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The orchestrated organization of actin filaments is controlled by various actin regulatory proteins. Wiskott\u2012Aldrich syndrome protein-family verprolin-homologous protein (WAVE) members are key activators of ARP2\/3 complex-mediated actin polymerization. WAVE proteins exist as heteropentameric complexes together with regulatory proteins, including CYFIP, NCKAP, ABI and BRK1. The activity of the WAVE complex is tightly regulated by extracellular cues and intracellular signaling to execute its roles in specific intracellular events in brain cells. Notably, dysregulation of the WAVE complex and WAVE complex-mediated cellular processes confers vulnerability to a variety of brain disorders. De novo mutations in WAVE genes and other components of the WAVE complex have been identified in patients with developmental disorders such as intellectual disability, epileptic seizures, schizophrenia, and\/or autism spectrum disorder. In addition, alterations in the WAVE complex are implicated in the pathophysiology of Alzheimer\u2019s disease and Parkinson\u2019s disease, as well as in behavioral adaptations to psychostimulants or maladaptive feeding.<\/jats:p>","DOI":"10.1038\/s12276-024-01386-w","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:12:15Z","timestamp":1736215935000},"page":"13-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The WAVE complex in developmental and adulthood brain disorders"],"prefix":"10.1038","volume":"57","author":[{"given":"Hyung-Goo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Berdasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-0195","authenticated-orcid":false,"given":"Angus C.","family":"Nairn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-2962","authenticated-orcid":false,"given":"Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"1386_CR1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ceb.2020.08.012","volume":"68","author":"V Papalazarou","year":"2021","unstructured":"Papalazarou, V. & Machesky, L. 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