{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:29:50Z","timestamp":1787891390873,"version":"build-2784847793"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/pr.2016.9","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T17:23:16Z","timestamp":1452619396000},"page":"846-854","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Bacterial microbiome of breast milk and child saliva from low-income Mexican-American women and children"],"prefix":"10.1038","volume":"79","author":[{"given":"Veronica","family":"Dav\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Street","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asa","family":"Bradman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Eskenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"BFpr20169_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-genom-090711-163814","volume":"13","author":"EA Grice","year":"2012","unstructured":"Grice EA, Segre JA. The human microbiome: our second genome. Annu Rev Genomics Hum Genet 2012;13:151\u201370.","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"BFpr20169_CR2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nm.3145","volume":"19","author":"RA Koeth","year":"2013","unstructured":"Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of l -carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013;19:576\u201385.","journal-title":"Nat Med"},{"key":"BFpr20169_CR3","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1128\/CMR.00106-13","volume":"27","author":"LF de Sousa Moraes","year":"2014","unstructured":"de Sousa Moraes LF, Grzeskowiak LM, de Sales Teixeira TF, Gouveia Peluzio Mdo C. Intestinal microbiota and probiotics in celiac disease. Clin Microbiol Rev 2014;27:482\u20139.","journal-title":"Clin Microbiol Rev"},{"key":"BFpr20169_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/MOG.0b013e328333d751","volume":"26","author":"RE Ley","year":"2010","unstructured":"Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol 2010;26:5\u201311.","journal-title":"Curr Opin Gastroenterol"},{"key":"BFpr20169_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.phrs.2012.11.006","volume":"69","author":"WG Wade","year":"2013","unstructured":"Wade WG. The oral microbiome in health and disease. Pharmacol Res 2013;69:137\u201343.","journal-title":"Pharmacol Res"},{"key":"BFpr20169_CR6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1002\/ibd.21874","volume":"18","author":"MJ Docktor","year":"2012","unstructured":"Docktor MJ, Paster BJ, Abramowicz S, et al. Alterations in diversity of the oral microbiome in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2012;18:935\u201342.","journal-title":"Inflamm Bowel Dis"},{"key":"BFpr20169_CR7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/2049-2618-2-38","volume":"2","author":"MW Groer","year":"2014","unstructured":"Groer MW, Luciano AA, Dishaw LJ, Ashmeade TL, Miller E, Gilbert JA. Development of the preterm infant gut microbiome: a research priority. Microbiome 2014;2:38.","journal-title":"Microbiome"},{"key":"BFpr20169_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","unstructured":"Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012;486:207\u201314.","journal-title":"Nature"},{"key":"BFpr20169_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fcimb.2014.00085","volume":"4","author":"E Zaura","year":"2014","unstructured":"Zaura E, Nicu EA, Krom BP, Keijser BJ. Acquiring and maintaining a normal oral microbiome: current perspective. Front Cell Infect Microbiol 2014;4:85.","journal-title":"Front Cell Infect Microbiol"},{"key":"BFpr20169_CR10","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.1073\/pnas.1002601107","volume":"107","author":"MG Dominguez-Bello","year":"2010","unstructured":"Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010;107:11971\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr20169_CR11","doi-asserted-by":"publisher","first-page":"e23503","DOI":"10.1371\/journal.pone.0023503","volume":"6","author":"KD Cephas","year":"2011","unstructured":"Cephas KD, Kim J, Mathai RA, et al. Comparative analysis of salivary bacterial microbiome diversity in edentulous infants and their mothers or primary care givers using pyrosequencing. PLoS One 2011;6:e23503.","journal-title":"PLoS One"},{"key":"BFpr20169_CR12","first-page":"375","volume":"30","author":"JM Douglass","year":"2008","unstructured":"Douglass JM, Li Y, Tinanoff N. Association of mutans streptococci between caregivers and their children. Pediatr Dent 2008;30:375\u201387.","journal-title":"Pediatr Dent"},{"key":"BFpr20169_CR13","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1128\/JCM.00771-07","volume":"45","author":"Y Li","year":"2007","unstructured":"Li Y, Ismail AI, Ge Y, Tellez M, Sohn W. Similarity of bacterial populations in saliva from African-American mother\u2013child dyads. J Clin Microbiol 2007;45:3082\u20135.","journal-title":"J Clin Microbiol"},{"key":"BFpr20169_CR14","first-page":"291","volume":"11","author":"B Sampaio-Maia","year":"2014","unstructured":"Sampaio-Maia B, Monteiro-Silva F. Acquisition and maturation of oral microbiome throughout childhood: an update. Dent Res J (Isfahan) 2014;11:291\u2013301.","journal-title":"Dent Res J (Isfahan)"},{"key":"BFpr20169_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2012.09.001","volume":"69","author":"L Fern\u00e1ndez","year":"2013","unstructured":"Fern\u00e1ndez L, Langa S, Mart\u00edn V, et al. The human milk microbiota: origin and potential roles in health and disease. Pharmacol Res 2013;69:1\u201310.","journal-title":"Pharmacol Res"},{"key":"BFpr20169_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/MPG.0b013e31826f2bc6","volume":"56","author":"PL Holgerson","year":"2013","unstructured":"Holgerson PL, Vestman NR, Claesson R, et al. Oral microbial profile discriminates breast-fed from formula-fed infants. J Pediatr Gastroenterol Nutr 2013;56:127\u201336.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BFpr20169_CR17","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/ijo.2011.27","volume":"35","author":"TA Ajslev","year":"2011","unstructured":"Ajslev TA, Andersen CS, Gamborg M, S\u00f8rensen TI, Jess T. Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int J Obes (Lond) 2011;35:522\u20139.","journal-title":"Int J Obes (Lond)"},{"key":"BFpr20169_CR18","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/ajcn\/87.3.534","volume":"87","author":"M Kalliom\u00e4ki","year":"2008","unstructured":"Kalliom\u00e4ki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 2008;87:534\u20138.","journal-title":"Am J Clin Nutr"},{"key":"BFpr20169_CR19","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1289\/ehp.6789","volume":"112","author":"B Eskenazi","year":"2004","unstructured":"Eskenazi B, Harley K, Bradman A, et al. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect 2004;112:1116\u201324.","journal-title":"Environ Health Perspect"},{"key":"BFpr20169_CR20","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1096\/fj.12-220806","volume":"27","author":"K Aagaard","year":"2013","unstructured":"Aagaard K, Petrosino J, Keitel W, et al. The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters. FASEB J 2013;27:1012\u201322.","journal-title":"FASEB J"},{"key":"BFpr20169_CR21","doi-asserted-by":"publisher","first-page":"544","DOI":"10.3945\/ajcn.112.037382","volume":"96","author":"R Cabrera-Rubio","year":"2012","unstructured":"Cabrera-Rubio R, Collado MC, Laitinen K, Salminen S, Isolauri E, Mira A. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J Clin Nutr 2012;96:544\u201351.","journal-title":"Am J Clin Nutr"},{"key":"BFpr20169_CR22","doi-asserted-by":"publisher","first-page":"e21313","DOI":"10.1371\/journal.pone.0021313","volume":"6","author":"KM Hunt","year":"2011","unstructured":"Hunt KM, Foster JA, Forney LJ, et al. Characterization of the diversity and temporal stability of bacterial communities in human milk. PLoS One 2011;6:e21313.","journal-title":"PLoS One"},{"key":"BFpr20169_CR23","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1017\/S0007114513000597","volume":"110","author":"T Jost","year":"2013","unstructured":"Jost T, Lacroix C, Braegger C, Chassard C. Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches. Br J Nutr 2013;110:1253\u201362.","journal-title":"Br J Nutr"},{"key":"BFpr20169_CR24","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3945\/ajcn.2010.29877","volume":"92","author":"MC Collado","year":"2010","unstructured":"Collado MC, Isolauri E, Laitinen K, Salminen S. Effect of mother\u2019s weight on infant\u2019s microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy. Am J Clin Nutr 2010;92:1023\u201330.","journal-title":"Am J Clin Nutr"},{"key":"BFpr20169_CR25","doi-asserted-by":"publisher","first-page":"e113026","DOI":"10.1371\/journal.pone.0113026","volume":"9","author":"JD Galley","year":"2014","unstructured":"Galley JD, Bailey M, Kamp Dush C, Schoppe-Sullivan S, Christian LM. Maternal obesity is associated with alterations in the gut microbiome in toddlers. PLoS One 2014;9:e113026.","journal-title":"PLoS One"},{"key":"BFpr20169_CR26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1109\/18.61115","volume":"37","author":"J Lin","year":"1991","unstructured":"Lin J. Divergence measures based on the Shannon entropy. IEEE Trans Inform Theory 1991;37:145\u201351.","journal-title":"IEEE Trans Inform Theory"},{"key":"BFpr20169_CR27","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00248-012-0123-x","volume":"65","author":"Z Ling","year":"2013","unstructured":"Ling Z, Liu X, Wang Y, Li L, Xiang C. Pyrosequencing analysis of the salivary microbiota of healthy Chinese children and adults. Microb Ecol 2013;65:487\u201395.","journal-title":"Microb Ecol"},{"key":"BFpr20169_CR28","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/1471-2180-9-259","volume":"9","author":"E Zaura","year":"2009","unstructured":"Zaura E, Keijser BJ, Huse SM, Crielaard W. Defining the healthy \u201ccore microbiome\u201d of oral microbial communities. BMC Microbiol 2009;9:259.","journal-title":"BMC Microbiol"},{"key":"BFpr20169_CR29","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1017\/S0007114508111461","volume":"101","author":"K Laitinen","year":"2009","unstructured":"Laitinen K, Poussa T, Isolauri E ; Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota Group. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br J Nutr 2009;101:1679\u201387.","journal-title":"Br J Nutr"},{"key":"BFpr20169_CR30","doi-asserted-by":"publisher","first-page":"e02419","DOI":"10.1128\/mBio.02419-14","volume":"6","author":"S Dogra","year":"2015","unstructured":"Dogra S, Sakwinska O, Soh SE, et al.; GUSTO Study Group. Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. mBio 2015;6:e02419\u201314.","journal-title":"mBio"},{"key":"BFpr20169_CR31","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1038\/ismej.2012.8","volume":"6","author":"JG Caporaso","year":"2012","unstructured":"Caporaso JG, Lauber CL, Walters WA, et al. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms. ISME J 2012;6:1621\u20134.","journal-title":"ISME J"},{"key":"BFpr20169_CR32","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.1000080107","volume":"108:Suppl 1","author":"JG Caporaso","year":"2011","unstructured":"Caporaso JG, Lauber CL, Walters WA, et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci USA 2011;108:Suppl 1:4516\u201322.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr20169_CR33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010;7:335\u20136.","journal-title":"Nat Methods"},{"key":"BFpr20169_CR34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nmeth.2276","volume":"10","author":"NA Bokulich","year":"2013","unstructured":"Bokulich NA, Subramanian S, Faith JJ, et al. Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods 2013;10:57\u20139.","journal-title":"Nat Methods"},{"key":"BFpr20169_CR35","doi-asserted-by":"publisher","first-page":"e545","DOI":"10.7717\/peerj.545","volume":"2","author":"JR Rideout","year":"2014","unstructured":"Rideout JR, He Y, Navas-Molina JA, et al. Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences. PeerJ 2014;2:e545.","journal-title":"PeerJ"},{"key":"BFpr20169_CR36","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/bioinformatics\/btp636","volume":"26","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Bittinger K, Bushman FD, DeSantis TZ, Andersen GL, Knight R. PyNAST: a flexible tool for aligning sequences to a template alignment. Bioinformatics 2010;26:266\u20137.","journal-title":"Bioinformatics"},{"key":"BFpr20169_CR37","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.1128\/AEM.03006-05","volume":"72","author":"TZ DeSantis","year":"2006","unstructured":"DeSantis TZ, Hugenholtz P, Larsen N, et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol 2006;72:5069\u201372.","journal-title":"Appl Environ Microbiol"},{"key":"BFpr20169_CR38","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","volume":"26","author":"RC Edgar","year":"2010","unstructured":"Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics 2010;26:2460\u20131.","journal-title":"Bioinformatics"},{"key":"BFpr20169_CR39","doi-asserted-by":"publisher","first-page":"e1003531","DOI":"10.1371\/journal.pcbi.1003531","volume":"10","author":"PJ McMurdie","year":"2014","unstructured":"McMurdie PJ, Holmes S. Waste not, want not: why rarefying microbiome data is inadmissible. PLoS Comput Biol 2014;10:e1003531.","journal-title":"PLoS Comput Biol"},{"key":"BFpr20169_CR40","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2307\/1934352","volume":"54","author":"MO Hill","year":"1973","unstructured":"Hill MO. Diversity and evenness: a unifying notation and its consequences. Ecology 1973;54:427\u201332.","journal-title":"Ecology"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr20169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr20169","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr20169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:02:19Z","timestamp":1684616539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr20169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFpr20169"],"URL":"https:\/\/doi.org\/10.1038\/pr.2016.9","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,12]]},"assertion":[{"value":"15 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}