{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:20:39Z","timestamp":1790796039098,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41366-018-0148-4","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T09:19:47Z","timestamp":1531473587000},"page":"556-566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes"],"prefix":"10.1038","volume":"43","author":[{"given":"Marie-Sophie","family":"Nguyen-Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Nivoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Or\u00e9a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Lemoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Acquaviva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Pagnon-Minot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9reng\u00e8re","family":"Fromy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-0475","authenticated-orcid":false,"given":"Jaswinder K.","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sigaudo-Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"148_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.2337\/diaclin.33.1.40","volume":"33","author":"M Duff","year":"2015","unstructured":"Duff M, Demidova O, Blackburn S, Shubrook J. Cutaneous manifestations of diabetes mellitus. Clin Diabetes. 2015;33:40\u20138.","journal-title":"Clin Diabetes"},{"key":"148_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/01.NCQ.0000347449.83052.1a","volume":"24","author":"C VanGilder","year":"2009","unstructured":"VanGilder C, MacFarlane G, Meyer S, Lachenbruch C. Body mass index, weight, and pressure ulcer prevalence: an analysis of the 2006\u20132007 International Pressure Ulcer Prevalence Surveys. J Nurs Care Qual. 2009;24:127\u201335.","journal-title":"J Nurs Care Qual"},{"key":"148_CR3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/SLA.0b013e3181ad8935","volume":"250","author":"JT Mullen","year":"2009","unstructured":"Mullen JT, Moorman DW, Davenport DL. The obesity paradox: body mass index and outcomes in patients undergoing nonbariatric general surgery. Ann Surg. 2009;250:166\u201372.","journal-title":"Ann Surg"},{"key":"148_CR4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/j.1600-0625.2011.01409.x","volume":"21","author":"A Ibuki","year":"2011","unstructured":"Ibuki A, Akase T, Nagase T, Minematsu T, Nakagami G, Horii M, et al. Skin fragility in obese diabetic mice: possible involvement of elevated oxidative stress and upregulation of matrix metalloproteinases. Exp Dermatol. 2011;21:178\u201383.","journal-title":"Exp Dermatol"},{"key":"148_CR5","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/j.1600-0625.2009.00970.x","volume":"19","author":"T Ezure","year":"2010","unstructured":"Ezure T, Amano S. Increased subcutaneous adipose tissue impairs dermal function in diet-induced obese mice. Exp Dermatol. 2010;19:878\u201382.","journal-title":"Exp Dermatol"},{"key":"148_CR6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/exd.12816","volume":"24","author":"T Ezure","year":"2015","unstructured":"Ezure T, Amano S. Increment of subcutaneous adipose tissue is associated with decrease of elastic fibres in the dermal layer. Exp Dermatol. 2015;24:924\u20139.","journal-title":"Exp Dermatol"},{"key":"148_CR7","doi-asserted-by":"publisher","first-page":"494","DOI":"10.4037\/ajcc2014535","volume":"23","author":"S Hyun","year":"2014","unstructured":"Hyun S, Li X, Vermillion B, Newton C, Fall M, Kaewprag P, et al. Body mass index and pressure ulcers: improved predictability of pressure ulcers in intensive care patients. Am J Crit Care. 2014;23:494\u2013500.","journal-title":"Am J Crit Care"},{"key":"148_CR8","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.mvr.2013.10.001","volume":"90","author":"MS Nguyen-Tu","year":"2013","unstructured":"Nguyen-Tu MS, Begey AL, Decorps J, Boizot J, Sommer P, Fromy B, et al. Skin microvascular response to pressure load in obese mice. Microvasc Res. 2013;90:138\u201343.","journal-title":"Microvasc Res"},{"key":"148_CR9","doi-asserted-by":"crossref","unstructured":"Engin A. Obesity and lipotoxicity. Springer; 2017. p. 1\u2013619.","DOI":"10.1007\/978-3-319-48382-5_1"},{"key":"148_CR10","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1194\/jlr.R700005-JLR200","volume":"48","author":"JK Sethi","year":"2007","unstructured":"Sethi JK, Vidal-Puig AJ. Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007;48:1253\u201362.","journal-title":"J Lipid Res"},{"key":"148_CR11","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2337\/db08-1180","volume":"58","author":"C Lagathu","year":"2009","unstructured":"Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, et al. Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt\/beta-catenin signaling network. Diabetes. 2009;58:609\u201319.","journal-title":"Diabetes"},{"key":"148_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00441-008-0685-6","volume":"335","author":"W Bakker","year":"2009","unstructured":"Bakker W, Eringa EC, Sipkema P, van Hinsbergh VW. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. Cell Tissue Res. 2009;335:165\u201389.","journal-title":"Cell Tissue Res"},{"key":"148_CR13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/10739680701303584","volume":"14","author":"EC Eringa","year":"2007","unstructured":"Eringa EC, Bakker W, Smulders YM, Serne EH, Yudkin JS, Stehouwer CD. Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissue. Microcirculation. 2007;14:389\u2013402.","journal-title":"Microcirculation"},{"key":"148_CR14","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.2337\/db07-1111","volume":"57","author":"ER Duncan","year":"2008","unstructured":"Duncan ER, Crossey PA, Walker S, Anilkumar N, Poston L, Douglas G, et al. Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes. 2008;57:3307\u201314.","journal-title":"Diabetes"},{"key":"148_CR15","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.2337\/diabetes.51.12.3517","volume":"51","author":"KJ Mather","year":"2002","unstructured":"Mather KJ, Mirzamohammadi B, Lteif A, Steinberg HO, Baron AD. Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes. Diabetes. 2002;51:3517\u201323.","journal-title":"Diabetes"},{"key":"148_CR16","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.2337\/db05-1433","volume":"55","author":"C Demiot","year":"2006","unstructured":"Demiot C, Tartas M, Fromy B, Abraham P, Saumet JL, Sigaudo-Roussel D. Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy. Diabetes. 2006;55:1478\u201383.","journal-title":"Diabetes"},{"key":"148_CR17","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/nm.2844","volume":"18","author":"B Fromy","year":"2012","unstructured":"Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M. Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers. Nat Med. 2012;18:1205\u20137.","journal-title":"Nat Med"},{"key":"148_CR18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.mvr.2003.12.001","volume":"67","author":"A Koitka","year":"2004","unstructured":"Koitka A, Legrand-Fernandez MS, Abraham P, Fizanne L, Fromy B, Sigaudo-Roussel D, et al. Low skin temperature impairs the cutaneous vasodilator response to local progressive pressure strain. Microvasc Res. 2004;67:203\u20136.","journal-title":"Microvasc Res"},{"key":"148_CR19","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.2337\/diabetes.53.6.1564","volume":"53","author":"D Sigaudo-Roussel","year":"2004","unstructured":"Sigaudo-Roussel D, Demiot C, Fromy B, Koitka A, Leftheriotis G, Abraham P, et al. Early endothelial dysfunction severely impairs skin blood flow response to local pressure application in streptozotocin-induced diabetic mice. Diabetes. 2004;53:1564\u20139.","journal-title":"Diabetes"},{"key":"148_CR20","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.107.763730","volume":"118","author":"BI Levy","year":"2008","unstructured":"Levy BI, Schiffrin EL, Mourad JJ, Agostini D, Vicaut E, Safar ME, et al. Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus. Circulation. 2008;118:968\u201376.","journal-title":"Circulation"},{"key":"148_CR21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2337\/diabetes.47.3.457","volume":"47","author":"A Veves","year":"1998","unstructured":"Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes. 1998;47:457\u201363.","journal-title":"Diabetes"},{"key":"148_CR22","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.2337\/diacare.24.8.1468","volume":"24","author":"AI Vinik","year":"2001","unstructured":"Vinik AI, Erbas T, Park TS, Stansberry KB, Scanelli JA, Pittenger GL. Dermal neurovascular dysfunction in type 2 diabetes. Diabetes Care. 2001;24:1468\u201375.","journal-title":"Diabetes Care"},{"key":"148_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3389\/fphys.2018.00197","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Wang L, Li Y, Wuang L, Liu Y, Pang N, et al. Transplantation of normal adipose tissue improves blood flow and reduces inflammation in high fat fed mice with hindlimb ischemia. Front Physiol. 2018;9:197.","journal-title":"Front Physiol"},{"key":"148_CR24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1161\/HYPERTENSIONAHA.107.101477","volume":"51","author":"AM Samuelsson","year":"2008","unstructured":"Samuelsson AM, Matthews PA, Argenton M, Christie MR, McConnell JM, Jansen EH, et al. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension. 2008;51:383\u201392.","journal-title":"Hypertension"},{"key":"148_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04308-1","volume":"7","author":"LN Masi","year":"2017","unstructured":"Masi LN, Martins AR, Crisma AR, do Amaral CL, Davanso MR, Serdan TDA, et al. Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice. Sci Rep. 2017;7:3937.","journal-title":"Sci Rep"},{"key":"148_CR26","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1210\/er.2006-0035","volume":"28","author":"SM Clee","year":"2007","unstructured":"Clee SM, Attie AD. The genetic landscape of type 2 diabetes in mice. Endocr Rev. 2007;28:48\u201383.","journal-title":"Endocr Rev"},{"key":"148_CR27","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1002\/jbmr.2210","volume":"29","author":"RJ Fajardo","year":"2014","unstructured":"Fajardo RJ, Karim L, Calley VI, Bouxsein ML. A review of rodent models of type 2 diabetic skeletal fragility. J Bone Miner Res. 2014;29:1025\u201340.","journal-title":"J Bone Miner Res"},{"key":"148_CR28","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1113\/jphysiol.2007.143750","volume":"585","author":"ML Gaubert","year":"2007","unstructured":"Gaubert ML, Sigaudo-Roussel D, Tartas M, Berrut G, Saumet JL,Fromy B, Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice. J Physiol. 2007;585:617\u201326.","journal-title":"J Physiol"},{"key":"148_CR29","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1161\/01.CIR.0000012529.00367.0F","volume":"105","author":"F Gao","year":"2002","unstructured":"Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002;105:1497\u2013502.","journal-title":"Circulation"},{"key":"148_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-0115(97)02141-1","volume":"70","author":"N Friese","year":"1997","unstructured":"Friese N, Diop L, Chevalier E, Angel F, Riviere PJ, Dahl SG. Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain. Regul Pept. 1997;70:1\u20137.","journal-title":"Regul Pept"},{"key":"148_CR31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/284271a0","volume":"284","author":"BJ Whittle","year":"1980","unstructured":"Whittle BJ, Higgs GA, Eakins KE, Moncada S, Vane JR. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature. 1980;284:271\u20133.","journal-title":"Nature"},{"key":"148_CR32","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1172\/JCI21382","volume":"114","author":"T Fujino","year":"2004","unstructured":"Fujino T, Nakagawa N, Yuhki K, Hara A, Yamada T, Takayama K, et al. Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. J Clin Invest. 2004;114:805\u201312.","journal-title":"J Clin Invest"},{"key":"148_CR33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/exd.12450","volume":"23","author":"RR Driskell","year":"2014","unstructured":"Driskell RR, Jahoda CA, Chuong CM, Watt FM, Horsley V. Defining dermal adipose tissue. Exp Dermatol. 2014;23:629\u201331.","journal-title":"Exp Dermatol"},{"key":"148_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.beem.2013.06.006","volume":"28","author":"KK Cheng","year":"2014","unstructured":"Cheng KK, Lam KS, Wang B, Xu A. Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract Res Clin Endocrinol Metab. 2014;28:3\u201313.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"148_CR35","doi-asserted-by":"publisher","first-page":"H2107","DOI":"10.1152\/ajpheart.00389.2006","volume":"291","author":"N Erdei","year":"2006","unstructured":"Erdei N, Toth A, Pasztor ET, Papp Z, Edes I, Koller A, et al. High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion. Am J Physiol Heart Circ Physiol. 2006;291:H2107\u201315.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"148_CR36","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.2337\/diabetes.53.5.1352","volume":"53","author":"B Erdos","year":"2004","unstructured":"Erdos B, Snipes JA, Miller AW, Busija DW. Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C. Diabetes. 2004;53:1352\u20139.","journal-title":"Diabetes"},{"key":"148_CR37","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S0002-9149(96)00760-6","volume":"79","author":"RA Vogel","year":"1997","unstructured":"Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997;79:350\u20134.","journal-title":"Am J Cardiol"},{"key":"148_CR38","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1161\/ATVBAHA.115.305530","volume":"35","author":"J Loader","year":"2015","unstructured":"Loader J, Montero D, Lorenzen C, Watts R, Meziat C, Reboul C, et al. Acute hyperglycemia impairs vascular function in healthy and cardiometabolic diseased subjects: systematic review and meta-analysis. Arterioscler Thromb Vasc Biol. 2015;35:2060\u201372.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"148_CR39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.nutres.2012.08.002","volume":"32","author":"E Mah","year":"2012","unstructured":"Mah E, Bruno RS. Postprandial hyperglycemia on vascular endothelial function: mechanisms and consequences. Nutr Res. 2012;32:727\u201340.","journal-title":"Nutr Res"},{"key":"148_CR40","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/sji.12419","volume":"83","author":"P Ramos-Ramirez","year":"2016","unstructured":"Ramos-Ramirez P, Malmhall C, Johansson K, Lotvall J, Bossios A. Weight gain alters adiponectin receptor 1 expression on adipose tissue-resident Helios+ regulatory T cells. Scand J Immunol. 2016;83:244\u201354.","journal-title":"Scand J Immunol"},{"key":"148_CR41","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1161\/01.CIR.0000099542.57313.C5","volume":"108","author":"T Mazurek","year":"2003","unstructured":"Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108:2460\u20136.","journal-title":"Circulation"},{"key":"148_CR42","doi-asserted-by":"publisher","first-page":"590","DOI":"10.2337\/db11-1603","volume":"62","author":"RI Meijer","year":"2013","unstructured":"Meijer RI, Bakker W, Alta CL, Sipkema P, Yudkin JS, Viollet B, et al. Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db\/db mice. Diabetes. 2013;62:590\u20138.","journal-title":"Diabetes"},{"key":"148_CR43","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1161\/ATVBAHA.115.306263","volume":"36","author":"N Xia","year":"2016","unstructured":"Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, et al. Uncoupling of endothelial nitric oxide synthase in perivascular adipose tissue of diet-induced obese mice. Arterioscler Thromb Vasc Biol. 2016;36:78\u201385.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"148_CR44","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.pain.2011.10.001","volume":"153","author":"J Pelletier","year":"2012","unstructured":"Pelletier J, Fromy B, Morel G, Roquelaure Y, Saumet JL, Sigaudo-Roussel D. Chronic sciatic nerve injury impairs the local cutaneous neurovascular interaction in rats. Pain. 2012;153:149\u201357.","journal-title":"Pain"},{"key":"148_CR45","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/sj.bjp.0703685","volume":"131","author":"B Fromy","year":"2000","unstructured":"Fromy B, Merzeau S, Abraham P, Saumet JL. Mechanisms of the cutaneous vasodilator response to local external pressure application in rats: involvement of CGRP, neurokinins, prostaglandins and NO. Br J Pharmacol. 2000;131:1161\u201371.","journal-title":"Br J Pharmacol"},{"key":"148_CR46","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.tips.2010.06.006","volume":"31","author":"CS Walker","year":"2010","unstructured":"Walker CS, Conner AC, Poyner DR, Hay DL. Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends Pharmacol Sci. 2010;31:476\u201383.","journal-title":"Trends Pharmacol Sci"},{"key":"148_CR47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13018-016-0460-4","volume":"11","author":"A Minatani","year":"2016","unstructured":"Minatani A, Uchida K, Inoue G, Takano S, Aikawa J, Miyagi M, et al. Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1\/EP2\/EP4 receptor pathway in synovium of knee osteoarthritis patients. J Orthop Surg Res. 2016;11:117.","journal-title":"J Orthop Surg Res"},{"key":"148_CR48","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/cei.12712","volume":"183","author":"S Takano","year":"2016","unstructured":"Takano S, Uchida K, Miyagi M, Inoue G, Aikawa J, Fujimaki H, et al. Synovial macrophage-derived IL-1beta regulates the calcitonin receptor in osteoarthritic mice. Clin Exp Immunol. 2016;183:143\u20139.","journal-title":"Clin Exp Immunol"},{"key":"148_CR49","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.tips.2007.09.007","volume":"28","author":"N Delcourt","year":"2007","unstructured":"Delcourt N, Bockaert J, Marin P. GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation. Trends Pharmacol Sci. 2007;28:602\u20137.","journal-title":"Trends Pharmacol Sci"},{"key":"148_CR50","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.semcdb.2003.12.020","volume":"15","author":"C Waters","year":"2004","unstructured":"Waters C, Pyne S, Pyne NJ. The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin Cell Dev Biol. 2004;15:309\u201323.","journal-title":"Semin Cell Dev Biol"},{"key":"148_CR51","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.2337\/diabetes.53.11.2873","volume":"53","author":"RT Jongh de","year":"2004","unstructured":"de Jongh RT, Serne EH, Ijzerman RG, de Vries G, Stehouwer CD. Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes. 2004;53:2873\u201382.","journal-title":"Diabetes"},{"key":"148_CR52","doi-asserted-by":"publisher","first-page":"2902351","DOI":"10.1155\/2016\/2902351","volume":"2016","author":"A Heydemann","year":"2016","unstructured":"Heydemann A. An overview of murine high fat diet as a model for type 2 diabetes mellitus. J Diabetes Res. 2016;2016:2902351.","journal-title":"J Diabetes Res"},{"key":"148_CR53","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.amjcard.2007.07.055","volume":"101","author":"JM Arkin","year":"2008","unstructured":"Arkin JM, Alsdorf R, Bigornia S, Palmisano J, Beal R, Istfan N, et al. Relation of cumulative weight burden to vascular endothelial dysfunction in obesity. Am J Cardiol. 2008;101:98\u2013101.","journal-title":"Am J Cardiol"},{"key":"148_CR54","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/S0002-9149(01)02088-4","volume":"88","author":"RD Brook","year":"2001","unstructured":"Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist\/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol. 2001;88:1264\u20139.","journal-title":"Am J Cardiol"},{"key":"148_CR55","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1161\/01.RES.0000241051.83067.62","volume":"99","author":"T Szerafin","year":"2006","unstructured":"Szerafin T, Erdei N, Fulop T, Pasztor ET, Edes I, Koller A, et al. Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus. Circ Res. 2006;99:e12\u20137.","journal-title":"Circ Res"},{"key":"148_CR56","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.atherosclerosis.2010.09.022","volume":"213","author":"A Sanchez","year":"2010","unstructured":"Sanchez A, Contreras C, Martinez P, Villalba N, Benedito S, Garcia-Sacristan A, et al. Enhanced cyclooxygenase 2-mediated vasorelaxation in coronary arteries from insulin-resistant obese Zucker rats. Atherosclerosis. 2010;213:392\u20139.","journal-title":"Atherosclerosis"},{"key":"148_CR57","doi-asserted-by":"publisher","first-page":"R556","DOI":"10.1152\/ajpregu.90817.2008","volume":"297","author":"Z Bagi","year":"2009","unstructured":"Bagi Z. Mechanisms of coronary microvascular adaptation to obesity. Am J Physiol Regul Integr Comp Physiol. 2009;297:R556\u201367.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"148_CR58","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.prostaglandins.2013.06.002","volume":"107","author":"G Ozen","year":"2013","unstructured":"Ozen G, Topal G, Gomez I, Ghorreshi A, Boukais K, Benyahia C, et al. Control of human vascular tone by prostanoids derived from perivascular adipose tissue. Prostaglandins Other Lipid Mediat. 2013;107:13\u20137.","journal-title":"Prostaglandins Other Lipid Mediat"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41366-018-0148-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41366-018-0148-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41366-018-0148-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:13:48Z","timestamp":1684617228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41366-018-0148-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["148"],"URL":"https:\/\/doi.org\/10.1038\/s41366-018-0148-4","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]},"assertion":[{"value":"4 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}