{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:23:00Z","timestamp":1790821380157,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1038\/pr.2015.265","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T17:18:55Z","timestamp":1450372735000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms"],"prefix":"10.1038","volume":"79","author":[{"given":"Jana","family":"Kopincova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Calkovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"BFpr2015265_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1203\/00006450-199808000-00008","volume":"44","author":"CW Bae","year":"1998","unstructured":"Bae CW, Takahashi A, Chida S, Sasaki M. Morphology and function of pulmonary surfactant inhibited by meconium. Pediatr Res 1998;44:187\u201391.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1542\/peds.97.1.48","volume":"97","author":"RD Findlay","year":"1996","unstructured":"Findlay RD, Taeusch HW, Walther FJ. Surfactant replacement therapy for meconium aspiration syndrome. Pediatrics 1996;97:48\u201352.","journal-title":"Pediatrics"},{"key":"BFpr2015265_CR3","first-page":"1203","volume":"54","author":"SM Donn","year":"2009","unstructured":"Donn SM, Dalton J. Surfactant replacement therapy in the neonate: beyond respiratory distress syndrome. Respir Care 2009;54:1203\u20138.","journal-title":"Respir Care"},{"key":"BFpr2015265_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1203\/00006450-199104000-00005","volume":"29","author":"T Kobayashi","year":"1991","unstructured":"Kobayashi T, Nitta K, Ganzuka M, Inui S, Grossmann G, Robertson B. Inactivation of exogenous surfactant by pulmonary edema fluid. Pediatr Res 1991;29:353\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-94-007-4549-0_24","volume":"756","author":"D Mokra","year":"2013","unstructured":"Mokra D, Drgova A, Kopincova J, Pullmann R, Calkovska A. Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury. Adv Exp Med Biol 2013;756:189\u201396.","journal-title":"Adv Exp Med Biol"},{"issue":"Suppl 4","key":"BFpr2015265_CR6","doi-asserted-by":"publisher","first-page":"S629","DOI":"10.33549\/physiolres.932938","volume":"63","author":"J Kopincov\u00e1","year":"2014","unstructured":"Kopincov\u00e1 J, Mokr\u00e1 D, Mikolka P, Kolomazn\u00edk M, \u010calkovsk\u00e1 A. N-acetylcysteine advancement of surfactant therapy in experimental meconium aspiration syndrome: possible mechanisms. Physiol Res 2014;63:Suppl 4:S629\u201342.","journal-title":"Physiol Res"},{"key":"BFpr2015265_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000369373","volume":"107","author":"PH Lindenskov","year":"2015","unstructured":"Lindenskov PH, Castellheim A, Saugstad OD, Mollnes TE. Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies. Neonatology 2015;107:225\u201330.","journal-title":"Neonatology"},{"key":"BFpr2015265_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0002-9378(11)80003-7","volume":"164","author":"D Moses","year":"1991","unstructured":"Moses D, Holm BA, Spitale P, Liu MY, Enhorning G. Inhibition of pulmonary surfactant function by meconium. Am J Obstet Gynecol 1991;164:477\u201381.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr2015265_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.resp.2013.02.030","volume":"187","author":"D Mokra","year":"2013","unstructured":"Mokra D, Calkovska A. How to overcome surfactant dysfunction in meconium aspiration syndrome? Respir Physiol Neurobiol 2013;187:58\u201363.","journal-title":"Respir Physiol Neurobiol"},{"key":"BFpr2015265_CR10","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1465-9921-7-86","volume":"7","author":"M Ochs","year":"2006","unstructured":"Ochs M, Sch\u00fcttler M, Stichtenoth G, Herting E. Morphological alterations of exogenous surfactant inhibited by meconium can be prevented by dextran. Respir Res 2006;7:86.","journal-title":"Respir Res"},{"key":"BFpr2015265_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1203\/00006450-200107000-00010","volume":"50","author":"E Herting","year":"2001","unstructured":"Herting E, Rauprich P, Stichtenoth G, Walter G, Johansson J, Robertson B. Resistance of different surfactant preparations to inactivation by meconium. Pediatr Res 2001;50:44\u20139.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR12","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1159\/000073643","volume":"84","author":"PA T\u00f8ll\u00f8fsrud","year":"2003","unstructured":"T\u00f8ll\u00f8fsrud PA, Lindenskov PH, Drevon CA, Speer CP, Seidenspinner S, Saugstad OD. Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn piglets. Biol Neonate 2003;84:330\u20137.","journal-title":"Biol Neonate"},{"key":"BFpr2015265_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.colsurfa.2010.08.002","volume":"370","author":"V Pallem","year":"2010","unstructured":"Pallem V, Kaviratna AS, Chimote G, Banerjee R. Effect of meconium on surface properties of surfactant monolayers and liposomes. Colloid Surface A 2010;370:6\u201314.","journal-title":"Colloid Surface A"},{"key":"BFpr2015265_CR14","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.bpj.2010.12.3715","volume":"100","author":"E Lopez-Rodriguez","year":"2011","unstructured":"Lopez-Rodriguez E, Echaide M, Cruz A, Taeusch HW, Perez-Gil J. Meconium impairs pulmonary surfactant by a combined action of cholesterol and bile acids. Biophys J 2011;100:646\u201355.","journal-title":"Biophys J"},{"key":"BFpr2015265_CR15","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.bbamem.2014.12.009","volume":"1848","author":"JQ Hiansen","year":"2015","unstructured":"Hiansen JQ, Keating E, Aspros A, et al. Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A. Biochim Biophys Acta 2015;1848:813\u201320.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2015265_CR16","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1016\/j.bbamem.2014.01.028","volume":"1838","author":"E Lopez-Rodriguez","year":"2014","unstructured":"Lopez-Rodriguez E, P\u00e9rez-Gil J. Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy. Biochim Biophys Acta 2014;1838:1568\u201385.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2015265_CR17","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1152\/jappl.1992.72.5.1708","volume":"72","author":"SB Hall","year":"1992","unstructured":"Hall SB, Lu RZ, Venkitaraman AR, Hyde RW, Notter RH. Inhibition of pulmonary surfactant by oleic acid: mechanisms and characteristics. J Appl Physiol (1985) 1992;72:1708\u201316.","journal-title":"J Appl Physiol (1985)"},{"key":"BFpr2015265_CR18","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1248\/bpb.27.1158","volume":"27","author":"M Murakami","year":"2004","unstructured":"Murakami M, Kudo I. Secretory phospholipase A2. Biol Pharm Bull 2004;27:1158\u201364.","journal-title":"Biol Pharm Bull"},{"issue":"Suppl 3","key":"BFpr2015265_CR19","doi-asserted-by":"publisher","first-page":"S120","DOI":"10.1038\/jp.2008.147","volume":"28","author":"P K\u00e4\u00e4p\u00e4","year":"2008","unstructured":"K\u00e4\u00e4p\u00e4 P, Soukka H. Phospholipase A2 in meconium-induced lung injury. J Perinatol 2008;28:Suppl 3:S120\u20132.","journal-title":"J Perinatol"},{"key":"BFpr2015265_CR20","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/s00134-011-2243-z","volume":"37","author":"D De Luca","year":"2011","unstructured":"De Luca D, Minucci A, Tripodi D, et al. Role of distinct phospholipases A2 and their modulators in meconium aspiration syndrome in human neonates. Intensive Care Med 2011;37:1158\u201365.","journal-title":"Intensive Care Med"},{"key":"BFpr2015265_CR21","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.biochem.76.062405.154007","volume":"77","author":"G Lambeau","year":"2008","unstructured":"Lambeau G, Gelb MH. Biochemistry and physiology of mammalian secreted phospholipases A2. Annu Rev Biochem 2008;77:495\u2013520.","journal-title":"Annu Rev Biochem"},{"key":"BFpr2015265_CR22","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1203\/00006450-199911000-00022","volume":"46","author":"R Holopainen","year":"1999","unstructured":"Holopainen R, Aho H, Laine J, Peuravuori H, Soukka H, K\u00e4\u00e4p\u00e4 P. Human meconium has high phospholipase A2 activity and induces cellular injury and apoptosis in piglet lungs. Pediatr Res 1999;46:626\u201332.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1651-2227.2001.tb00442.x","volume":"90","author":"AJ Schrama","year":"2001","unstructured":"Schrama AJ, de Beaufort AJ, Sukul YR, Jansen SM, Poorthuis BJ, Berger HM. Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study. Acta Paediatr 2001;90:412\u20136.","journal-title":"Acta Paediatr"},{"key":"BFpr2015265_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bbamem.2005.10.014","volume":"1720","author":"RD Hite","year":"2005","unstructured":"Hite RD, Seeds MC, Jacinto RB, Grier BL, Waite BM, Bass DA. Lysophospholipid and fatty acid inhibition of pulmonary surfactant: non-enzymatic models of phospholipase A2 surfactant hydrolysis. Biochim Biophys Acta 2005;1720:14\u201321.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2015265_CR25","doi-asserted-by":"publisher","first-page":"995","DOI":"10.4049\/jimmunol.171.2.995","volume":"171","author":"S Chabot","year":"2003","unstructured":"Chabot S, Koumanov K, Lambeau G, et al. Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2. J Immunol 2003;171:995\u20131000.","journal-title":"J Immunol"},{"key":"BFpr2015265_CR26","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1111\/j.1600-6143.2006.01357.x","volume":"6","author":"F D\u2019Ovidio","year":"2006","unstructured":"D\u2019Ovidio F, Mura M, Ridsdale R, et al. The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D. Am J Transplant 2006;6:1930\u20138.","journal-title":"Am J Transplant"},{"key":"BFpr2015265_CR27","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1021\/la0521241","volume":"22","author":"T Gross","year":"2006","unstructured":"Gross T, Zmora E, Levi-Kalisman Y, Regev O, Berman A. Lung-surfactant-meconium interaction: in vitro study in bulk and at the air-solution interface. Langmuir 2006;22:3243\u201350.","journal-title":"Langmuir"},{"key":"BFpr2015265_CR28","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00134-008-1321-3","volume":"35","author":"D De Luca","year":"2009","unstructured":"De Luca D, Minucci A, Zecca E, et al. Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration. Intensive Care Med 2009;35:321\u20136.","journal-title":"Intensive Care Med"},{"key":"BFpr2015265_CR29","volume-title":"Meconium Toxicity to Human Surfactant Proteins","author":"VA Ivanov","year":"2012","unstructured":"Ivanov VA. Meconium Toxicity to Human Surfactant Proteins. American Academy of Pediatrics, 2012. (https:\/\/aap.confex.com\/aap\/2012\/webprogrampress\/Paper16405.html.)"},{"issue":"Suppl 3","key":"BFpr2015265_CR30","doi-asserted-by":"publisher","first-page":"S102","DOI":"10.1038\/jp.2008.153","volume":"28","author":"D Vidyasagar","year":"2008","unstructured":"Vidyasagar D, Zagariya A. Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis. J Perinatol 2008;28:Suppl 3:S102\u20137.","journal-title":"J Perinatol"},{"key":"BFpr2015265_CR31","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1203\/01.PDR.0000100902.76021.8E","volume":"55","author":"A Castellheim","year":"2004","unstructured":"Castellheim A, Lindenskov PH, Pharo A, Fung M, Saugstad OD, Mollnes TE. Meconium is a potent activator of complement in human serum and in piglets. Pediatr Res 2004;55:310\u20138.","journal-title":"Pediatr Res"},{"issue":"Suppl 3","key":"BFpr2015265_CR32","doi-asserted-by":"publisher","first-page":"S116","DOI":"10.1038\/jp.2008.148","volume":"28","author":"TE Mollnes","year":"2008","unstructured":"Mollnes TE, Castellheim A, Lindenskov PH, Salvesen B, Saugstad OD. The role of complement in meconium aspiration syndrome. J Perinatol 2008;28:Suppl 3:S116\u20139.","journal-title":"J Perinatol"},{"key":"BFpr2015265_CR33","doi-asserted-by":"publisher","first-page":"e496","DOI":"10.1542\/peds.2007-0878","volume":"121","author":"B Salvesen","year":"2008","unstructured":"Salvesen B, Fung M, Saugstad OD, Mollnes TE. Role of complement and CD14 in meconium-induced cytokine formation. Pediatrics 2008;121:e496\u2013505.","journal-title":"Pediatrics"},{"key":"BFpr2015265_CR34","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.molimm.2009.12.015","volume":"47","author":"B Salvesen","year":"2010","unstructured":"Salvesen B, Stenvik J, Rossetti C, Saugstad OD, Espevik T, Mollnes TE. Meconium-induced release of cytokines is mediated by the TRL4\/MD-2 complex in a CD14-dependent manner. Mol Immunol 2010;47:1226\u201334.","journal-title":"Mol Immunol"},{"key":"BFpr2015265_CR35","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1203\/01.PDR.0000141983.32466.2A","volume":"56","author":"PH Lindenskov","year":"2004","unstructured":"Lindenskov PH, Castellheim A, Aamodt G, Saugstad OD, Mollnes TE. Complement activation reflects severity of meconium aspiration syndrome in newborn pigs. Pediatr Res 2004;56:810\u20137.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR36","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.molimm.2008.09.001","volume":"46","author":"B Salvesen","year":"2009","unstructured":"Salvesen B, Nielsen EW, Harboe M, Saugstad OD, Mollnes TE. Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood. Mol Immunol 2009;46:688\u201394.","journal-title":"Mol Immunol"},{"key":"BFpr2015265_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/cc8850","volume":"14","author":"A Anas","year":"2010","unstructured":"Anas A, van der Poll T, de Vos AF. Role of CD14 in lung inflammation and infection. Crit Care 2010;14:209.","journal-title":"Crit Care"},{"key":"BFpr2015265_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/916425","volume":"2010","author":"Meng Xiang","year":"2010","unstructured":"Xiang M, Fan J, Fan J. Association of Toll-like receptor signaling and reactive oxygen species: a potential therapeutic target for posttrauma acute lung injury. Mediators Inflamm 2010;2010.","journal-title":"Mediators of Inflammation"},{"key":"BFpr2015265_CR39","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/ni0605-544","volume":"6","author":"PJ Godowski","year":"2005","unstructured":"Godowski PJ. A smooth operator for LPS responses. Nat Immunol 2005;6:544\u20136.","journal-title":"Nat Immunol"},{"key":"BFpr2015265_CR40","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1172\/JCI16510","volume":"111","author":"G Andonegui","year":"2003","unstructured":"Andonegui G, Bonder CS, Green F, et al. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 2003;111:1011\u201320.","journal-title":"J Clin Invest"},{"key":"BFpr2015265_CR41","doi-asserted-by":"publisher","first-page":"L143","DOI":"10.1152\/ajplung.00030.2004","volume":"287","author":"SJ Skerrett","year":"2004","unstructured":"Skerrett SJ, Liggitt HD, Hajjar AM, Ernst RK, Miller SI, Wilson CB. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol 2004;287:L143\u201352.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015265_CR42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1743-8977-7-13","volume":"7","author":"D van Berlo","year":"2010","unstructured":"van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C. NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells. Part Fibre Toxicol 2010;7:13.","journal-title":"Part Fibre Toxicol"},{"key":"BFpr2015265_CR43","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.molimm.2005.08.004","volume":"43","author":"U Kishore","year":"2006","unstructured":"Kishore U, Greenhough TJ, Waters P, et al. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol 2006;43:1293\u2013315.","journal-title":"Mol Immunol"},{"key":"BFpr2015265_CR44","doi-asserted-by":"publisher","first-page":"6593","DOI":"10.4049\/jimmunol.167.11.6593","volume":"167","author":"WT Watford","year":"2001","unstructured":"Watford WT, Wright JR, Hester CG, Jiang H, Frank MM. Surfactant protein A regulates complement activation. J Immunol 2001;167:6593\u2013600.","journal-title":"J Immunol"},{"key":"BFpr2015265_CR45","first-page":"L165","volume":"267","author":"RS Oosting","year":"1994","unstructured":"Oosting RS, Wright JR. Characterization of the surfactant protein A receptor: cell and ligand specificity. Am J Physiol 1994;267:L165\u201372.","journal-title":"Am J Physiol"},{"key":"BFpr2015265_CR46","doi-asserted-by":"publisher","first-page":"9633","DOI":"10.1007\/s11357-014-9633-4","volume":"36","author":"JI Moliva","year":"2014","unstructured":"Moliva JI, Rajaram MV, Sidiki S, et al. Molecular composition of the alveolar lining fluid in the aging lung. Age (Dordr) 2014;36:9633.","journal-title":"Age (Dordr)"},{"key":"BFpr2015265_CR47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0092-8674(03)00758-X","volume":"115","author":"SJ Gardai","year":"2003","unstructured":"Gardai SJ, Xiao YQ, Dickinson M, et al. By binding SIRPalpha or calreticulin\/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003;115:13\u201323.","journal-title":"Cell"},{"key":"BFpr2015265_CR48","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.bbamem.2008.05.003","volume":"1778","author":"J P\u00e9rez-Gil","year":"2008","unstructured":"P\u00e9rez-Gil J. Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions. Biochim Biophys Acta 2008;1778:1676\u201395.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2015265_CR49","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1177\/1753425910368716","volume":"16","author":"BA Seaton","year":"2010","unstructured":"Seaton BA, Crouch EC, McCormack FX, Head JF, Hartshorn KL, Mendelsohn R. Review: structural determinants of pattern recognition by lung collectins. Innate Immun 2010;16:143\u201350.","journal-title":"Innate Immun"},{"key":"BFpr2015265_CR50","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nri1528","volume":"5","author":"JR Wright","year":"2005","unstructured":"Wright JR. Immunoregulatory functions of surfactant proteins. Nat Rev Immunol 2005;5:58\u201368.","journal-title":"Nat Rev Immunol"},{"key":"BFpr2015265_CR51","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.4049\/jimmunol.169.7.3978","volume":"169","author":"RW Vandivier","year":"2002","unstructured":"Vandivier RW, Ogden CA, Fadok VA, et al. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol 2002;169:3978\u201386.","journal-title":"J Immunol"},{"key":"BFpr2015265_CR52","doi-asserted-by":"publisher","first-page":"21771","DOI":"10.1074\/jbc.M513041200","volume":"281","author":"C Yamada","year":"2006","unstructured":"Yamada C, Sano H, Shimizu T, et al. Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization. J Biol Chem 2006;281:21771\u201380.","journal-title":"J Biol Chem"},{"key":"BFpr2015265_CR53","doi-asserted-by":"publisher","first-page":"5989","DOI":"10.4049\/jimmunol.168.12.5989","volume":"168","author":"L Guillot","year":"2002","unstructured":"Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002;168:5989\u201392.","journal-title":"J Immunol"},{"key":"BFpr2015265_CR54","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.it.2010.01.002","volume":"31","author":"G Hajishengallis","year":"2010","unstructured":"Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol 2010;31:154\u201363.","journal-title":"Trends Immunol"},{"key":"BFpr2015265_CR55","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1203\/01.PDR.0000082017.97479.39","volume":"54","author":"AJ de Beaufort","year":"2003","unstructured":"de Beaufort AJ, Bakker AC, van Tol MJ, Poorthuis BJ, Schrama AJ, Berger HM. Meconium is a source of pro-inflammatory substances and can induce cytokine production in cultured A549 epithelial cells. Pediatr Res 2003;54:491\u20135.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR56","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.8755-8920.2000.440504.x","volume":"44","author":"T Yamada","year":"2000","unstructured":"Yamada T, Matsubara S, Minakami H, Kohmura Y, Hiratsuka M, Sato I. Chemotactic activity for polymorphonuclear leukocytes: meconium versus meconium-stained amniotic fluid. Am J Reprod Immunol 2000;44:275\u20138.","journal-title":"Am J Reprod Immunol"},{"key":"BFpr2015265_CR57","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0165-0378(99)00048-0","volume":"46","author":"T Yamada","year":"2000","unstructured":"Yamada T, Minakami H, Matsubara S, Yatsuda T, Kohmura Y, Sato I. Meconium-stained amniotic fluid exhibits chemotactic activity for polymorphonuclear leukocytes in vitro. J Reprod Immunol 2000;46:21\u201330.","journal-title":"J Reprod Immunol"},{"key":"BFpr2015265_CR58","first-page":"205","volume":"43","author":"S Matsubara","year":"1999","unstructured":"Matsubara S, Yamada T, Minakami H, Takizawa T, Sato I. Meconium-stained amniotic fluid activates polymorphonuclear leukocytes ultrastructural and enzyme-cytochemical evidence. Eur J Histochem 1999;43:205\u201310.","journal-title":"Eur J Histochem"},{"key":"BFpr2015265_CR59","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.plefa.2004.03.017","volume":"71","author":"A Berdeli","year":"2004","unstructured":"Berdeli A, Akisu M, Dagci T, Akisu C, Yalaz M, Kultursay N. Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. Prostaglandins Leukot Essent Fatty Acids 2004;71:227\u201332.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"BFpr2015265_CR60","doi-asserted-by":"publisher","first-page":"e748","DOI":"10.1542\/peds.2007-1697","volume":"121","author":"K Okazaki","year":"2008","unstructured":"Okazaki K, Kondo M, Kato M, et al. Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. Pediatrics 2008;121:e748\u201353.","journal-title":"Pediatrics"},{"key":"BFpr2015265_CR61","doi-asserted-by":"publisher","first-page":"464","DOI":"10.4049\/jimmunol.174.1.464","volume":"174","author":"F Granata","year":"2005","unstructured":"Granata F, Petraroli A, Boilard E, et al. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol 2005;174:464\u201374.","journal-title":"J Immunol"},{"key":"BFpr2015265_CR62","doi-asserted-by":"publisher","first-page":"H741","DOI":"10.1152\/ajpheart.01182.2005","volume":"291","author":"P Qin","year":"2006","unstructured":"Qin P, Tang X, Elloso MM, Harnish DC. Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38. Am J Physiol Heart Circ Physiol 2006;291:H741\u20137.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFpr2015265_CR63","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","volume":"72","author":"G Gloire","year":"2006","unstructured":"Gloire G, Legrand-Poels S, Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006;72:1493\u2013505.","journal-title":"Biochem Pharmacol"},{"key":"BFpr2015265_CR64","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2478\/v10102-011-0012-z","volume":"4","author":"J Kopincov\u00e1","year":"2011","unstructured":"Kopincov\u00e1 J, P\u00fazserov\u00e1 A, Bern\u00e1tov\u00e1 I. Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide. Interdiscip Toxicol 2011;4:63\u20138.","journal-title":"Interdiscip Toxicol"},{"key":"BFpr2015265_CR65","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.bcp.2012.05.005","volume":"84","author":"IT Lee","year":"2012","unstructured":"Lee IT, Yang CM. Role of NADPH oxidase\/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol 2012;84:581\u201390.","journal-title":"Biochem Pharmacol"},{"key":"BFpr2015265_CR66","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1172\/JCI18696","volume":"112","author":"J Fan","year":"2003","unstructured":"Fan J, Frey RS, Malik AB. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest 2003;112:1234\u201343.","journal-title":"J Clin Invest"},{"key":"BFpr2015265_CR67","doi-asserted-by":"publisher","first-page":"3546","DOI":"10.1073\/pnas.0914351107","volume":"107","author":"H Hattori","year":"2010","unstructured":"Hattori H, Subramanian KK, Sakai J, et al. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci USA 2010;107:3546\u201351.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr2015265_CR68","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0140-6736(98)85013-7","volume":"352","author":"AJ de Beaufort","year":"1998","unstructured":"de Beaufort AJ, Pelikan DM, Elferink JG, Berger HM. Effect of interleukin 8 in meconium on in-vitro neutrophil chemotaxis. Lancet 1998;352:102\u20135.","journal-title":"Lancet"},{"key":"BFpr2015265_CR69","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1165\/ajrcmb\/8.2.134","volume":"8","author":"JH Williams Jr","year":"1993","unstructured":"Williams JH Jr, Patel SK, Hatakeyama D, et al. Activated pulmonary vascular neutrophils as early mediators of endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol 1993;8:134\u201344.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"Suppl 5","key":"BFpr2015265_CR70","first-page":"389","volume":"58","author":"D Mokra","year":"2007","unstructured":"Mokra D, Mokry J, Drgova A, Petraskova M, Bulikova J, Calkovska A. Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits. J Physiol Pharmacol 2007;58:Suppl 5:389\u201398.","journal-title":"J Physiol Pharmacol"},{"key":"BFpr2015265_CR71","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1055\/s-2002-33089","volume":"19","author":"HR Soukka","year":"2002","unstructured":"Soukka HR, Ahotupa M, Ruutu M, K\u00e4\u00e4p\u00e4 PO. Meconium stimulates neutrophil oxidative burst. Am J Perinatol 2002;19:279\u201384.","journal-title":"Am J Perinatol"},{"key":"BFpr2015265_CR72","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2119\/molmed.2010.00138","volume":"17","author":"J Grommes","year":"2011","unstructured":"Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med 2011;17:293\u2013307.","journal-title":"Mol Med"},{"key":"BFpr2015265_CR73","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1203\/00006450-200106000-00018","volume":"49","author":"YH Li","year":"2001","unstructured":"Li YH, Yan ZQ, Brauner A, Tullus K. Meconium induces expression of inducible NO synthase and activation of NF-kappaB in rat alveolar macrophages. Pediatr Res 2001;49:820\u20135.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR74","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1529\/biophysj.105.073106","volume":"90","author":"K Rodr\u00edguez-Capote","year":"2006","unstructured":"Rodr\u00edguez-Capote K, Manzanares D, Haines T, Possmayer F. Reactive oxygen species inactivation of surfactant involves structural and functional alterations to surfactant proteins SP-B and SP-C. Biophys J 2006;90:2808\u201321.","journal-title":"Biophys J"},{"key":"BFpr2015265_CR75","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4049\/jimmunol.159.1.391","volume":"159","author":"L Arbibe","year":"1997","unstructured":"Arbibe L, Vial D, Rosinski-Chupin I, et al. Endotoxin induces expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs: involvement of TNF-alpha in lipopolysaccharide-induced type II phospholipase A2 synthesis. J Immunol 1997;159:391\u2013400.","journal-title":"J Immunol"},{"key":"BFpr2015265_CR76","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1124\/mol.61.4.786","volume":"61","author":"M Alaoui-El-Azher","year":"2002","unstructured":"Alaoui-El-Azher M, Wu Y, Havet N, Isra\u00ebl A, Lilienbaum A, Touqui L. Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways. Mol Pharmacol 2002;61:786\u201394.","journal-title":"Mol Pharmacol"},{"key":"BFpr2015265_CR77","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1164\/rccm.200304-467OC","volume":"168","author":"YZ Wu","year":"2003","unstructured":"Wu YZ, Medjane S, Chabot S, et al. Surfactant protein-A and phosphatidylglycerol suppress type IIA phospholipase A2 synthesis via nuclear factor-kappaB. Am J Respir Crit Care Med 2003;168:692\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr2015265_CR78","doi-asserted-by":"publisher","first-page":"L257","DOI":"10.1152\/ajplung.00054.2011","volume":"302","author":"RD Hite","year":"2012","unstructured":"Hite RD, Grier BL, Waite BM, et al. Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids. Am J Physiol Lung Cell Mol Physiol 2012;302:L257\u201365.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015265_CR79","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0005-2760(96)00042-2","volume":"1302","author":"DF Liau","year":"1996","unstructured":"Liau DF, Yin NX, Huang J, Ryan SF. Effects of human polymorphonuclear leukocyte elastase upon surfactant proteins in vitro. Biochim Biophys Acta 1996;1302:117\u201328.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2015265_CR80","doi-asserted-by":"publisher","first-page":"27688","DOI":"10.1074\/jbc.M402936200","volume":"279","author":"TO Hirche","year":"2004","unstructured":"Hirche TO, Crouch EC, Espinola M, et al. Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. J Biol Chem 2004;279:27688\u201398.","journal-title":"J Biol Chem"},{"key":"BFpr2015265_CR81","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/thx.2003.014902","volume":"59","author":"F Rubio","year":"2004","unstructured":"Rubio F, Cooley J, Accurso FJ, Remold-O\u2019Donnell E. Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease. Thorax 2004;59:318\u201323.","journal-title":"Thorax"},{"key":"BFpr2015265_CR82","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1023\/A:1009616228304","volume":"5","author":"HU Simon","year":"2000","unstructured":"Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000;5:415\u20138.","journal-title":"Apoptosis"},{"key":"BFpr2015265_CR83","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1165\/rcmb.2002-0156OC","volume":"28","author":"X Zhang","year":"2003","unstructured":"Zhang X, Shan P, Sasidhar M, et al. Reactive oxygen species and extracellular signal-regulated kinase \u00bd mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol 2003;28:305\u201315.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2015265_CR84","first-page":"L789","volume":"273","author":"YM Janssen","year":"1997","unstructured":"Janssen YM, Matalon S, Mossman BT. Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS. Am J Physiol 1997;273:L789\u201396.","journal-title":"Am J Physiol"},{"key":"BFpr2015265_CR85","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.prp.2009.12.002","volume":"206","author":"V Galani","year":"2010","unstructured":"Galani V, Tatsaki E, Bai M, et al. The role of apoptosis in the pathophysiology of acute respiratory distress syndrome (ARDS): an up-to-date cell-specific review. Pathol Res Pract 2010;206:145\u201350.","journal-title":"Pathol Res Pract"},{"key":"BFpr2015265_CR86","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/ppul.21262","volume":"45","author":"MJ Jeng","year":"2010","unstructured":"Jeng MJ, Soong WJ, Lee YS, et al. Meconium exposure dependent cell death and apoptosis in human alveolar epithelial cells. Pediatr Pulmonol 2010;45:816\u201323.","journal-title":"Pediatr Pulmonol"},{"key":"BFpr2015265_CR87","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1203\/01.PDR.0000100901.88697.66","volume":"55","author":"H Lukkarinen","year":"2004","unstructured":"Lukkarinen H, Laine J, Lehtonen J, et al. Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. Pediatr Res 2004;55:326\u201333.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR88","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1203\/PDR.0b013e318163a2b8","volume":"63","author":"CR Rosenfeld","year":"2008","unstructured":"Rosenfeld CR, Zagariya AM, Liu XT, Willis BC, Fluharty S, Vidyasagar D. Meconium increases type 1 angiotensin II receptor expression and alveolar cell death. Pediatr Res 2008;63:251\u20136.","journal-title":"Pediatr Res"},{"key":"BFpr2015265_CR89","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/j.lfs.2004.10.033","volume":"76","author":"A Zagariya","year":"2005","unstructured":"Zagariya A, Bhat R, Chari G, Uhal B, Navale S, Vidyasagar D. Apoptosis of airway epithelial cells in response to meconium. Life Sci 2005;76:1849\u201358.","journal-title":"Life Sci"},{"key":"BFpr2015265_CR90","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/BF02719707","volume":"168","author":"DG Oelberg","year":"1990","unstructured":"Oelberg DG, Downey SA, Flynn MM. Bile salt-induced intracellular Ca++ accumulation in type II pneumocytes. Lung 1990;168:297\u2013308.","journal-title":"Lung"},{"key":"BFpr2015265_CR91","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1165\/ajrcmb.22.3.3788","volume":"22","author":"V Glumoff","year":"2000","unstructured":"Glumoff V, V\u00e4yrynen O, Kangas T, Hallman M. Degree of lung maturity determines the direction of the interleukin-1- induced effect on the expression of surfactant proteins. Am J Respir Cell Mol Biol 2000;22:280\u20138.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2015265_CR92","doi-asserted-by":"publisher","first-page":"L950","DOI":"10.1152\/ajplung.00210.2004","volume":"288","author":"JW Lee","year":"2005","unstructured":"Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Am J Physiol Lung Cell Mol Physiol 2005;288:L950\u20137.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015265_CR93","doi-asserted-by":"publisher","first-page":"L966","DOI":"10.1152\/ajplung.00103.2011","volume":"301","author":"JE Damas","year":"2011","unstructured":"Damas JE, Cake MH. An albumin-associated PLA2-like activity inactivates surfactant phosphatidylcholine secreted from fetal type II pneumocytes. Am J Physiol Lung Cell Mol Physiol 2011;301:L966\u201374.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFpr2015265_CR94","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3346\/jkms.1998.13.2.123","volume":"13","author":"J Park","year":"1998","unstructured":"Park J, Bae CW, Choi YM. In vitro inhibition of biophysical surface properties and change in ultrastructures of exogenous pulmonary surfactant by albumin or fibrinogen. J Korean Med Sci 1998;13:123\u201330.","journal-title":"J Korean Med Sci"},{"key":"BFpr2015265_CR95","doi-asserted-by":"publisher","first-page":"e47631","DOI":"10.1371\/journal.pone.0047631","volume":"7","author":"M Seehase","year":"2012","unstructured":"Seehase M, Collins JJ, Kuypers E, et al. New surfactant with SP-B and C analogs gives survival benefit after inactivation in preterm lambs. PLoS One 2012;7:e47631.","journal-title":"PLoS One"},{"key":"BFpr2015265_CR96","first-page":"CD003486","volume":"4","author":"S Hahn","year":"2013","unstructured":"Hahn S, Choi HJ, Soll R, Dargaville PA. Lung lavage for meconium aspiration syndrome in newborn infants. Cochrane Database Syst Rev 2013;4:CD003486.","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/pr2015265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/pr2015265","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/pr2015265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T05:47:56Z","timestamp":1692164876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2015265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["BFpr2015265"],"URL":"https:\/\/doi.org\/10.1038\/pr.2015.265","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]},"assertion":[{"value":"2 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}