{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:36:48Z","timestamp":1791877008898,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1038\/pr.2016.97","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T19:04:40Z","timestamp":1460574280000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants"],"prefix":"10.1038","volume":"80","author":[{"name":"; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-5325","authenticated-orcid":false,"given":"Dale L.","family":"Phelps","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick L.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Nolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi L.","family":"Watterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goedecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Ehrenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Fennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda B.","family":"Poindexter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Cotten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Ivan D.","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger G.","family":"Faix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Zaterka-Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Bethany","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conra Backstrom","family":"Lacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar A.","family":"Carlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo J.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetha","family":"Shankaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Carlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia R.","family":"Chess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary D.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"BFpr201697_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/pr.2013.205","volume":"74","author":"H Blencowe","year":"2013","unstructured":"Blencowe H, Lawn JE, Vazquez T, Fielder A, Gilbert C. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Ped Res 2013;74:35\u201349.","journal-title":"Ped Res"},{"key":"BFpr201697_CR2","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJM199205073261901","volume":"326","author":"M Hallman","year":"1992","unstructured":"Hallman M, Bry K, Hoppu K, Lappi M, Pohjavuori M. Inositol supplementation in premature infants with respiratory distress syndrome. N Engl J Med 1992;326:1233\u20139.","journal-title":"N Engl J Med"},{"key":"BFpr201697_CR3","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1136\/adc.61.11.1076","volume":"61","author":"M Hallman","year":"1986","unstructured":"Hallman M, J\u00e4rvenp\u00e4\u00e4 AL, Pohjavuori M. Respiratory distress syndrome and inositol supplementation in preterm infants. Arch Dis Child 1986;61:1076\u201383.","journal-title":"Arch Dis Child"},{"key":"BFpr201697_CR4","doi-asserted-by":"crossref","unstructured":"Howlett A, Ohlsson A, Plakkal N. Inositol in preterm infants at risk for or having respiratory distress syndrome. Cochrane Database Syst Rev, 2015 Feb 4; 2: CD00036. DOI:10.1002\/14651858. CD000366.pub3. PMID25927089.","DOI":"10.1002\/14651858"},{"key":"BFpr201697_CR5","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/pr.2013.162","volume":"74","author":"DL Phelps","year":"2013","unstructured":"Phelps DL, Ward RM, Williams RL, et al. Pharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23-29\u2009wk. Pediatr Res 2013;74:721\u20139.","journal-title":"Pediatr Res"},{"key":"BFpr201697_CR6","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S0022-3476(87)80561-9","volume":"110","author":"M Hallman","year":"1987","unstructured":"Hallman M, Arjomaa P, Hoppu K. Inositol supplementation in respiratory distress syndrome: relationship between serum concentration, renal excretion, and lung effluent phospholipids. J Pediatr 1987;110:604\u201310.","journal-title":"J Pediatr"},{"key":"BFpr201697_CR7","first-page":"e84","volume":"16","author":"M Hallman","year":"2015","unstructured":"Hallman M. Inositol during perinatal transition. Neo Rev 2015;16:e84\u2013e93.","journal-title":"Neo Rev"},{"key":"BFpr201697_CR8","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","volume":"382","author":"A Hellstr\u00f6m","year":"2013","unstructured":"Hellstr\u00f6m A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet 2013;382:1445\u201357.","journal-title":"Lancet"},{"key":"BFpr201697_CR9","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1542\/peds.2004-1915","volume":"114","author":"WA Engle","year":"2004","unstructured":"Engle WA, Blackmon LR, et al; American Academy of Pediatrics Committee on Fetus and Newborn. Age terminology during the perinatal period. Pediatrics 2004;114:1362\u201364.","journal-title":"Pediatrics"},{"key":"BFpr201697_CR10","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.3945\/jn.109.109108","volume":"139","author":"LD Brown","year":"2009","unstructured":"Brown LD, Cheung A, Harwood JE, Battaglia FC. Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes. J Nutr 2009;139:1648\u201352.","journal-title":"J Nutr"},{"key":"BFpr201697_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2165\/00003495-198600322-00003","volume":"32 Suppl 2","author":"RS Clements Jr","year":"1986","unstructured":"Clements RS Jr . The polyol pathway. A historical review. Drugs 1986;32 Suppl 2:3\u20135.","journal-title":"Drugs"},{"key":"BFpr201697_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000243416","volume":"60","author":"K Bry","year":"1991","unstructured":"Bry K, Hallman M. Perinatal development of inositol synthesis and catabolism in rabbit kidney. Biol Neonate 1991;60:249\u201357.","journal-title":"Biol Neonate"},{"key":"BFpr201697_CR13","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1172\/JCI119006","volume":"98","author":"P Xia","year":"1996","unstructured":"Xia P, Aiello LP, Ishii H, et al. Characterization of vascular endothelial growth factor\u2019s effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 1996;98:2018\u201326.","journal-title":"J Clin Invest"},{"key":"BFpr201697_CR14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3928\/0191-3913-20000301-06","volume":"37","author":"CA Friedman","year":"2000","unstructured":"Friedman CA, McVey J, Borne MJ, et al. Relationship between serum inositol concentration and development of retinopathy of prematurity: a prospective study. J Pediatr Ophthalmol Strabismus 2000;37:79\u201386.","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"BFpr201697_CR15","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1002\/bmc.3470","volume":"29","author":"KJ Schimpf","year":"2015","unstructured":"Schimpf KJ, Meek CC, Leff RD, Phelps DL, Schmitz DJ, Cordle CT. Quantification of myo-inositol, 1,5-anhydro- D-sorbitol, and D-chiro-inositol using high-performance liquid chromatography with electrochemical detection in very small volume clinical samples. Biomed Chromatogr 2015;29:1629\u201336.","journal-title":"Biomed Chromatogr"},{"key":"BFpr201697_CR16","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1542\/peds.2005-2749","volume":"117","author":"Section on Ophthalmology American Academy of Pediatrics, American Academy of Ophthalmology, American Association of Pediatric Ophthalmology and Strabismus.","year":"2006","unstructured":"Section on Ophthalmology American Academy of Pediatrics, American Academy of Ophthalmology, American Association of Pediatric Ophthalmology and Strabismus. Screening examination of premature infants for retinopathy of prematurity. Pediatr 2006;117:572\u20136.","journal-title":"Pediatr"},{"key":"BFpr201697_CR17","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1001\/archopht.123.7.991","volume":"123","author":"International Committee for Classification of ROP.","year":"2005","unstructured":"International Committee for Classification of ROP. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthal 2005;123:991\u20139.","journal-title":"Arch Ophthal"},{"key":"BFpr201697_CR18","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","volume":"121","author":"ETROP Cooperative Group.","year":"2003","unstructured":"ETROP Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthal 2003;121:1684\u201394.","journal-title":"Arch Ophthal"},{"key":"BFpr201697_CR19","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1001\/archopht.120.11.1470","volume":"120","author":"JD Reynolds","year":"2002","unstructured":"Reynolds JD, Dobson V, Quinn GE, et al.; CRYO-ROP and LIGHT-ROP Cooperative Study Groups. Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies. Arch Ophthalmol 2002;120:1470\u20136.","journal-title":"Arch Ophthalmol"},{"key":"BFpr201697_CR20","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1167\/iovs.13-13744","volume":"55","author":"YQ Ni","year":"2014","unstructured":"Ni YQ, Huang X, Xue K, et al. Natural involution of acute retinopathy of prematurity not requiring treatment: factors associated with the time course of involution. Invest Ophthalmol Vis Sci 2014;55:3165\u201370.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFpr201697_CR21","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","volume":"126","author":"BJ Stoll","year":"2010","unstructured":"Stoll BJ, Hansen NI, Bell EF, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatr 2010;126:443\u201356.","journal-title":"Pediatr"},{"key":"BFpr201697_CR22","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jpeds.2013.04.034","volume":"163","author":"I Adams-Chapman","year":"2013","unstructured":"Adams-Chapman I, Bann CM, Das A, et al.; Eunice Kennedy Shriver National Institutes of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcome of extremely low birth weight infants with Candida infection. J Pediatr 2013;163:961\u20137.e3.","journal-title":"J Pediatr"},{"key":"BFpr201697_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2165\/00003088-199937010-00003","volume":"37","author":"H Sun","year":"1999","unstructured":"Sun H, Fadiran EO, Jones CD, et al. Population pharmacokinetics. A regulatory perspective. Clin Pharmacokinet 1999;37:41\u201358.","journal-title":"Clin Pharmacokinet"},{"key":"BFpr201697_CR24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10928-005-0034-2","volume":"32","author":"S Duffull","year":"2005","unstructured":"Duffull S, Waterhouse T, Eccleston J. Some considerations on the design of population pharmacokinetic studies. J Pharmacokinet Pharmacodyn 2005;32:441\u201357.","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"BFpr201697_CR25","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1080\/10543400802369012","volume":"18","author":"J Bertrand","year":"2008","unstructured":"Bertrand J, Comets E, Mentre F. Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters. J Biopharm Stat 2008;18:1084\u2013102.","journal-title":"J Biopharm Stat"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr201697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201697","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr201697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:02:22Z","timestamp":1684616542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr201697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,13]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["BFpr201697"],"URL":"https:\/\/doi.org\/10.1038\/pr.2016.97","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,13]]},"assertion":[{"value":"5 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}