:65\u201372.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BFpr2014187_CR32","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1021\/pr050341h","volume":"5","author":"B Ghafouri","year":"2006","unstructured":"Ghafouri B, Irander K, Lindbom J, Tagesson C, Lindahl M . Comparative proteomics of nasal fluid in seasonal allergic rhinitis. J Proteome Res 2006;5:330\u20138.","journal-title":"J Proteome Res"},{"key":"BFpr2014187_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF00171697","volume":"250","author":"M Fukami","year":"1993","unstructured":"Fukami M, Stierna P, Veress B, Carls\u00f6\u00f6 B . Lysozyme and lactoferrin in human maxillary sinus mucosa during chronic sinusitis. An immunohistochemical study. Eur Arch Otorhinolaryngol 1993;250:133\u20139.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"BFpr2014187_CR34","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1128\/MCB.05234-11","volume":"31","author":"DB Johnstone","year":"2011","unstructured":"Johnstone DB, Zhang J, George B, et al. Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy. Mol Cell Biol 2011;31:2162\u201370.","journal-title":"Mol Cell Biol"},{"key":"BFpr2014187_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1006\/geno.1996.0338","volume":"35","author":"HK Kang","year":"1996","unstructured":"Kang HK, Cox DW . Tandem repeats 3\u2019 of the IGHA genes in the human immunoglobulin heavy chain gene cluster. Genomics 1996;35:189\u201395.","journal-title":"Genomics"},{"key":"BFpr2014187_CR36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/00016488409130975","volume":"97","author":"M Tos","year":"1984","unstructured":"Tos M, Mogensen C . Mucus production in chronic maxillary sinusitis. A quantitative histopathological study. Acta Otolaryngol 1984;97:151\u20139.","journal-title":"Acta Otolaryngol"},{"key":"BFpr2014187_CR37","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2500\/105065899782106742","volume":"13","author":"DM Nadel","year":"1999","unstructured":"Nadel DM, Lanza DC, Kennedy DW . Endoscopically guided sinus cultures in normal subjects. Am J Rhinol 1999;13:87\u201390.","journal-title":"Am J Rhinol"},{"key":"BFpr2014187_CR38","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1086\/323813","volume":"33","author":"GH Talbot","year":"2001","unstructured":"Talbot GH, Kennedy DW, Scheld WM, Granito K ; Endoscopy Study Group. Rigid nasal endoscopy versus sinus puncture and aspiration for microbiologic documentation of acute bacterial maxillary sinusitis. Clin Infect Dis 2001;33:1668\u201375.","journal-title":"Clin Infect Dis"},{"key":"BFpr2014187_CR39","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1203\/PDR.0b013e3181eb2ecc","volume":"68","author":"D Preciado","year":"2010","unstructured":"Preciado D, Goyal S, Rahimi M, et al. MUC5B Is the predominant mucin glycoprotein in chronic otitis media fluid. Pediatr Res 2010;68:231\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr2014187_CR40","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1165\/ajrcmb.20.3.3383","volume":"20","author":"JT Berger","year":"1999","unstructured":"Berger JT, Voynow JA, Peters KW, Rose MC . Respiratory carcinoma cell lines. MUC genes and glycoconjugates. Am J Respir Cell Mol Biol 1999;20:500\u201310.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2014187_CR41","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1042\/bj3160967","volume":"316 (Pt 3)","author":"DJ Thornton","year":"1996","unstructured":"Thornton DJ, Carlstedt I, Howard M, Devine PL, Price MR, Sheehan JK . Respiratory mucins: identification of core proteins and glycoforms. Biochem J 1996;316 (Pt 3):967\u201375.","journal-title":"Biochem J"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2014187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2014187","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2014187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:01:45Z","timestamp":1684472505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2014187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["BFpr2014187"],"URL":"https:\/\/doi.org\/10.1038\/pr.2014.187","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,24]]},"assertion":[{"value":"24 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}