{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:37:47Z","timestamp":1787002667402,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21dk0207045"],"award-info":[{"award-number":["JP21dk0207045"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22dk0207060"],"award-info":[{"award-number":["JP22dk0207060"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21de0107002"],"award-info":[{"award-number":["JP21de0107002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21dk0207052"],"award-info":[{"award-number":["JP21dk0207052"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18kk0205009"],"award-info":[{"award-number":["JP18kk0205009"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18kk0205012"],"award-info":[{"award-number":["JP18kk0205012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21dk0207045"],"award-info":[{"award-number":["JP21dk0207045"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22dk0207060"],"award-info":[{"award-number":["JP22dk0207060"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21de0107002"],"award-info":[{"award-number":["JP21de0107002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21dk0207052"],"award-info":[{"award-number":["JP21dk0207052"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","award":["21-23"],"award-info":[{"award-number":["21-23"]}],"id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","award":["21-24"],"award-info":[{"award-number":["21-24"]}],"id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","award":["23-7"],"award-info":[{"award-number":["23-7"]}],"id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005694","name":"Hori Sciences and Arts Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005694","name":"Hori Sciences and Arts Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005694","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chukyo Longevity Medical Research and Promotion Foundation"},{"DOI":"10.13039\/501100008593","name":"Japan Foundation for Aging and Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1038\/s10038-024-01224-x","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T02:02:53Z","timestamp":1707789773000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CRISPR\/Cas9-mediated knock-in cells of the late-onset Alzheimer\u2019s disease-risk variant, SHARPIN G186R, reveal reduced NF-\u03baB pathway and accelerated A\u03b2 secretion"],"prefix":"10.1038","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-4729","authenticated-orcid":false,"given":"Yuya","family":"Asanomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-104X","authenticated-orcid":false,"given":"Tetsuaki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Shigemizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Niida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-1570","authenticated-orcid":false,"given":"Kouichi","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","volume":"63","author":"M Gatz","year":"2006","unstructured":"Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry. 2006;63:168.","journal-title":"Arch Gen Psychiatry"},{"key":"1224_CR2","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","volume":"54","author":"C Bellenguez","year":"2022","unstructured":"Bellenguez C, K\u00fc\u00e7\u00fckali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, et al. New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias. Nat Genet. 2022;54:412\u201336.","journal-title":"Nat Genet"},{"key":"1224_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s10020-019-0090-5","volume":"25","author":"Y Asanomi","year":"2019","unstructured":"Asanomi Y, Shigemizu D, Miyashita A, Mitsumori R, Mori T, Hara N, et al. A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer\u2019s disease. Mol Med. 2019;25:20.","journal-title":"Mol Med"},{"key":"1224_CR4","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature09816","volume":"471","author":"B Gerlach","year":"2011","unstructured":"Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 2011;471:591\u20136.","journal-title":"Nature"},{"key":"1224_CR5","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nature09815","volume":"471","author":"F Tokunaga","year":"2011","unstructured":"Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, et al. SHARPIN is a component of the NF-\u03baB-activating linear ubiquitin chain assembly complex. Nature. 2011;471:633\u20136.","journal-title":"Nature"},{"key":"1224_CR6","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nature09814","volume":"471","author":"F Ikeda","year":"2011","unstructured":"Ikeda F, Deribe YL, Sk\u00e5nland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-\u03baB activity and apoptosis. Nature. 2011;471:637\u201341.","journal-title":"Nature"},{"key":"1224_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms12547","volume":"7","author":"S Nakazawa","year":"2016","unstructured":"Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:1\u201314.","journal-title":"Nat Commun"},{"key":"1224_CR8","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3389\/fchem.2019.00915","volume":"7","author":"G Dittmar","year":"2019","unstructured":"Dittmar G, Winklhofer KF. Linear ubiquitin chains: Cellular functions and strategies for detection and quantification. Front Chem. 2019;7:915.","journal-title":"Front Chem"},{"key":"1224_CR9","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.3390\/ijms21093381","volume":"21","author":"D Oikawa","year":"2020","unstructured":"Oikawa D, Sato Y, Ito H, Tokunaga F. Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders. Int J Mol Sci. 2020;21:3381.","journal-title":"Int J Mol Sci"},{"key":"1224_CR10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41418-020-00676-w","volume":"28","author":"AS Jahan","year":"2021","unstructured":"Jahan AS, Elb\u00e6k CR, Damgaard RB. Met1-linked ubiquitin signalling in health and disease: inflammation, immunity, cancer, and beyond. Cell Death Differ. 2021;28:473\u201392.","journal-title":"Cell Death Differ"},{"key":"1224_CR11","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1074\/jbc.RA119.011622","volume":"295","author":"T Douglas","year":"2020","unstructured":"Douglas T, Saleh M. Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation. J Biol Chem. 2020;295:5216\u201328.","journal-title":"J Biol Chem"},{"key":"1224_CR12","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.ajpath.2015.12.026","volume":"186","author":"M-V Nastase","year":"2016","unstructured":"Nastase M-V, Zeng-Brouwers J, Frey H, Hsieh LT-H, Poluzzi C, Beckmann J, et al. An essential role for SHARPIN in the regulation of caspase 1 activity in sepsis. Am J Pathol. 2016;186:1206\u201320.","journal-title":"Am J Pathol"},{"key":"1224_CR13","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1172\/JCI40778","volume":"120","author":"L He","year":"2010","unstructured":"He L, Ingram A, Rybak AP, Tang D. Shank-interacting protein\u2013like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest. 2010;120:2094\u2013108.","journal-title":"J Clin Invest"},{"key":"1224_CR14","doi-asserted-by":"publisher","first-page":"e277","DOI":"10.1038\/oncsis.2016.76","volume":"5","author":"Y Tanaka","year":"2016","unstructured":"Tanaka Y, Tateishi K, Nakatsuka T, Kudo Y, Takahashi R, Miyabayashi K, et al. Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression. Oncogenesis. 2016;5:e277.","journal-title":"Oncogenesis"},{"key":"1224_CR15","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neo.2016.12.002","volume":"19","author":"H Yang","year":"2017","unstructured":"Yang H, Yu S, Wang W, Li X, Hou Y, Liu Z, et al. SHARPIN facilitates p53 degradation in breast cancer cells. Neoplasia. 2017;19:84\u201392.","journal-title":"Neoplasia"},{"key":"1224_CR16","doi-asserted-by":"publisher","first-page":"109414","DOI":"10.1016\/j.biopha.2019.109414","volume":"119","author":"Z Tian","year":"2019","unstructured":"Tian Z, Tang J, Yang Q, Li X, Zhu J, Wu G. Atypical ubiquitin-binding protein SHARPIN promotes breast cancer progression. Biomed Pharmacother. 2019;119:109414.","journal-title":"Biomed Pharmacother"},{"key":"1224_CR17","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jid.2019.07.696","volume":"140","author":"S Zhou","year":"2020","unstructured":"Zhou S, Liang Y, Zhang X, Liao L, Yang Y, Ouyang W, et al. SHARPIN promotes melanoma progression via Rap1 signaling pathway. J Invest Dermatol. 2020;140:395\u2013403.e6.","journal-title":"J Invest Dermatol"},{"key":"1224_CR18","first-page":"1799","volume":"21","author":"Y Yang","year":"2020","unstructured":"Yang Y, Liang Y, Zheng Y, Tang L, Zhou S, Zhu J. SHARPIN regulates cell proliferation of cutaneous basal cell carcinoma via inactivation of the transcriptional factors GLI2 and c\u2011JUN. Mol Med Rep. 2020;21:1799\u2013808.","journal-title":"Mol Med Rep"},{"key":"1224_CR19","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neo.2019.12.001","volume":"22","author":"A Zhang","year":"2020","unstructured":"Zhang A, Wang W, Chen Z, Pang D, Zhou X, Lu K, et al. SHARPIN inhibits esophageal squamous cell carcinoma progression by modulating Hippo signaling. Neoplasia. 2020;22:76\u201385.","journal-title":"Neoplasia"},{"key":"1224_CR20","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.3892\/ol.2020.11850","volume":"20","author":"C Zeng","year":"2020","unstructured":"Zeng C, Xiong D, Zhang K, Yao J. Shank\u2011associated RH domain interactor signaling in tumorigenesis. Oncol Lett. 2020;20:2579\u201386.","journal-title":"Oncol Lett"},{"key":"1224_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22491-8","volume":"12","author":"I de Rojas","year":"2021","unstructured":"de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, et al. Common variants in Alzheimer\u2019s disease and risk stratification by polygenic risk scores. Nat Commun. 2021;12:3417.","journal-title":"Nat Commun"},{"key":"1224_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s10038-021-00987-x","volume":"67","author":"Y Asanomi","year":"2022","unstructured":"Asanomi Y, Shigemizu D, Akiyama S, Miyashita A, Mitsumori R, Hara N, et al. A functional variant of SHARPIN confers increased risk of late-onset Alzheimer\u2019s disease. J Hum Genet. 2022;67:203\u20138.","journal-title":"J Hum Genet"},{"key":"1224_CR23","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s100380170047","volume":"46","author":"Y Ohnishi","year":"2001","unstructured":"Ohnishi Y, Tanaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y. A high-throughput SNP typing system for genome-wide association studies. J Hum Genet. 2001;46:471\u20137.","journal-title":"J Hum Genet"},{"key":"1224_CR24","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1038\/s41380-022-01483-0","volume":"27","author":"D Shigemizu","year":"2022","unstructured":"Shigemizu D, Asanomi Y, Akiyama S, Mitsumori R, Niida S, Ozaki K. Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer\u2019s disease. Mol Psychiatry. 2022;27:2554\u201362.","journal-title":"Mol Psychiatry"},{"key":"1224_CR25","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","volume":"26","author":"H Hampel","year":"2021","unstructured":"Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, et al. The amyloid-\u03b2 pathway in Alzheimer\u2019s disease. Mol Psychiatry. 2021;26:5481\u2013503.","journal-title":"Mol Psychiatry"},{"key":"1224_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neulet.2006.12.029","volume":"415","author":"D Paris","year":"2007","unstructured":"Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, et al. Inhibition of A\u03b2 production by NF-\u03baB inhibitors. Neurosci Lett. 2007;415:11\u20136.","journal-title":"Neurosci Lett"},{"key":"1224_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1017\/S1461145711000149","volume":"15","author":"C-H Chen","year":"2012","unstructured":"Chen C-H, Zhou W, Liu S, Deng Y, Cai F, Tone M, et al. Increased NF-\u03baB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer\u2019s disease. Int J Neuropsychopharmacol. 2012;15:77\u201390.","journal-title":"Int J Neuropsychopharmacol"},{"key":"1224_CR28","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1073\/pnas.94.6.2642","volume":"94","author":"B Kaltschmidt","year":"1997","unstructured":"Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-\u03baB is activated in primary neurons by amyloid \u03b2 peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci. 1997;94:2642\u20137.","journal-title":"Proc Natl Acad Sci"},{"key":"1224_CR29","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.1073\/pnas.95.10.5795","volume":"95","author":"KT Akama","year":"1998","unstructured":"Akama KT, Albanese C, Pestell RG, Van Eldik LJ. Amyloid \u03b2-peptide stimulates nitric oxide production in astrocytes through an NF\u03baB-dependent mechanism. Proc Natl Acad Sci. 1998;95:5795\u2013800.","journal-title":"Proc Natl Acad Sci"},{"key":"1224_CR30","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fimmu.2020.00724","volume":"11","author":"J Yang","year":"2020","unstructured":"Yang J, Wise L, Fukuchi K-I. TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer\u2019s disease. Front Immunol. 2020;11:724.","journal-title":"Front Immunol"},{"key":"1224_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neurobiolaging.2020.02.001","volume":"93","author":"D Krishnan","year":"2020","unstructured":"Krishnan D, Menon RN, Mathuranath PS, Gopala S. A novel role for SHARPIN in amyloid-\u03b2 phagocytosis and inflammation by peripheral blood-derived macrophages in Alzheimer\u2019s disease. Neurobiol Aging. 2020;93:131\u201341.","journal-title":"Neurobiol Aging"},{"key":"1224_CR32","doi-asserted-by":"crossref","unstructured":"Krishnan D, Menon RN, Gopala S. SHARPIN: Role in finding NEMO and in amyloid-beta clearance and degradation (ABCD) pathway in Alzheimer\u2019s disease? Cell Mol Neurobiol. 2022;42:1267\u201381.","DOI":"10.1007\/s10571-020-01023-w"},{"key":"1224_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep30953","volume":"6","author":"J Hernandez-Rapp","year":"2016","unstructured":"Hernandez-Rapp J, Rainone S, Goupil C, Dorval V, Smith PY, Saint-Pierre M, et al. microRNA-132\/212 deficiency enhances A\u03b2 production and senile plaque deposition in Alzheimer\u2019s disease triple transgenic mice. Sci Rep. 2016;6:1\u201311.","journal-title":"Sci Rep"},{"key":"1224_CR34","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1111\/jcmm.12863","volume":"20","author":"NS Leal","year":"2016","unstructured":"Leal NS, Schreiner B, Pinho CM, Filadi R, Wiehager B, Karlstr\u00f6m H, et al. Mitofusin-2 knockdown increases ER\u2013mitochondria contact and decreases amyloid \u03b2-peptide production. J Cell Mol Med. 2016;20:1686\u201395.","journal-title":"J Cell Mol Med"},{"key":"1224_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-30788-w","volume":"8","author":"I Khan","year":"2018","unstructured":"Khan I, Krishnaswamy S, Sabale M, Groth D, Wijaya L, Morici M, et al. Efficient production of a mature and functional gamma secretase protease. Sci Rep. 2018;8:1\u201315.","journal-title":"Sci Rep"},{"key":"1224_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmolb.2023.1089213","volume":"10","author":"Y Sato","year":"2023","unstructured":"Sato Y, Terawaki S, Oikawa D, Shimizu K, Okina Y, Ito H, et al. Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer\u2019s disease and amyotrophic lateral sclerosis. Front Mol Biosci. 2023;10:1\u201315.","journal-title":"Front Mol Biosci"},{"key":"1224_CR37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al. Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol. 2015;14:388\u2013405.","journal-title":"Lancet Neurol"},{"key":"1224_CR38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","volume":"17","author":"F Leng","year":"2021","unstructured":"Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol. 2021;17:157\u201372.","journal-title":"Nat Rev Neurol"},{"key":"1224_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-023-01155-w","volume":"15","author":"M Jorfi","year":"2023","unstructured":"Jorfi M, Maaser-Hecker A, Tanzi RE. The neuroimmune axis of Alzheimer\u2019s disease. Genome Med. 2023;15:6.","journal-title":"Genome Med"},{"key":"1224_CR40","doi-asserted-by":"publisher","first-page":"eabi8654","DOI":"10.1126\/science.abi8654","volume":"377","author":"YA Cooper","year":"2022","unstructured":"Cooper YA, Teyssier N, Dr\u00e4ger NM, Guo Q, Davis JE, Sattler SM, et al. Functional regulatory variants implicate distinct transcriptional networks in dementia. Science. 2022;377:eabi8654.","journal-title":"Science"},{"key":"1224_CR41","doi-asserted-by":"crossref","unstructured":"Alves F, Kallinowski P, Ayton S. Accelerated Brain Volume Loss Caused by Anti\u2013\u03b2-Amyloid Drugs: A Systematic Review and Meta-analysis. Neurology. 2023;100:e2114\u201324.","DOI":"10.1212\/WNL.0000000000207156"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01224-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01224-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01224-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T19:03:00Z","timestamp":1713985380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01224-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1038\/s10038-024-01224-x","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"10 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}