{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:21:41Z","timestamp":1774084901611,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/pr.2017.309","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T17:01:20Z","timestamp":1513357280000},"page":"606-614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NF\u03baB signaling"],"prefix":"10.1038","volume":"83","author":[{"given":"Kohei","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"P\u00e9rez-Losada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E","family":"Hoptay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M","family":"Mansbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Teach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro A","family":"Piedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Carlos A","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Freishtat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"BFpr2017309_CR1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1542\/peds.2012-3877","volume":"132","author":"K Hasegawa","year":"2013","unstructured":"Hasegawa K, Tsugawa Y, Brown DF, Mansbach JM, Camargo CA Jr . Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics 2013;132:28\u201336.","journal-title":"Pediatrics"},{"key":"BFpr2017309_CR2","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1586\/14787210.2014.906901","volume":"12","author":"K Hasegawa","year":"2014","unstructured":"Hasegawa K, Mansbach JM, Camargo CA Jr . Infectious pathogens and bronchiolitis outcomes. Expert Rev Anti Infect Ther 2014;12:817\u2013828.","journal-title":"Expert Rev Anti Infect Ther"},{"key":"BFpr2017309_CR3","doi-asserted-by":"publisher","first-page":"e1001549","DOI":"10.1371\/journal.pmed.1001549","volume":"10","author":"A Mejias","year":"2013","unstructured":"Mejias A, Dimo B, Suarez NM et al. Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med 2013;10:e1001549.","journal-title":"PLoS Med"},{"key":"BFpr2017309_CR4","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1080\/17476348.2016.1190647","volume":"10","author":"K Hasegawa","year":"2016","unstructured":"Hasegawa K, Dumas O, Hartert TV, Camargo CA Jr . Advancing our understanding of infant bronchiolitis through phenotyping and endotyping: clinical and molecular approaches. Exp Rev Respir Med 2016;10:891\u2013899.","journal-title":"Exp Rev Respir Med"},{"key":"BFpr2017309_CR5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/imr.12058","volume":"253","author":"PS Foster","year":"2013","unstructured":"Foster PS, Plank M, Collison A et al. The emerging role of microRNAs in regulating immune and inflammatory responses in the lung. Immunol Rev 2013;253:198\u2013215.","journal-title":"Immunol Rev"},{"key":"BFpr2017309_CR6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","volume":"19","author":"RC Friedman","year":"2009","unstructured":"Friedman RC, Farh KK, Burge CB, Bartel DP . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009;19:92\u2013105.","journal-title":"Genome Res"},{"key":"BFpr2017309_CR7","doi-asserted-by":"publisher","first-page":"e0162244","DOI":"10.1371\/journal.pone.0162244","volume":"11","author":"MJ Gutierrez","year":"2016","unstructured":"Gutierrez MJ, Gomez JL, Perez GF et al. Airway secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. PLoS One 2016;11:e0162244.","journal-title":"PLoS One"},{"key":"BFpr2017309_CR8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jaci.2012.11.041","volume":"131","author":"R Ilarraza","year":"2013","unstructured":"Ilarraza R, Wu Y, Skappak CD, Ajamian F, Proud D, Adamko DJ . Rhinovirus has the unique ability to directly activate human T cells in vitro. J Allergy Clin Immunol 2013;131:395\u2013404.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR9","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.jaci.2013.05.028","volume":"132","author":"A Papi","year":"2013","unstructured":"Papi A, Contoli M, Adcock IM et al. Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor kappaB and c-Jun N-terminal kinase activation. J Allergy Clin Immunol 2013;132:1075\u201385 e6.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR10","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/emmm.201201650","volume":"4","author":"NW Bartlett","year":"2012","unstructured":"Bartlett NW, Slater L, Glanville N et al. Defining critical roles for NF-kappaB p65 and type I interferon in innate immunity to rhinovirus. EMBO Mol Med 2012;4:1244\u20131260.","journal-title":"EMBO Mol Med"},{"key":"BFpr2017309_CR11","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1183\/09031936.00026910","volume":"36","author":"CA Hewson","year":"2010","unstructured":"Hewson CA, Haas JJ, Bartlett NW et al. Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways. Eur Respir J 2010;36:1425\u20131435.","journal-title":"Eur Respir J"},{"key":"BFpr2017309_CR12","doi-asserted-by":"publisher","first-page":"4924","DOI":"10.4049\/jimmunol.1401362","volume":"194","author":"J Girkin","year":"2015","unstructured":"Girkin J, Hatchwell L, Foster P et al. CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection. J Immunol 2015;194:4924\u20134930.","journal-title":"J Immunol"},{"key":"BFpr2017309_CR13","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1183\/13993003.00152-2016","volume":"48","author":"K Hasegawa","year":"2016","unstructured":"Hasegawa K, Mansbach JM, Ajami NJ et al. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalized for bronchiolitis. Eur Respir J 2016;48:1329\u20131339.","journal-title":"Eur Respir J"},{"key":"BFpr2017309_CR14","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1164\/rccm.201701-0071OC","volume":"196","author":"CJ Stewart","year":"2017","unstructured":"Stewart CJ, Mansbach JM, Wong MC et al. Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis: a multi-omic analysis. Am J Respir Crit Care Med 2017;196:882\u2013891.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr2017309_CR15","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.jaci.2016.09.037","volume":"139","author":"K Hasegawa","year":"2016","unstructured":"Hasegawa K, Mansbach JM, Ajami NJ et al. Serum cathelicidin, nasopharyngeal microbiota, and disease severity in infants hospitalized with bronchiolitis. J Allergy Clin Immunol 2016;139:1383\u20131386.e6.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR16","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/j.jaci.2016.01.036","volume":"137","author":"JM Mansbach","year":"2016","unstructured":"Mansbach JM, Hasegawa K, Henke DM et al. Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota. J Allergy Clin Immunol 2016;137:1909\u201313 e4.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR17","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1111\/all.13160","volume":"72","author":"K Hasegawa","year":"2017","unstructured":"Hasegawa K, Mansbach JM, Ajami NJ et al. The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis. Allergy 2017;72:1796\u20131800.","journal-title":"Allergy"},{"key":"BFpr2017309_CR18","doi-asserted-by":"publisher","first-page":"e1474","DOI":"10.1542\/peds.2014-2742","volume":"134","author":"SL Ralston","year":"2014","unstructured":"Ralston SL, Lieberthal AS, Meissner HC et al. American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics 2014;134:e1474\u2013e1502.","journal-title":"Pediatrics"},{"key":"BFpr2017309_CR19","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.jaci.2013.11.025","volume":"133","author":"A Poole","year":"2014","unstructured":"Poole A, Urbanek C, Eng C et al. Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol 2014;133:670\u20138e12.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/1471-2164-9-259","volume":"9","author":"S Sridhar","year":"2008","unstructured":"Sridhar S, Schembri F, Zeskind J et al. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics 2008;9:259.","journal-title":"BMC Genomics"},{"key":"BFpr2017309_CR21","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1165\/rcmb.2007-0325OC","volume":"39","author":"CM McDougall","year":"2008","unstructured":"McDougall CM, Blaylock MG, Douglas JG, Brooker RJ, Helms PJ, Walsh GM . Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies. Am J Respir Cell Mol Biol 2008;39:560\u2013568.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFpr2017309_CR22","doi-asserted-by":"publisher","first-page":"e63871","DOI":"10.1371\/journal.pone.0063871","volume":"8","author":"SB Lambert","year":"2013","unstructured":"Lambert SB, Ware RS, Cook AL et al. Observational research in childhood infectious diseases (ORChID): a dynamic birth cohort study. PLoS One 2013;8:e63871.","journal-title":"PLoS One"},{"key":"BFpr2017309_CR23","doi-asserted-by":"publisher","first-page":"e63871","DOI":"10.1371\/journal.pone.0063871","volume":"8","author":"JM Damsker","year":"2013","unstructured":"Damsker JM, Dillingham BC, Rose MC et al. VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice. PLoS One 2013;8:e63871.","journal-title":"PLoS One"},{"key":"BFpr2017309_CR24","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1111\/j.1476-5381.2012.02237.x","volume":"169","author":"DM Kerr","year":"2013","unstructured":"Kerr DM, Harhen B, Okine BN, Egan LJ, Finn DP, Roche M . The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. Br J Pharmacol 2013;169:808\u2013819.","journal-title":"Br J Pharmacol"},{"key":"BFpr2017309_CR25","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1159\/000090050","volume":"73","author":"O Yagi","year":"2006","unstructured":"Yagi O, Aoshiba K, Nagai A . Activation of nuclear factor-kappaB in airway epithelial cells in patients with chronic obstructive pulmonary disease. Respiration 2006;73:610\u2013616.","journal-title":"Respiration"},{"key":"BFpr2017309_CR26","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1084\/jem.179.2.503","volume":"179","author":"MA Read","year":"1994","unstructured":"Read MA, Whitley MZ, Williams AJ, Collins T . NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation. J Exp Med 1994;179:503\u2013512.","journal-title":"J Exp Med"},{"issue":"Suppl 6","key":"BFpr2017309_CR27","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/1753-6561-9-S6-S2","volume":"9","author":"Daekyoung Jung","year":"2015","unstructured":"Jung D, Kim B, Freishtat RJ, Giri M, Hoffman E, Seo J . miRTarVis: an interactive visual analysis tool for microRNA-mRNA expression profile data. BMC Proc. 2015;9 (Suppl 6 Proceedings of the 5th Symposium on Biological Data):S2.","journal-title":"BMC Proceedings"},{"key":"BFpr2017309_CR28","doi-asserted-by":"publisher","first-page":"e84062","DOI":"10.1371\/journal.pone.0084062","volume":"8","author":"YC Tu","year":"2013","unstructured":"Tu YC, Huang DY, Shiah SG, Wang JS, Lin WW . Regulation of c-Fos gene expression by NF-kappaB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells. PLoS ONE 2013;8:e84062.","journal-title":"PLoS ONE"},{"key":"BFpr2017309_CR29","doi-asserted-by":"publisher","first-page":"7806","DOI":"10.1128\/MCB.24.17.7806-7819.2004","volume":"24","author":"S Fujioka","year":"2004","unstructured":"Fujioka S, Niu J, Schmidt C et al. NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol Cell Biol 2004;24:7806\u20137819.","journal-title":"Mol Cell Biol"},{"key":"BFpr2017309_CR30","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1084\/jem.20020062","volume":"196","author":"M Hinz","year":"2002","unstructured":"Hinz M, Lemke P, Anagnostopoulos I et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med 2002;196:605\u2013617.","journal-title":"J Exp Med"},{"key":"BFpr2017309_CR31","doi-asserted-by":"publisher","first-page":"26041","DOI":"10.1074\/jbc.M602222200","volume":"281","author":"S Cao","year":"2006","unstructured":"Cao S, Zhang X, Edwards JP, Mosser DM . NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J Biol Chem 2006;281:26041\u201326050.","journal-title":"J Biol Chem"},{"key":"BFpr2017309_CR32","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1465-9921-10-85","volume":"10","author":"T Jartti","year":"2009","unstructured":"Jartti T, Paul-Anttila M, Lehtinen P et al. Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study. Respir Res 2009;10:85.","journal-title":"Respir Res"},{"key":"BFpr2017309_CR33","doi-asserted-by":"crossref","unstructured":"Thornburg NJ, Hayward SL, Crowe JE Jr . Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-kappaB. MBio 2012;3 pii: e00220-12.","DOI":"10.1128\/mBio.00220-12"},{"key":"BFpr2017309_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12879-015-0878-z","volume":"15","author":"CS Inchley","year":"2015","unstructured":"Inchley CS, Sonerud T, Fjaerli HO, Nakstad B . Nasal mucosal microRNA expression in children with respiratory syncytial virus infection. BMC Infect Dis 2015;15:150.","journal-title":"BMC Infect Dis"},{"key":"BFpr2017309_CR35","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/all.12643","volume":"70","author":"A Zech","year":"2015","unstructured":"Zech A, Ayata CK, Pankratz F et al. MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice. Allergy 2015;70:1121\u20131129.","journal-title":"Allergy"},{"key":"BFpr2017309_CR36","doi-asserted-by":"publisher","first-page":"E3081","DOI":"10.1073\/pnas.1406322111","volume":"111","author":"IS Okoye","year":"2014","unstructured":"Okoye IS, Czieso S, Ktistaki E et al. Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity. Proc Natl Acad Sci USA 2014;111:E3081\u2013E3090.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFpr2017309_CR37","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1074\/jbc.M110.169367","volume":"286","author":"RT Martinez-Nunez","year":"2011","unstructured":"Martinez-Nunez RT, Louafi F, Sanchez-Elsner T . The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J Biol Chem. 2011;286:1786\u20131794.","journal-title":"J Biol Chem."},{"key":"BFpr2017309_CR38","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/j.jaci.2013.11.008","volume":"133","author":"C Malmhall","year":"2014","unstructured":"Malmhall C, Alawieh S, Lu Y et al. MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung. J Allergy Clin Immunol 2014;133:1429\u201338,38 e1-7.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR39","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.4049\/jimmunol.1301329","volume":"191","author":"JE Tully","year":"2013","unstructured":"Tully JE, Hoffman SM, Lahue KG et al. Epithelial NF-kappaB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling. J Immunol 2013;191:5811\u20135821.","journal-title":"J Immunol"},{"key":"BFpr2017309_CR40","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1165\/rcmb.2010-0106OC","volume":"44","author":"JL Ather","year":"2011","unstructured":"Ather JL, Hodgkins SR, Janssen-Heininger YM, Poynter ME . Airway epithelial NF-kappaB activation promotes allergic sensitization to an innocuous inhaled antigen. Am J Respir Cell Mol Biol 2011;44:631\u2013638.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5 Pt 1","key":"BFpr2017309_CR41","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1164\/ajrccm.158.5.9706116","volume":"158","author":"LA Hart","year":"1998","unstructured":"Hart LA, Krishnan VL, Adcock IM, Barnes PJ, Chung KF . Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med 1998;158 (5 Pt 1): 1585\u20131592.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFpr2017309_CR42","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1164\/rccm.200205-479OC","volume":"168","author":"R Gagliardo","year":"2003","unstructured":"Gagliardo R, Chanez P, Mathieu M et al. Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma. Am J Respir Crit Care Med. 2003;168:1190\u20131198.","journal-title":"Am J Respir Crit Care Med."},{"key":"BFpr2017309_CR43","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.jaci.2016.01.029","volume":"137","author":"RP Panganiban","year":"2016","unstructured":"Panganiban RP, Wang Y, Howrylak J et al. Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma. J Allergy Clin Immunol 2016;137:1423\u20131432.","journal-title":"J Allergy Clin Immunol"},{"key":"BFpr2017309_CR44","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1164\/rccm.200407-970OC","volume":"171","author":"AG Mosser","year":"2005","unstructured":"Mosser AG, Vrtis R, Burchell L et al. Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues. Am J Respir Crit Care Med. 2005;171:645\u2013651.","journal-title":"Am J Respir Crit Care Med."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2017309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017309","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2017.309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:04:12Z","timestamp":1684616652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2017309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["BFpr2017309"],"URL":"https:\/\/doi.org\/10.1038\/pr.2017.309","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,17]]},"assertion":[{"value":"23 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.M.M. has provided bronchiolitis-related consultation for Regeneron. P.A.P. received research grants from Gilead, Janssen Vaccines and Prevention, Novavax, and Regeneron, and provided bronchiolitis-related consultation for Ablynx, LFB, MedImmune, Novavax, and Regeneron. All the remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}