{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:31:41Z","timestamp":1788823901481,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1038\/pr.2017.316","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T17:01:20Z","timestamp":1513357280000},"page":"897-903","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of epinephrine on hemodynamic changes during cardiopulmonary resuscitation in a neonatal piglet model"],"prefix":"10.1038","volume":"83","author":[{"given":"Michael","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott S","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Fun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Olischar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"BFpr2017316_CR1","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.clp.2012.09.011","volume":"39","author":"V Kapadia","year":"2012","unstructured":"Kapadia V, Wyckoff MH . Chest compressions for bradycardia or asystole in neonates. Clin Perinatol 2012;39:833\u2013842.","journal-title":"Clin Perinatol"},{"key":"BFpr2017316_CR2","doi-asserted-by":"publisher","first-page":"F272","DOI":"10.1136\/archdischild-2015-309761","volume":"101","author":"AL Solev\u00e5g","year":"2016","unstructured":"Solev\u00e5g AL, Cheung P-Y, O'Reilly M, Schm\u00f6lzer GM . A review of approaches to optimise chest compressions in the resuscitation of asphyxiated newborns. Arch Dis Child Fetal Neonatal Ed 2016;101:F272\u20136.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFpr2017316_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000447960","volume":"111","author":"M Pinto","year":"2016","unstructured":"Pinto M, Solev\u00e5g AL, O'Reilly M, Aziz K, Cheung P-Y, Schm\u00f6lzer GM . Evidence on adrenaline use in resuscitation and its relevance to newborn infants: a non-systematic review. Neonatology 2016;111:37\u201344.","journal-title":"Neonatology"},{"key":"BFpr2017316_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fped.2017.00097","volume":"5","author":"VS Kapadia","year":"2017","unstructured":"Kapadia VS, Wyckoff MH . Epinephrine use during newborn resuscitation. Front Pediatr 2017;5:97.","journal-title":"Front Pediatr"},{"key":"BFpr2017316_CR5","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1542\/peds.2006-0416","volume":"118","author":"CA Barber","year":"2006","unstructured":"Barber CA, Wyckoff MH . Use and efficacy of endotracheal versus intravenous epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. Pediatrics 2006;118:1028\u20131034.","journal-title":"Pediatrics"},{"key":"BFpr2017316_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.joca.2012.02.010","volume":"20","author":"C Kilkenny","year":"2012","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG . Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Osteoarthr Cartil 2012;20:256\u2013260.","journal-title":"Osteoarthr Cartil"},{"key":"BFpr2017316_CR7","doi-asserted-by":"publisher","first-page":"e0157249","DOI":"10.1371\/journal.pone.0157249","volume":"11","author":"ES Li","year":"2016","unstructured":"Li ES, Cheung P-Y, Lee T-F, Lu M, O'Reilly M, Schm\u00f6lzer GM . Return of spontaneous circulation is not affected by different chest compression rates superimposed with sustained inflations during cardiopulmonary resuscitation in newborn piglets. PLoS ONE 2016;11:e0157249\u201314.","journal-title":"PLoS ONE"},{"key":"BFpr2017316_CR8","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1159\/000477998","volume":"112","author":"ES Li","year":"2017","unstructured":"Li ES, G\u00f6rens I, Cheung P-Y et al. Chest compressions during sustained inflations improve recovery when compared to a 3:1 compression:ventilation ratio during cardiopulmonary resuscitation in a neonatal porcine model of asphyxia. Neonatology 2017;112:337\u2013346.","journal-title":"Neonatology"},{"issue":"Suppl 2","key":"BFpr2017316_CR9","doi-asserted-by":"publisher","first-page":"S196","DOI":"10.1542\/peds.2015-3373G","volume":"136","author":"MH Wyckoff","year":"2015","unstructured":"Wyckoff MH, Aziz K, Escobedo MB et al. Part 13: neonatal resuscitation: 2015 American Heart Association Guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care (reprint). Pediatrics 2015;136 (Suppl 2): S196\u2013S218.","journal-title":"Pediatrics"},{"key":"BFpr2017316_CR10","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.clp.2012.09.005","volume":"39","author":"GM Weiner","year":"2012","unstructured":"Weiner GM, Niermeyer S . Medications in neonatal resuscitation: epinephrine and the search for better alternative strategies. Clin Perinatol 2012;39:843\u2013855.","journal-title":"Clin Perinatol"},{"key":"BFpr2017316_CR11","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1161\/01.CIR.90.6.3063","volume":"90","author":"AH Idris","year":"1994","unstructured":"Idris AH, Becker LB, Fuerst RS et al. Effect of ventilation on resuscitation in an animal model of cardiac arrest. Circulation 1994;90:3063\u20133069.","journal-title":"Circulation"},{"key":"BFpr2017316_CR12","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.resuscitation.2012.02.030","volume":"83","author":"R Linner","year":"2012","unstructured":"Linner R, Werner O, Perez-de-Sa V, Cunha-Goncalves D . Early adrenaline administration does not improve circulatory recovery during resuscitation from severe asphyxia in newborn piglets. Resuscitation 2012;83:1298\u20131303.","journal-title":"Resuscitation"},{"key":"BFpr2017316_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/pr.2015.117","volume":"78","author":"KS Sobotka","year":"2015","unstructured":"Sobotka KS, Polglase GR, Schm\u00f6lzer GM, Davis PG, Klingenberg C, Hooper SB . Effects of chest compressions on cardiovascular and cerebral hemodynamics in asphyxiated near-term lambs. Pediatr Res 2015;78:395\u2013400.","journal-title":"Pediatr Res"},{"key":"BFpr2017316_CR14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jpeds.2017.02.024","volume":"185","author":"C Halling","year":"2017","unstructured":"Halling C, Sparks JE, Christie L, Wyckoff MH . Efficacy of intravenous and endotracheal epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. J Pediatr 2017;185:232\u2013236.","journal-title":"J Pediatr"},{"key":"BFpr2017316_CR15","doi-asserted-by":"publisher","first-page":"e004402","DOI":"10.1161\/JAHA.116.004402","volume":"6","author":"P Vali","year":"2017","unstructured":"Vali P, Chandrasekharan P, Rawat M et al. Evaluation of timing and route of epinephrine in a neonatal model of asphyxial arrest. J Am Heart Assoc 2017;6:e004402\u2013e004413.","journal-title":"J Am Heart Assoc"},{"key":"BFpr2017316_CR16","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/pr.2014.38","volume":"75","author":"PJ McNamara","year":"2014","unstructured":"McNamara PJ, Engelberts D, Finelli M, Adeli K, Kavanagh BP . Vasopressin improves survival compared with epinephrine in a neonatal piglet model of asphyxial cardiac arrest. Pediatr Res 2014;75:738\u2013748.","journal-title":"Pediatr Res"},{"key":"BFpr2017316_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1056\/NEJMoa025431","volume":"350","author":"V Wenzel","year":"2004","unstructured":"Wenzel V, Krismer AC, Arntz HR, Sitter H, Stadlbauer KH, Lindner KH . A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med 2004;350:105\u2013113.","journal-title":"N Engl J Med"},{"key":"BFpr2017316_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.resuscitation.2016.11.018","volume":"111","author":"RW Morgan","year":"2017","unstructured":"Morgan RW, Kilbaugh TJ, Shoap W et al. A hemodynamic-directed approach to pediatric cardiopulmonary resuscitation (HD-CPR) improves survival. Resuscitation 2017;111:41\u201347.","journal-title":"Resuscitation"},{"key":"BFpr2017316_CR19","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1056\/NEJMoa032440","volume":"350","author":"MBM Perondi","year":"2004","unstructured":"Perondi MBM, Reis AG, Paiva EF, Nadkarni VM, Berg RA . A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med 2004;350:1722\u20131730.","journal-title":"N Engl J Med"},{"key":"BFpr2017316_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resuscitation.2017.03.009","volume":"115","author":"M Savani","year":"2017","unstructured":"Savani M, Upadhyay K, Talati AJ . Characteristics and outcomes of very low birth weight infants receiving epinephrine during delivery room resuscitation. Resuscitation 2017;115:1\u20134.","journal-title":"Resuscitation"},{"key":"BFpr2017316_CR21","first-page":"III394","volume":"84","author":"J Caspi","year":"1991","unstructured":"Caspi J, Coles JG, Benson LN et al. Age-related response to epinephrine-induced myocardial stress. A functional and ultrastructural study. Circulation 1991;84:III394\u2013III399.","journal-title":"Circulation"},{"issue":"Suppl 2","key":"BFpr2017316_CR22","doi-asserted-by":"publisher","first-page":"S120","DOI":"10.1542\/peds.2015-3373D","volume":"136","author":"JM Perlman","year":"2015","unstructured":"Perlman JM, Wyllie J, Kattwinkel J et al. Part 7: neonatal resuscitation: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (Reprint). Pediatrics 2015;136 (Suppl 2): S120\u2013S166.","journal-title":"Pediatrics"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/pr2017316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017316","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/pr.2017.316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/pr2017316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:04:16Z","timestamp":1684616656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/pr2017316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["BFpr2017316"],"URL":"https:\/\/doi.org\/10.1038\/pr.2017.316","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]},"assertion":[{"value":"24 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}