{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:26:58Z","timestamp":1778801218252,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/pr.2014.53","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T16:04:16Z","timestamp":1396973056000},"page":"46-53","source":"Crossref","is-referenced-by-count":50,"title":["Hypoxic preconditioning protection is eliminated in HIF-1\u03b1 knockout mice subjected to neonatal hypoxia\u2013ischemia"],"prefix":"10.1038","volume":"76","author":[{"given":"R. Ann","family":"Sheldon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina L.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renatta N.","family":"Knox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Ferriero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"BFpr201453_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/1531-8249(200009)48:3<285::AID-ANA2>3.0.CO;2-8","volume":"48","author":"M Bergeron","year":"2000","unstructured":"Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR . Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 2000;48:285\u201396.","journal-title":"Ann Neurol"},{"key":"BFpr201453_CR2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0304-3940(94)90455-3","volume":"168","author":"JM Gidday","year":"1994","unstructured":"Gidday JM, Fitzgibbons JC, Shah AR, Park TS . Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat. Neurosci Lett 1994;168:221\u20134.","journal-title":"Neurosci Lett"},{"key":"BFpr201453_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1203\/01.PDR.0000151122.58665.70","volume":"57","author":"M Gustavsson","year":"2005","unstructured":"Gustavsson M, Anderson MF, Mallard C, Hagberg H . Hypoxic preconditioning confers long-term reduction of brain injury and improvement of neurological ability in immature rats. Pediatr Res 2005;57:305\u20139.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR4","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1089\/ars.2010.3581","volume":"14","author":"C Ikonomidou","year":"2011","unstructured":"Ikonomidou C, Kaindl AM . Neuronal death and oxidative stress in the developing brain. Antioxid Redox Signal 2011;14:1535\u201350.","journal-title":"Antioxid Redox Signal"},{"key":"BFpr201453_CR5","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1203\/pdr.0b013e3180332be4","volume":"61","author":"M Gustavsson","year":"2007","unstructured":"Gustavsson M, Wilson MA, Mallard C, Rousset C, Johnston MV, Hagberg H . Global gene expression in the developing rat brain after hypoxic preconditioning: involvement of apoptotic mechanisms? Pediatr Res 2007;61:444\u201350.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000085979","volume":"27","author":"R Ran","year":"2005","unstructured":"Ran R, Xu H, Lu A, Bernaudin M, Sharp FR . Hypoxia preconditioning in the brain. Dev Neurosci 2005;27:87\u201392.","journal-title":"Dev Neurosci"},{"key":"BFpr201453_CR7","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.brainresrev.2009.09.006","volume":"62","author":"X Fan","year":"2009","unstructured":"Fan X, Heijnen CJ, van der Kooij MA, Groenendaal F, van Bel F . The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury. Brain Res Rev 2009;62:99\u2013108.","journal-title":"Brain Res Rev"},{"key":"BFpr201453_CR8","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"JA Forsythe","year":"1996","unstructured":"Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604\u201313.","journal-title":"Mol Cell Biol"},{"key":"BFpr201453_CR9","doi-asserted-by":"publisher","first-page":"5447","DOI":"10.1128\/MCB.12.12.5447","volume":"12","author":"GL Semenza","year":"1992","unstructured":"Semenza GL, Wang GL . A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447\u201354.","journal-title":"Mol Cell Biol"},{"key":"BFpr201453_CR10","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1161\/01.STR.0000173406.04891.8c","volume":"36","author":"Y Sun","year":"2005","unstructured":"Sun Y, Calvert JW, Zhang JH . Neonatal hypoxia\/ischemia is associated with decreased inflammatory mediators after erythropoietin administration. Stroke 2005;36:1672\u20138.","journal-title":"Stroke"},{"key":"BFpr201453_CR11","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.nbd.2006.12.020","volume":"26","author":"V Laudenbach","year":"2007","unstructured":"Laudenbach V, Fontaine RH, Medja F, et al. Neonatal hypoxic preconditioning involves vascular endothelial growth factor. Neurobiol Dis 2007;26:243\u201352.","journal-title":"Neurobiol Dis"},{"key":"BFpr201453_CR12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1159\/000232558","volume":"31","author":"FF Gonzalez","year":"2009","unstructured":"Gonzalez FF, Abel R, Almli CR, Mu D, Wendland M, Ferriero DM . Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev Neurosci 2009;31:403\u201311.","journal-title":"Dev Neurosci"},{"key":"BFpr201453_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ejphar.2010.02.008","volume":"633","author":"PW Chu","year":"2010","unstructured":"Chu PW, Beart PM, Jones NM . Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes. Eur J Pharmacol 2010;633:24\u201332.","journal-title":"Eur J Pharmacol"},{"key":"BFpr201453_CR14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1203\/PDR.0b013e318180ebe6","volume":"64","author":"Y Feng","year":"2008","unstructured":"Feng Y, Rhodes PG, Bhatt AJ . Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats. Pediatr Res 2008;64:370\u20134.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR15","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/S0387-7604(03)00039-1","volume":"25","author":"A Aydin","year":"2003","unstructured":"Aydin A, Gen\u00e7 K, Akhisaroglu M, Yorukoglu K, Gokmen N, Gonullu E . Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury. Brain Dev 2003;25:494\u20138.","journal-title":"Brain Dev"},{"key":"BFpr201453_CR16","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1159\/000232563","volume":"31","author":"RA Sheldon","year":"2009","unstructured":"Sheldon RA, Osredkar D, Lee CL, Jiang X, Mu D, Ferriero DM . HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia. Dev Neurosci 2009;31:452\u20138.","journal-title":"Dev Neurosci"},{"key":"BFpr201453_CR17","doi-asserted-by":"publisher","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","volume":"27","author":"O Baranova","year":"2007","unstructured":"Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC . Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci 2007;27:6320\u201332.","journal-title":"J Neurosci"},{"key":"BFpr201453_CR18","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1056\/NEJMra041996","volume":"351","author":"DM Ferriero","year":"2004","unstructured":"Ferriero DM . Neonatal brain injury. N Engl J Med 2004;351:1985\u201395.","journal-title":"N Engl J Med"},{"key":"BFpr201453_CR19","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1203\/01.pdr.0000214891.35363.6a","volume":"59","author":"MJ Lafemina","year":"2006","unstructured":"Lafemina MJ, Sheldon RA, Ferriero DM . Acute hypoxia-ischemia results in hydrogen peroxide accumulation in neonatal but not adult mouse brain. Pediatr Res 2006;59:680\u20133.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR20","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1203\/01.PDR.0000139413.27864.50","volume":"56","author":"RA Sheldon","year":"2004","unstructured":"Sheldon RA, Jiang X, Francisco C, et al. Manipulation of antioxidant pathways in neonatal murine brain. Pediatr Res 2004;56:656\u201362.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR21","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1203\/pdr.0b013e318053664c","volume":"61","author":"RA Sheldon","year":"2007","unstructured":"Sheldon RA, Aminoff A, Lee CL, Christen S, Ferriero DM . Hypoxic preconditioning reverses protection after neonatal hypoxia-ischemia in glutathione peroxidase transgenic murine brain. Pediatr Res 2007;61:666\u201370.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neulet.2008.06.005","volume":"441","author":"S Chang","year":"2008","unstructured":"Chang S, Jiang X, Zhao C, Lee C, Ferriero DM . Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons. Neurosci Lett 2008;441:134\u20138.","journal-title":"Neurosci Lett"},{"key":"BFpr201453_CR23","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.freeradbiomed.2008.09.043","volume":"46","author":"G Millonig","year":"2009","unstructured":"Millonig G, Heged\u00fcsch S, Becker L, Seitz HK, Schuppan D, Mueller S . Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense decrements of oxygen but not hypoxia per se. Free Radic Biol Med 2009;46:182\u201391.","journal-title":"Free Radic Biol Med"},{"key":"BFpr201453_CR24","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.jcbfm.9600085","volume":"25","author":"M Liu","year":"2005","unstructured":"Liu M, Alkayed NJ . Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. J Cereb Blood Flow Metab 2005;25:939\u201348.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFpr201453_CR25","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.freeradbiomed.2005.08.040","volume":"40","author":"K Blomgren","year":"2006","unstructured":"Blomgren K, Hagberg H . Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med 2006;40:388\u201397.","journal-title":"Free Radic Biol Med"},{"key":"BFpr201453_CR26","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/pr.2012.124","volume":"72","author":"D Autheman","year":"2012","unstructured":"Autheman D, Sheldon RA, Chaudhuri N, et al. Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning. Pediatr Res 2012;72:568\u201375.","journal-title":"Pediatr Res"},{"key":"BFpr201453_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s00401-008-0339-5","volume":"115","author":"L Li","year":"2008","unstructured":"Li L, Xiong Y, Qu Y, et al. The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1 alpha in the developing rat brain after hypoxia-ischemia. Acta Neuropathol 2008;115:297\u2013303.","journal-title":"Acta Neuropathol"},{"key":"BFpr201453_CR28","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1002\/jnr.21597","volume":"86","author":"Q Li","year":"2008","unstructured":"Li Q, Michaud M, Stewart W, Schwartz M, Madri JA . Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn. J Neurosci Res 2008;86:1227\u201342.","journal-title":"J Neurosci Res"},{"key":"BFpr201453_CR29","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.jocn.2008.09.024","volume":"16","author":"S Taie","year":"2009","unstructured":"Taie S, Ono J, Iwanaga Y, et al. Hypoxia-inducible factor-1 alpha has a key role in hypoxic preconditioning. J Clin Neurosci 2009;16:1056\u201360.","journal-title":"J Clin Neurosci"},{"key":"BFpr201453_CR30","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/cvr\/cvm035","volume":"77","author":"Z Cai","year":"2008","unstructured":"Cai Z, Zhong H, Bosch-Marce M, et al. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res 2008;77:463\u201370.","journal-title":"Cardiovasc Res"},{"key":"BFpr201453_CR31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/jcbfm.2008.124","volume":"29","author":"C Zhu","year":"2009","unstructured":"Zhu C, Qiu L, Wang X, et al. Age-dependent regenerative responses in the striatum and cortex after hypoxia-ischemia. J Cereb Blood Flow Metab 2009;29:342\u201354.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFpr201453_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2010.02.029","volume":"1325","author":"Y Feng","year":"2010","unstructured":"Feng Y, Rhodes PG, Bhatt AJ . Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemic model. Brain Res 2010;1325:1\u20139.","journal-title":"Brain Res"},{"key":"BFpr201453_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.brainres.2007.08.059","volume":"1180","author":"L Li","year":"2007","unstructured":"Li L, Qu Y, Li J, Xiong Y, Mao M, Mu D . Relationship between HIF-1alpha expression and neuronal apoptosis in neonatal rats with hypoxia-ischemia brain injury. Brain Res 2007;1180:133\u20139.","journal-title":"Brain Res"},{"key":"BFpr201453_CR34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0006-8993(98)00892-0","volume":"810","author":"RA Sheldon","year":"1998","unstructured":"Sheldon RA, Sedik C, Ferriero DM . Strain-related brain injury in neonatal mice subjected to hypoxia-ischemia. Brain Res 1998;810:114\u201322.","journal-title":"Brain Res"},{"key":"BFpr201453_CR35","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s12264-012-1268-9","volume":"28","author":"F Xu","year":"2012","unstructured":"Xu F, Gu JH, Qin ZH . Neuronal autophagy in cerebral ischemia. Neurosci Bull 2012;28:658\u201366.","journal-title":"Neurosci Bull"},{"key":"BFpr201453_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","volume":"32","author":"S Carloni","year":"2008","unstructured":"Carloni S, Buonocore G, Balduini W . Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 2008;32:329\u201339.","journal-title":"Neurobiol Dis"},{"key":"BFpr201453_CR37","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1177\/1073858409332405","volume":"15","author":"G Vangeison","year":"2009","unstructured":"Vangeison G, Rempe DA . The Janus-faced effects of hypoxia on astrocyte function. Neuroscientist 2009;15:579\u201388.","journal-title":"Neuroscientist"},{"key":"BFpr201453_CR38","doi-asserted-by":"publisher","first-page":"e00062","DOI":"10.1042\/AN20100029","volume":"3","author":"E Sen","year":"2011","unstructured":"Sen E, Basu A, Willing LB, et al. Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro 2011;3:e00062.","journal-title":"ASN Neuro"},{"key":"BFpr201453_CR39","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1523\/JNEUROSCI.4555-04.2005","volume":"25","author":"R Helton","year":"2005","unstructured":"Helton R, Cui J, Scheel JR, et al. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci 2005;25:4099\u2013107.","journal-title":"J Neurosci"},{"key":"BFpr201453_CR40","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<133::AID-GENE10>3.0.CO;2-V","volume":"26","author":"I Dragatsis","year":"2000","unstructured":"Dragatsis I, Zeitlin S . CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis 2000;26:133\u20135.","journal-title":"Genesis"},{"key":"BFpr201453_CR41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice III","year":"1981","unstructured":"Rice JE III, Vannucci RC, Brierley JB . The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131\u201341.","journal-title":"Ann Neurol"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201453","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:02:31Z","timestamp":1684472551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,8]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["BFpr201453"],"URL":"https:\/\/doi.org\/10.1038\/pr.2014.53","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,8]]}}}