{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:00:41Z","timestamp":1789340441995,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Mol Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved in tumor formation. However, the molecular mechanisms underlying this phenomenon remain largely unclear. Using a well-established model of oxidatively damaged IVF mouse embryos, we applied the iTRAQ method to identify proteins differentially expressed between control and oxidatively damaged zygotes and explored the possible tumorigenic mechanisms, especially with regard to the effects of oxidative damage on ribosome biogenesis closely related to tumorigenesis. The iTRAQ results revealed that ribosomal proteins were upregulated by oxidative stress through the Nucleolin\/\u03b2-Catenin\/n-Myc pathway, which stimulated ribosomes to synthesize an abundance of repair proteins to correct the damaged DNA\/chromosomes in IVF-derived embryos. However, the increased percentages of \u03b3H2AX-positive cells and apoptotic cells in the blastocyst suggested that DNA repair was insufficient, resulting in aberrant ribosome biogenesis. Overexpression of ribosomal proteins, particularly Rpl15, which gradually increased from the 1-cell to 8-cell stages, indicated persistent hyperactivation of ribosome biogenesis, which promoted tumorigenesis in offspring derived from oxidatively damaged IVF embryos by selectively enhancing the translation of \u03b2-Catenin and TGF-\u03b21. The antioxidant epigallocatechin-3-gallate (EGCG) was added to the in vitro culture medium to protect embryos from oxidative damage, and the expression of ribosome-\/tumor-related proteins returned to normal after EGCG treatment. This study suggests that regulation of ribosome biogenesis by EGCG may be a means of preventing tumor formation in human IVF-derived offspring, providing a scientific basis for optimizing in vitro culture conditions and improving human-assisted reproductive technology.<\/jats:p>","DOI":"10.1038\/s12276-021-00700-0","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T17:04:15Z","timestamp":1638291855000},"page":"1792-1806","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-\u03b21 pathways in IVF embryos"],"prefix":"10.1038","volume":"53","author":[{"given":"Yue","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaizhen","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"700_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1542\/peds.2009-3225","volume":"126","author":"B K\u00e4ll\u00e9n","year":"2010","unstructured":"K\u00e4ll\u00e9n, B. et al. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics 126, 270\u2013276 (2010).","journal-title":"Pediatrics"},{"key":"700_CR2","doi-asserted-by":"publisher","first-page":"e190392","DOI":"10.1001\/jamapediatrics.2019.0392","volume":"173","author":"LG Spector","year":"2019","unstructured":"Spector, L. G. et al. Association of in vitro fertilization with childhood cancer in the United States. JAMA Pediatr. 173, e190392 (2019).","journal-title":"JAMA Pediatr."},{"key":"700_CR3","doi-asserted-by":"publisher","first-page":"e20154509","DOI":"10.1542\/peds.2015-4509","volume":"137","author":"ES Amirian","year":"2016","unstructured":"Amirian, E. S. & Bondy, M. L. Assisted reproductive technology and risk of cancer in children. Pediatrics 137, e20154509 (2016).","journal-title":"Pediatrics"},{"key":"700_CR4","doi-asserted-by":"publisher","first-page":"314.e1","DOI":"10.1016\/j.ajog.2017.01.015","volume":"216","author":"T Wainstock","year":"2017","unstructured":"Wainstock, T. et al. Fertility treatments and pediatric neoplasms of the offspring: results of a population-based cohort with a\u2002median follow-up of 10 years. Am. J. Obstet. Gynecol. 216, 314.e1\u2013314.e14 (2017).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"700_CR5","doi-asserted-by":"publisher","first-page":"1521428","DOI":"10.1155\/2016\/1521428","volume":"2016","author":"D Qian","year":"2016","unstructured":"Qian, D. et al. Response of mouse zygotes treated with mild hydrogen peroxide as a model to reveal novel mechanisms of oxidative stress-induced injury in early embryos. Oxid. Med. Cell. Longev. 2016, 1521428 (2016).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"700_CR6","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s12192-016-0693-5","volume":"21","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y. et al. Oxidative stress-induced DNA damage of mouse zygotes triggers G2\/M checkpoint and phosphorylates Cdc25 and Cdc2. Cell Stress Chaperones 21, 687\u2013696 (2016).","journal-title":"Cell Stress Chaperones"},{"key":"700_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.freeradbiomed.2019.04.037","volume":"137","author":"Y Huang","year":"2019","unstructured":"Huang, Y., Ha, S., Li, Z., Li, J. & Xiao, W. CHK1-CENP B\/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilization. Free Radic. Biol. Med. 137, 181\u2013193 (2019).","journal-title":"Free Radic. Biol. Med."},{"key":"700_CR8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.21037\/atm.2016.07.11","volume":"4","author":"M Liontos","year":"2016","unstructured":"Liontos, M., Anastasiou, I., Bamias, A. & Dimopoulos, M. A. DNA damage, tumor mutational load and their impact on immune responses against cancer. Ann. Transl. Med. 4, 264 (2016).","journal-title":"Ann. Transl. Med."},{"key":"700_CR9","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1002\/cncr.31667","volume":"24","author":"LA Williams","year":"2018","unstructured":"Williams, L. A. et al. Klinefelter syndrome in males with germ cell tumors: a report from the Children\u2019s Oncology Group. Cancer 24, 3900\u20133908 (2018).","journal-title":"Cancer"},{"key":"700_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1146\/annurev-biochem-013118-110817","volume":"88","author":"J Ba\u00dfler","year":"2019","unstructured":"Ba\u00dfler, J. & Hurt, E. Eukaryotic ribosome assembly. Annu. Rev. Biochem. 88, 281\u2013306 (2019).","journal-title":"Annu. Rev. Biochem."},{"key":"700_CR11","doi-asserted-by":"publisher","first-page":"ra56","DOI":"10.1126\/scisignal.2001754","volume":"4","author":"JC Chan","year":"2011","unstructured":"Chan, J. C. et al. AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. Sci. Signal. 4, ra56 (2011).","journal-title":"Sci. Signal."},{"key":"700_CR12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.gde.2017.10.003","volume":"48","author":"XR Bustelo","year":"2018","unstructured":"Bustelo, X. R. & Dosil, M. Ribosome biogenesis and cancer: basic and translational challenges. Curr. Opin. Genet. Dev. 48, 22\u201329 (2018).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"700_CR13","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.3390\/cells9112361","volume":"9","author":"SN Slimane","year":"2020","unstructured":"Slimane, S. N. et al. Ribosome biogenesis alterations in colorectal cancer. Cells 9, 2361 (2020).","journal-title":"Cells"},{"key":"700_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nrm3359","volume":"13","author":"S Xue","year":"2012","unstructured":"Xue, S. & Barna, M. Specialized ribosomes: a new frontier in gene regulation and organismal biology. Nat. Rev. Mol. Cell Biol. 13, 355\u2013369 (2012).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"700_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1182\/blood.2019003439","volume":"137","author":"S Le Goff","year":"2021","unstructured":"Le Goff, S. et al. p53 activation during ribosome biogenesis regulates normal erythroid differentiation. Blood 137, 89\u2013102 (2021).","journal-title":"Blood"},{"key":"700_CR16","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3390\/cells8111379","volume":"8","author":"N Shcherbik","year":"2019","unstructured":"Shcherbik, N. & Pestov, D. G. The impact of oxidative stress on ribosomes: from injury to regulation. Cells 8, 1379 (2019).","journal-title":"Cells"},{"key":"700_CR17","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1080\/19396368.2020.1756525","volume":"66","author":"M Chen","year":"2020","unstructured":"Chen, M., Liu, W., Li, Z. & Xiao, W. Effect of epigallocatechin-3-gallate (EGCG) on embryos inseminated with oxidative stress-induced DNA damage sperm. Syst. Biol. Reprod. Med. 66, 244\u2013254 (2020).","journal-title":"Syst. Biol. Reprod. Med."},{"key":"700_CR18","doi-asserted-by":"publisher","first-page":"951","DOI":"10.3390\/cancers12040951","volume":"12","author":"AA Farooqi","year":"2020","unstructured":"Farooqi, A. A. et al. EGCG mediated targeting of deregulated signaling pathways and non-coding RNAs in different cancers: focus on JAK\/STAT, Wnt\/beta-Catenin, TGF\/SMAD, NOTCH, SHH\/GLI, and TRAIL mediated signaling pathways. Cancers 12, 951 (2020).","journal-title":"Cancers"},{"key":"700_CR19","doi-asserted-by":"publisher","first-page":"609290","DOI":"10.3389\/fcell.2020.609290","volume":"8","author":"E Lin","year":"2021","unstructured":"Lin, E., Li, Z., Huang, Y., Ru, G. & He, P. High dosages of equine chorionic gonadotropin exert adverse effects on the developmental competence of IVF-derived mouse embryos and cause oxidative stress-induced aneuploidy. Front. Cell Dev. Biol. 8, 609290 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"700_CR20","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1159\/000430283","volume":"36","author":"H Li","year":"2015","unstructured":"Li, H. et al. Differential proteomic analysis of syncytiotrophoblast extracellular vesicles from early-onset severe preeclampsia, using 8-plex iTRAQ labeling coupled with 2D Nano LC-MS\/MS. Cell. Physiol. Biochem. 36, 1116\u20131130 (2015).","journal-title":"Cell. Physiol. Biochem."},{"key":"700_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1083\/jcb.201407095","volume":"207","author":"GJ Brouhard","year":"2014","unstructured":"Brouhard, G. J. & Rice, L. M. The contribution of \u03b1\u03b2-tubulin curvature to microtubule dynamics. J. Cell Biol. 207, 323\u2013334 (2014).","journal-title":"J. Cell Biol."},{"key":"700_CR22","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1126\/science.aar7462","volume":"361","author":"J Reichmann","year":"2018","unstructured":"Reichmann, J. et al. Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos. Science 361, 189\u2013193 (2018).","journal-title":"Science"},{"key":"700_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/humrep\/16.2.313","volume":"16","author":"T Hardarson","year":"2001","unstructured":"Hardarson, T., Hanson, C., Sjogren, A. & Lundin, K. Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation. Hum. Reprod. 16, 313\u2013318 (2001).","journal-title":"Hum. Reprod."},{"key":"700_CR24","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1007\/s00018-019-03078-5","volume":"76","author":"KI Cho","year":"2019","unstructured":"Cho, K. I., Yoon, D., Yu, M., Peachey, N. S. & Ferreira, P. A. Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons. Cell. Mol. Life Sci. 76, 3407\u20133432 (2019).","journal-title":"Cell. Mol. Life Sci."},{"key":"700_CR25","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s13046-019-1290-0","volume":"38","author":"W Zhang","year":"2019","unstructured":"Zhang, W. et al. IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation. J. Exp. Clin. Cancer Res. 38, 296 (2019).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"700_CR26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/carcin\/bgx006","volume":"38","author":"N Wiesmann","year":"2017","unstructured":"Wiesmann, N. et al. Knockdown of hnRNPK leads to increased DNA damage after irradiation and reduces survival of tumor cells. Carcinogenesis 38, 321\u2013328 (2017).","journal-title":"Carcinogenesis"},{"key":"700_CR27","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1159\/000487978","volume":"45","author":"H Yoon","year":"2018","unstructured":"Yoon, H. et al. Knockdown of PRKAR2B results in the failure of oocyte maturation. Cell. Physiol. Biochem. 45, 2009\u20132020 (2018).","journal-title":"Cell. Physiol. Biochem."},{"key":"700_CR28","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1016\/j.jmb.2020.03.020","volume":"432","author":"M Moreno-Onate","year":"2020","unstructured":"Moreno-Onate, M., Herrero-Ruiz, A. M., Garcia-Dominguez, M., Cortes-Ledesma, F. & Ruiz, J. F. RanBP2-mediated SUMOylation promotes human DNA polymerase Lambda nuclear localization and DNA repair. J. Mol. Biol. 432, 3965\u20133979 (2020).","journal-title":"J. Mol. Biol."},{"key":"700_CR29","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1093\/nar\/gkz1242","volume":"48","author":"MN Okur","year":"2020","unstructured":"Okur, M. N. et al. Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation. Nucleic Acids Res. 48, 2473\u20132485 (2020).","journal-title":"Nucleic Acids Res."},{"key":"700_CR30","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/emboj\/20.6.1383","volume":"20","author":"K Boon","year":"2001","unstructured":"Boon, K. et al. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J. 20, 1383\u20131393 (2001).","journal-title":"EMBO J."},{"key":"700_CR31","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/s41375-019-0401-4","volume":"33","author":"S Reister","year":"2019","unstructured":"Reister, S., Mahotka, C., van den Hofel, N. & Grinstein, E. Nucleolin promotes Wnt signaling in human hematopoietic stem\/progenitor cells. Leukemia 33, 1052\u20131054 (2019).","journal-title":"Leukemia"},{"key":"700_CR32","doi-asserted-by":"publisher","first-page":"e7656","DOI":"10.15252\/msb.20177656","volume":"14","author":"B Rauscher","year":"2018","unstructured":"Rauscher, B. et al. Toward an integrated map of genetic interactions in cancer cells. Mol. Syst. Biol. 14, e7656 (2018).","journal-title":"Mol. Syst. Biol."},{"key":"700_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.biocel.2017.07.023","volume":"90","author":"Y Wu","year":"2017","unstructured":"Wu, Y. et al. Calreticulin regulates TGF-\u03b21-induced epithelial mesenchymal transition through modulating Smad signaling and calcium signaling. Int. J. Biochem. Cell Biol. 90, 103\u2013113 (2017).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"700_CR34","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ebiom.2019.09.013","volume":"48","author":"T Zhou","year":"2019","unstructured":"Zhou, T. et al. Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2(-\/-) mouse model of primary sclerosing cholangitis (PSC). EBioMedicine 48, 130\u2013142 (2019).","journal-title":"EBioMedicine"},{"key":"700_CR35","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.bbamcr.2018.05.017","volume":"1865","author":"S Yang","year":"2018","unstructured":"Yang, S., Jia, R. & Bian, Z. SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma. Biochim. Biophys. Acta Mol. Cell Res. 1865, 1161\u20131172 (2018).","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"700_CR36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.canlet.2020.07.008","volume":"490","author":"H Zhang","year":"2020","unstructured":"Zhang, H. et al. Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B. Cancer Lett. 490, 54\u201365 (2020).","journal-title":"Cancer Lett."},{"key":"700_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.trecan.2020.08.003","volume":"7","author":"S Bursa\u0107","year":"2021","unstructured":"Bursa\u0107, S., Prodan, Y., Pullen, N., Bartek, J. & Volarevi\u0107, S. Dysregulated ribosome biogenesis reveals therapeutic liabilities in cancer. Trends Cancer 7, 57\u201376 (2021).","journal-title":"Trends Cancer"},{"key":"700_CR38","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1126\/science.aay0939","volume":"367","author":"RY Ebright","year":"2020","unstructured":"Ebright, R. Y. et al. Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science 367, 1468\u20131473 (2020).","journal-title":"Science"},{"key":"700_CR39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrc.2017.104","volume":"18","author":"J Pelletier","year":"2018","unstructured":"Pelletier, J., Thomas, G. & Volarevic, S. Ribosome biogenesis in cancer: new players and therapeutic avenues. Nat. Rev. Cancer 18, 51\u201363 (2018).","journal-title":"Nat. Rev. Cancer"},{"key":"700_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10100-8","volume":"10","author":"V Prakash","year":"2019","unstructured":"Prakash, V. et al. Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease. Nat. Commun. 10, 2110 (2019).","journal-title":"Nat. Commun."},{"key":"700_CR41","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.canlet.2016.08.016","volume":"382","author":"SJ He","year":"2016","unstructured":"He, S. J. et al. Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB\/p70S6K\/RPL15 axis in human leukemia cells. Cancer Lett. 382, 215\u2013230 (2016).","journal-title":"Cancer Lett."},{"key":"700_CR42","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1038\/s41388-018-0611-7","volume":"38","author":"\u00d8H Hald","year":"2019","unstructured":"Hald, \u00d8. H. et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene 38, 2800\u20132813 (2019).","journal-title":"Oncogene"},{"key":"700_CR43","doi-asserted-by":"crossref","first-page":"e1519","DOI":"10.1002\/wrna.1519","volume":"10","author":"X Zheng","year":"2019","unstructured":"Zheng, X., Ma, W. K. & Tran, E. J. The DDX5\/Dbp2 subfamily of DEAD-box RNA helicases. Wiley Interdiscip. Rev. RNA 10, e1519 (2019).","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"700_CR44","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1053\/j.gastro.2017.03.050","volume":"153","author":"L Cui","year":"2017","unstructured":"Cui, L. et al. Small nucleolar noncoding RNA SNORA23, up-regulated in human pancreatic ductal adenocarcinoma, regulates expression of spectrin repeat-containing nuclear envelope 2 to promote growth and metastasis of xenograft tumors in mice. Gastroenterology 153, 292\u2013306.e2 (2017).","journal-title":"Gastroenterology"},{"key":"700_CR45","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1002\/jcp.24604","volume":"229","author":"T Chaillou","year":"2014","unstructured":"Chaillou, T., Kirby, T. J. & McCarthy, J. J. Ribosome biogenesis: emerging evidence for a central role in the regulation of skeletal muscle mass. J. Cell. Physiol. 229, 1584\u20131594 (2014).","journal-title":"J. Cell. Physiol."},{"key":"700_CR46","doi-asserted-by":"publisher","first-page":"e00451","DOI":"10.1128\/MCB.00451-18","volume":"39","author":"G Davuluri","year":"2019","unstructured":"Davuluri, G. et al. Impaired ribosomal biogenesis by noncanonical degradation of beta-catenin during hyperammonemia. Mol. Cell. Biol. 39, e00451\u201318 (2019).","journal-title":"Mol. Cell. Biol."},{"key":"700_CR47","doi-asserted-by":"publisher","first-page":"5620","DOI":"10.1172\/JCI122383","volume":"128","author":"B Madan","year":"2018","unstructured":"Madan, B. et al. Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt\/MYC\/ribosome axis. J. Clin. Invest. 128, 5620\u20135633 (2018).","journal-title":"J. Clin. Invest."},{"key":"700_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02804-3","volume":"11","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer. Cell Death Dis. 11, 604 (2020).","journal-title":"Cell Death Dis."},{"key":"700_CR49","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1080\/15548627.2018.1427022","volume":"14","author":"MN Sutton","year":"2018","unstructured":"Sutton, M. N. et al. RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells. Autophagy 14, 637\u2013653 (2018).","journal-title":"Autophagy"},{"key":"700_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2019.02.026","volume":"304","author":"J Liang","year":"2019","unstructured":"Liang, J. et al. Overexpression of microRNA-519d-3p suppressed the growth of pancreatic cancer cells by inhibiting ribosomal protein S15A-mediated Wnt\/beta-catenin signaling. Chem. Biol. Interact. 304, 1\u20139 (2019).","journal-title":"Chem. Biol. Interact."},{"key":"700_CR51","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.celrep.2016.12.034","volume":"18","author":"Y Zhang","year":"2017","unstructured":"Zhang, Y. et al. Ribosomal proteins Rpl22 and Rpl22l1 control morphogenesis by regulating pre-mRNA splicing. Cell Rep. 18, 545\u2013556 (2017).","journal-title":"Cell Rep."},{"key":"700_CR52","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1002\/jcp.29186","volume":"235","author":"Z Wang","year":"2020","unstructured":"Wang, Z. et al. The emerging roles of hnRNPK. J. Cell. Physiol. 235, 1995\u20132008 (2020).","journal-title":"J. Cell. Physiol."},{"key":"700_CR53","doi-asserted-by":"publisher","first-page":"e00803","DOI":"10.1128\/JVI.00803-20","volume":"94","author":"W Liu","year":"2020","unstructured":"Liu, W. et al. hnRNP K is a novel internal ribosomal entry site-transacting factor that negatively regulates foot-and-mouth disease virus translation and replication and is antagonized by viral 3C protease. J. Virol. 94, e00803\u2013e00820 (2020).","journal-title":"J. Virol."},{"key":"700_CR54","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.canlet.2016.03.022","volume":"376","author":"Z Zhang","year":"2016","unstructured":"Zhang, Z. et al. Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT\/\u03b2-catenin pathway to promote growth and metastasis in colorectal cancer. Cancer Lett. 376, 62\u201373 (2016).","journal-title":"Cancer Lett."},{"key":"700_CR55","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.redox.2013.01.013","volume":"1","author":"G Yang","year":"2013","unstructured":"Yang, G. et al. Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: role of \u03b2-catenin\/hnRNPK signaling. Redox Biol. 1, 234\u2013243 (2013).","journal-title":"Redox Biol."},{"key":"700_CR56","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/pmic.200900819","volume":"11","author":"LP Li","year":"2011","unstructured":"Li, L. P. et al. Subcellular proteomics revealed the epithelial-mesenchymal transition phenotype in lung cancer. Proteomics 11, 429\u2013439 (2011).","journal-title":"Proteomics"},{"key":"700_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6119-x","volume":"19","author":"L Li","year":"2019","unstructured":"Li, L. et al. Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-\u03b21-mediated epithelial to mesenchymal transition in lung cancer cells. BMC Cancer 19, 894 (2019).","journal-title":"BMC Cancer"},{"key":"700_CR58","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.fertnstert.2019.03.006","volume":"112","author":"H He","year":"2019","unstructured":"He, H. et al. Neonatal outcomes of live births after blastocyst biopsy in preimplantation genetic testing cycles: a follow-up of 1,721 children. Fertil. Steril. 112, 82\u201388 (2019).","journal-title":"Fertil. Steril."},{"key":"700_CR59","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.fertnstert.2016.07.1095","volume":"106","author":"N Desai","year":"2016","unstructured":"Desai, N. et al. Delayed blastulation, multinucleation, and expansion grade are independently associated with live-birth rates in frozen blastocyst transfer cycles. Fertil. Steril. 106, 1370\u20131378 (2016).","journal-title":"Fertil. Steril."},{"key":"700_CR60","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1093\/humrep\/dew098","volume":"31","author":"TT Truong","year":"2016","unstructured":"Truong, T. T., Soh, Y. M. & Gardner, D. K. Antioxidants improve mouse preimplantation embryo development and viability. Hum. Reprod. 31, 1445\u20131454 (2016).","journal-title":"Hum. Reprod."}],"container-title":["Experimental &amp; Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s12276-021-00700-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s12276-021-00700-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s12276-021-00700-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T10:50:52Z","timestamp":1699872652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s12276-021-00700-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["700"],"URL":"https:\/\/doi.org\/10.1038\/s12276-021-00700-0","relation":{},"ISSN":["1226-3613","2092-6413"],"issn-type":[{"value":"1226-3613","type":"print"},{"value":"2092-6413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"1 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPETING INTERESTS"}}]}}