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In this Review, we integrate findings from spatial transcriptomics\/proteomics, single-cell and multimodal omics, and computational systems modelling to frame brain metastasis as a multiscale communication disorder in which immune, glial, vascular and systemic networks collectively shape tumour-permissive ecosystems. We discuss how network-based analyses identify communication hubs that can be translated into therapeutic hypotheses and provide a rationale to guide drug repurposing and rational combination strategies targeting tumour\u2013microenvironment interactions. We further examine how multiscale modelling and artificial-intelligence-enabled integration of spatial and molecular data may enable patient stratification, response prediction, and adaptive trial designs, while highlighting key barriers, including data harmonization, spatial resolution limits, model interpretability and clinical deployment constraints. 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