{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:43:44Z","timestamp":1789177424078,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1038\/pr.2017.277","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T16:01:29Z","timestamp":1508860889000},"page":"491-497","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice"],"prefix":"10.1038","volume":"83","author":[{"given":"Prateek V","family":"Sahni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Sosunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Galkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoya","family":"Niatsetskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly","family":"Starkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim S","family":"Ten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"BFpr2017277_CR1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.clp.2016.04.011","volume":"43","author":"HC Glass","year":"2016","unstructured":"Glass HC, Rowitch DH . The role of the neurointensive care nursery for neonatal encephalopathy. Clin Perinatol 2016;43:547\u2013557.","journal-title":"Clin Perinatol"},{"key":"BFpr2017277_CR2","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1042\/BST20160108","volume":"44","author":"MP Murphy","year":"2016","unstructured":"Murphy MP . Understanding and preventing mitochondrial oxidative damage. Biochem Soc Trans 2016;44:1219\u20131226.","journal-title":"Biochem Soc Trans"},{"key":"BFpr2017277_CR3","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/185666a0","volume":"185","author":"B Chance","year":"1960","unstructured":"Chance B, Hollunger G . Energy-linked reduction of mitochondrial pyridine nucleotide. Nature 1960;185:666\u2013672.","journal-title":"Nature"},{"key":"BFpr2017277_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0005-2728(90)90137-S","volume":"1019","author":"AB Kotlyar","year":"1990","unstructured":"Kotlyar AB, Vinogradov AD . Slow active\/inactive transition of the mitochondrial NADH- ubiquinone reductase. Biochim Biophys Acta 1990;1019:151\u2013158.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2017277_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1196\/annals.1427.015","volume":"1147","author":"AA Starkov","year":"2008","unstructured":"Starkov AA . The role of mitochondria in reactive oxygen species metabolism and signaling. Ann N Y Acad Sci 2008;1147:37\u201352.","journal-title":"Ann N Y Acad Sci"},{"key":"BFpr2017277_CR6","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1523\/JNEUROSCI.6303-11.2012","volume":"32","author":"ZV Niatsetskaya","year":"2012","unstructured":"Niatsetskaya ZV, Sosunov SA, Matsiukevich D et al. The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. J Neurosci 2012;32:3235\u20133244.","journal-title":"J Neurosci"},{"key":"BFpr2017277_CR7","doi-asserted-by":"publisher","first-page":"e0120456","DOI":"10.1371\/journal.pone.0120456","volume":"10","author":"SA Sosunov","year":"2015","unstructured":"Sosunov SA, Ameer X, Niatsetskaya ZV et al. Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury. PLoS ONE 2015;10:e0120456.","journal-title":"PLoS ONE"},{"key":"BFpr2017277_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/01.STR.27.2.327","volume":"27","author":"CA Piantadosi","year":"1996","unstructured":"Piantadosi CA, Zhang J . Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 1996;27:327\u2013331.","journal-title":"Stroke"},{"key":"BFpr2017277_CR9","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 2014;515:431\u2013435.","journal-title":"Nature"},{"key":"BFpr2017277_CR10","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1161\/01.STR.0000137768.25203.df","volume":"35","author":"VS Ten","year":"2004","unstructured":"Ten VS, Wu EX, Tang H et al. Late measures of brain injury after neonatal hypoxia-ischemia in mice. Stroke 2004;35:2183\u20132188.","journal-title":"Stroke"},{"key":"BFpr2017277_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice 3rd","year":"1981","unstructured":"Rice JE 3rd, Vannucci RC, Brierley JB . The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131\u2013134.","journal-title":"Ann Neurol"},{"key":"BFpr2017277_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.resuscitation.2009.11.024","volume":"81","author":"D Matsiukevich","year":"2010","unstructured":"Matsiukevich D, Randis TM, Utkina-Sosunova I, Polin RA, Ten VS . The state of systemic circulation, collapsed or preserved defines the need for hyperoxic or normoxic resuscitation in neonatal mice with hypoxia-ischemia. Resuscitation 2010;81:224\u2013229.","journal-title":"Resuscitation"},{"key":"BFpr2017277_CR13","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.bbabio.2008.03.025","volume":"1777","author":"AP Wojtovich","year":"2008","unstructured":"Wojtovich AP, Brookes PS . The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning. Biochim Biophys Acta 2008;1777:882\u2013889.","journal-title":"Biochim Biophys Acta"},{"key":"BFpr2017277_CR14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0006-8993(74)90690-8","volume":"80","author":"J Folbergrova","year":"1974","unstructured":"Folbergrova J, Ljunggren B, Norberg K et al. Influence of complete ischemia on glycolytic metabolites, citric acid cycle intermediates, and associated amino acids in the rat cerebral cortex. Brain Res 1974;80:265\u2013279.","journal-title":"Brain Res"},{"key":"BFpr2017277_CR15","doi-asserted-by":"publisher","first-page":"e9606","DOI":"10.1371\/journal.pone.0009606","volume":"5","author":"R Solberg","year":"2010","unstructured":"Solberg R, Enot D, Deigner HP et al. Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. PLoS ONE 2010;5:e9606.","journal-title":"PLoS ONE"},{"key":"BFpr2017277_CR16","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000370147","volume":"37","author":"PT Chun","year":"2015","unstructured":"Chun PT, McPherson RJ, Marney LC et al. Serial plasma metabolites following hypoxic-ischemic encephalopathy in a nonhuman primate model. Dev Neurosci 2015;37:161\u2013171.","journal-title":"Dev Neurosci"},{"key":"BFpr2017277_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1161\/ATVBAHA.113.302131","volume":"34","author":"D Hamel","year":"2014","unstructured":"Hamel D, Sanchez M, Duhamel F et al. G-protein-coupled receptor 91 and succinate are key contributors in neonatal postcerebral hypoxia-ischemia recovery. Arterioscler Thromb Vasc Biol 2014;34:285\u2013293.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFpr2017277_CR18","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1111\/j.1471-4159.1991.tb03438.x","volume":"56","author":"NR Sims","year":"1991","unstructured":"Sims NR . Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat. J Neurochem 1991;56:1836\u20131844.","journal-title":"J Neurochem"},{"key":"BFpr2017277_CR19","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1046\/j.1471-4159.1995.65041698.x","volume":"65","author":"A Almeida","year":"1995","unstructured":"Almeida A, Allen KL, Bates TE et al. Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 1995;65:698\u2013703.","journal-title":"J Neurochem"},{"key":"BFpr2017277_CR20","doi-asserted-by":"publisher","first-page":"542976","DOI":"10.1155\/2012\/542976","volume":"2012","author":"VS Ten","year":"2012","unstructured":"Ten VS, Starkov A . Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria. Neurol Res Int 2012;2012:542976.","journal-title":"Neurol Res Int"},{"key":"BFpr2017277_CR21","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1124\/jpet.106.110262","volume":"319","author":"Q Chen","year":"2006","unstructured":"Chen Q, Moghaddas S, Hoppel CL et al. Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion. J Pharmacol Exp Ther 2006;319:1405\u20131412.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFpr2017277_CR22","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s005950050177","volume":"28","author":"M Sakamoto","year":"1998","unstructured":"Sakamoto M, Takeshige K, Yasui H et al. Cardio protective effect of succinate against ischemia\/reperfusion injury. Surg Today 1998;28:522\u2013528.","journal-title":"Surg Today"},{"key":"BFpr2017277_CR23","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1038\/jcbfm.2008.79","volume":"28","author":"MA Puchowicz","year":"2008","unstructured":"Puchowicz MA, Zechel JL, Valerio J et al. Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab 2008;28:1907\u20131916.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFpr2017277_CR24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1093\/cvr\/cvw100","volume":"111","author":"VR Pell","year":"2016","unstructured":"Pell VR, Chouchani ET, Frezza C et al. Succinate metabolism: a new therapeutic target for myocardial reperfusion injury. Cardiovasc Res 2016;111:134\u2013141.","journal-title":"Cardiovasc Res"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2017277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017277","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2017.277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:21:40Z","timestamp":1719534100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2017277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["BFpr2017277"],"URL":"https:\/\/doi.org\/10.1038\/pr.2017.277","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,6]]},"assertion":[{"value":"19 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}