{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:48:46Z","timestamp":1774928926648,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1038\/pr.2016.42","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T17:01:56Z","timestamp":1457542916000},"page":"151-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["CpG island shore methylation of ZFPM2 is identified in tetralogy of fallot samples"],"prefix":"10.1038","volume":"80","author":[{"given":"Wei","family":"Sheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"BFpr201642_CR1","first-page":"II3","volume":"86 Suppl 2","author":"S Ho","year":"2001","unstructured":"Ho S, McCarthy KP, Josen M, Rigby ML. Anatomic-echocardiographic correlates: an introduction to normal and congenitally malformed hearts. Heart 2001;86 Suppl 2:II3\u201311.","journal-title":"Heart"},{"key":"BFpr201642_CR2","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.jacc.2009.06.040","volume":"54","author":"E B\u00e9dard","year":"2009","unstructured":"B\u00e9dard E, McCarthy KP, Dimopoulos K, Giannakoulas G, Gatzoulis MA, Ho SY. Structural abnormalities of the pulmonary trunk in tetralogy of Fallot and potential clinical implications: a morphological study. J Am Coll Cardiol 2009;54:1883\u201390.","journal-title":"J Am Coll Cardiol"},{"key":"BFpr201642_CR3","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s00268-009-0296-8","volume":"34","author":"JP Starr","year":"2010","unstructured":"Starr JP. Tetralogy of fallot: yesterday and today. World J Surg 2010;34:658\u201368.","journal-title":"World J Surg"},{"key":"BFpr201642_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.tcm.2009.07.004","volume":"19","author":"V Di Felice","year":"2009","unstructured":"Di Felice V, Zummo G. Tetralogy of fallot as a model to study cardiac progenitor cell migration and differentiation during heart development. Trends Cardiovasc Med 2009;19:130\u20135.","journal-title":"Trends Cardiovasc Med"},{"key":"BFpr201642_CR5","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/nature06801","volume":"451","author":"BG Bruneau","year":"2008","unstructured":"Bruneau BG. The developmental genetics of congenital heart disease. Nature 2008;451:943\u20138.","journal-title":"Nature"},{"key":"BFpr201642_CR6","doi-asserted-by":"publisher","first-page":"37640","DOI":"10.1074\/jbc.M401737200","volume":"279","author":"M Hirai","year":"2004","unstructured":"Hirai M, Ono K, Morimoto T, et al. FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. J Biol Chem 2004;279:37640\u201350.","journal-title":"J Biol Chem"},{"key":"BFpr201642_CR7","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0092-8674(00)80885-5","volume":"101","author":"SG Tevosian","year":"2000","unstructured":"Tevosian SG, Deconinck AE, Tanaka M, et al. FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell 2000;101:729\u201339.","journal-title":"Cell"},{"key":"BFpr201642_CR8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1399-0004.2010.01523.x","volume":"80","author":"A De Luca","year":"2011","unstructured":"De Luca A, Sarkozy A, Ferese R, et al. New mutations in ZFPM2\/FOG2 gene in tetralogy of Fallot and double outlet right ventricle. Clin Genet 2011;80:184\u201390.","journal-title":"Clin Genet"},{"key":"BFpr201642_CR9","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1399-0004.2011.01787.x","volume":"82","author":"ZP Tan","year":"2012","unstructured":"Tan ZP, Huang C, Xu ZB, Yang JF, Yang YF. Novel ZFPM2\/FOG2 variants in patients with double outlet right ventricle. Clin Genet 2012;82:466\u201371.","journal-title":"Clin Genet"},{"key":"BFpr201642_CR10","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1007\/s11033-014-3126-5","volume":"41","author":"X Huang","year":"2014","unstructured":"Huang X, Niu W, Zhang Z, et al. Identification of novel significant variants of ZFPM2\/FOG2 in non-syndromic Tetralogy of Fallot and double outlet right ventricle in a Chinese Han population. Mol Biol Rep 2014;41:2671\u20137.","journal-title":"Mol Biol Rep"},{"key":"BFpr201642_CR11","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1161\/CIRCULATIONAHA.106.183056","volume":"115","author":"ME Pierpont","year":"2007","unstructured":"Pierpont ME, Basson CT, Benson DW Jr, et al.; American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007;115:3015\u201338.","journal-title":"Circulation"},{"key":"BFpr201642_CR12","first-page":"25","volume":"10","author":"L Liu","year":"2008","unstructured":"Liu L, Li Y, Tollefsbol TO. Gene-environment interactions and epigenetic basis of human diseases. Curr Issues Mol Biol 2008;10:25\u201336.","journal-title":"Curr Issues Mol Biol"},{"key":"BFpr201642_CR13","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","volume":"74","author":"MG Goll","year":"2005","unstructured":"Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005;74:481\u2013514.","journal-title":"Annu Rev Biochem"},{"key":"BFpr201642_CR14","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1093\/nar\/gkt482","volume":"41","author":"ND Vanderkraats","year":"2013","unstructured":"Vanderkraats ND, Hiken JF, Decker KF, Edwards JR. Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes. Nucleic Acids Res 2013;41:6816\u201327.","journal-title":"Nucleic Acids Res"},{"key":"BFpr201642_CR15","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/ng.298","volume":"41","author":"RA Irizarry","year":"2009","unstructured":"Irizarry RA, Ladd-Acosta C, Wen B, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009;41:178\u201386.","journal-title":"Nat Genet"},{"key":"BFpr201642_CR16","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1038\/ng.471","volume":"41","author":"A Doi","year":"2009","unstructured":"Doi A, Park IH, Wen B, et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 2009;41:1350\u20133.","journal-title":"Nat Genet"},{"key":"BFpr201642_CR17","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1161\/CIRCGENETICS.110.958744","volume":"3","author":"A Baccarelli","year":"2010","unstructured":"Baccarelli A, Rienstra M, Benjamin EJ. Cardiovascular epigenetics: basic concepts and results from animal and human studies. Circ Cardiovasc Genet 2010;3:567\u201373.","journal-title":"Circ Cardiovasc Genet"},{"key":"BFpr201642_CR18","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/nbt.1685","volume":"28","author":"A Portela","year":"2010","unstructured":"Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010;28:1057\u201368.","journal-title":"Nat Biotechnol"},{"key":"BFpr201642_CR19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1093\/cvr\/cvr019","volume":"90","author":"K Ohtani","year":"2011","unstructured":"Ohtani K, Dimmeler S. Epigenetic regulation of cardiovascular differentiation. Cardiovasc Res 2011;90:404\u201312.","journal-title":"Cardiovasc Res"},{"key":"BFpr201642_CR20","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1755-8794-5-20","volume":"5","author":"W Sheng","year":"2012","unstructured":"Sheng W, Wang H, Ma X, et al. LINE-1 methylation status and its association with tetralogy of fallot in infants. BMC Med Genomics 2012;5:20.","journal-title":"BMC Med Genomics"},{"key":"BFpr201642_CR21","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3892\/ijmm.2013.1427","volume":"32","author":"W Sheng","year":"2013","unstructured":"Sheng W, Qian Y, Wang H, et al. Association between mRNA levels of DNMT1, DNMT3A, DNMT3B, MBD2 and LINE-1 methylation status in infants with tetralogy of Fallot. Int J Mol Med 2013;32:694\u2013702.","journal-title":"Int J Mol Med"},{"key":"BFpr201642_CR22","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1073\/pnas.0712251105","volume":"105","author":"M Ehrich","year":"2008","unstructured":"Ehrich M, Turner J, Gibbs P, et al. Cytosine methylation profiling of cancer cell lines. Proc Natl Acad Sci USA 2008;105:4844\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr201642_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1755-8794-6-46","volume":"6","author":"W Sheng","year":"2013","unstructured":"Sheng W, Qian Y, Wang H, et al. DNA methylation status of NKX2-5, GATA4 and HAND1 in patients with tetralogy of fallot. BMC Med Genomics 2013;6:46.","journal-title":"BMC Med Genomics"},{"key":"BFpr201642_CR24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/77146","volume":"25","author":"EC Svensson","year":"2000","unstructured":"Svensson EC, Huggins GS, Lin H, et al. A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet 2000;25:353\u20136.","journal-title":"Nat Genet"},{"key":"BFpr201642_CR25","doi-asserted-by":"publisher","first-page":"e6161","DOI":"10.1371\/journal.pone.0006161","volume":"4","author":"GH Kim","year":"2009","unstructured":"Kim GH, Samant SA, Earley JU, Svensson EC. Translational control of FOG-2 expression in cardiomyocytes by microRNA-130a. PLoS One 2009;4:e6161.","journal-title":"PLoS One"},{"key":"BFpr201642_CR26","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/ng1834","volume":"38","author":"DJ Weisenberger","year":"2006","unstructured":"Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006;38:787\u201393.","journal-title":"Nat Genet"},{"key":"BFpr201642_CR27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/FPC.0b013e32833eecbc","volume":"21","author":"V Yuferov","year":"2011","unstructured":"Yuferov V, Nielsen DA, Levran O, et al. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenet Genomics 2011;21:185\u201396.","journal-title":"Pharmacogenet Genomics"},{"key":"BFpr201642_CR28","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1038\/onc.2012.474","volume":"32","author":"X Rao","year":"2013","unstructured":"Rao X, Evans J, Chae H, et al. CpG island shore methylation regulates caveolin-1 expression in breast cancer. Oncogene 2013;32:4519\u201328.","journal-title":"Oncogene"},{"key":"BFpr201642_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1126\/science.1083557","volume":"300","author":"A Eden","year":"2003","unstructured":"Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003;300:455.","journal-title":"Science"},{"key":"BFpr201642_CR30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ab.2009.10.021","volume":"397","author":"K Reed","year":"2010","unstructured":"Reed K, Poulin ML, Yan L, Parissenti AM. Comparison of bisulfite sequencing PCR with pyrosequencing for measuring differences in DNA methylation. Anal Biochem 2010;397:96\u2013106.","journal-title":"Anal Biochem"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201642","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:01:57Z","timestamp":1684616517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["BFpr201642"],"URL":"https:\/\/doi.org\/10.1038\/pr.2016.42","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]},"assertion":[{"value":"5 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}