{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:20:53Z","timestamp":1784100053744,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1038\/pr.2015.271","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T17:06:37Z","timestamp":1450717597000},"page":"559-564","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study"],"prefix":"10.1038","volume":"79","author":[{"given":"An-Chyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-1068","authenticated-orcid":false,"given":"Te-Chun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai-Chung","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung-Chang","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ching","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"BFpr2015271_CR1","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/S0140-6736(07)60474-7","volume":"369","author":"FT Saulsbury","year":"2007","unstructured":"Saulsbury FT. Clinical update: Henoch\u2013Schonlein purpura. Lancet 2007;369: 976\u20138.","journal-title":"Lancet"},{"key":"BFpr2015271_CR2","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0140-6736(02)11279-7","volume":"360","author":"JMM Gardner-Medwin","year":"2002","unstructured":"Gardner-Medwin JMM, Dolezalova P, Cummins C, Southwood TR. Incidence of Henoch\u2013Sch\u00f6nlein, Kawasaki disease and rare vasculitides in children of different ethnic origins. Lancet 2002;360:1197\u2013202.","journal-title":"Lancet"},{"key":"BFpr2015271_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF00442205","volume":"147","author":"M Stewart","year":"1988","unstructured":"Stewart M, Savage JM, Bell B, McCord B. Long term renal prognosis of Henoch\u2013Sch\u00f6nlein purpura in an unselected childhood population. Eur J Pediatr 1988;147:113\u20135.","journal-title":"Eur J Pediatr"},{"key":"BFpr2015271_CR4","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1046\/j.1523-1755.1998.00915.x","volume":"53","author":"Y Kaku","year":"1998","unstructured":"Kaku Y, Nohara K, Honda S. Renal involvement in Henoch\u2013Sch\u00f6nlein purpura: a multivariate analysis of prognostic factors. Kidney Int 1998;53:1755\u20139.","journal-title":"Kidney Int"},{"key":"BFpr2015271_CR5","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s00431-002-0922-z","volume":"161","author":"H Sano","year":"2002","unstructured":"Sano H, Izumida M, Shimizu H, Ogawa Y. Risk factors of renal involvement and significant proteinuria in Henoch\u2013Sch\u00f6nlein purpura. Eur J Pediatr 2002;161:196\u2013201.","journal-title":"Eur J Pediatr"},{"key":"BFpr2015271_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00296-004-0452-2","volume":"25","author":"D Rigante","year":"2005","unstructured":"Rigante D, Candelli M, Federico G, Bartolozzi F, Porri MG, Stabile A. Predictive factors of renal involvement or relapsing disease in children with Henoch\u2013Sch\u00f6nlein purpura. Rheumatol Int 2005;25:45\u20138.","journal-title":"Rheumatol Int"},{"key":"BFpr2015271_CR7","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s00467-005-1903-z","volume":"20","author":"WL Chang","year":"2005","unstructured":"Chang WL, Yang YH, Wang LC, Lin YT, Chiang BL. Renal manifestations in Henoch\u2013Sch\u00f6nlein purpura: a 10-year clinical study. Pediatr Nephrol 2005;20:1269\u201372.","journal-title":"Pediatr Nephrol"},{"key":"BFpr2015271_CR8","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/rheumatology\/keh544","volume":"44","author":"YH Yang","year":"2005","unstructured":"Yang YH, Hung CF, Hsu CR, et al. A nationwide survey on epidemiological characteristics of childhood Henoch\u2013Sch\u00f6nlein purpura in Taiwan. Rheumatology (Oxford) 2005;44:618\u201322.","journal-title":"Rheumatology (Oxford)"},{"key":"BFpr2015271_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.autrev.2007.11.012","volume":"7","author":"YH Yang","year":"2008","unstructured":"Yang YH, Chuang YH, Wang LC, Huang HY, Gershwin ME, Chiang BL. The immunobiology of Henoch\u2013Sch\u00f6nlein purpura. Autoimmun Rev 2008;7:179\u201384.","journal-title":"Autoimmun Rev"},{"key":"BFpr2015271_CR10","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/j.1365-2222.2004.02029.x","volume":"34","author":"Y Tsuji","year":"2004","unstructured":"Tsuji Y, Abe Y, Hisano M, Sakai T. Urinary leukotriene E4 in Henoch\u2013Schonlein purpura. Clin Exp Allergy 2004;34:1259\u201361.","journal-title":"Clin Exp Allergy"},{"key":"BFpr2015271_CR11","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/j.1442-200x.2005.02115.x","volume":"47","author":"Y Kawasaki","year":"2005","unstructured":"Kawasaki Y, Hosoya M, Suzuki H. Possible pathologenic role of interleukin-5 and eosino cationic protein in Henoch\u2013Sch\u00f6nlein purpura nephritis. Pediatr Int 2005;47:512\u20137.","journal-title":"Pediatr Int"},{"key":"BFpr2015271_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF00865470","volume":"8","author":"JC Davin","year":"1994","unstructured":"Davin JC, Pierard G, Dechenne C, et al. Possible pathogenic role of IgE in Henoch\u2013Sch\u00f6nlein purpura. Pediatr Nephrol 1994;8:169\u201371.","journal-title":"Pediatr Nephrol"},{"key":"BFpr2015271_CR13","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s004670050370","volume":"11","author":"MK Namgoong","year":"1997","unstructured":"Namgoong MK, Lim BK, Kim JS. Eosinophil cationic protein in Henoch\u2013Sch\u00f6nlein purpura and in IgA nephropathy. Pediatr Nephrol 1997;11:703\u20136.","journal-title":"Pediatr Nephrol"},{"issue":"1 Suppl","key":"BFpr2015271_CR14","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.1111\/1523-1747.ep12275678","volume":"85","author":"WM Sams Jr","year":"1985","unstructured":"Sams WM Jr . Human hypersensitivity angiitis, an immune complex disease. J Invest Dermatol 1985;85:1 Suppl:S144\u20138.","journal-title":"J Invest Dermatol"},{"key":"BFpr2015271_CR15","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/0002-9343(53)90377-5","volume":"14","author":"JF Ackroyd","year":"1953","unstructured":"Ackroyd JF. Allergic purpura, including purpura due to foods, drugs and infections. Am J Med 1953;14:605\u201332.","journal-title":"Am J Med"},{"key":"BFpr2015271_CR16","first-page":"772","volume":"88","author":"DM Burke","year":"1954","unstructured":"Burke DM, Jellinek HL. Nearly fatal case of Schoenlein\u2013Henoch syndrome following insect bite. AMA Am J Dis Child 1954;88:772\u20134.","journal-title":"AMA Am J Dis Child"},{"key":"BFpr2015271_CR17","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3109\/03009749709065719","volume":"26","author":"N Besbas","year":"1997","unstructured":"Besbas N, Saatci U, Ruacan S, et al. The role of cytokines in Henoch Schonlein purpura. Scand J Rheumatol 1997;26:456\u201360.","journal-title":"Scand J Rheumatol"},{"key":"BFpr2015271_CR18","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/08923970802278102","volume":"30","author":"GC Del Vecchio","year":"2008","unstructured":"Del Vecchio GC, Penza R, Altomare M, et al. Cytokine pattern and endothelium damage markers in Henoch\u2013Schonlein purpura. Immunopharmacol Immunotoxicol 2008;30:623\u20139.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"BFpr2015271_CR19","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/med.20071","volume":"27","author":"V Capra","year":"2007","unstructured":"Capra V, Thompson MD, Sala A, Cole DE, Folco G, Rovati GE. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. Med Res Rev 2007;27:469\u2013527.","journal-title":"Med Res Rev"},{"key":"BFpr2015271_CR20","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.1007\/s00296-011-2266-3","volume":"32","author":"YY Li","year":"2012","unstructured":"Li YY, Li CR, Wang GB, Yang J, Zu Y. Investigation of the change in CD4+ T cell subset in children with Henoch\u2013Schonlein purpura. Rheumatol Int 2012;32:3785\u201392.","journal-title":"Rheumatol Int"},{"key":"BFpr2015271_CR21","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s00296-012-2661-4","volume":"33","author":"X He","year":"2013","unstructured":"He X, Yu C, Zhao P, et al. The genetics of Henoch\u2013Sch\u00f6nlein purpura: a systematic review and meta-analysis. Rheumatol Int 2013;33:1387\u201395.","journal-title":"Rheumatol Int"},{"key":"BFpr2015271_CR22","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.humimm.2014.06.022","volume":"75","author":"E Kontakioti","year":"2014","unstructured":"Kontakioti E, Domvri K, Papakosta D, Daniilidis M. HLA and asthma phenotypes\/endotypes: a review. Hum Immunol\ufeff\ufeff 2014;75:930\u20139.","journal-title":"Hum Immunol\ufeff\ufeff"},{"key":"BFpr2015271_CR23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1177\/1470320313502107","volume":"15","author":"H Lin","year":"2014","unstructured":"Lin H, Lin D, Zheng CQ. Angiotensin-converting enzyme insertion\/deletion polymorphism associated with allergic rhinitis susceptibility: evidence from 1410 subjects. J Renin Angiotensin Aldosterone Syst 2014;15:593\u2013600.","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"BFpr2015271_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1398-9995.2010.02438.x","volume":"66","author":"YG Zhang","year":"2011","unstructured":"Zhang YG, Li XB, Zhang J, et al. The I\/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy 2011;66:197\u2013205.","journal-title":"Allergy"},{"key":"BFpr2015271_CR25","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","volume":"351","author":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee.","year":"1998","unstructured":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet. 1998;351:1225\u201332.","journal-title":"Lancet"},{"key":"BFpr2015271_CR26","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","volume":"59","author":"M Masoli","year":"2004","unstructured":"Masoli M, Fabian D, Holt S, Beasley R ; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469\u201378.","journal-title":"Allergy"},{"key":"BFpr2015271_CR27","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/S0140-6736(08)60765-5","volume":"371","author":"V Harjutsalo","year":"2008","unstructured":"Harjutsalo V, Sj\u00f6berg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008;371:1777\u201382.","journal-title":"Lancet"},{"key":"BFpr2015271_CR28","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1056\/NEJMra020100","volume":"347","author":"JF Bach","year":"2002","unstructured":"Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911\u201320.","journal-title":"N Engl J Med"},{"key":"BFpr2015271_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04139.x","volume":"160","author":"H Okada","year":"2010","unstructured":"Okada H, Kuhn C, Feillet H, Bach JF. The \u2018hygiene hypothesis\u2019 for autoimmune and allergic diseases: an update. Clin Exp Immunol 2010;160:1\u20139.","journal-title":"Clin Exp Immunol"},{"key":"BFpr2015271_CR30","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1365-2567.2004.01925.x","volume":"112","author":"S Romagnani","year":"2004","unstructured":"Romagnani S. The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology 2004;112:352\u201363.","journal-title":"Immunology"},{"key":"BFpr2015271_CR31","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1177\/0961203314543920","volume":"23","author":"CC Wei","year":"2014","unstructured":"Wei CC, Lin CL, Tsai JD, Shen TC, Sung FC. Increased Incidence of juvenile onset systemic lupus erythematosus in children with atopic dermatitis. Lupus 2014;23:1494\u20139.","journal-title":"Lupus"},{"key":"BFpr2015271_CR32","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/pai.12228","volume":"25","author":"CC Wei","year":"2014","unstructured":"Wei CC, Lin CL, Shen TC, Tsai JD, Chung CJ, Li TC. Increased incidence of juvenile-onset systemic lupus erythematosus among children with asthma. Pediatr Allergy Immunol 2014;25:374\u20139.","journal-title":"Pediatr Allergy Immunol"},{"key":"BFpr2015271_CR33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1159\/000167202","volume":"6","author":"J Laurent","year":"1986","unstructured":"Laurent J, Lagrue G, Sobel A. Increased serum IgE levels in patients with lupus nephritis. Am J Nephrol 1986;6:413\u20134.","journal-title":"Am J Nephrol"},{"key":"BFpr2015271_CR34","first-page":"94","volume":"50","author":"O Elkayam","year":"1995","unstructured":"Elkayam O, Tamir R, Pick AI, Wysenbeek A. Serum IgE concentrations, disease activity, and atopic disorders in systemic lupus erythematosus. Allergy 1995;50:94\u20136.","journal-title":"Allergy"},{"key":"BFpr2015271_CR35","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nm.2159","volume":"16","author":"N Charles","year":"2010","unstructured":"Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med\ufeff\ufeff 2010;16:701\u20137.","journal-title":"Nat Med\ufeff\ufeff"},{"key":"BFpr2015271_CR36","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s11882-011-0216-5","volume":"11","author":"N Charles","year":"2011","unstructured":"Charles N, Rivera J. Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus. Curr Allergy Asthma Rep 2011;11:378\u201387.","journal-title":"Curr Allergy Asthma Rep"},{"key":"BFpr2015271_CR37","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.autrev.2013.04.003","volume":"12","author":"D Rigante","year":"2013","unstructured":"Rigante D, Castellazzi L, Bosco A, Esposito S. Is there a crossroad between infections, genetics, and Henoch\u2013Sch\u00f6nlein purpura? Autoimmun Rev 2013;12:1016\u201321.","journal-title":"Autoimmun Rev"},{"key":"BFpr2015271_CR38","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1002\/art.1780330809","volume":"33","author":"JA Mills","year":"1990","unstructured":"Mills JA, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Henoch\u2013Sch\u00f6nlein purpura. Arthritis Rheum 1990;33:1114\u201321.","journal-title":"Arthritis Rheum"},{"key":"BFpr2015271_CR39","doi-asserted-by":"publisher","first-page":"370","DOI":"10.2188\/jea.JE20140167","volume":"25","author":"CC Wei","year":"2015","unstructured":"Wei CC, Lin CL, Shen TC, Sung FC. Occurrence of common allergic diseases in children with idiopathic nephrotic syndrome. J Epidemiol\ufeff\ufeff 2015;25:370\u20137.","journal-title":"J Epidemiol\ufeff\ufeff"},{"key":"BFpr2015271_CR40","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/jcpp.12303","volume":"56","author":"CC Wei","year":"2015","unstructured":"Wei CC, Chang CH, Lin CL, Chang SN, Li TC, Kao CH. Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. J Child Psychol Psychiatry 2015;56:460\u20137.","journal-title":"J Child Psychol Psychiatry"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2015271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2015271","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2015271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T20:59:20Z","timestamp":1684616360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2015271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["BFpr2015271"],"URL":"https:\/\/doi.org\/10.1038\/pr.2015.271","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]},"assertion":[{"value":"8 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}