{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:47:46Z","timestamp":1790801266682,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1038\/pr.2015.28","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T18:03:47Z","timestamp":1423505027000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Heart rate variability in hypoxic ischemic encephalopathy: correlation with EEG grade and 2-y neurodevelopmental outcome"],"prefix":"10.1038","volume":"77","author":[{"given":"Robert M.","family":"Goulding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Filan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"BFpr201528_CR1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1089\/neu.2008.0678","volume":"26","author":"S Shankaran","year":"2009","unstructured":"Shankaran S. Neonatal encephalopathy: treatment with hypothermia. J Neurotrauma 2009;26:437\u201343.","journal-title":"J Neurotrauma"},{"key":"BFpr201528_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","volume":"86","author":"JJ Kurinczuk","year":"2010","unstructured":"Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev 2010;86:329\u201338.","journal-title":"Early Hum Dev"},{"key":"BFpr201528_CR3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.ajog.2008.06.094","volume":"199","author":"EM Graham","year":"2008","unstructured":"Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 2008;199:587\u201395.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201528_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000085978","volume":"27","author":"RC Vannucci","year":"2005","unstructured":"Vannucci RC, Vannucci SJ. Perinatal hypoxic-ischemic brain damage: evolution of an animal model. Dev Neurosci 2005;27:81\u20136.","journal-title":"Dev Neurosci"},{"key":"BFpr201528_CR5","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.1542\/peds.2008-2190","volume":"124","author":"DM Murray","year":"2009","unstructured":"Murray DM, Boylan GB, Ryan CA, Connolly S. Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years. Pediatrics 2009;124:e459\u201367.","journal-title":"Pediatrics"},{"key":"BFpr201528_CR6","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/j.1651-2227.2010.01809.x","volume":"99","author":"G Boylan","year":"2010","unstructured":"Boylan G, Burgoyne L, Moore C, O\u2019Flaherty B, Rennie J. An international survey of EEG use in the neonatal intensive care unit. Acta Paediatr 2010;99:1150\u20135.","journal-title":"Acta Paediatr"},{"key":"BFpr201528_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00421-003-0917-0","volume":"91","author":"L Mourot","year":"2004","unstructured":"Mourot L, Bouhaddi M, Perrey S, Rouillon JD, Regnard J. Quantitative Poincar\u00e9 plot analysis of heart rate variability: effect of endurance training. Eur J Appl Physiol 2004;91:79\u201387.","journal-title":"Eur J Appl Physiol"},{"key":"BFpr201528_CR8","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","volume":"93","author":"M Malik","year":"1996","unstructured":"Malik M. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 1996;93:1043\u201365.","journal-title":"Circulation"},{"issue":"3 Pt 1","key":"BFpr201528_CR9","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.ajog.2005.01.058","volume":"193","author":"B Wibbens","year":"2005","unstructured":"Wibbens B, Westgate JA, Bennet L, et al. Profound hypotension and associated electrocardiographic changes during prolonged cord occlusion in the near term fetal sheep. Am J Obstet Gynecol 2005;193(3 Pt 1):803\u201310.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr201528_CR10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S0140-6736(77)92060-8","volume":"1","author":"RI Lowensohn","year":"1977","unstructured":"Lowensohn RI, Weiss M, Hon EH. Heart-rate variability in brain-damaged adults. Lancet 1977;1:626\u20138.","journal-title":"Lancet"},{"key":"BFpr201528_CR11","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1007\/s12098-012-0703-2","volume":"79","author":"D Aliefendio\u011flu","year":"2012","unstructured":"Aliefendio\u011flu D, Do\u011fru T, Albayrak M, DibekM\u0131s\u0131rl\u0131o\u011flu E, \u015eanl\u0131 C. Heart rate variability in neonates with hypoxic ischemic encephalopathy. Indian J Pediatr 2012;79:1468\u201372.","journal-title":"Indian J Pediatr"},{"key":"BFpr201528_CR12","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1055\/s-0033-1361937","volume":"31","author":"BD Vergales","year":"2013","unstructured":"Vergales BD, Zanelli SA, Matsumoto JA et al. Depressed heart rate variability is associated with abnormal EEG, MRI, and death in neonates with hypoxic ischemic encephalopathy. Am J Perinatol 2013;31:855\u201362.","journal-title":"Am J Perinatol"},{"key":"BFpr201528_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jpeds.2012.06.042","volume":"162","author":"TL DuPont","year":"2013","unstructured":"DuPont TL, Chalak LF, Morriss MC, Burchfield PJ, Christie L, S\u00e1nchez PJ. Short-term outcomes of newborns with perinatal acidemia who are not eligible for systemic hypothermia therapy. J Pediatr 2013;162:35\u201341.","journal-title":"J Pediatr"},{"key":"BFpr201528_CR14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/BF01845495","volume":"5","author":"V Novak","year":"1995","unstructured":"Novak V, Novak P, deMarchie M, Schondorf R. The effect of severe brainstem injury on heart rate and blood pressure oscillations. Clin Auton Res 1995;5:24\u201330.","journal-title":"Clin Auton Res"},{"key":"BFpr201528_CR15","volume-title":"Neurology of the Newborn. 3rd edn","author":"JJ Volpe","year":"1995","unstructured":"Volpe JJ. Neurology of the Newborn. 3rd edn. Philadelphia: WB Saunders, 1995."},{"key":"BFpr201528_CR16","doi-asserted-by":"publisher","first-page":"R925","DOI":"10.1152\/ajpregu.00263.2004","volume":"287","author":"S George","year":"2004","unstructured":"George S, Gunn AJ, Westgate JA, Brabyn C, Guan J, Bennet L. Fetal heart rate variability and brain stem injury after asphyxia in preterm fetal sheep. Am J Physiol Regul Integr Comp Physiol 2004;287:R925\u201333.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFpr201528_CR17","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00234-010-0674-9","volume":"52","author":"LS de Vries","year":"2010","unstructured":"de Vries LS, Groenendaal F. Patterns of neonatal hypoxic-ischaemic brain injury. Neuroradiology 2010;52:555\u201366.","journal-title":"Neuroradiology"},{"key":"BFpr201528_CR18","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1097\/00003246-200012000-00030","volume":"28","author":"AK Biswas","year":"2000","unstructured":"Biswas AK, Scott WA, Sommerauer JF, Luckett PM. Heart rate variability after acute traumatic brain injury in children. Crit Care Med 2000;28:3907\u201312.","journal-title":"Crit Care Med"},{"issue":"1 Pt 2","key":"BFpr201528_CR19","first-page":"H151","volume":"248","author":"B Pomeranz","year":"1985","unstructured":"Pomeranz B, Macaulay RJ, Caudill MA, et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 1985;248(1 Pt 2):H151\u20133.","journal-title":"Am J Physiol"},{"key":"BFpr201528_CR20","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/01.CIR.84.2.482","volume":"84","author":"A Malliani","year":"1991","unstructured":"Malliani A, Pagani M, Lombardi F, Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 1991;84:482\u201392.","journal-title":"Circulation"},{"key":"BFpr201528_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10286-010-0098-y","volume":"21","author":"F Rahman","year":"2011","unstructured":"Rahman F, Pechnik S, Gross D, Sewell L, Goldstein DS. Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation. Clin Auton Res 2011;21:133\u201341.","journal-title":"Clin Auton Res"},{"key":"BFpr201528_CR22","first-page":"31","volume":"41","author":"M Moldovan","year":"2004","unstructured":"Moldovan M, Spulber S, Saravan V, Iosifescu R, Zagrean AM, Zagrean L. The relationship between respiratory sinus arrhythmia and heart rate during anesthesia in rat. Rom J Physiol 2004;41:31\u20139.","journal-title":"Rom J Physiol"},{"key":"BFpr201528_CR23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.clp.2010.06.002","volume":"37","author":"KD Fairchild","year":"2010","unstructured":"Fairchild KD, O\u2019Shea TM. Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis. Clin Perinatol 2010;37:581\u201398.","journal-title":"Clin Perinatol"},{"key":"BFpr201528_CR24","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/PCC.0b013e318291793f","volume":"14","author":"BH Walsh","year":"2013","unstructured":"Walsh BH, Boylan GB, Livingstone V, Kenny LC, Dempsey EM, Murray DM. Cord blood proteins and multichannel-electroencephalography in hypoxic-ischemic encephalopathy. Pediatr Crit Care Med 2013;14:621\u201330.","journal-title":"Pediatr Crit Care Med"},{"key":"BFpr201528_CR25","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1046\/j.1365-2362.2003.01136.x","volume":"33","author":"C Chiesa","year":"2003","unstructured":"Chiesa C, Pellegrini G, Panero A, et al. Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia. Eur J Clin Invest 2003;33:352\u20138.","journal-title":"Eur J Clin Invest"},{"key":"BFpr201528_CR26","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/oxfordjournals.aje.a009049","volume":"145","author":"JM Dekker","year":"1997","unstructured":"Dekker JM, Schouten EG, Klootwijk P, Pool J, Swenne CA, Kromhout D. Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. Am J Epidemiol 1997;145:899\u2013908.","journal-title":"Am J Epidemiol"},{"key":"BFpr201528_CR27","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00003246-199802000-00040","volume":"26","author":"B Goldstein","year":"1998","unstructured":"Goldstein B, Fiser DH, Kelly MM, Mickelsen D, Ruttimann U, Pollack MM. Decomplexification in critical illness and injury: relationship between heart rate variability, severity of illness, and outcome. Crit Care Med 1998;26:352\u20137.","journal-title":"Crit Care Med"},{"key":"BFpr201528_CR28","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.jcrc.2007.04.006","volume":"23","author":"V Papaioannou","year":"2008","unstructured":"Papaioannou V, Giannakou M, Maglaveras N, Sofianos E, Giala M. Investigation of heart rate and blood pressure variability, baroreflex sensitivity, and approximate entropy in acute brain injury patients. J Crit Care 2008;23:380\u20136.","journal-title":"J Crit Care"},{"key":"BFpr201528_CR29","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1097\/00003246-200007000-00066","volume":"28","author":"PG Haji-Michael","year":"2000","unstructured":"Haji-Michael PG, Vincent JL, Degaute JP, van de Borne P. Power spectral analysis of cardiovascular variability in critically ill neurosurgical patients. Crit Care Med 2000;28:2578\u201383.","journal-title":"Crit Care Med"},{"key":"BFpr201528_CR30","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.clinph.2009.03.015","volume":"120","author":"I Korotchikova","year":"2009","unstructured":"Korotchikova I, Connolly S, Ryan CA, et al. EEG in the healthy term newborn within 12 hours of birth. Clin Neurophysiol 2009;120:1046\u201353.","journal-title":"Clin Neurophysiol"},{"key":"BFpr201528_CR31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1109\/TBME.1985.325532","volume":"32","author":"P Pan","year":"1985","unstructured":"Pan P, Tompkins WJ. A real-time QRS detection algorithm. IEEE Trans Biomed Eng 1985;32:230\u20136.","journal-title":"IEEE Trans Biomed Eng"},{"key":"BFpr201528_CR32","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.earlhumdev.2005.03.015","volume":"81","author":"E Longin","year":"2005","unstructured":"Longin E, Schaible T, Lenz T, K\u00f6nig S. Short term heart rate variability in healthy neonates: normative data and physiological observations. Early Hum Dev 2005;81:663\u201371.","journal-title":"Early Hum Dev"},{"key":"BFpr201528_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1109\/MEMB.2009.934629","volume":"28","author":"K Chon","year":"2009","unstructured":"Chon K, Scully CG, Lu S. Approximate entropy for all signals. IEEE Eng Med Biol Mag 2009;28:18\u201323.","journal-title":"IEEE Eng Med Biol Mag"},{"key":"BFpr201528_CR34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1088\/0967-3334\/30\/8\/009","volume":"30","author":"OM Doyle","year":"2009","unstructured":"Doyle OM, Korotchikova I, Lightbody G, Marnane W, Kerins D, Boylan GB. Heart rate variability during sleep in healthy term newborns in the early postnatal period. Physiol Meas 2009;30:847\u201360.","journal-title":"Physiol Meas"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201528","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2015.28","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr201528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T20:59:26Z","timestamp":1684616366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,9]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["BFpr201528"],"URL":"https:\/\/doi.org\/10.1038\/pr.2015.28","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,9]]},"assertion":[{"value":"10 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}