{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:06:50Z","timestamp":1794049610393,"version":"4.8.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1038\/pr.2017.104","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T16:01:28Z","timestamp":1491580888000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cannabidiol reduces lung injury induced by hypoxic\u2013ischemic brain damage in newborn piglets"],"prefix":"10.1038","volume":"82","author":[{"given":"Luis","family":"Arruza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ruth","family":"Pazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagat","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Lafuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Alvarez-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Mart\u00ednez-Orgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"BFpr2017104_CR1","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/S0022-3476(95)70174-5","volume":"127","author":"A Mart\u00edn-Ancel","year":"1995","unstructured":"Mart\u00edn-Ancel A, Garc\u00eda-Alix A, Gay\u00e1 F, Caba\u00f1as F, Burgueros M, Quero J . Multiple organ involvement in perinatal asphyxia. J Pediatr 1995;127:786\u2013793.","journal-title":"J Pediatr"},{"key":"BFpr2017104_CR2","doi-asserted-by":"publisher","first-page":"F152","DOI":"10.1136\/adc.2002.023093","volume":"89","author":"P Shah","year":"2004","unstructured":"Shah P, Riphagen S, Beyene J, Perlman M . Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2004;89:F152\u2013F155.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr2017104_CR3","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/0002-9378(88)90567-4","volume":"159","author":"AD Bocking","year":"1988","unstructured":"Bocking AD, Gagnon R, White SE, Homan J, Milne KM, Richardson BS . Circulatory responses to prolonged hypoxemia in fetal sheep. Am J Obstet Gynecol 1988;159:1418\u201324.","journal-title":"Am J Obstet Gynecol"},{"key":"BFpr2017104_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/pr.2015.87","volume":"79","author":"L Arruza","year":"2015","unstructured":"Arruza L, Pazos MR, Mohammed N et al, Hypoxic-ischemic brain damage induces distant inflammatory lung injury in newborn piglets. Pediatr Res 2015;79:401\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2017104_CR5","doi-asserted-by":"publisher","first-page":"8268","DOI":"10.1073\/pnas.95.14.8268","volume":"95","author":"AJ Hampson","year":"1998","unstructured":"Hampson AJ, Grimaldi M, Axelrod J, Wink D . Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 1998;95:8268\u201373.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr2017104_CR6","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1002\/cbdv.200790147","volume":"4","author":"R Mechoulam","year":"2007","unstructured":"Mechoulam R, Peters M, Murillo-Rodriguez E, Hanus LO . Cannabidiol\u2014recent advances. Chem Biodivers 2007;4:1678\u201392.","journal-title":"Chem Biodivers"},{"key":"BFpr2017104_CR7","unstructured":"Pertwee R. The pharmacology and therapeutic potential of cannabidiol. In: Di Marzo V, ed. Cannabinoids. New York: Kluwer Academic\/Plenum Publishers, 2004:32\u201383."},{"key":"BFpr2017104_CR8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.nbd.2009.10.023","volume":"37","author":"A Castillo","year":"2010","unstructured":"Castillo A, Tol\u00f3n MR, Fern\u00e1ndez-Ruiz J, Romero J, Martinez-Orgado J . The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis 2010;37:434\u2013440.","journal-title":"Neurobiol Dis"},{"key":"BFpr2017104_CR9","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1203\/PDR.0b013e318186e5dd","volume":"64","author":"FJ Alvarez","year":"2008","unstructured":"Alvarez FJ, Lafuente H, Rey-Santano MC et al, Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Pediatr Res 2008;64:653\u20138.","journal-title":"Pediatr Res"},{"key":"BFpr2017104_CR10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1203\/PDR.0b013e3182276b11","volume":"70","author":"H Lafuente","year":"2011","unstructured":"Lafuente H, Alvarez FJ, Pazos MR et al, Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs. Pediatr Res 2011;70:272\u20137.","journal-title":"Pediatr Res"},{"key":"BFpr2017104_CR11","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.neuropharm.2012.05.034","volume":"63","author":"MR Pazos","year":"2012","unstructured":"Pazos MR, Cinquina V, G\u00f3mez A et al, Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology 2012;63:776\u201383.","journal-title":"Neuropharmacology"},{"key":"BFpr2017104_CR12","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.neuropharm.2013.03.027","volume":"71","author":"MR Pazos","year":"2013","unstructured":"Pazos MR, Mohammed N, Lafuente H et al, Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors. Neuropharmacology 2013;71:282\u201391.","journal-title":"Neuropharmacology"},{"key":"BFpr2017104_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3389\/fnins.2016.00323","volume":"10","author":"H Lafuente","year":"2016","unstructured":"Lafuente H, Pazos MR, Alvarez A et al, Effects of cannabidiol and hypothermia on short-term brain damage in new-born piglets after acute hypoxia-ischemia. Front Neurosci 2016;10:323.","journal-title":"Front Neurosci"},{"key":"BFpr2017104_CR14","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s11064-005-6978-1","volume":"30","author":"EB Russo","year":"2005","unstructured":"Russo EB, Burnett A, Hall B, Parker KK . Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 2005;30:1037\u201343.","journal-title":"Neurochem Res"},{"key":"BFpr2017104_CR15","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1161\/01.STR.0000163083.59201.34","volume":"36","author":"K Mishima","year":"2005","unstructured":"Mishima K, Hayakawa K, Abe K et al, Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 2005;36:1071\u20131076.","journal-title":"Stroke"},{"key":"BFpr2017104_CR16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ejphar.2011.12.043","volume":"678","author":"A Ribeiro","year":"2012","unstructured":"Ribeiro A, Ferraz-de-Paula V, Pinheiro ML et al, Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor. Eur J Pharmacol 2012;678:78\u201385.","journal-title":"Eur J Pharmacol"},{"key":"BFpr2017104_CR17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/08923973.2014.976794","volume":"37","author":"A Ribeiro","year":"2015","unstructured":"Ribeiro A, Almeida VI, Costola-de-Souza C et al, Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Immunopharmacol Immunotoxicol 2015;37:35\u201341.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"BFpr2017104_CR18","doi-asserted-by":"publisher","first-page":"12023","DOI":"10.1523\/JNEUROSCI.2435-08.2008","volume":"28","author":"S Muhammad","year":"2008","unstructured":"Muhammad S, Barakat W, Stoyanov S et al, The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci 2008;28:12023\u201331.","journal-title":"J Neurosci"},{"key":"BFpr2017104_CR19","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1523\/JNEUROSCI.2439-14.2015","volume":"35","author":"A Liesz","year":"2015","unstructured":"Liesz A, Dalpke A, Mracsko E et al, DAMP signaling is a key pathway inducing immune modulation after brain injury. J Neurosci 2015;35:583\u201398.","journal-title":"J Neurosci"},{"key":"BFpr2017104_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5492\/wjccm.v5.i1.65","volume":"5","author":"A Koutsoukou","year":"2016","unstructured":"Koutsoukou A, Katsiari M, Orfanos SE et al, Respiratory mechanics in brain injury: a review. World J Crit Care Med 2016;5:65.","journal-title":"World J Crit Care Med"},{"key":"BFpr2017104_CR21","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1248\/bpb.32.1538","volume":"32","author":"K Hayakawa","year":"2009","unstructured":"Hayakawa K, Irie K, Sano K et al, Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol Pharm Bull 2009;32:1538\u201344.","journal-title":"Biol Pharm Bull"},{"key":"BFpr2017104_CR22","doi-asserted-by":"publisher","first-page":"538670","DOI":"10.1155\/2015\/538670","volume":"2015","author":"F Vuolo","year":"2015","unstructured":"Vuolo F, Petronilho F, Sonai B et al, Evaluation of serum cytokines levels and the role of cannabidiol treatment in animal model of asthma. Mediators Inflamm 2015;2015:538670.","journal-title":"Mediators Inflamm"},{"key":"BFpr2017104_CR23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/pr.2016.88","volume":"80","author":"YE Kim","year":"2016","unstructured":"Kim YE, Park WS, Sung DK et al, Intratracheal transplantation of mesenchymal stem cells simultaneously attenuates both lung and brain injuries in hyperoxic newborn rats. Pediatr Res 2016;80:415\u201324.","journal-title":"Pediatr Res"},{"key":"BFpr2017104_CR24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jtcvs.2014.09.021","volume":"149","author":"EJ Seeley","year":"2015","unstructured":"Seeley EJ . A dry lung is a happy lung: More supporting evidence. J Thorac Cardiovasc Surg 2015;149:321\u20132.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BFpr2017104_CR25","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S1474-4422(11)70016-3","volume":"10","author":"MV Johnston","year":"2011","unstructured":"Johnston MV, Fatemi A, Wilson MA, Northington F . Treatment advances in neonatal neuroprotection and neurointensive care. Lancet Neurol 2011;10:372\u201382.","journal-title":"Lancet Neurol"},{"key":"BFpr2017104_CR26","first-page":"S1","volume":"20","author":"MJ Gdovin","year":"2010","unstructured":"Gdovin MJ, Zamora DA, Ravindran CRM, Leiter JC . Serotonergic modulation of respiratory rhythmogenesis and central chemoreception. Ethn Dis 2010;20:S1\u201339-44.","journal-title":"Ethn Dis"},{"key":"BFpr2017104_CR27","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1152\/japplphysiol.00939.2012","volume":"113","author":"KT Barrett","year":"2012","unstructured":"Barrett KT, Kinney HC, Li A, Daubenspeck JA, Leiter JC, Nattie EE . Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development. J Appl Physiol 2012;113:1585\u201393.","journal-title":"J Appl Physiol"},{"key":"BFpr2017104_CR28","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/sj.bjp.0704941","volume":"137","author":"MR Skinner","year":"2002","unstructured":"Skinner MR, Ramage AG, Jordan D . Modulation of reflexly evoked vagal bradycardias by central 5-HT1A receptors in anaesthetized rabbits. Br J Pharmacol 2002;137:861\u201373.","journal-title":"Br J Pharmacol"},{"key":"BFpr2017104_CR29","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.tips.2008.06.009","volume":"29","author":"AG Ramage","year":"2008","unstructured":"Ramage AG, Villal\u00f3n CM . 5-Hydroxytryptamine and cardiovascular regulation. Trends Pharmacol Sci 2008;29:472\u201381.","journal-title":"Trends Pharmacol Sci"},{"key":"BFpr2017104_CR30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.pupt.2013.02.002","volume":"26","author":"A Dud\u00e1\u0161ov\u00e1","year":"2013","unstructured":"Dud\u00e1\u0161ov\u00e1 A, Keir SD, Parsons ME, Molleman A, Page CP . The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig. Pulm Pharmacol Ther 2013;26:373\u20139.","journal-title":"Pulm Pharmacol Ther"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2017104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017104","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2017.104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:02:26Z","timestamp":1684616546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2017104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["BFpr2017104"],"URL":"https:\/\/doi.org\/10.1038\/pr.2017.104","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]},"assertion":[{"value":"2 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Jose Martinez-Orgado has a Research Agreement with GW Research (Cambridge, UK). The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}