{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:33:20Z","timestamp":1778855600620,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/s10038-017-0362-2","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T09:39:23Z","timestamp":1507196363000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population"],"prefix":"10.1038","volume":"63","author":[{"given":"Aya","family":"Kawasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ei","family":"Sada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurumi","family":"Asako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-0767","authenticated-orcid":false,"given":"Hiroshi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nagasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Tohma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Kono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Arimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Harigai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-5580","authenticated-orcid":false,"given":"Naoyuki","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"362_CR1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/ncprheum0355","volume":"2","author":"CG Kallenberg","year":"2006","unstructured":"Kallenberg CG, Heeringa P, Stegeman CA. Mechanisms of disease: pathogenesis and treatment of ANCA-associated vasculitides. Nat Clin Pract Rheumatol. 2006;2:661\u201370.","journal-title":"Nat Clin Pract Rheumatol"},{"key":"362_CR2","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1093\/rheumatology\/ker205","volume":"50","author":"S Fujimoto","year":"2011","unstructured":"Fujimoto S, Watts RA, Kobayashi S, Suzuki K, Jayne DR, Scott DG, et al. Comparison of the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis between Japan and the UK. Rheumatology. 2011;50:1916\u201320.","journal-title":"Rheumatology"},{"key":"362_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/ar4550","volume":"16","author":"KE Sada","year":"2014","unstructured":"Sada KE, Yamamura M, Harigai M, Fujii T, Dobashi H, Takasaki Y, et al. Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study. Arthritis Res Ther. 2014;16:R101; \n                    https:\/\/doi.org\/10.1186\/ar4550\n                    \n                  .","journal-title":"Arthritis Res Ther"},{"key":"362_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154393","volume":"11","author":"A Kawasaki","year":"2016","unstructured":"Kawasaki A, Hasebe N, Hidaka M, Hirano F, Sada KE, Kobayashi S, et al. Protective role of HLA-DRB1*13:02 against microscopic polyangiitis and MPO-ANCA-positive vasculitides in a Japanese population: a case-control study. PLoS ONE. 2016;11:e0154393; \n                    https:\/\/doi.org\/10.1371\/journal.pone.0154393\n                    \n                  .","journal-title":"PLoS ONE"},{"key":"362_CR5","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1136\/ard.2007.077693","volume":"67","author":"M Heckmann","year":"2008","unstructured":"Heckmann M, Holle JU, Arning L, Knaup S, Hellmich B, Nothnagel M, et al. The Wegener\u2019s granulomatosis quantitative trait locus on chromosome 6p21.3 as characterized by tagSNP genotyping. Ann Rheum Dis. 2008;67:972\u20139.","journal-title":"Ann Rheum Dis"},{"key":"362_CR6","doi-asserted-by":"publisher","first-page":"D784","DOI":"10.1093\/nar\/gku1166","volume":"43","author":"FF Gonzalez-Galarza","year":"2015","unstructured":"Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, da Silva AL, et al. Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Nucleic Acids Res. 2015;43:D784\u2013D788.","journal-title":"Nucleic Acids Res"},{"key":"362_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1056\/NEJMoa1108735","volume":"367","author":"PA Lyons","year":"2012","unstructured":"Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, et al. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med. 2012;367:214\u201323.","journal-title":"N Engl J Med"},{"key":"362_CR8","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1002\/art.38036","volume":"65","author":"G Xie","year":"2013","unstructured":"Xie G, Roshandel D, Sherva R, Monach PA, Lu EY, Kung T, et al. Association of granulomatosis with polyangiitis (Wegener\u2019s) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis Rheum. 2013;65:2457\u201368.","journal-title":"Arthritis Rheum"},{"key":"362_CR9","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/art.40034","volume":"69","author":"PA Merkel","year":"2017","unstructured":"Merkel PA, Xie G, Monach PA, Ji X, Ciavatta DJ, Byun J, et al. Identification of functional and expression polymorphisms associated with risk for antineutrophil cytoplasmic autoantibody-associated vasculitis. Arthritis Rheumatol. 2017;69:1054\u201366.","journal-title":"Arthritis Rheumatol"},{"key":"362_CR10","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1002\/art.27742","volume":"62","author":"AD Mahr","year":"2010","unstructured":"Mahr AD, Edberg JC, Stone JH, Hoffman GS, St Clair EW, Specks U, et al. Alpha1-antitrypsin deficiency-related alleles Z and S and the risk of Wegener\u2019s granulomatosis. Arthritis Rheum. 2010;62:3760\u20137.","journal-title":"Arthritis Rheum"},{"key":"362_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jaut.2016.08.001","volume":"74","author":"M Teruel","year":"2016","unstructured":"Teruel M, Alarcon-Riquelme ME. The genetic basis of systemic lupus erythematosus: what are the risk factors and what have we learned. J Autoimmun. 2016;74:161\u201375.","journal-title":"J Autoimmun"},{"key":"362_CR12","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/art.23216","volume":"58","author":"A Kawasaki","year":"2008","unstructured":"Kawasaki A, Kyogoku C, Ohashi J, Miyashita R, Hikami K, Kusaoi M, et al. Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms. Arthritis Rheum. 2008;58:826\u201334.","journal-title":"Arthritis Rheum"},{"key":"362_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/ar2516","volume":"10","author":"A Kawasaki","year":"2008","unstructured":"Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, et al. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Arthritis Res Ther. 2008;10:R113; \n                    https:\/\/doi.org\/10.1186\/ar2516\n                    \n                  .","journal-title":"Arthritis Res Ther"},{"key":"362_CR14","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/art.27303","volume":"62","author":"I Ito","year":"2010","unstructured":"Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, Ohashi J, Kawamoto M, et al. Association of the FAM167A-BLK region with systemic sclerosis. Arthritis Rheum. 2010;62:890\u20135.","journal-title":"Arthritis Rheum"},{"key":"362_CR15","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/acr.20194","volume":"62","author":"K Shimane","year":"2010","unstructured":"Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, et al. The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. Arthritis Rheum. 2010;62:574\u20139.","journal-title":"Arthritis Rheum"},{"key":"362_CR16","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1093\/rheumatology\/kes427","volume":"52","author":"K Shimane","year":"2013","unstructured":"Shimane K, Kochi Y, Suzuki A, Okada Y, Ishii T, Horita T, et al. An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. Rheumatology. 2013;52:1172\u201382.","journal-title":"Rheumatology"},{"key":"362_CR17","doi-asserted-by":"publisher","first-page":"545","DOI":"10.2337\/diabetes.51.2.545","volume":"51","author":"Y Kawabata","year":"2002","unstructured":"Kawabata Y, Ikegami H, Kawaguchi Y, Fujisawa T, Shintani M, Ono M, et al. Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes. Diabetes. 2002;51:545\u201351.","journal-title":"Diabetes"},{"key":"362_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087792","volume":"9","author":"H Furukawa","year":"2014","unstructured":"Furukawa H, Kawasaki A, Oka S, Ito I, Shimada K, Sugii S, et al. Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03. PLoS ONE. 2014;9:e87792; \n                    https:\/\/doi.org\/10.1371\/journal.pone.0087792\n                    \n                  .","journal-title":"PLoS ONE"},{"key":"362_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099453","volume":"9","author":"S Oka","year":"2014","unstructured":"Oka S, Furukawa H, Kawasaki A, Shimada K, Sugii S, Hashimoto A, et al. Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients. PLoS ONE. 2014;9:e99453; \n                    https:\/\/doi.org\/10.1371\/journal.pone.0099453\n                    \n                  .","journal-title":"PLoS ONE"},{"key":"362_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154255","volume":"11","author":"H Furukawa","year":"2016","unstructured":"Furukawa H, Oka S, Kawasaki A, Shimada K, Sugii S, Matsushita T, et al. Human leukocyte antigen and systemic sclerosis in Japanese: the sign of the four independent protective alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01. PLoS ONE. 2016;11:e0154255; \n                    https:\/\/doi.org\/10.1371\/journal.pone.0154255\n                    \n                  .","journal-title":"PLoS ONE"},{"key":"362_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.semcancer.2015.09.010","volume":"35","author":"J Dittmer","year":"2015","unstructured":"Dittmer J. The role of the transcription factor Ets1 in carcinoma. Semin Cancer Biol. 2015;35:20\u201338.","journal-title":"Semin Cancer Biol"},{"key":"362_CR22","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1007\/s00018-012-1243-7","volume":"70","author":"LA Garrett-Sinha","year":"2013","unstructured":"Garrett-Sinha LA. Review of Ets1 structure, function, and roles in immunity. Cell Mol Life Sci. 2013;70:3375\u201390.","journal-title":"Cell Mol Life Sci"},{"key":"362_CR23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.cyto.2010.03.006","volume":"51","author":"L Russell","year":"2010","unstructured":"Russell L, Garrett-Sinha LA. Transcription factor Ets-1 in cytokine and chemokine gene regulation. Cytokine. 2010;51:217\u201326.","journal-title":"Cytokine"},{"key":"362_CR24","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/ng.472","volume":"41","author":"JW Han","year":"2009","unstructured":"Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009;41:1234\u20137.","journal-title":"Nat Genet"},{"key":"362_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000841","volume":"6","author":"W Yang","year":"2010","unstructured":"Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX, et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet. 2010;6:e1000841; \n                    https:\/\/doi.org\/10.1371\/journal.pgen.1000841\n                    \n                  .","journal-title":"PLoS Genet"},{"key":"362_CR26","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/ejhg.2012.277","volume":"21","author":"C Wang","year":"2013","unstructured":"Wang C, Ahlford A, J\u00e4rvinen TM, Nordmark G, Eloranta ML, Gunnarsson I, et al. Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. Eur J Hum Genet. 2013;21:994\u20139.","journal-title":"Eur J Hum Genet"},{"key":"362_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/ar4530","volume":"16","author":"S Shan","year":"2014","unstructured":"Shan S, Dang J, Li J, Yang Z, Zhao H, Xin Q, et al. ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese. Arthritis Res Ther. 2014;16:R87; \n                    https:\/\/doi.org\/10.1186\/ar4530\n                    \n                  .","journal-title":"Arthritis Res Ther"},{"key":"362_CR28","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/ard.2006.054593","volume":"66","author":"R Watts","year":"2007","unstructured":"Watts R, Lane S, Hanslik T, Hauser T, Hellmich B, Koldingsnes W, et al. Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis. 2007;66:222\u20137.","journal-title":"Ann Rheum Dis"},{"key":"362_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/ar3134","volume":"12","author":"A Kawasaki","year":"2010","unstructured":"Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, et al. Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study. Arthritis Res Ther. 2010;12:R174; \n                    https:\/\/doi.org\/10.1186\/ar3134\n                    \n                  .","journal-title":"Arthritis Res Ther"},{"key":"362_CR30","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1002\/art.34496","volume":"64","author":"SA Chung","year":"2012","unstructured":"Chung SA, Xie G, Roshandel D, Sherva R, Edberg JC, Kravitz M, et al. Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener\u2019s) reveals shared susceptibility loci with rheumatoid arthritis. Arthritis Rheum. 2012;64:3463\u201371.","journal-title":"Arthritis Rheum"},{"key":"362_CR31","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.ajhg.2015.03.002","volume":"96","author":"X Lu","year":"2015","unstructured":"Lu X, Zoller EE, Weirauch MT, Wu Z, Namjou B, Williams AH, et al. Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression. Am J Hum Genet. 2015;96:731\u20139.","journal-title":"Am J Hum Genet"},{"key":"362_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/ar4066","volume":"14","author":"B Wilde","year":"2012","unstructured":"Wilde B, Thewissen M, Damoiseaux J, Hilhorst M, van Paassen P, Witzke O, et al. Th17 expansion in granulomatosis with polyangiitis (Wegener\u2019s): the role of disease activity, immune regulation and therapy. Arthritis Res Ther. 2012;14:R227; \n                    https:\/\/doi.org\/10.1186\/ar4066\n                    \n                  .","journal-title":"Arthritis Res Ther"},{"key":"362_CR33","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1002\/art.23557","volume":"58","author":"WH Abdulahad","year":"2008","unstructured":"Abdulahad WH, Stegeman CA, Limburg PC, Kallenberg CG. Skewed distribution of Th17 lymphocytes in patients with Wegener\u2019s granulomatosis in remission. Arthritis Rheum. 2008;58:2196\u2013205.","journal-title":"Arthritis Rheum"},{"key":"362_CR34","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1093\/intimm\/dxh295","volume":"17","author":"D Wang","year":"2005","unstructured":"Wang D, John SA, Clements JL, Percy DH, Barton KP, Garrett-Sinha LA. Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease. Int Immunol. 2005;17:1179\u201391.","journal-title":"Int Immunol"},{"key":"362_CR35","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ajhg.2008.08.019","volume":"83","author":"Y Yamaguchi-Kabata","year":"2008","unstructured":"Yamaguchi-Kabata Y, Nakazono K, Takahashi A, Saito S, Hosono N, Kubo M, et al. Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. Am J Hum Genet. 2008;83:445\u201356.","journal-title":"Am J Hum Genet"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s10038-017-0362-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s10038-017-0362-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s10038-017-0362-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:05:32Z","timestamp":1684616732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s10038-017-0362-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["362"],"URL":"https:\/\/doi.org\/10.1038\/s10038-017-0362-2","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]},"assertion":[{"value":"18 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"FH is employed by the Department of Lifetime Clinical Immunology, Tokyo Medical and Dental University (TMDU), which has received unrestricted research grants from Chugai Pharmaceutical Co., Ltd., Ono Pharmaceuticals, Mitsubishi Tanabe Pharma Co., UCB Japan, CSL Behring, Towa Pharmaceutical Co., Ltd., Abbvie Japan Co., Ltd., Japan Blood Products Organization, Ayumi Pharmaceutical Co., and Nippon Kayaku Co., Ltd. TS received honoraria for lectures from Mitsubishi Tanabe Pharma Co., Ltd., and research grants from Mitsubishi Tanabe Pharma Co., Ltd., Chugai Pharmaceutical Co., Ltd., Astellas Pharma Co., Ltd., and Ono Pharmaceutical Co., Ltd. ST received honoraria for lectures from Pfizer, and a research grant from Chugai Pharmaceutical Co., Ltd. HM serves as a consultant for Abbvie Japan Co., Ltd. and Teijin Pharma Ltd. MH has received a research grant from Abbvie. Tokyo Women\u2019s Medical University (TWMU), particularly the Division of Epidemiology and Pharmacoepidemiology in Rheumatic Diseases, has received unrestricted research grants from Ayumi Pharmaceutical Co., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Nippon Kayaku Co., Ltd., Taisho Toyama Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., and Teijin Pharma Ltd., with which TWMU paid the salary of MH. NT received 2017 Novartis\u2014Japan Rheumatism Foundation Rheumatology Prize. The remaining authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}