{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:52:03Z","timestamp":1791615123544,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1038\/pr.2017.139","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T16:00:45Z","timestamp":1497283245000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Physical exercise intervention at school improved hepcidin, inflammation, and iron metabolism in overweight and obese children and adolescents"],"prefix":"10.1038","volume":"82","author":[{"given":"Susana","family":"Coimbra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Catarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"In\u00eas Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Filipa Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Bronze-da-Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edsio","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Aires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Seabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Ferreira Mansilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"R\u00eago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Belo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"BFpr2017139_CR1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1017\/S1368980008002401","volume":"12","author":"E McLean","year":"2009","unstructured":"McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B . Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993-2005. Public Health Nutr 2009;12:444\u201354.","journal-title":"Public Health Nutr"},{"key":"BFpr2017139_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1542\/peds.114.1.104","volume":"114","author":"KG Nead","year":"2004","unstructured":"Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M . Overweight children and adolescents: a risk group for iron deficiency. Pediatrics 2004;114:104\u20138.","journal-title":"Pediatrics"},{"key":"BFpr2017139_CR3","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1038\/sj.ijo.0803625","volume":"31","author":"LB Yanoff","year":"2007","unstructured":"Yanoff LB, Menzie CM, Denkinger B et al. Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes 2007;31:1412\u20139.","journal-title":"Int J Obes"},{"key":"BFpr2017139_CR4","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1038\/oby.2006.198","volume":"14","author":"A Lecube","year":"2006","unstructured":"Lecube A, Carrera A, Losada E, Hernandez C, Simo R, Mesa J . Iron deficiency in obese postmenopausal women. Obesity 2006;14:1724\u201330.","journal-title":"Obesity"},{"key":"BFpr2017139_CR5","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1038\/ijo.2008.43","volume":"32","author":"MB Zimmermann","year":"2008","unstructured":"Zimmermann MB, Zeder C, Muthayya S et al. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes 2008;32:1098\u2013104.","journal-title":"Int J Obes"},{"key":"BFpr2017139_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/sj.ijo.0802224","volume":"27","author":"O Pinhas-Hamiel","year":"2003","unstructured":"Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M . Greater prevalence of iron deficiency in overweight and obese children and adolescents. Int J Obes Relat Metab Disord 2003;27:416\u20138.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFpr2017139_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jada.2008.10.044","volume":"109","author":"LM Tussing-Humphreys","year":"2009","unstructured":"Tussing-Humphreys LM, Liang H, Nemeth E, Freels S, Braunschweig CA . Excess adiposity, inflammation, and iron-deficiency in female adolescents. J Am Diet Assoc 2009;109:297\u2013302.","journal-title":"J Am Diet Assoc"},{"key":"BFpr2017139_CR8","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1038\/oby.2009.319","volume":"18","author":"LM Tussing-Humphreys","year":"2010","unstructured":"Tussing-Humphreys LM, Nemeth E, Fantuzzi G et al. Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity 2010;18:1449\u201356.","journal-title":"Obesity"},{"key":"BFpr2017139_CR9","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1038\/oby.2008.353","volume":"16","author":"KJ Ausk","year":"2008","unstructured":"Ausk KJ, Ioannou GN . Is obesity associated with anemia of chronic disease? A population-based study. Obesity 2008;16:2356\u201361.","journal-title":"Obesity"},{"key":"BFpr2017139_CR10","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/obr.12057","volume":"14","author":"S Coimbra","year":"2013","unstructured":"Coimbra S, Catarino C, Santos-Silva A . The role of adipocytes in the modulation of iron metabolism in obesity. Obes Rev 2013;14:771\u20139.","journal-title":"Obes Rev"},{"key":"BFpr2017139_CR11","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s11695-007-9276-y","volume":"18","author":"R Anty","year":"2008","unstructured":"Anty R, Dahman M, Iannelli A et al. Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation. Obes Surg 2008;18:709\u201314.","journal-title":"Obes Surg"},{"key":"BFpr2017139_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3748\/wjg.15.538","volume":"15","author":"A Piperno","year":"2009","unstructured":"Piperno A, Mariani R, Trombini P, Girelli D . Hepcidin modulation in human diseases: from research to clinic. World J Gastroenterol 2009;15:538\u201351.","journal-title":"World J Gastroenterol"},{"key":"BFpr2017139_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1080\/13813450701318583","volume":"113","author":"AM Koorts","year":"2007","unstructured":"Koorts AM, Viljoen M . Ferritin and ferritin isoforms I: structure-function relationships, synthesis, degradation and secretion. Arch Physiol Biochem 2007;113:30\u201354.","journal-title":"Arch Physiol Biochem"},{"key":"BFpr2017139_CR14","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1182\/blood-2006-06-027631","volume":"108","author":"DM Wrighting","year":"2006","unstructured":"Wrighting DM, Andrews NC . Interleukin-6 induces hepcidin expression through STAT3. Blood 2006;108:3204\u201309.","journal-title":"Blood"},{"key":"BFpr2017139_CR15","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1182\/blood-2006-07-033969","volume":"109","author":"MV Verga Falzacappa","year":"2007","unstructured":"Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU . STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007;109:353\u20138.","journal-title":"Blood"},{"key":"BFpr2017139_CR16","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1172\/JCI200420945","volume":"113","author":"E Nemeth","year":"2004","unstructured":"Nemeth E, Rivera S, Gabayan V et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271\u20136.","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"BFpr2017139_CR17","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.2215\/CJN.01490506","volume":"1","author":"JB Wish","year":"2006","unstructured":"Wish JB . Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol 2006;1 (Suppl 1): S4\u2013S8.","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFpr2017139_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/ijo.2012.145","volume":"37","author":"J Baumgartner","year":"2013","unstructured":"Baumgartner J, Smuts CM, Aeberli I, Malan L, Tjalsma H, Zimmermann MB . Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention. Int J Obes) 2013;37:24\u201330.","journal-title":"Int J Obes)"},{"key":"BFpr2017139_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/pr.2014.73","volume":"76","author":"H Nascimento","year":"2014","unstructured":"Nascimento H, Costa E, Rocha S et al. Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program. Pediatr Res 2014;76:159\u2013165.","journal-title":"Pediatr Res"},{"key":"BFpr2017139_CR20","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1038\/ijo.2010.204","volume":"34","author":"A Amato","year":"2010","unstructured":"Amato A, Santoro N, Calabro P et al. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int J Obes 2010;34:1772\u20134.","journal-title":"Int J Obes"},{"issue":"795-800","key":"BFpr2017139_CR21","first-page":"e2","volume":"164","author":"L Gong","year":"2014","unstructured":"Gong L, Yuan F, Teng J et al. Weight loss, inflammatory markers, and improvements of iron status in overweight and obese children. J Pediatr 2014;164 (795-800): e2.","journal-title":"J Pediatr"},{"key":"BFpr2017139_CR22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1123\/pes.2015-0261","volume":"28","author":"H Nascimento","year":"2016","unstructured":"Nascimento H, Alves AI, Medeiros AF et al. Impact of a school-based intervention protocol - ACORDA Project - on adipokines in an overweight and obese pediatric population. Pediatr Exerc Sci 2016;28:407\u201316.","journal-title":"Pediatr Exerc Sci"},{"key":"BFpr2017139_CR23","doi-asserted-by":"publisher","first-page":"660","DOI":"10.2471\/BLT.07.043497","volume":"85","author":"M de Onis","year":"2007","unstructured":"de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J . Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007;85:660\u20137.","journal-title":"Bull World Health Organ"},{"key":"BFpr2017139_CR24","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0300-595X(86)80005-6","volume":"15","author":"JM Tanner","year":"1986","unstructured":"Tanner JM . Normal growth and techniques of growth assessment. Clin Endocrinol Metab 1986;15:411\u2013451.","journal-title":"Clin Endocrinol Metab"},{"key":"BFpr2017139_CR25","unstructured":"WHO. Global Recommendations on Physical Activity for Health. World Health Organization: Geneva, Switzerland, 2010."},{"issue":"Suppl 2F","key":"BFpr2017139_CR26","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.1139\/H07-163","volume":"32","author":"I Janssen","year":"2007","unstructured":"Janssen I . Guidelines for physical activity in children and young people. Appl Physiol Nutr Metab 2007;32 (Suppl 2F): S122\u201335.","journal-title":"Appl Physiol Nutr Metab"},{"key":"BFpr2017139_CR27","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.jpeds.2005.01.055","volume":"146","author":"WB Strong","year":"2005","unstructured":"Strong WB, Malina RM, Blimkie CJ et al. Evidence based physical activity for school-age youth. J Pediatr 2005;146:732\u20137.","journal-title":"J Pediatr"},{"key":"BFpr2017139_CR28","doi-asserted-by":"publisher","first-page":"9163","DOI":"10.3390\/nu7115458","volume":"7","author":"A Grandone","year":"2015","unstructured":"Grandone A, Marzuillo P, Perrone L, Del Giudice EM . Iron metabolism dysregulation and cognitive dysfunction in pediatric obesity: is there a connection? Nutrients 2015;7:9163\u201370.","journal-title":"Nutrients"},{"key":"BFpr2017139_CR29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000351941","volume":"80","author":"RT Hamza","year":"2013","unstructured":"Hamza RT, Hamed AI, Kharshoum RR . Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: relation to body mass index. Horm Res Paediatr 2013;80:11\u20137.","journal-title":"Horm Res Paediatr"},{"key":"BFpr2017139_CR30","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/ijo.2009.146","volume":"33","author":"I Aeberli","year":"2009","unstructured":"Aeberli I, Hurrell RF, Zimmermann MB . Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes 2009;33:1111\u20137.","journal-title":"Int J Obes"},{"key":"BFpr2017139_CR31","doi-asserted-by":"publisher","first-page":"5102","DOI":"10.1210\/jc.2009-1361","volume":"94","author":"EM del Giudice","year":"2009","unstructured":"del Giudice EM, Santoro N, Amato A et al. Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency. J Clin Endocrinol Metab 2009;94:5102\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFpr2017139_CR32","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1172\/JCI0215686","volume":"110","author":"G Nicolas","year":"2002","unstructured":"Nicolas G, Chauvet C, Viatte L et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037\u201344.","journal-title":"J Clin Invest"},{"key":"BFpr2017139_CR33","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jada.2011.08.038","volume":"112","author":"L Tussing-Humphreys","year":"2012","unstructured":"Tussing-Humphreys L, Pusatcioglu C, Nemeth E, Braunschweig C . Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin. J Acad Nutr Diet 2012;112:391\u2013400.","journal-title":"J Acad Nutr Diet"},{"key":"BFpr2017139_CR34","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1053\/j.gastro.2006.07.007","volume":"131","author":"S Bekri","year":"2006","unstructured":"Bekri S, Gual P, Anty R et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006;131:788\u201396.","journal-title":"Gastroenterology"},{"key":"BFpr2017139_CR35","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3945\/ajcn.115.115592","volume":"104","author":"AC Cepeda-Lopez","year":"2016","unstructured":"Cepeda-Lopez AC, Allende-Labastida J, Melse-Boonstra A et al. The effects of fat loss after bariatric surgery on inflammation, serum hepcidin, and iron absorption: a prospective 6-mo iron stable isotope study. Am J Clin Nutr 2016;104:1030\u20138.","journal-title":"Am J Clin Nutr"},{"key":"BFpr2017139_CR36","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1038\/oby.2009.490","volume":"18","author":"LM Tussing-Humphreys","year":"2010","unstructured":"Tussing-Humphreys LM, Nemeth E, Fantuzzi G et al. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. Obesity 2010;18:2010\u20136.","journal-title":"Obesity"},{"key":"BFpr2017139_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/1874091X01206010043","volume":"6","author":"H Nascimento","year":"2012","unstructured":"Nascimento H, Costa E, Rocha-Pereira P et al. Cardiovascular risk factors in portuguese obese children and adolescents: impact of small reductions in body mass index imposed by lifestyle modifications. Open Biochem J 2012;6:43\u201350.","journal-title":"Open Biochem J"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2017139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017139","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2017.139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:02:43Z","timestamp":1684616563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2017139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,19]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["BFpr2017139"],"URL":"https:\/\/doi.org\/10.1038\/pr.2017.139","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,19]]},"assertion":[{"value":"24 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}