{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:55:54Z","timestamp":1793796954324,"version":"4.6.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1038\/s41366-018-0145-7","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T08:52:40Z","timestamp":1531471960000},"page":"906-916","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity"],"prefix":"10.1038","volume":"43","author":[{"given":"Jennifer A.","family":"Salati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H. J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias C.","family":"Schabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie O.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Kroenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Grove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio E.","family":"Frias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"145_CR1","unstructured":"Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009\u20132010. NCHS Data Brief. 2012;82:1\u20138."},{"key":"145_CR2","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.ypmed.2013.02.015","volume":"56","author":"SC Fisher","year":"2013","unstructured":"Fisher SC, Kim SY, Sharma AJ, Rochat R, Morrow B. Is obesity still increasing among pregnant women? Prepregnancy obesity trends in 20 states, 2003\u20132009. Prev Med. 2013;56:372\u20138.","journal-title":"Prev Med"},{"key":"145_CR3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/AOG.0000000000000591","volume":"125","author":"L Schummers","year":"2015","unstructured":"Schummers L, Hutcheon JA, Bodnar LM, Lieberman E, Himes KP. Risk of adverse pregnancy outcomes by prepregnancy body mass index: a population-based study to inform prepregnancy weight loss counseling. Obstet Gynecol. 2015;125:133\u201343.","journal-title":"Obstet Gynecol"},{"key":"145_CR4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.placenta.2009.05.009","volume":"30","author":"D Kidron","year":"2009","unstructured":"Kidron D, Bernheim J, Aviram R. Placental findings contributing to fetal death, a study of 120 stillbirths between 23 and 40 weeks gestation. Placenta. 2009;30:700\u20134.","journal-title":"Placenta"},{"key":"145_CR5","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/01.AOG.0000172422.81496.57","volume":"106","author":"EA Nohr","year":"2005","unstructured":"Nohr EA, Bech BH, Davies MJ, Frydenberg M, Henriksen TB, Olsen J. Prepregnancy obesity and fetal death: a study within the Danish National Birth Cohort. Obstet Gynecol. 2005;106:250\u20139.","journal-title":"Obstet Gynecol"},{"key":"145_CR6","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1136\/jcp.2008.055236","volume":"61","author":"DJ Roberts","year":"2008","unstructured":"Roberts DJ, Post MD. The placenta in preeclampsia and intrauterine growth restriction. J Clin Pathol. 2008;61:1254\u201360.","journal-title":"J Clin Pathol"},{"key":"145_CR7","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.placenta.2007.12.010","volume":"29","author":"JC Challier","year":"2008","unstructured":"Challier JC, Basu S, Bintein T, et al. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008;29:274\u201381.","journal-title":"Placenta"},{"key":"145_CR8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJM199801153380302","volume":"338","author":"S Cnattingius","year":"1998","unstructured":"Cnattingius S, Bergstrom R, Lipworth L, Kramer MS. Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med. 1998;338:147\u201352.","journal-title":"N Engl J Med"},{"key":"145_CR9","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1210\/jc.2006-2083","volume":"92","author":"FM Stewart","year":"2007","unstructured":"Stewart FM, Freeman DJ, Ramsay JE, Greer IA, Caslake M, Ferrell WR. Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. J Clin Endocrinol Metab. 2007;92:969\u201375.","journal-title":"J Clin Endocrinol Metab"},{"key":"145_CR10","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1210\/en.2010-1332","volume":"152","author":"AE Frias","year":"2011","unstructured":"Frias AE, Morgan TK, Evans AE, et al. Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. Endocrinology. 2011;152:2456\u201364.","journal-title":"Endocrinology"},{"key":"145_CR11","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1096\/fj.13-245472","volume":"28","author":"VH Roberts","year":"2014","unstructured":"Roberts VH, Pound LD, Thorn SR, et al. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014;28:2466\u201377.","journal-title":"FASEB J"},{"key":"145_CR12","doi-asserted-by":"publisher","first-page":"e33370","DOI":"10.1371\/journal.pone.0033370","volume":"7","author":"EK Hayes","year":"2012","unstructured":"Hayes EK, Lechowicz A, Petrik JJ, et al. Adverse fetal and neonatal outcomes associated with a life-long high-fat diet: role of altered development of the placental vasculature. PLoS One. 2012;7:e33370.","journal-title":"PLoS One"},{"key":"145_CR13","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.metabol.2009.10.015","volume":"59","author":"C Liang","year":"2010","unstructured":"Liang C, DeCourcy K, Prater MR. High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL\/6 mice. Metabolism. 2010;59:943\u201350.","journal-title":"Metabolism"},{"key":"145_CR14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1053\/plac.1999.0440","volume":"21","author":"JM Wallace","year":"2000","unstructured":"Wallace JM, Bourke DA, Aitken RP, Palmer RM, Da Silva P, Cruickshank MA. Relationship between nutritionally mediated placental growth restriction and fetal growth, body composition and endocrine status during late gestation in adolescent sheep. Placenta. 2000;21:100\u20138.","journal-title":"Placenta"},{"key":"145_CR15","first-page":"323","volume":"119","author":"CE McCurdy","year":"2009","unstructured":"McCurdy CE, Bishop JM, Williams SM, et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest. 2009;119:323\u201335.","journal-title":"J Clin Invest"},{"key":"145_CR16","doi-asserted-by":"publisher","first-page":"e86612","DOI":"10.1172\/jci.insight.86612","volume":"1","author":"CE McCurdy","year":"2016","unstructured":"McCurdy CE, Schenk S, Hetrick B, et al. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016;1:e86612.","journal-title":"JCI Insight"},{"key":"145_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1530\/JOE-12-0424","volume":"217","author":"LE Nicol","year":"2013","unstructured":"Nicol LE, Grant WF, Comstock SM, et al. Pancreatic inflammation and increased islet macrophages in insulin-resistant juvenile primates. J Endocrinol. 2013;217:207\u201313.","journal-title":"J Endocrinol"},{"key":"145_CR18","doi-asserted-by":"publisher","first-page":"E115","DOI":"10.1152\/ajpendo.00131.2014","volume":"307","author":"LD Pound","year":"2014","unstructured":"Pound LD, Comstock SM, Grove KL. Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model. Am J Physiol Endocrinol Metab. 2014;307:E115\u2013123.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"145_CR19","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.placenta.2014.02.012","volume":"35","author":"AE Guttmacher","year":"2014","unstructured":"Guttmacher AE, Maddox YT, Spong CY. The Human Placenta Project: placental structure, development, and function in real time. Placenta. 2014;35:303\u20134.","journal-title":"Placenta"},{"key":"145_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cpcardiol.2006.10.004","volume":"32","author":"BA Kaufmann","year":"2007","unstructured":"Kaufmann BA, Wei K, Lindner JR. Contrast echocardiography. Curr Probl Cardiol. 2007;32:51\u201396.","journal-title":"Curr Probl Cardiol"},{"key":"145_CR21","first-page":"369 e361","volume":"214","author":"VH Roberts","year":"2016","unstructured":"Roberts VH, Lo JO, Salati JA, et al. Quantitative assessment of placental perfusion by contrast-enhanced ultrasound in macaques and human subjects. Am J Obstet Gynecol. 2016;214:369 e361\u2013368.","journal-title":"Am J Obstet Gynecol"},{"key":"145_CR22","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1177\/1933719117704907","volume":"25","author":"VHJ Roberts","year":"2017","unstructured":"Roberts VHJ, Lo JO, Lewandowski KS, et al. Adverse placental perfusion and pregnancy outcomes in a new nonhuman primate model of gestational protein restriction. Reprod Sci. 2017;25:110\u20139.","journal-title":"Reprod Sci"},{"key":"145_CR23","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1002\/mrm.25264","volume":"73","author":"AE Frias","year":"2015","unstructured":"Frias AE, Schabel MC, Roberts VH, et al. Using dynamic contrast-enhanced MRI to quantitatively characterize maternal vascular organization in the primate placenta. Magn Reson Med. 2015;73:1570\u20138.","journal-title":"Magn Reson Med"},{"key":"145_CR24","first-page":"370 e371","volume":"212","author":"JO Lo","year":"2015","unstructured":"Lo JO, Schabel MC, Roberts VH, et al. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. Am J Obstet Gynecol. 2015;212:370 e371\u2013378.","journal-title":"Am J Obstet Gynecol"},{"key":"145_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.placenta.2011.10.003","volume":"33","author":"VH Roberts","year":"2012","unstructured":"Roberts VH, Rasanen JP, Novy MJ, et al. Restriction of placental vasculature in a nonhuman primate: a unique model to study placental plasticity. Placenta. 2012;33:73\u20136.","journal-title":"Placenta"},{"key":"145_CR26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1292\/jvms.10-0501","volume":"74","author":"JY Lee","year":"2012","unstructured":"Lee JY, Kim MC. Anesthesia of growing pigs with tiletamine-zolazepam and reversal with flumazenil. J Vet Med Sci. 2012;74:335\u20139.","journal-title":"J Vet Med Sci"},{"key":"145_CR27","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/uog.3977","volume":"29","author":"G Acharya","year":"2007","unstructured":"Acharya G, Sitras V, Erkinaro T, et al. Experimental validation of uterine artery volume blood flow measurement by Doppler ultrasonography in pregnant sheep. Ultrasound Obstet Gynecol. 2007;29:401\u20136.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"145_CR28","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1067\/mob.2001.117187","volume":"185","author":"JC Konje","year":"2001","unstructured":"Konje JC, Kaufmann P, Bell SC, Taylor DJ. A longitudinal study of quantitative uterine blood flow with the use of color power angiography in appropriate for gestational age pregnancies. Am J Obstet Gynecol. 2001;185:608\u201313.","journal-title":"Am J Obstet Gynecol"},{"key":"145_CR29","doi-asserted-by":"publisher","first-page":"N1","DOI":"10.1088\/0031-9155\/54\/1\/N01","volume":"54","author":"MC Schabel","year":"2009","unstructured":"Schabel MC, Morrell GR. Uncertainty in T(1) mapping using the variable flip angle method with two flip angles. Phys Med Biol. 2009;54:N1\u20138.","journal-title":"Phys Med Biol"},{"key":"145_CR30","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1148\/radiol.15141488","volume":"276","author":"KY Oh","year":"2015","unstructured":"Oh KY, Roberts VH, Schabel MC, Grove KL, Woods M, Frias AE. Gadolinium chelate contrast material in pregnancy: fetal biodistribution in the nonhuman primate. Radiology. 2015;276:110\u20138.","journal-title":"Radiology"},{"key":"145_CR31","first-page":"112","volume":"286","author":"J Prola-Netto","year":"2017","unstructured":"Prola-Netto J, Woods M, Roberts VHJ, et al. Gadolinium chelate safety in pregnancy: barely detectable gadolinium levels in the juvenile nonhuman primate after in utero exposure. Radiology. 2017;286:112\u201328.","journal-title":"Radiology"},{"key":"145_CR32","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/0143-4004(88)90001-X","volume":"9","author":"TM Mayhew","year":"1988","unstructured":"Mayhew TM, Burton GJ. Methodological problems in placental morphometry: apologia for the use of stereology based on sound sampling practice. Placenta. 1988;9:565\u201381.","journal-title":"Placenta"},{"key":"145_CR33","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1098\/rsta.2011.0170","volume":"369","author":"IL Chernyavsky","year":"2011","unstructured":"Chernyavsky IL, Leach L, Dryden IL, Jensen OE. Transport in the placenta: homogenizing haemodynamics in a disordered medium. Philos Trans A Math Phys Eng Sci. 2011;369:4162\u201382.","journal-title":"Philos Trans A Math Phys Eng Sci"},{"key":"145_CR34","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.placenta.2003.10.010","volume":"25","author":"TM Mayhew","year":"2004","unstructured":"Mayhew TM, Charnock-Jones DS, Kaufmann P. Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies. Placenta. 2004;25:127\u201339.","journal-title":"Placenta"},{"key":"145_CR35","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1161\/CIRCULATIONAHA.113.003645","volume":"129","author":"SM Chadderdon","year":"2014","unstructured":"Chadderdon SM, Belcik JT, Bader L, et al. Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively increases with duration of insulin resistance. Circulation. 2014;129:471\u20138.","journal-title":"Circulation"},{"key":"145_CR36","doi-asserted-by":"publisher","first-page":"e48119","DOI":"10.1371\/journal.pone.0048119","volume":"7","author":"WF Grant","year":"2012","unstructured":"Grant WF, Nicol LE, Thorn SR, Grove KL, Friedman JE, Marks DL. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One. 2012;7:e48119.","journal-title":"PLoS One"},{"issue":"5 Pt 1","key":"145_CR37","first-page":"1022","volume":"102","author":"TJ Rosenberg","year":"2003","unstructured":"Rosenberg TJ, Garbers S, Chavkin W, Chiasson MA. Prepregnancy weight and adverse perinatal outcomes in an ethnically diverse population. Obstet Gynecol. 2003;102(5 Pt 1):1022\u20137.","journal-title":"Obstet Gynecol"},{"issue":"Pt 1","key":"145_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1113\/jphysiol.2004.079756","volume":"565","author":"JA Armitage","year":"2005","unstructured":"Armitage JA, Taylor PD, Poston L. Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J Physiol. 2005;565(Pt 1):3\u20138.","journal-title":"J Physiol"},{"key":"145_CR39","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJM199709253371301","volume":"337","author":"RC Whitaker","year":"1997","unstructured":"Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997;337:869\u201373.","journal-title":"N Engl J Med"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41366-018-0145-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41366-018-0145-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41366-018-0145-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:13:47Z","timestamp":1684617227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41366-018-0145-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["145"],"URL":"https:\/\/doi.org\/10.1038\/s41366-018-0145-7","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]},"assertion":[{"value":"8 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}