{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:18:25Z","timestamp":1792635505938,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1038\/pr.2015.155","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T16:01:03Z","timestamp":1441814463000},"page":"641-649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gene expression profile in newborn rat lungs after two days of recovery of mechanical ventilation"],"prefix":"10.1038","volume":"78","author":[{"given":"Val\u00e9rie","family":"D\u00e9nervaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Gremlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Trummer-Menzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes C.","family":"Schittny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Roth-Kleiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"BFpr2015155_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1165\/rcmb.2008-0287OC","volume":"42","author":"E B\u00e4ckstr\u00f6m","year":"2010","unstructured":"B\u00e4ckstr\u00f6m E, Lappalainen U, Bry K. Maternal IL-1beta production prevents lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol 2010;42:149\u201360.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2015155_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1053\/j.semperi.2006.05.004","volume":"30","author":"JJ Coalson","year":"2006","unstructured":"Coalson JJ. Pathology of bronchopulmonary dysplasia. Semin Perinatol 2006;30:179\u201384.","journal-title":"Semin Perinatol"},{"issue":"5 Pt 2","key":"BFpr2015155_CR3","doi-asserted-by":"publisher","first-page":"38R","DOI":"10.1203\/01.PDR.0000159630.35883.BE","volume":"57","author":"J Bourbon","year":"2005","unstructured":"Bourbon J, Boucherat O, Chailley-Heu B, Delacourt C. Control mechanisms of lung alveolar development and their disorders in bronchopulmonary dysplasia. Pediatr Res 2005;57(5 Pt 2):38R\u201346R.","journal-title":"Pediatr Res"},{"key":"BFpr2015155_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1203\/PDR.0b013e3181e17caa","volume":"68","author":"AA Kroon","year":"2010","unstructured":"Kroon AA, Wang J, Huang Z, Cao L, Kuliszewski M, Post M. Inflammatory response to oxygen and endotoxin in newborn rat lung ventilated with low tidal volume. Pediatr Res 2010;68:63\u20139.","journal-title":"Pediatr Res"},{"key":"BFpr2015155_CR5","doi-asserted-by":"publisher","first-page":"L23","DOI":"10.1152\/ajplung.00251.2009","volume":"298","author":"LM Mokres","year":"2010","unstructured":"Mokres LM, Parai K, Hilgendorff A, et al. Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Am J Physiol Lung Cell Mol Physiol 2010;298:L23\u201335.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015155_CR6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1164\/rccm.201012-2010OC","volume":"184","author":"A Hilgendorff","year":"2011","unstructured":"Hilgendorff A, Parai K, Ertsey R, et al. Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. Am J Respir Crit Care Med 2011;184:537\u201346.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr2015155_CR7","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1002\/ppul.22613","volume":"47","author":"E Trummer-Menzi","year":"2012","unstructured":"Trummer-Menzi E, Gremlich S, Schittny JC, et al. Evolution of gene expression changes in newborn rats after mechanical ventilation with reversible intubation. Pediatr Pulmonol 2012;47:1204\u201314.","journal-title":"Pediatr Pulmonol"},{"key":"BFpr2015155_CR8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1365-2613.2012.00823.x","volume":"93","author":"AC Nagato","year":"2012","unstructured":"Nagato AC, Bezerra FS, Lanzetti M, et al. Time course of inflammation, oxidative stress and tissue damage induced by hyperoxia in mouse lungs. Int J Exp Pathol 2012;93:269\u201378.","journal-title":"Int J Exp Pathol"},{"key":"BFpr2015155_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1203\/01.pdr.0000252437.51779.21","volume":"61","author":"M Roth-Kleiner","year":"2007","unstructured":"Roth-Kleiner M, Ridsdale R, Cao L, et al. Lipopolysaccharide exposure modifies high tidal volume ventilation-induced proinflammatory mediator expression in newborn rat lungs. Pediatr Res 2007;61:191\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr2015155_CR10","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1365-2559.2005.02228.x","volume":"47","author":"K Masumoto","year":"2005","unstructured":"Masumoto K, de Rooij JD, Suita S, Rottier R, Tibboel D, de Krijger RR. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development. Histopathology 2005;47:410\u20139.","journal-title":"Histopathology"},{"key":"BFpr2015155_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ppul.20135","volume":"39","author":"F Tambunting","year":"2005","unstructured":"Tambunting F, Beharry KD, Hartleroad J, Waltzman J, Stavitsky Y, Modanlou HD. Increased lung matrix metalloproteinase-9 levels in extremely premature baboons with bronchopulmonary dysplasia. Pediatr Pulmonol 2005;39:5\u201314.","journal-title":"Pediatr Pulmonol"},{"key":"BFpr2015155_CR12","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1084\/jem.192.11.1587","volume":"192","author":"Z Wang","year":"2000","unstructured":"Wang Z, Zheng T, Zhu Z, et al. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000;192:1587\u2013600.","journal-title":"J Exp Med"},{"key":"BFpr2015155_CR13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1165\/rcmb.2010-0058OC","volume":"44","author":"A Harijith","year":"2011","unstructured":"Harijith A, Choo-Wing R, Cataltepe S, et al. A role for matrix metalloproteinase 9 in IFN\u03b3-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. Am J Respir Cell Mol Biol 2011;44:621\u201330.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2015155_CR14","doi-asserted-by":"publisher","first-page":"L747","DOI":"10.1152\/ajplung.00415.2001","volume":"283","author":"S Buckley","year":"2002","unstructured":"Buckley S, Warburton D. Dynamics of metalloproteinase-2 and -9, TGF-beta, and uPA activities during normoxic vs. hyperoxic alveolarization. Am J Physiol Lung Cell Mol Physiol 2002;283:L747\u201354.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015155_CR15","doi-asserted-by":"publisher","first-page":"L584","DOI":"10.1152\/ajplung.00441.2007","volume":"295","author":"A Chetty","year":"2008","unstructured":"Chetty A, Cao GJ, Severgnini M, Simon A, Warburton R, Nielsen HC. Role of matrix metalloprotease-9 in hyperoxic injury in developing lung. Am J Physiol Lung Cell Mol Physiol 2008;295:L584\u201392.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015155_CR16","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1651-2227.2004.tb03020.x","volume":"93","author":"DG Sweet","year":"2004","unstructured":"Sweet DG, Curley AE, Chesshyre E, et al. The role of matrix metalloproteinases -9 and -2 in development of neonatal chronic lung disease. Acta Paediatr 2004;93:791\u20136.","journal-title":"Acta Paediatr"},{"key":"BFpr2015155_CR17","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1542\/peds.113.6.1709","volume":"113","author":"II Ekekezie","year":"2004","unstructured":"Ekekezie II, Thibeault DW, Simon SD, et al. Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9\/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease. Pediatrics 2004;113:1709\u201314.","journal-title":"Pediatrics"},{"key":"BFpr2015155_CR18","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/0014-5793(92)81511-J","volume":"314","author":"S Triebel","year":"1992","unstructured":"Triebel S, Bl\u00e4ser J, Reinke H, Tschesche H. A 25\u2009kDa alpha 2-microglobulin-related protein is a component of the 125\u2009kDa form of human gelatinase. FEBS Lett 1992;314:386\u20138.","journal-title":"FEBS Lett"},{"key":"BFpr2015155_CR19","doi-asserted-by":"publisher","first-page":"37258","DOI":"10.1074\/jbc.M106089200","volume":"276","author":"L Yan","year":"2001","unstructured":"Yan L, Borregaard N, Kjeldsen L, Moses MA. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B\/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 2001;276:37258\u201365.","journal-title":"J Biol Chem"},{"key":"BFpr2015155_CR20","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s00134-007-0793-x","volume":"33","author":"E Capoluongo","year":"2007","unstructured":"Capoluongo E, Vento G, Rocchetti S, et al. Mannose-binding lectin polymorphisms and pulmonary outcome in premature neonates: a pilot study. Intensive Care Med 2007;33:1787\u201394.","journal-title":"Intensive Care Med"},{"key":"BFpr2015155_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.earlhumdev.2012.12.011","volume":"89","author":"H Inoue","year":"2013","unstructured":"Inoue H, Ohga S, Kusuda T, et al. Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Early Hum Dev 2013;89:425\u20139.","journal-title":"Early Hum Dev"},{"key":"BFpr2015155_CR22","first-page":"1124","volume":"36","author":"C Lafuma","year":"1988","unstructured":"Lafuma C. [Elastases and pulmonary pathologies]. Pathol Biol (Paris) 1988;36:1124\u201332.","journal-title":"Pathol Biol (Paris)"},{"issue":"Suppl 1","key":"BFpr2015155_CR23","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3109\/15412555.2013.764403","volume":"10","author":"RA Sandhaus","year":"2013","unstructured":"Sandhaus RA, Turino G. Neutrophil elastase-mediated lung disease. COPD 2013;10:Suppl 1:60\u20133.","journal-title":"COPD"},{"key":"BFpr2015155_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(02)02182-9","volume":"451","author":"K Kawabata","year":"2002","unstructured":"Kawabata K, Hagio T, Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 2002;451:1\u201310.","journal-title":"Eur J Pharmacol"},{"key":"BFpr2015155_CR25","doi-asserted-by":"publisher","first-page":"L215","DOI":"10.1152\/ajplung.00405.2011","volume":"303","author":"A Hilgendorff","year":"2012","unstructured":"Hilgendorff A, Parai K, Ertsey R, et al. Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth. Am J Physiol Lung Cell Mol Physiol 2012;303:L215\u201327.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015155_CR26","doi-asserted-by":"publisher","first-page":"e22596","DOI":"10.1371\/journal.pone.0022596","volume":"6","author":"MY Kong","year":"2011","unstructured":"Kong MY, Li Y, Oster R, Gaggar A, Clancy JP. Early elevation of matrix metalloproteinase-8 and -9 in pediatric ARDS is associated with an increased risk of prolonged mechanical ventilation. PLoS One 2011;6:e22596.","journal-title":"PLoS One"},{"key":"BFpr2015155_CR27","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1203\/01.pdr.0000238342.16081.f9","volume":"60","author":"K Cederqvist","year":"2006","unstructured":"Cederqvist K, Janer J, Tervahartiala T, et al. Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat. Pediatr Res 2006;60:395\u2013400.","journal-title":"Pediatr Res"},{"key":"BFpr2015155_CR28","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1165\/rcmb.2009-0034OC","volume":"43","author":"GM Albaiceta","year":"2010","unstructured":"Albaiceta GM, Gutierrez-Fern\u00e1ndez A, Garc\u00eda-Prieto E, et al. Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury. Am J Respir Cell Mol Biol 2010;43:555\u201363.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2015155_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1152\/physrev.00022.2006","volume":"87","author":"KJ Greenlee","year":"2007","unstructured":"Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev 2007;87:69\u201398.","journal-title":"Physiol Rev"},{"key":"BFpr2015155_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrm2125","volume":"8","author":"A Page-McCaw","year":"2007","unstructured":"Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 2007;8:221\u201333.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFpr2015155_CR31","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nri3499","volume":"13","author":"R Khokha","year":"2013","unstructured":"Khokha R, Murthy A, Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nat Rev Immunol 2013;13:649\u201365.","journal-title":"Nat Rev Immunol"},{"key":"BFpr2015155_CR32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1183\/09031936.00146510","volume":"38","author":"S L\u00f6ffek","year":"2011","unstructured":"L\u00f6ffek S, Schilling O, Franzke CW. Series \u201cmatrix metalloproteinases in lung health and disease\u201d: biological role of matrix metalloproteinases: a critical balance. Eur Respir J 2011;38:191\u2013208.","journal-title":"Eur Respir J"},{"key":"BFpr2015155_CR33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bbamcr.2009.09.015","volume":"1803","author":"D Rodr\u00edguez","year":"2010","unstructured":"Rodr\u00edguez D, Morrison CJ, Overall CM. Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta 2010;1803:39\u201354.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2015155_CR34","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s12013-013-9675-8","volume":"67","author":"K Liu","year":"2013","unstructured":"Liu K, Mao YF, Zheng J, et al. SC5b-9-induced pulmonary microvascular endothelial hyperpermeability participates in ventilator-induced lung injury. Cell Biochem Biophys 2013;67:1421\u201331.","journal-title":"Cell Biochem Biophys"},{"key":"BFpr2015155_CR35","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1016\/j.intimp.2011.09.008","volume":"11","author":"K Takahashi","year":"2011","unstructured":"Takahashi K, Saha D, Shattino I, et al. Complement 3 is involved with ventilator-induced lung injury. Int Immunopharmacol 2011;11:2138\u201343.","journal-title":"Int Immunopharmacol"},{"key":"BFpr2015155_CR36","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jss.2008.03.046","volume":"152","author":"JA Tsai","year":"2009","unstructured":"Tsai JA, Lund M, Lundell L, Nilsson-Ekdahl K. One-lung ventilation during thoracoabdominal esophagectomy elicits complement activation. J Surg Res 2009;152:331\u20137.","journal-title":"J Surg Res"},{"key":"BFpr2015155_CR37","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","volume-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","author":"GK Smyth","year":"2005","unstructured":"Smyth GK. Limma: linear models for microarray data. In: Gentleman R, Carey V, Huber W, Irizarry R, Dudoit S, eds. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. New York: Springer, 2005:397\u2013420."},{"key":"BFpr2015155_CR38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B 1995;57:289\u2013300.","journal-title":"J R Stat Soc Series B"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2015155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2015155","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2015.155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr2015155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T01:06:59Z","timestamp":1718068019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2015155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,9]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["BFpr2015155"],"URL":"https:\/\/doi.org\/10.1038\/pr.2015.155","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,9]]},"assertion":[{"value":"17 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}