{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:46:29Z","timestamp":1773305189485,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Genet"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1038\/s10038-024-01251-8","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T06:01:53Z","timestamp":1714024913000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study"],"prefix":"10.1038","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-4466","authenticated-orcid":false,"given":"Reeta","family":"Mahey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Dada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani","family":"Kalaivani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohitha","family":"Cheluvaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neena","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Saini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeta","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neerja","family":"Bhatla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"1251_CR1","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1093\/humrep\/der106","volume":"26","author":"SK Sunkara","year":"2011","unstructured":"Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod. 2011;26:1768\u201374.","journal-title":"Hum Reprod"},{"key":"1251_CR2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/humupd\/dmr034","volume":"17","author":"S Altm\u00e4e","year":"2011","unstructured":"Altm\u00e4e S, Hovatta O, Stavreus-Evers A, Salumets A. Genetic predictors of controlled ovarian hyperstimulation: where do we stand today? Hum Reprod Update. 2011;17:813\u201328.","journal-title":"Hum Reprod Update"},{"key":"1251_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-1-4939-0659-8_4","volume":"1154","author":"L Casarini","year":"2014","unstructured":"Casarini L, Simoni M. Gene polymorphisms in female reproduction. Methods Mol Biol. 2014;1154:75\u201390.","journal-title":"Methods Mol Biol"},{"key":"1251_CR4","first-page":"78","volume":"27","author":"F Dieamant","year":"2023","unstructured":"Dieamant F, Petersen CG, Vagnini LD, Petersen B, Ricci J, Nicoletti A, et al. The Ala307Thr polymorphism of the follicle-stimulating hormone receptor (FSHR) gene is associated with the dose of recombinant FSH received during IVF\/ICSI treatment. JBRA Assist Reprod. 2023;27:78\u201384.","journal-title":"JBRA Assist Reprod"},{"key":"1251_CR5","first-page":"3365","volume":"85","author":"M Perez Mayorga","year":"2000","unstructured":"Perez Mayorga M, Gromoll J, Behre HM, Gassner C, Nieschlag E, Simoni M. Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab. 2000;85:3365\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"1251_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/humupd\/dmy019","volume":"24","author":"C Alviggi","year":"2018","unstructured":"Alviggi C, Conforti A, Santi D, Esteves SC, Andersen CY, Humaidan P, et al. Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled. ovarian stimulation: a systematic review and meta-analysis. Hum Reprod Update. 2018b;24:1\u201316.","journal-title":"Hum Reprod Update"},{"key":"1251_CR7","doi-asserted-by":"crossref","unstructured":"Nenonen HA, Lindgren IA, Prahl AS, Trzybulska D, Kharraziha I, Hult\u00e9n M. The N680S variant in the follicle-stimulating hormone receptor gene identifies hyperresponders to controlled ovarian stimulation. Pharmacogenet Genomics 2019;29:114\u201320.","DOI":"10.1097\/FPC.0000000000000374"},{"key":"1251_CR8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.fertnstert.2007.11.093","volume":"91","author":"SK Achrekar","year":"2009","unstructured":"Achrekar SK, Modi DN, Desai SK, Mangoli VS, Mangoli RV, Mahale SD. Follicle-stimulating hormone receptor polymorphism (Thr307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women. Fertil Steril. 2009;91:432\u20139.","journal-title":"Fertil Steril"},{"key":"1251_CR9","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1093\/humrep\/deab068","volume":"36","author":"NP Plozos","year":"2021","unstructured":"Plozos NP, Neves AR, Drakopoulos P, Spits C, Mercadal BA, Gracia S, et al. The effect of polymorphisms in FSHR and FSHB genes on ovarian response: a prospective multicenter multinational study in Europe and Asia. Hum Reprod. 2021;36:1711\u201321.","journal-title":"Hum Reprod"},{"key":"1251_CR10","doi-asserted-by":"publisher","first-page":"R91","DOI":"10.1530\/EJE-13-0624","volume":"170","author":"M Simoni","year":"2014","unstructured":"Simoni M, Casarini L. Mechanisms in endocrinology: genetics of FSH action a 2014-and-beyond view. Eur J Endocrinol. 2014;170:R91\u2013107.","journal-title":"Eur J Endocrinol"},{"key":"1251_CR11","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.fertnstert.2013.01.086","volume":"99","author":"A La Marca","year":"2013","unstructured":"La Marca A, Sighinolfi G, Argento C, Grisendi V, Casarini L, Volpe A, et al. Polymorphisms in gonadotropin and gonadotropin receptor genes as markers of ovarian reserve and response in. in vitro fertilization. Fertil Steril. 2013;99:970\u20138.e1.","journal-title":"Fertil Steril"},{"key":"1251_CR12","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1159\/000366356","volume":"34","author":"CM Trevisan","year":"2014","unstructured":"Trevisan CM, Peluso C, Cordts EB, R De O, Christofolini DM, Barbosa CP, et al. Ala307Thr and Asn680Ser polymorphisms of FSHR gene in human reproduction outcomes. Cell Physiol Biochem. 2014;34:1527\u201335.","journal-title":"Cell Physiol Biochem"},{"key":"1251_CR13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.rbmo.2019.05.018","volume":"39","author":"TE K\u00f6nig","year":"2019","unstructured":"K\u00f6nig TE, J van der L, Schats R, Lambalk CB. The relationship between FSH receptor polymorphism status and IVF cycle outcome: a retro- spective observational study. Reprod Biomed Online. 2019;39:231\u201340.","journal-title":"Reprod Biomed Online"},{"key":"1251_CR14","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1023\/B:JARG.0000013651.37866.0c","volume":"20","author":"YC Lin","year":"2003","unstructured":"Lin YC, Chang SY, Lan KC, Huang HW, Chang CY, Tsai MY, et al. Human oocyte maturity in vivo determines the outcome of blastocyst development in vitro. J Assist Reprod Genet. 2003;20:506\u201312.","journal-title":"J Assist Reprod Genet"},{"key":"1251_CR15","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/S1472-6483(11)60010-2","volume":"22","author":"EAM Kuijper","year":"2011","unstructured":"Kuijper EAM, Blankenstein MA, Luttikhof LJ, Roek SJM, Overbeek A, Hompes PG, et al. Frequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicity. Reprod Biomed Online. 2011;22:S60\u201365.","journal-title":"Reprod Biomed Online"},{"key":"1251_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.797365","volume":"12","author":"A Conforti","year":"2022","unstructured":"Conforti A, T\u00fcttelmann F, Alviggi C, Behre HM, Fischer R, Hu L, et al. Effect of genetic variants of gonadotropins and their receptors on ovarian stimulation outcomes: a delphi consensus. Front Endocrinol (Lausanne). 2022;12:797365.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1251_CR17","doi-asserted-by":"publisher","first-page":"e78138","DOI":"10.1371\/journal.pone.0078138","volume":"8","author":"Y Yan","year":"2013","unstructured":"Yan Y, Gong Z, Zhang L, Li Y, Li X, Zhu L, et al. Association of follicle-stimulating hormone receptor polymorphisms with ovarian response in Chinese women: a prospective clinical study. PloS One. 2013;8:e78138.","journal-title":"PloS One"},{"key":"1251_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/cen.12573","volume":"82","author":"X Huang","year":"2015","unstructured":"Huang X, Li L, Hong L, Zhou W, Shi H, Zhang H, et al. The Ser680Asn polymorphism in the follicle-stimulating hormone receptor gene is associated with the ovarian response in controlled ovarian hyperstimulation. Clin Endocrinol. 2015;82:577\u201383.","journal-title":"Clin Endocrinol"},{"key":"1251_CR19","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.rbmo.2013.07.007","volume":"27","author":"SS Desai","year":"2013","unstructured":"Desai SS, Achrekar SK, Paranjape SR, Desai SK, Mangoli VS, Mahale SD. Association of allelic combinations of FSHR gene polymorphisms with ovarian response. Reprod Biomed Online. 2013;27:400\u20136.","journal-title":"Reprod Biomed Online"},{"key":"1251_CR20","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3390\/ijms24021080","volume":"24","author":"MG Baldini","year":"2023","unstructured":"Baldini MG, Catino A, Palini S, Sciorio R, Ferri D, Vinciguerra M, et al. The polymorphism Asn680Ser on the FSH receptor and abnormal ovarian response in patients with normal values of AMH and AFC. Int J Mol Sci 2023;24:1080.","journal-title":"Int J Mol Sci"},{"key":"1251_CR21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4103\/jhrs.jhrs_165_21","volume":"15","author":"B Bayraktar","year":"2022","unstructured":"Bayraktar B, G\u00fclec\u0327 ES, Kutbay YB, K\u00f6se C, G\u00fcr EB, Demir A. Does follicle-stimulating hormone receptor polymorphism status affect In vitro fertilization-intracytoplasmic sperm injection results and live birth rate? A retrospective study. J Hum Reprod Sci. 2022;15:58\u201363.","journal-title":"J Hum Reprod Sci"},{"key":"1251_CR22","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S1472-6483(10)60660-8","volume":"13","author":"ER Klinkert","year":"2006","unstructured":"Klinkert ER, te Velde ER, Weima S, van Zandvoort PM. Hanssen RGJM, Nilsson PR, et al. FSH receptor genotype is associated with pregnancy but not with ovarian response in IVF. Reprod Biomed Online. 2006;13:687\u201395.","journal-title":"Reprod Biomed Online"},{"key":"1251_CR23","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.rbmo.2017.04.012","volume":"35","author":"A Revelli","year":"2017","unstructured":"Revelli A, Carosso A, Grassi G, Gennarelli G. Stefano Canosa 2, Benedetto C. Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment. Reprod Biomed Online. 2017;35:132\u20138.","journal-title":"Reprod Biomed Online"},{"key":"1251_CR24","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10038-006-0005-5","volume":"51","author":"JK Jun","year":"2006","unstructured":"Jun JK, Yoon JS, Ku S-Y, Choi YM, Hwang KR, Park SY, et al. Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET. J Hum Genet. 2006;51:665\u201370.","journal-title":"J Hum Genet"},{"key":"1251_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10815-018-1318-y","volume":"36","author":"I Lindgren","year":"2019","unstructured":"Lindgren I, Nenonen H, Henic E, Bungum L, Prahl A, Bungum M, et al. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization. J Assist Reprod Genet. 2019;36:29\u201338.","journal-title":"J Assist Reprod Genet"}],"container-title":["Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01251-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01251-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01251-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T23:03:34Z","timestamp":1721862214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s10038-024-01251-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1251"],"URL":"https:\/\/doi.org\/10.1038\/s10038-024-01251-8","relation":{},"ISSN":["1434-5161","1435-232X"],"issn-type":[{"value":"1434-5161","type":"print"},{"value":"1435-232X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,25]]},"assertion":[{"value":"11 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was done after ethical approval from the Institute Ethics Committee (IEC).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}