{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:54:47Z","timestamp":1773410087570,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/pr.2014.50","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T16:04:16Z","timestamp":1396973056000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats"],"prefix":"10.1038","volume":"76","author":[{"given":"Vesna D.","family":"Stojanovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada M.","family":"Vu\u010dkovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad A.","family":"Bari\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Srdi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra D.","family":"Doronjski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira E.","family":"Peco Anti\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"BFpr201450_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00467-008-1060-2","volume":"24","author":"DJ Askenazi","year":"2009","unstructured":"Askenazi DJ, Namasiwayam A, Goldstein SL . Acute kidney injury in critically ill newborns: What do we know? What do we need to learn? Ped Nephrol 2009;24:265\u2013274.","journal-title":"Ped Nephrol"},{"key":"BFpr201450_CR2","first-page":"928","volume":"42","author":"BD Gupta","year":"2005","unstructured":"Gupta BD, Sharma P, Bagla J, Parakh M, Soni JP . Renal failure in asphyxiated neonates. Indian Pediatr 2005;42:928\u201334.","journal-title":"Indian Pediatr"},{"key":"BFpr201450_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1081\/JDI-200026749","volume":"26","author":"PI Agras","year":"2004","unstructured":"Agras PI, Tarcan A, Baskin E, Cengiz N, G\u00fcrakan B, Saatci U . Acute renal failure in the neonatal period. Ren Fail 2004;26:305\u20139.","journal-title":"Ren Fail"},{"key":"BFpr201450_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/01.shk.0000225415.5969694.ce","volume":"26","author":"RJ Trof","year":"2006","unstructured":"Trof RJ, Di Maggio F, Leemreis J, Groeneveld AB . Biomarkers of acute renal injury and renal failure. Shock 2006;26:245\u201353.","journal-title":"Shock"},{"key":"BFpr201450_CR5","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1681\/ASN.2006030221","volume":"18","author":"O Liangos","year":"2007","unstructured":"Liangos O, Perianayagam MC, Vaidya VS, et al. Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 2007;18:904\u201312.","journal-title":"J Am Soc Nephrol"},{"key":"BFpr201450_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/adc.82.1.71","volume":"82","author":"H Finney","year":"2000","unstructured":"Finney H, Newman DJ, Thakkar H, Fell JM, Price CP . Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child 2000;82:71\u20135.","journal-title":"Arch Dis Child"},{"key":"BFpr201450_CR7","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/sj.ki.5002729","volume":"73","author":"SG Coca","year":"2008","unstructured":"Coca SG, Yalavarthy R, Concato J, Parikh CR . Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int 2008;73:1008\u201316.","journal-title":"Kidney Int"},{"key":"BFpr201450_CR8","doi-asserted-by":"publisher","first-page":"F313","DOI":"10.1152\/ajprenal.00180.2006","volume":"292","author":"MH de Borst","year":"2007","unstructured":"de Borst MH, van Timmeren MM, Vaidya VS, et al. Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol 2007;292:F313\u201320.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFpr201450_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433.x","volume":"62","author":"WK Han","year":"2002","unstructured":"Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV . Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 2002;62:237\u201344.","journal-title":"Kidney Int"},{"key":"BFpr201450_CR10","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1007\/s00467-007-0470-x","volume":"23","author":"MT Nguyen","year":"2008","unstructured":"Nguyen MT, Devarajan P . Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol 2008;23:2151\u20137.","journal-title":"Pediatr Nephrol"},{"key":"BFpr201450_CR11","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/j.1523-1755.2004.00861.x","volume":"66","author":"S Herget-Rosenthal","year":"2004","unstructured":"Herget-Rosenthal S, Marggraf G, H\u00fcsing J, et al. Early detection of acute renal failure by serum cystatin C. Kidney Int 2004;66:1115\u201322.","journal-title":"Kidney Int"},{"key":"BFpr201450_CR12","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1124\/jpet.107.127357","volume":"323","author":"M Joyeux-Faure","year":"2007","unstructured":"Joyeux-Faure M . Cellular protection by erythropoietin: new therapeutic implications? J Pharmacol Exp Ther 2007;323:759\u201362.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFpr201450_CR13","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.cardiores.2004.03.017","volume":"63","author":"MA Bogoyevitch","year":"2004","unstructured":"Bogoyevitch MA . An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection. Cardiovasc Res 2004;63:208\u201316.","journal-title":"Cardiovasc Res"},{"key":"BFpr201450_CR14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/00004647-200205000-00001","volume":"22","author":"ZZ Chong","year":"2002","unstructured":"Chong ZZ, Kang JQ, Maiese K . Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab 2002;22:503\u201314.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFpr201450_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2110-5820-1-3","volume":"1","author":"E Moore","year":"2011","unstructured":"Moore E, Bellomo R . Erythropoietin (EPO) in acute kidney injury. Ann Intensive Care 2011;1:3.","journal-title":"Ann Intensive Care"},{"key":"BFpr201450_CR16","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1007\/s00467-008-1014-8","volume":"23","author":"RH Mak","year":"2008","unstructured":"Mak RH . Acute kidney injury in children: the dawn of a new era. Pediatr Nephrol 2008;23:2147\u20139.","journal-title":"Pediatr Nephrol"},{"key":"BFpr201450_CR17","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s00467-006-0173-8","volume":"21","author":"SL Goldstein","year":"2006","unstructured":"Goldstein SL . Pediatric acute kidney injury: it\u2019s time for real progress. Pediatr Nephrol 2006;21:891\u20135.","journal-title":"Pediatr Nephrol"},{"key":"BFpr201450_CR18","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1681\/ASN.2005030285","volume":"16","author":"American Society of Nephrology.","year":"2005","unstructured":"American Society of Nephrology. American Society of Nephrology Renal Research Report. J Am Soc Nephrol 2005;16:1886\u20131893.","journal-title":"J Am Soc Nephrol"},{"key":"BFpr201450_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1126\/science.1091867","volume":"302","author":"E Zerhouni","year":"2003","unstructured":"Zerhouni E . The NIH roadmap. Science 2003;302:63\u201365.","journal-title":"Science"},{"key":"BFpr201450_CR20","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.2215\/CJN.02040310","volume":"5","author":"CD Krawczeski","year":"2010","unstructured":"Krawczeski CD, Vandevoorde RG, Kathman T, et al. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol 2010;5:1552\u20137.","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFpr201450_CR21","first-page":"233","volume":"37","author":"M Zaffanello","year":"2007","unstructured":"Zaffanello M, Franchini M, Fanos V . Is serum cystatin-C a suitable marker of renal function in children? Ann Clin Lab Sci 2007;37:233\u201340.","journal-title":"Ann Clin Lab Sci"},{"key":"BFpr201450_CR22","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jpeds.2012.02.007","volume":"161","author":"DJ Askenazi","year":"2012","unstructured":"Askenazi DJ, Koralkar R, Hundley HE, et al. Urine biomarkers predict acute kidney injury in newborns. J Pediatr 2012;161:270\u20135.e1.","journal-title":"J Pediatr"},{"key":"BFpr201450_CR23","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00134-010-2087-y","volume":"37","author":"AA Royakkers","year":"2011","unstructured":"Royakkers AA, Korevaar JC, van Suijlen JD, et al. Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy. Intensive Care Med 2011;37:493\u2013501.","journal-title":"Intensive Care Med"},{"key":"BFpr201450_CR24","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00467-012-2331-5","volume":"28","author":"AT Elmas","year":"2013","unstructured":"Elmas AT, Tabel Y, Elmas ON . Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome. Pediatr Nephrol 2013;28:477\u201384.","journal-title":"Pediatr Nephrol"},{"key":"BFpr201450_CR25","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/PCC.0b013e318271f4a5","volume":"14","author":"Y Kandasamy","year":"2013","unstructured":"Kandasamy Y, Smith R, Wright IM . Measuring cystatin C to determine renal function in neonates. Pediatr Crit Care Med 2013;14:318\u201322.","journal-title":"Pediatr Crit Care Med"},{"key":"BFpr201450_CR26","doi-asserted-by":"publisher","first-page":"F519","DOI":"10.1152\/ajprenal.00291.2005","volume":"290","author":"VS Vaidya","year":"2006","unstructured":"Vaidya VS, Remirez V, Ichimura T, Bobadilla NA, Bonventre JV . Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol 2006;290:F519\u2013F529.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFpr201450_CR27","doi-asserted-by":"publisher","first-page":"873","DOI":"10.2215\/CJN.04810908","volume":"4","author":"WK Han","year":"2009","unstructured":"Han WK, Wagener G, Zhu Y, Wang S, Lee HT . Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 2009;4:873\u201382.","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFpr201450_CR28","doi-asserted-by":"publisher","first-page":"9226","DOI":"10.1073\/pnas.1100629108","volume":"108","author":"BD Humphreys","year":"2011","unstructured":"Humphreys BD, Czerniak S, DiRocco DP, Hasnain W, Cheema R, Bonventre JV . Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci USA 2011;108:9226\u201331.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr201450_CR29","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1093\/ndt\/gfp010","volume":"24","author":"JV Bonventre","year":"2009","unstructured":"Bonventre JV . Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant 2009;24:3265\u20138.","journal-title":"Nephrol Dial Transplant"},{"key":"BFpr201450_CR30","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.tips.2004.09.006","volume":"25","author":"K Maiese","year":"2004","unstructured":"Maiese K, Li F, Chong ZZ . Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol Sci 2004;25:577\u201383.","journal-title":"Trends Pharmacol Sci"},{"key":"BFpr201450_CR31","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1111\/j.1445-2197.2005.03612.x","volume":"75","author":"E Ates","year":"2005","unstructured":"Ates E, Yalcin AU, Yilmaz S, Koken T, Tokyol C, Ates E . Protective effect of erythropoietin on renal ischemia and repercussion injury. ANZ J Surg 2005;75:1100\u20131105.","journal-title":"ANZ J Surg"},{"key":"BFpr201450_CR32","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1097\/01.ASN.0000135059.67385.5D","volume":"15","author":"EJ Sharples","year":"2004","unstructured":"Sharples EJ, Patel N, Brown P, et al. Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 2004;15:2115\u201324.","journal-title":"J Am Soc Nephrol"},{"key":"BFpr201450_CR33","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/ndt\/gfi177","volume":"21","author":"E Spandou","year":"2006","unstructured":"Spandou E, Tsouchnikas I, Karkavelas G, Dounousi E, Simenidou C, Guiba-Tziampiri O . Erythropoietin attenuates renal injury in experimental acute renal failure ischaemic\/reperfusion model. Nephrol Dial Transplant 2006;21:330\u2013336.","journal-title":"Nephrol Dial Transplant"},{"key":"BFpr201450_CR34","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1093\/ndt\/gfg547","volume":"19","author":"DA Vesey","year":"2004","unstructured":"Vesey DA, Cheung C, Pat B, Endre Z, Gob\u00e9 G, Johnson DW . Erythropoietin protects against ischaemic acute renal injury. Nephrol Dial Transplant 2004;19:348\u201355.","journal-title":"Nephrol Dial Transplant"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201450","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201450.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:02:29Z","timestamp":1684472549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,8]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["BFpr201450"],"URL":"https:\/\/doi.org\/10.1038\/pr.2014.50","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,8]]},"assertion":[{"value":"27 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}