{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:26:46Z","timestamp":1766158006331},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1038\/pr.2016.268","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T17:01:06Z","timestamp":1482253266000},"page":"646-653","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Renal dysfunction in early adulthood following birth asphyxia in male spiny mice, and its amelioration by maternal creatine supplementation during pregnancy"],"prefix":"10.1038","volume":"81","author":[{"given":"Stacey J.","family":"Ellery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenic A.","family":"LaRosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise A.","family":"Cullen-McEwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod J.","family":"Snow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Kett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"BFpr2016268_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/tropej\/fmi017","volume":"51","author":"A Aggarwal","year":"2005","unstructured":"Aggarwal A, Kumar P, Chowdhary G, Majumdar S, Narang A. Evaluation of renal functions in asphyxiated newborns. J Trop Pediatr 2005;51:295\u20139.","journal-title":"J Trop Pediatr"},{"key":"BFpr2016268_CR2","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0022-3476(88)80023-4","volume":"113","author":"JM Periman","year":"1988","unstructured":"Periman JM, Tack ED. Renal injury in the asphyxiated newborn infant: Relationship to neurologic outcome. J Pediatr 1988;113:875\u20139.","journal-title":"J Pediatr"},{"key":"BFpr2016268_CR3","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s004670050068","volume":"14","author":"JB Gouyon","year":"2000","unstructured":"Gouyon JB, Guignard JP. Management of acute renal failure in newborns. Pediatr Nephrol 2000;14:1037\u201344.","journal-title":"Pediatr Nephrol"},{"key":"BFpr2016268_CR4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/0002-9378(70)90341-8","volume":"108","author":"RE Behrman","year":"1970","unstructured":"Behrman RE, Lees MH, Peterson EN, De Lannoy CW, Seeds AE. Distribution of the circulation in the normal and asphyxiated fetal primate. Am J Obstet Gynecol 1970;108:956\u201369.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr2016268_CR5","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1053\/S0270-9295(03)00130-X","volume":"23","author":"P Saikumar","year":"2003","unstructured":"Saikumar P, Venkatachalam MA. Role of apoptosis in hypoxic\/ischemic damage in the kidney. Semin Nephrol 2003;23:511\u201321.","journal-title":"Semin Nephrol"},{"key":"BFpr2016268_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/apa.12116","volume":"102","author":"DU Sweetman","year":"2013","unstructured":"Sweetman DU, Riordan M, Molloy EJ. Management of renal dysfunction following term perinatal hypoxia-ischaemia. Acta Paediatr 2013;102:233\u201341.","journal-title":"Acta Paediatr"},{"key":"BFpr2016268_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1177\/000992289803700609","volume":"37","author":"C Polito","year":"1998","unstructured":"Polito C, Papale MR, La Manna A. Long-term prognosis of acute renal failure in the full-term neonate. Clin Pediatr (Phila) 1998;37:381\u20135.","journal-title":"Clin Pediatr (Phila)"},{"key":"BFpr2016268_CR8","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1053\/j.ajkd.2012.01.007","volume":"59","author":"DJ Askenazi","year":"2012","unstructured":"Askenazi DJ. Do children with acute kidney injury require long-term evaluation for CKD? Am J Kidney Dis 2012;59:478\u201380.","journal-title":"Am J Kidney Dis"},{"key":"BFpr2016268_CR9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1053\/j.ajkd.2011.10.048","volume":"59","author":"C Mammen","year":"2012","unstructured":"Mammen C, Al Abbas A, Skippen P, et al. Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study. Am J Kidney Dis 2012;59:523\u201330.","journal-title":"Am J Kidney Dis"},{"key":"BFpr2016268_CR10","doi-asserted-by":"publisher","first-page":"F273","DOI":"10.1152\/ajprenal.00400.2004","volume":"289","author":"H Dickinson","year":"2005","unstructured":"Dickinson H, Walker DW, Cullen-McEwen L, Wintour EM, Moritz K. The spiny mouse (Acomys cahirinus) completes nephrogenesis before birth. Am J Physiol Renal Physiol 2005;289:F273\u20139.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFpr2016268_CR11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/pr.2012.174","volume":"73","author":"SJ Ellery","year":"2013","unstructured":"Ellery SJ, Ireland Z, Kett MM, Snow R, Walker DW, Dickinson H. Creatine pretreatment prevents birth asphyxia-induced injury of the newborn spiny mouse kidney. Pediatr Res 2013;73:201\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2016268_CR12","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1152\/ajpregu.00481.2006","volume":"292","author":"H Dickinson","year":"2007","unstructured":"Dickinson H, Walker DW, Wintour EM, Moritz K. Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. Am J Physiol Regul Integr Comp Physiol 2007;292:R453\u201361.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFpr2016268_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/2042-6410-4-21","volume":"4","author":"H Dickinson","year":"2013","unstructured":"Dickinson H, Moritz KM, Kett MM. A comparative study of renal function in male and female spiny mice - sex specific responses to a high salt challenge. Biol Sex Differ 2013;4:21.","journal-title":"Biol Sex Differ"},{"key":"BFpr2016268_CR14","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1111\/j.1523-1755.2002.kid590.x","volume":"62","author":"V M\u00fcller","year":"2002","unstructured":"M\u00fcller V, Losonczy G, Heemann U, et al. Sexual dimorphism in renal ischemia-reperfusion injury in rats: possible role of endothelin. Kidney Int 2002;62:1364\u201371.","journal-title":"Kidney Int"},{"key":"BFpr2016268_CR15","doi-asserted-by":"publisher","first-page":"52282","DOI":"10.1074\/jbc.M407629200","volume":"279","author":"KM Park","year":"2004","unstructured":"Park KM, Kim JI, Ahn Y, Bonventre AJ, Bonventre JV. Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem 2004;279:52282\u201392.","journal-title":"J Biol Chem"},{"key":"BFpr2016268_CR16","first-page":"4","volume":"20","author":"H Dickinson","year":"2007","unstructured":"Dickinson H, Walker D. Managing a colony of spiny mice (Acomys cahirinus) for perinatal research. Australian and New Zealand Council for the Care of Animals in Research and Training (ANZCCART) News 2007;20:4\u201311.","journal-title":"Australian and New Zealand Council for the Care of Animals in Research and Training (ANZCCART) News"},{"key":"BFpr2016268_CR17","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuroscience.2011.05.012","volume":"194","author":"Z Ireland","year":"2011","unstructured":"Ireland Z, Castillo-Melendez M, Dickinson H, Snow R, Walker DW. A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia. Neuroscience 2011;194:372\u20139.","journal-title":"Neuroscience"},{"key":"BFpr2016268_CR18","first-page":"393","volume":"68","author":"DJ Cannata","year":"2010","unstructured":"Cannata DJ, Ireland Z, Dickinson H, et al. Maternal creatine supplementation from mid-pregnancy protects the diaphragm of the newborn spiny mouse from intrapartum hypoxia-induced damage. Pediatr Res 2010;68:393\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2016268_CR19","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","volume":"96","author":"HJ Gundersen","year":"1988","unstructured":"Gundersen HJ, Bagger P, Bendtsen TF, et al. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988;96:857\u201381.","journal-title":"APMIS"},{"key":"BFpr2016268_CR20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0074-7696(08)62497-3","volume":"161","author":"JF Bertram","year":"1995","unstructured":"Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cytol 1995;161:111\u201372.","journal-title":"Int Rev Cytol"},{"key":"BFpr2016268_CR21","doi-asserted-by":"publisher","first-page":"F783","DOI":"10.1152\/ajprenal.00279.2012","volume":"303","author":"A Schreiber","year":"2012","unstructured":"Schreiber A, Shulhevich Y, Geraci S, et al. Transcutaneous measurement of renal function in conscious mice. Am J Physiol Renal Physiol 2012;303:F783\u20138.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFpr2016268_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/nep.12363","volume":"20","author":"SJ Ellery","year":"2015","unstructured":"Ellery SJ, Cai X, Walker DD, Dickinson H, Kett MM. Transcutaneous measurement of glomerular filtration rate in small rodents: through the skin for the win? Nephrology (Carlton) 2015;20:117\u201323.","journal-title":"Nephrology (Carlton)"},{"key":"BFpr2016268_CR23","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1523-1755.2004.00367.x","volume":"65","author":"F Chow","year":"2004","unstructured":"Chow F, Ozols E, Nikolic-Paterson DJ, Atkins RC, Tesch GH. Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int 2004;65:116\u201328.","journal-title":"Kidney Int"},{"key":"BFpr2016268_CR24","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1038\/ki.1996.265","volume":"49","author":"BM Brenner","year":"1996","unstructured":"Brenner BM, Lawler EV, Mackenzie HS. The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 1996;49:1774\u20137.","journal-title":"Kidney Int"},{"key":"BFpr2016268_CR25","first-page":"F85","volume":"241","author":"TH Hostetter","year":"1981","unstructured":"Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol 1981;241:F85\u201393.","journal-title":"Am J Physiol"},{"key":"BFpr2016268_CR26","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physrev.1979.59.1.137","volume":"59","author":"JP Hayslett","year":"1979","unstructured":"Hayslett JP. Functional adaptation to reduction in renal mass. Physiol Rev 1979;59:137\u201364.","journal-title":"Physiol Rev"},{"key":"BFpr2016268_CR27","first-page":"455","volume":"1","author":"AB Morrison","year":"1966","unstructured":"Morrison AB. Experimental chronic renal insufficiency. Methods Achiev Exp Pathol 1966;1:455\u201375.","journal-title":"Methods Achiev Exp Pathol"},{"key":"BFpr2016268_CR28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.571144","volume":"204","author":"MM McMillen","year":"1979","unstructured":"McMillen MM. Differential mortality by sex in fetal and neonatal deaths. Science 1979;204:89\u201391.","journal-title":"Science"},{"key":"BFpr2016268_CR29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1542\/peds.48.6.902","volume":"48","author":"RL Naeye","year":"1971","unstructured":"Naeye RL, Burt LS, Wright DL, Blanc WA, Tatter D. Neonatal mortality, the male disadvantage. Pediatrics 1971;48:902\u20136.","journal-title":"Pediatrics"},{"key":"BFpr2016268_CR30","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1542\/peds.2013-0339","volume":"132","author":"SL Balsara","year":"2013","unstructured":"Balsara SL, Faerber JA, Spinner NB, Feudtner C. Pediatric mortality in males versus females in the United States, 1999-2008. Pediatrics 2013;132:631\u20138.","journal-title":"Pediatrics"},{"key":"BFpr2016268_CR31","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/ajhb.20995","volume":"22","author":"JG Eriksson","year":"2010","unstructured":"Eriksson JG, Kajantie E, Osmond C, Thornburg K, Barker DJ. Boys live dangerously in the womb. Am J Hum Biol 2010;22:330\u20135.","journal-title":"Am J Hum Biol"},{"issue":"2 Pt 2","key":"BFpr2016268_CR32","first-page":"F223","volume":"254","author":"K Munger","year":"1988","unstructured":"Munger K, Baylis C. Sex differences in renal hemodynamics in rats. Am J Physiol 1988;254(2 Pt 2):F223\u201331.","journal-title":"Am J Physiol"},{"key":"BFpr2016268_CR33","doi-asserted-by":"publisher","first-page":"F1093","DOI":"10.1152\/ajpcell.00225.2007","volume":"293","author":"H Dickinson","year":"2007","unstructured":"Dickinson H, Moritz K, Wintour EM, Walker DW, Kett MM. A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL\/6 mouse: response to dietary salt load. Am Physiol Soci 2007;293:F1093\u201398.","journal-title":"Am Physiol Soci"},{"key":"BFpr2016268_CR34","doi-asserted-by":"crossref","unstructured":"Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids 2011:1\u201326.","DOI":"10.1007\/s00726-011-0877-3"},{"key":"BFpr2016268_CR35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/bj2810021","volume":"281 (Pt 1)","author":"T Wallimann","year":"1992","unstructured":"Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the \u2018phosphocreatine circuit\u2019 for cellular energy homeostasis. Biochem J 1992;281 (Pt 1):21\u201340.","journal-title":"Biochem J"},{"key":"BFpr2016268_CR36","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s00726-011-0875-5","volume":"40","author":"P Sestili","year":"2011","unstructured":"Sestili P, Martinelli C, Colombo E, et al. Creatine as an antioxidant. Amino Acids 2011;40:1385\u201396.","journal-title":"Amino Acids"},{"key":"BFpr2016268_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00726-009-0263-6","volume":"38","author":"B Gualano","year":"2010","unstructured":"Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH. Exploring the therapeutic role of creatine supplementation. Amino Acids 2010;38:31\u201344.","journal-title":"Amino Acids"},{"key":"BFpr2016268_CR38","doi-asserted-by":"publisher","first-page":"e0149840","DOI":"10.1371\/journal.pone.0149840","volume":"11","author":"DA LaRosa","year":"2016","unstructured":"LaRosa DA, Ellery SJ, Parkington HC, Snow RJ, Walker DW, Dickinson H. Maternal creatine supplementation during pregnancy prevents long-term changes in diaphragm muscle structure and function after birth asphyxia. PLoS One 2016;11:e0149840.","journal-title":"PLoS One"},{"key":"BFpr2016268_CR39","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/pr.2016.153","volume":"80","author":"DA LaRosa","year":"2016","unstructured":"LaRosa DA, Ellery SJ, Snow RJ, Walker DW, Dickinson H. Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse. Pediatr Res 2016;80:852\u201360.","journal-title":"Pediatr Res"},{"key":"BFpr2016268_CR40","doi-asserted-by":"crossref","unstructured":"Ellery SJ, LaRosa DA, Kett MM, et al. Dietary creatine supplementation during pregnancy: a study on the effects of creatine supplementation on creatine homeostasis and renal excretory function in spiny mice. Amino acids 2015:1\u201312.","DOI":"10.1007\/s00726-015-2150-7"},{"key":"BFpr2016268_CR41","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1177\/1933719113477478","volume":"20","author":"H Dickinson","year":"2013","unstructured":"Dickinson H, Ireland ZJ, Larosa DA, et al. Maternal dietary creatine supplementation does not alter the capacity for creatine synthesis in the newborn spiny mouse. Reprod Sci 2013;20:1096\u2013102.","journal-title":"Reprod Sci"},{"key":"BFpr2016268_CR42","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1053\/j.ajkd.2009.10.053","volume":"55","author":"B Gualano","year":"2010","unstructured":"Gualano B, Ferreira DC, Sapienza MT, Seguro AC, Lancha AH Jr . Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney. Am J Kidney Dis 2010;55:e7\u20139.","journal-title":"Am J Kidney Dis"},{"key":"BFpr2016268_CR43","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00421-010-1676-3","volume":"111","author":"B Gualano","year":"2011","unstructured":"Gualano B, de Salles Painelli V, Roschel H, et al. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Eur J Appl Physiol 2011;111:749\u201356.","journal-title":"Eur J Appl Physiol"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2016268.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2016268","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2016268.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:01:44Z","timestamp":1684616504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2016268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["BFpr2016268"],"URL":"https:\/\/doi.org\/10.1038\/pr.2016.268","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]},"assertion":[{"value":"22 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}