{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:57:10Z","timestamp":1778129830498,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/s10038-017-0384-9","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T03:57:48Z","timestamp":1515556668000},"page":"327-337","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study"],"prefix":"10.1038","volume":"63","author":[{"given":"Laura M.","family":"Raffield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nels C.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Durda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Pankratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan J.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina L.","family":"Wassel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Cushman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron D.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell P.","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen S.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex P.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-5816","authenticated-orcid":false,"given":"Monte S.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan M.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie A.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"384_CR1","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1161\/CIR.0000000000000152","volume":"131","author":"D Mozaffarian","year":"2015","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation. 2015;131:e29\u2013322.","journal-title":"Circulation"},{"key":"384_CR2","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","volume":"338","author":"GN Welch","year":"1998","unstructured":"Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042\u201350.","journal-title":"N Engl J Med"},{"key":"384_CR3","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","author":"Homocysteine Studies Collaboration.","year":"2002","unstructured":"Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015\u201322.","journal-title":"JAMA"},{"key":"384_CR4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.atherosclerosis.2014.04.010","volume":"235","author":"ML Bertoia","year":"2014","unstructured":"Bertoia ML, Pai JK, Cooke JP, Joosten MM, Mittleman MA, Rimm EB, et al. Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease. Atherosclerosis. 2014;235:94\u2013101.","journal-title":"Atherosclerosis."},{"key":"384_CR5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.ejvs.2009.05.007","volume":"38","author":"N Khandanpour","year":"2009","unstructured":"Khandanpour N, Loke YK, Meyer FJ, Jennings B, Armon MP. Homocysteine and peripheral arterial disease: systematic review and meta-analysis. Eur J Vasc Endovasc Surg 2009;38:316\u201322.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"384_CR6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1055\/s-2000-8471","volume":"26","author":"J Schneede","year":"2000","unstructured":"Schneede J, Refsum H, Ueland PM. Biological and environmental determinants of plasma homocysteine. Semin Thromb Hemost. 2000;26:263\u201379.","journal-title":"Semin Thromb Hemost."},{"key":"384_CR7","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMoa011613","volume":"346","author":"S Seshadri","year":"2002","unstructured":"Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D\u2019Agostino RB, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer\u2019s disease. N Engl J Med. 2002;346:476\u201383.","journal-title":"N Engl J Med."},{"key":"384_CR8","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/qjmed\/hcm054","volume":"100","author":"A Siva","year":"2007","unstructured":"Siva A, De Lange M, Clayton D, Monteith S, Spector T, Brown MJ. The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. QJM. 2007;100:495\u20139.","journal-title":"QJM."},{"key":"384_CR9","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1080\/00365510902814646","volume":"69","author":"SE Nilsson","year":"2009","unstructured":"Nilsson SE, Read S, Berg S, Johansson B. Heritabilities for fifteen routine biochemical values: findings in 215 Swedish twin pairs 82 years of age or older. Scand J Clin Lab Invest. 2009;69:562\u20139.","journal-title":"Scand J Clin Lab Invest."},{"key":"384_CR10","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1161\/01.STR.0000225929.96190.b3","volume":"37","author":"IJ Kullo","year":"2006","unstructured":"Kullo IJ, Ding K, Boerwinkle E, Turner ST, Mosley TH Jr, Kardia SL, et al. Novel genomic loci influencing plasma homocysteine levels. Stroke. 2006;37:1703\u20139.","journal-title":"Stroke."},{"key":"384_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s00439-002-0757-8","volume":"111","author":"SH Jee","year":"2002","unstructured":"Jee SH, Song KS, Shim WH, Kim HK, Suh I, Park JY, et al. Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography. Hum Genet. 2002;111:128\u201335.","journal-title":"Hum Genet."},{"key":"384_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","volume":"43","author":"S Brustolin","year":"2010","unstructured":"Brustolin S, Giugliani R, Felix TM. Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res. 2010;43:1\u20137.","journal-title":"Braz J Med Biol Res."},{"key":"384_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","volume":"19","author":"J Selhub","year":"1999","unstructured":"Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217\u201346.","journal-title":"Annu Rev Nutr."},{"key":"384_CR14","doi-asserted-by":"crossref","unstructured":"Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005;82:806\u201312.","DOI":"10.1093\/ajcn\/82.4.806"},{"key":"384_CR15","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/CIRCGENETICS.108.829804","volume":"2","author":"G Pare","year":"2009","unstructured":"Pare G, Chasman DI, Parker AN, Zee RR, Malarstig A, Seedorf U, et al. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13,974 participants in the Women\u2019s Genome Health Study. Circ Cardiovasc Genet. 2009;2:142\u201350.","journal-title":"Circ Cardiovasc Genet."},{"key":"384_CR16","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.ajhg.2009.02.011","volume":"84","author":"T Tanaka","year":"2009","unstructured":"Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet. 2009;84:477\u201382.","journal-title":"Am J Hum Genet."},{"key":"384_CR17","doi-asserted-by":"publisher","first-page":"4677","DOI":"10.1093\/hmg\/ddp428","volume":"18","author":"A Hazra","year":"2009","unstructured":"Hazra A, Kraft P, Lazarus R, Chen C, Chanock SJ, Jacques P, et al. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet. 2009;18:4677\u201387.","journal-title":"Hum Mol Genet."},{"key":"384_CR18","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1182\/blood-2009-04-215269","volume":"114","author":"A Malarstig","year":"2009","unstructured":"Malarstig A, Buil A, Souto JC, Clarke R, Blanco-Vaca F, Fontcuberta J, et al. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. Blood. 2009;114:1417\u201322.","journal-title":"Blood."},{"key":"384_CR19","doi-asserted-by":"publisher","first-page":"668","DOI":"10.3945\/ajcn.112.044545","volume":"98","author":"JB Meurs van","year":"2013","unstructured":"van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, et al. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013;98:668\u201376.","journal-title":"Am J Clin Nutr."},{"key":"384_CR20","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1093\/hmg\/ddq062","volume":"19","author":"LA Lange","year":"2010","unstructured":"Lange LA, Croteau-Chonka DC, Marvelle AF, Qin L, Gaulton KJ, Kuzawa CW, et al. Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults. Hum Mol Genet. 2010;19:2050\u20138.","journal-title":"Hum Mol Genet."},{"key":"384_CR21","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","volume":"325","author":"DS Wald","year":"2002","unstructured":"Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002;325:1202.","journal-title":"BMJ."},{"key":"384_CR22","doi-asserted-by":"publisher","first-page":"e1004214","DOI":"10.1371\/journal.pgen.1004214","volume":"10","author":"SR Williams","year":"2014","unstructured":"Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, et al. Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. PLoS Genet. 2014;10:e1004214.","journal-title":"PLoS Genet."},{"key":"384_CR23","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1161\/STROKEAHA.114.005208","volume":"45","author":"I Cotlarciuc","year":"2014","unstructured":"Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Pare G, Psaty BM, et al. Effect of genetic variants associated with plasma homocysteine levels on stroke risk. Stroke. 2014;45:1920\u20134.","journal-title":"Stroke."},{"key":"384_CR24","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.jvs.2008.10.004","volume":"49","author":"N Khandanpour","year":"2009","unstructured":"Khandanpour N, Willis G, Meyer FJ, Armon MP, Loke YK, Wright AJ, et al. Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis. J Vasc Surg. 2009;49:711\u20138.","journal-title":"J Vasc Surg."},{"key":"384_CR25","doi-asserted-by":"crossref","unstructured":"Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB, Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Heart Assoc. 2016;5:e003768.","DOI":"10.1161\/JAHA.116.003768"},{"key":"384_CR26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.2174\/1567205043332243","volume":"1","author":"K Beyer","year":"2004","unstructured":"Beyer K, Lao JI, Carrato C, Rodriguez-Vila A, Latorre P, Mataro M, et al. Cystathionine beta synthase as a risk factor for Alzheimer disease. Curr Alzheimer Res. 2004;1:127\u201333.","journal-title":"Curr Alzheimer Res."},{"key":"384_CR27","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s12035-016-9722-8","volume":"54","author":"V Rai","year":"2017","unstructured":"Rai V. Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and alzheimer disease risk: a meta-analysis. Mol Neurobiol. 2017;54:1173\u201386.","journal-title":"Mol Neurobiol."},{"key":"384_CR28","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/gepi.21788","volume":"38","author":"BA Charles","year":"2014","unstructured":"Charles BA, Shriner D, Rotimi CN. Accounting for linkage disequilibrium in association analysis of diverse populations. Genet Epidemiol. 2014;38:265\u201373.","journal-title":"Genet Epidemiol."},{"key":"384_CR29","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.ajhg.2017.03.004","volume":"100","author":"AR Martin","year":"2017","unstructured":"Martin AR, Gignoux CR, Walters RK, Wojcik GL, Neale BM, Gravel S, et al. Human demographic history impacts genetic risk prediction across diverse populations. Am J Hum Genet. 2017;100:635\u201349.","journal-title":"Am J Hum Genet."},{"key":"384_CR30","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3233\/JAD-150651","volume":"49","author":"S Kim","year":"2015","unstructured":"Kim S, Nho K, Ramanan VK, Lai D, Foroud TM, Lane K, et al. Genetic influences on plasma homocysteine levels in african americans and yoruba nigerians. J Alzheimers Dis. 2015;49:991\u20131003.","journal-title":"J Alzheimers Dis."},{"key":"384_CR31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ymgme.2009.05.012","volume":"98","author":"MY Tsai","year":"2009","unstructured":"Tsai MY, Loria CM, Cao J, Kim Y, Siscovick DS, Schreiner PJ, et al. Polygenic association with total homocysteine in the post-folic acid fortification era: the CARDIA study. Mol Genet Metab. 2009;98:181\u20136.","journal-title":"Mol Genet Metab."},{"key":"384_CR32","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.ahj.2008.12.012","volume":"157","author":"MA Albert","year":"2009","unstructured":"Albert MA, Pare G, Morris A, Rose L, Buring J, Ridker PM, et al. Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race\/ethnic groups: data from the Women\u2019s Genome Health Study. Am Heart J. 2009;157:777\u201383.e771.","journal-title":"Am Heart J."},{"key":"384_CR33","first-page":"S6-4","volume":"15","author":"HA Taylor Jr.","year":"2005","unstructured":"Taylor HA Jr., Wilson JG, Jones DW, Sarpong DF, Srinivasan A, Garrison RJ, et al. Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study. Ethn Dis. 2005;15:S6-4\u201317.","journal-title":"Ethn Dis."},{"key":"384_CR34","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1093\/aje\/kwf113","volume":"156","author":"DE Bild","year":"2002","unstructured":"Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol. 2002;156:871\u201381.","journal-title":"Am J Epidemiol."},{"key":"384_CR35","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1161\/01.CIR.0000157730.94423.4B","volume":"111","author":"DE Bild","year":"2005","unstructured":"Bild DE, Detrano R, Peterson D, Guerci A, Liu K, Shahar E, et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005;111:1313\u201320.","journal-title":"Circulation."},{"key":"384_CR36","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","volume":"41","author":"GD Friedman","year":"1988","unstructured":"Friedman GD, Cutter GR, Donahue RP, Hughes GH, Hulley SB, Jacobs DR Jr., et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol. 1988;41:1105\u201316.","journal-title":"J Clin Epidemiol"},{"key":"384_CR37","doi-asserted-by":"publisher","first-page":"1S","DOI":"10.1016\/0197-2456(91)90002-4","volume":"12","author":"GR Cutter","year":"1991","unstructured":"Cutter GR, Burke GL, Dyer AR, Friedman GD, Hilner JE, Hughes GH, et al. Cardiovascular risk factors in young adults. The CARDIA baseline monograph. Control Clin Trials. 1991;12:1S\u201377S.","journal-title":"Control Clin Trials."},{"key":"384_CR38","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/gepi.20533","volume":"34","author":"Y Li","year":"2010","unstructured":"Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol. 2010;34:816\u201334.","journal-title":"Genet Epidemiol."},{"key":"384_CR39","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38:904\u20139.","journal-title":"Nat Genet."},{"key":"384_CR40","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/ng.548","volume":"42","author":"HM Kang","year":"2010","unstructured":"Kang HM, Sul JH, Service SK, Zaitlen NA, Kong SY, Freimer NB, et al. Variance component model to account for sample structure in genome-wide association studies. Nat Genet. 2010;42:348\u201354.","journal-title":"Nat Genet."},{"key":"384_CR41","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26:2190\u20131.","journal-title":"Bioinformatics."},{"key":"384_CR42","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.freeradbiomed.2007.03.028","volume":"43","author":"JD Lambeth","year":"2007","unstructured":"Lambeth JD, Kawahara T, Diebold B. Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med. 2007;43:319\u201331.","journal-title":"Free Radic Biol Med."},{"key":"384_CR43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1755-5922.2011.00310.x","volume":"31","author":"J Streeter","year":"2013","unstructured":"Streeter J, Thiel W, Brieger K, Miller FJ Jr. Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease. Cardiovasc Ther. 2013;31:125\u201337.","journal-title":"Cardiovasc Ther."},{"key":"384_CR44","first-page":"412","volume":"3","author":"F Chen","year":"2012","unstructured":"Chen F, Haigh S, Barman S, Fulton DJ. From form to function: the role of Nox4 in the cardiovascular system. Front Physiol. 2012;3:412.","journal-title":"Front Physiol."},{"key":"384_CR45","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s12013-011-9297-y","volume":"67","author":"JA Sipkens","year":"2013","unstructured":"Sipkens JA, Hahn N, van den Brand CS, Meischl C, Cillessen SA, Smith DE, et al. Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity. Cell Biochem Biophys. 2013;67:341\u201352.","journal-title":"Cell Biochem Biophys."},{"key":"384_CR46","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"LD Ward","year":"2012","unstructured":"Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012;40:D930\u2013934.","journal-title":"Nucleic Acids Res."},{"key":"384_CR47","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/ng.3768","volume":"49","author":"HR Warren","year":"2017","unstructured":"Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017;49:403\u201315.","journal-title":"Nat Genet."},{"key":"384_CR48","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/ng1683","volume":"38","author":"JP Lerner-Ellis","year":"2006","unstructured":"Lerner-Ellis JP, Tirone JC, Pawelek PD, Dore C, Atkinson JL, Watkins D, et al. Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. Nat Genet. 2006;38:93\u2013100.","journal-title":"Nat Genet."},{"key":"384_CR49","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/nu3030370","volume":"3","author":"KS Crider","year":"2011","unstructured":"Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients. 2011;3:370\u201384.","journal-title":"Nutrients."},{"key":"384_CR50","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/S0140-6736(11)60872-6","volume":"378","author":"MV Holmes","year":"2011","unstructured":"Holmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J, et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet. 2011;378:584\u201394.","journal-title":"Lancet."},{"key":"384_CR51","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/aje\/152.2.140","volume":"152","author":"MS Morris","year":"2000","unstructured":"Morris MS, Jacques PF, Selhub J, Rosenberg IH. Total homocysteine and estrogen status indicators in the third national health and nutrition examination survey. Am J Epidemiol. 2000;152:140\u20138.","journal-title":"Am J Epidemiol."},{"key":"384_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10558","volume":"7","author":"JA Hartiala","year":"2016","unstructured":"Hartiala JA, Tang WH, Wang Z, Crow AL, Stewart AF, Roberts R, et al. Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. Nat Commun. 2016;7:10558.","journal-title":"Nat Commun."}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s10038-017-0384-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s10038-017-0384-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s10038-017-0384-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:05:41Z","timestamp":1684616741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s10038-017-0384-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["384"],"URL":"https:\/\/doi.org\/10.1038\/s10038-017-0384-9","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]},"assertion":[{"value":"13 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}