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ILCs are typically classified into three subsets, as is the case for T-cells. Recent studies have reported that IL-10-producing type 2 ILCs (ILC2<jats:sub>10<\/jats:sub>s) have an immunoregulatory function dependent on IL-10. However, the surface markers of ILC2<jats:sub>10<\/jats:sub>s and the role of ILC2<jats:sub>10<\/jats:sub>s in contact hypersensitivity (CHS) are largely unknown. Our study revealed that splenic ILC2<jats:sub>10<\/jats:sub>s are extensively included in PD-L1<jats:sup>high<\/jats:sup>Sca-1<jats:sup>+<\/jats:sup> ILCs and that IL-27 amplifies the development of PD-L1<jats:sup>high<\/jats:sup>Sca-1<jats:sup>+<\/jats:sup> ILCs and ILC2<jats:sub>10<\/jats:sub>s. Adoptive transfer of PD-L1<jats:sup>high<\/jats:sup>Sca-1<jats:sup>+<\/jats:sup> ILCs suppressed oxazolone-induced CHS in an IL-10-dependent manner Taken together, our results demonstrate that ILC2<jats:sub>10<\/jats:sub>s are critical for the control of CHS and suggest that ILC2<jats:sub>10<\/jats:sub>s can be used as target cells for the treatment of CHS.<\/jats:p>","DOI":"10.1038\/s12276-024-01187-1","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T02:02:17Z","timestamp":1709258537000},"page":"616-629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner"],"prefix":"10.1038","volume":"56","author":[{"given":"Keun Young","family":"Min","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-4868","authenticated-orcid":false,"given":"Do-Kyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Geun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"min Yeong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-4841","authenticated-orcid":false,"given":"Yeonseok","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-0142","authenticated-orcid":false,"given":"Hyuk Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahn Soo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"1187_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/ni.3489","volume":"17","author":"C Klose","year":"2016","unstructured":"Klose, C. & Artis, D. 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