{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:22:24Z","timestamp":1791588144015,"version":"4.3.4"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background\/objectives<\/jats:title>\n                <jats:p>Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life. Obesity is concurrent with a state of chronic inflammation, a well-known aetiological factor for DNA damage. In addition, obesity has been associated with micro-nutritional deficiencies. Vitamin D has attracted attention for its anti-inflammatory properties and role in genomic integrity and stability. The aim of this study was to determine a novel approach for predicting genomic instability via the combined assessment of adiposity, DNA damage, systemic inflammation, and vitamin D status.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Subjects\/methods<\/jats:title>\n                <jats:p>We carried out a cross-sectional study with 132 participants, aged 10\u201318, recruited from schools and paediatric obesity clinics in London. Anthropometric assessments included BMI Z-score, waist and hip circumference, and body fat percentage via bioelectrical impedance. Inflammation and vitamin D levels in saliva were assessed by enzyme-linked immunosorbent assay. Oxidative DNA damage was determined via quantification of 8-hydroxy-2\u2032-deoxyguanosine in urine. Exfoliated cells from the oral cavity were scored for genomic instability via the buccal cytome assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>As expected, comparisons between participants with obesity and normal range BMI showed significant differences in anthropometric measures (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Significant differences were also observed in some measures of genomic instability (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). When examining relationships between variables for all participants, markers of adiposity positively correlated with acquired oxidative DNA damage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and genomic instability (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and negatively correlated with vitamin D (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Multiple regression analyses identified obesity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), vitamin D (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and oxidative DNA damage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) as the three significant predictors of genomic instability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Obesity, oxidative DNA damage, and vitamin D deficiency are significant predictors of genomic instability. Non-invasive biomonitoring and predictive modelling of genomic instability in young patients with obesity may contribute to the prioritisation and severity of clinical intervention measures.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41366-021-00879-2","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T06:08:40Z","timestamp":1624342120000},"page":"2095-2107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents"],"prefix":"10.1038","volume":"45","author":[{"given":"Moonisah","family":"Usman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Woloshynowych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Carrilho","family":"Britto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivona","family":"Bilkevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Glassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Ford-Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-7626","authenticated-orcid":false,"given":"Ashish","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Tewfik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-9104","authenticated-orcid":false,"given":"Emanuela V.","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"879_CR1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/ijc.20423","volume":"112","author":"M Jeffreys","year":"2004","unstructured":"Jeffreys M, Davey Smith G, Martin RM, Frankel S, Gunnell D. Childhood body mass index and later cancer risk: a 50\u2010year follow\u2010up of the Boyd Orr study. Int J Cancer. 2004;112:348\u201351.","journal-title":"Int J Cancer"},{"key":"879_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/aje\/kwn096","volume":"168","author":"T Bj\u00f8rge","year":"2008","unstructured":"Bj\u00f8rge T, Engeland A, Tverdal A, Smith GD. Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. Am J Epidemiol. 2008;168:30\u20137.","journal-title":"Am J Epidemiol"},{"key":"879_CR3","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1467-789X.2012.01015.x","volume":"13","author":"MH Park","year":"2012","unstructured":"Park MH, Falconer C, Viner RM, Kinra S. The impact of childhood obesity on morbidity and mortality in adulthood: a systematic review. Obes Rev. 2012;13:985\u20131000.","journal-title":"Obes Rev"},{"key":"879_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/obr.12334","volume":"17","author":"M Simmonds","year":"2016","unstructured":"Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016;17:95\u2013107.","journal-title":"Obes Rev"},{"key":"879_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta19430","volume":"19","author":"M Simmonds","year":"2015","unstructured":"Simmonds M, Burch J, Llewellyn A, Griffiths C, Yang H, Owen C, et al. The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: a systematic review and meta-analysis. Heal Technol Assess. 2015;19:1\u2013336.","journal-title":"Heal Technol Assess"},{"key":"879_CR6","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.2337\/db14-0744","volume":"64","author":"K Landgraf","year":"2015","unstructured":"Landgraf K, Rockstroh D, Wagner IV, Weise S, Tauscher R, Schwartze JT, et al. Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children. Diabetes. 2015;64:1249\u201361.","journal-title":"Diabetes"},{"key":"879_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1042\/BJ20100285","volume":"430","author":"N Barbarroja","year":"2010","unstructured":"Barbarroja N, L\u00f3pez-Pedrera R, Mayas MD, Garcia-Fuentes E, Garrido-S\u00e1nchez L, Mac\u00edas-Gonz\u00e1lez M, et al. The obese healthy paradox: is inflammation the answer? Biochem J. 2010;430:141\u20139.","journal-title":"Biochem J"},{"key":"879_CR8","doi-asserted-by":"crossref","unstructured":"Bhattacharya I, Dom\u00ednguez AP, Dr\u00e4gert K, Humar R, Haas E, Battegay EJ. Hypoxia potentiates tumor necrosis factor-\u03b1 induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in white and brown adipocytes. Biochem Biophys Res Commun. 2015;461:287\u201392.","DOI":"10.1016\/j.bbrc.2015.04.020"},{"key":"879_CR9","doi-asserted-by":"crossref","unstructured":"Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis. 2000 Mar;149:139\u201350.","DOI":"10.1016\/S0021-9150(99)00312-3"},{"key":"879_CR10","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1161\/01.ATV.0000228818.11968.7a","volume":"26","author":"T R\u00f6nnemaa","year":"2006","unstructured":"R\u00f6nnemaa T, Juonala M, Marniemi J, Raitakari OT, Taittonen L, Viikari JSA. Childhood C-reactive protein in predicting CRP and carotid intima-media thickness in adulthood. Arterioscler Thromb Vasc Biol. 2006;26:1883\u20138.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"879_CR11","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1007\/s00125-012-2641-y","volume":"55","author":"HS Schipper","year":"2012","unstructured":"Schipper HS, Nuboer R, Prop S, Van Den Ham HJ, De Boer FK, Kesmir C, et al. Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes. Diabetologia. 2012;55:2800\u201310.","journal-title":"Diabetologia"},{"key":"879_CR12","first-page":"1548","volume":"32","author":"E Carmona-Montesinos","year":"2015","unstructured":"Carmona-Montesinos E, Ruiz-Fragoso Z, Ponce-Hinojosa G, Rivas-Arancibia S, CHANGES IN. C-reactive protein and biochemical profile in preschool children with obesity. Nutr Hosp. 2015;32:1548\u201353.","journal-title":"Nutr Hosp"},{"key":"879_CR13","doi-asserted-by":"crossref","unstructured":"Nishide R, Ando M, Funabashi H, Yoda Y, Nakano M, Shima M. Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan. Environ Health Prev Med. 2015;20:116\u201322.","DOI":"10.1007\/s12199-014-0433-3"},{"key":"879_CR14","doi-asserted-by":"crossref","unstructured":"Chang C-J, Jian D-Y, Lin M-W, Zhao J-Z, Ho L-T, Juan C-C. Evidence in obese children: contribution of hyperlipidemia, obesity-inflammation, and insulin sensitivity. PLoS ONE. 2015;10:e0125935\u2013e0125935.","DOI":"10.1371\/journal.pone.0125935"},{"key":"879_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4274\/Jcrpe.789","volume":"5","author":"K Kitsios","year":"2013","unstructured":"Kitsios K, Papadopoulou M, Kosta K, Kadoglou N, Papagianni M, Tsiroukidou K. High-sensitivity C-reactive protein levels and metabolic disorders in obese and overweight children and adolescents. J Clin Res Pediatr Endocrinol. 2013;5:44.","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"879_CR16","doi-asserted-by":"crossref","unstructured":"Rowicka G, Dyl\u0105g H, Ambroszkiewicz J, Riahi A, Weker H, Che\u0142chowska M. Total oxidant and antioxidant status in prepubertal children with obesity. Oxid Med Cell Longev. 2017;2017:5621989.","DOI":"10.1155\/2017\/5621989"},{"key":"879_CR17","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s13679-020-00387-w","volume":"9","author":"P Weihe","year":"2020","unstructured":"Weihe P, Spielmann J, Kielstein H, Henning-Klusmann J, Weihrauch-Bl\u00fcher S. Childhood obesity and cancer risk in adulthood. Curr Obes Rep. 2020;9:204\u201312.","journal-title":"Curr Obes Rep"},{"key":"879_CR18","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2016","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2016;144:646\u201374.","journal-title":"Cell"},{"key":"879_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jmcb\/mjq057","volume":"3","author":"Z Shen","year":"2011","unstructured":"Shen Z. Genomic instability and cancer: an introduction. J Mol Cell Biol. 2011;3:1\u20133.","journal-title":"J Mol Cell Biol"},{"key":"879_CR20","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1210\/jc.2007-0468","volume":"92","author":"I Aeberli","year":"2007","unstructured":"Aeberli I, Biebinger R, Lehmann R, L\u2019allemand D, Spinas GA, Zimmermann MB. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab. 2007;92:4359\u201365.","journal-title":"J Clin Endocrinol Metab"},{"key":"879_CR21","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.3390\/nu5125012","volume":"5","author":"OP Garc\u00eda","year":"2013","unstructured":"Garc\u00eda OP, Ronquillo D, del Carmen Caama\u00f1o M, Mart\u00ednez G, Camacho M, L\u00f3pez V, et al. Zinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. Nutrients. 2013;5:5012\u201330.","journal-title":"Nutrients."},{"key":"879_CR22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/jhn.12025","volume":"26","author":"Y Manios","year":"2013","unstructured":"Manios Y, Moschonis G, Chrousos GP, Lionis C, Mougios V, Kantilafti M, et al. The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet. 2013;26:470\u20138.","journal-title":"J Hum Nutr Diet"},{"key":"879_CR23","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1024\/0300-9831\/a000197","volume":"84","author":"E Rodriguez-Rodriguez","year":"2014","unstructured":"Rodriguez-Rodriguez E, Aparicio A, Andres P, Ortega RM. Moderate vitamin D deficiency and inflammation related markers in overweight\/obese schoolchildren. Int J Vitam Nutr Res. 2014;84:98\u2013107.","journal-title":"Int J Vitam Nutr Res"},{"key":"879_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1024\/0300-9831\/a000101","volume":"82","author":"M Ortega","year":"2012","unstructured":"Ortega M, Rodr\u00edguez-Rodr\u00edguez Aparicio, Jim\u00e9nez-Ortega I, Palmeros PereaM, et al. Young children with excess of weight show an impaired selenium status. Int J Vitam Nutr Res. 2012;82:121\u20139.","journal-title":"Int J Vitam Nutr Res"},{"key":"879_CR25","doi-asserted-by":"crossref","unstructured":"Basatemur E, Horsfall L, Marston L, Rait G, Sutcliffe A. Trends in the diagnosis of vitamin D deficiency. Pediatrics. 2017;139:e20162748.","DOI":"10.1542\/peds.2016-2748"},{"key":"879_CR26","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s40618-014-0108-3","volume":"37","author":"S Bellone","year":"2014","unstructured":"Bellone S, Esposito S, Giglione E, Genoni G, Fiorito C, Petri A, et al. Vitamin D levels in a paediatric population of normal weight and obese subjects. J Endocrinol Investig. 2014;37:805\u20139.","journal-title":"J Endocrinol Investig"},{"key":"879_CR27","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1111\/apa.13363","volume":"105","author":"K Ekbom","year":"2016","unstructured":"Ekbom K, Marcus C. Vitamin D deficiency is associated with prediabetes in obese Swedish children. Acta Paediatr. 2016;105:1192\u20137.","journal-title":"Acta Paediatr"},{"key":"879_CR28","doi-asserted-by":"crossref","unstructured":"Wakayo T, Whiting SJ, Belachew T. Vitamin D deficiency is associated with overweight and\/or obesity among schoolchildren in central Ethiopia: a cross-sectional study. Nutrients. 2016;8:190.","DOI":"10.3390\/nu8040190"},{"key":"879_CR29","doi-asserted-by":"crossref","first-page":"2333794X1774414","DOI":"10.1177\/2333794X17744141","volume":"4","author":"M Kumaratne","year":"2017","unstructured":"Kumaratne M, Early G, Cisneros J. Vitamin D deficiency and association with body mass index and lipid levels in hispanic American adolescents. Glob Pediatr Health. 2017;4:2333794X17744141.","journal-title":"Glob Pediatr Health"},{"key":"879_CR30","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12887-017-0963-0","volume":"17","author":"KO Alyahya","year":"2017","unstructured":"Alyahya KO. Vitamin D levels in schoolchildren: a cross-sectional study in Kuwait. BMC Pediatr. 2017;17:213.","journal-title":"BMC Pediatr"},{"key":"879_CR31","first-page":"133","volume":"115","author":"M Erol","year":"2017","unstructured":"Erol M, Bostan Gayret O, Hamilcikan S, Can E, Yigit OL. Vitamin D deficiency and insulin resistance as risk factors for dyslipidemia in obese children. Arch Argent Pediatr. 2017;115:133\u20139.","journal-title":"Arch Argent Pediatr"},{"key":"879_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1515\/jpem-2017-0246","volume":"31","author":"JL Plesner","year":"2018","unstructured":"Plesner JL, Dahl M, Fonvig CE, Nielsen TRH, Kloppenborg JT, Pedersen O, et al. Obesity is associated with vitamin D deficiency in Danish children and adolescents. J Pediatr Endocrinol Metab. 2018;31:53\u201361.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"879_CR33","doi-asserted-by":"publisher","first-page":"e1001383","DOI":"10.1371\/journal.pmed.1001383","volume":"10","author":"KS Vimaleswaran","year":"2013","unstructured":"Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10:e1001383.","journal-title":"PLoS Med"},{"key":"879_CR34","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.4049\/jimmunol.1102412","volume":"188","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Leung DYM, Richers BN, Liu Y, Remigio LK, Riches DW, et al. Vitamin D inhibits monocyte\/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012;188:2127\u201335.","journal-title":"J Immunol"},{"key":"879_CR35","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.rdc.2012.03.014","volume":"38","author":"AV Krishnan","year":"2012","unstructured":"Krishnan AV, Trump DL, Johnson CS, Feldman D. The role of vitamin D in cancer prevention and treatment. Rheum Dis Clin. 2012;38:161\u201378.","journal-title":"Rheum Dis Clin"},{"key":"879_CR36","doi-asserted-by":"crossref","unstructured":"Usman M, Volpi EV. DNA damage in obesity: initiator, promoter and predictor of cancer. Mutat Res Rev Mutat Res. 2018;778:23\u201337.","DOI":"10.1016\/j.mrrev.2018.08.002"},{"key":"879_CR37","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1096\/fj.10-168427","volume":"25","author":"R Scarpato","year":"2011","unstructured":"Scarpato R, Verola C, Fabiani B, Bianchi V, Saggese G, Federico G. Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the \u03b3-H2AX focus assay and micronucleus test. FASEB J. 2011;25:685\u201393.","journal-title":"FASEB J"},{"key":"879_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mrfmmm.2016.05.001","volume":"789","author":"A Azzar\u00e0","year":"2016","unstructured":"Azzar\u00e0 A, Pirillo C, Giovannini C, Federico G, Scarpato R. Different repair kinetic of DSBs induced by mitomycin C in peripheral lymphocytes of obese and normal weight adolescents. Mutat Res Mol Mech Mutagen. 2016;789:9\u201314.","journal-title":"Mutat Res Mol Mech Mutagen"},{"key":"879_CR39","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1080\/02772240802404966","volume":"91","author":"O Torres-Bugar\u00edn","year":"2009","unstructured":"Torres-Bugar\u00edn O, Fern\u00e1ndez-Garc\u00eda A, Torres-Mendoza BM, Zavala-Aguirre JL, Nava-Zavala A, Zamora-Perez AL. Genetic profile of overweight and obese school-age children. Toxicol Environ Chem. 2009;91:789\u201395.","journal-title":"Toxicol Environ Chem"},{"key":"879_CR40","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.3390\/ijerph15081659","volume":"15","author":"A Idolo","year":"2018","unstructured":"Idolo A, Grassi T, Bagordo F, Panico A, De Giorgi M, Serio F, et al. Micronuclei in exfoliated buccal cells of children living in a cluster area of Salento (Southern Italy) with a high incidence of lung cancer: the IMP.AIR study. Int J Environ Res Public Health. 2018;15:1659.","journal-title":"Int J Environ Res Public Health"},{"key":"879_CR41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3923\/jms.2011.231.235","volume":"11","author":"A El Wakkad","year":"2011","unstructured":"El Wakkad A, Giza AO, Elwakkad A, Hassan NE, Sibaii H, el Zayat S. Relationship between obesity and 8-hydroxy-2-deoxy guanosine as an oxidative marker in obese. J Med Sci. 2011;11:231\u20135.","journal-title":"J Med Sci"},{"key":"879_CR42","doi-asserted-by":"crossref","unstructured":"Ramachandra N, Rodriguez L, Devaraj S. Urinary biomarkers of oxidative stress and insulin resistance in childhood obesity. FASEB J. 2015;1:29.","DOI":"10.1096\/fasebj.29.1_supplement.927.2"},{"key":"879_CR43","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/17477160802248039","volume":"4","author":"K \u0160ebekov\u00e1","year":"2009","unstructured":"\u0160ebekov\u00e1 K, Somoza V, Jar\u010du\u0161kov\u00e1 M, Heidland A, Podrack\u00e1 L. Plasma advanced glycation end products are decreased in obese children compared with lean controls. Int J Pediatr Obes. 2009;4:112\u20138.","journal-title":"Int J Pediatr Obes"},{"key":"879_CR44","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.scitotenv.2014.08.095","volume":"500\u2013501","author":"C Protano","year":"2014","unstructured":"Protano C, Andreoli R, Mutti A, Petti S, Vitali M. Biomarkers of oxidative stress to nucleic acids: Background levels and effects of body mass index and life-style factors in an urban paediatric population. Sci Total Environ. 2014;500\u2013501:44\u201351.","journal-title":"Sci Total Environ"},{"key":"879_CR45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.mrgentox.2014.06.006","volume":"771","author":"H Donmez-Altuntas","year":"2014","unstructured":"Donmez-Altuntas H, Sahin F, Bayram F, Bitgen N, Mert M, Guclu K, et al. Evaluation of chromosomal damage, cytostasis, cytotoxicity, oxidative DNA damage and their association with body-mass index in obese subjects. Mutat Res Toxicol Environ Mutagen. 2014;771:30\u20136.","journal-title":"Mutat Res Toxicol Environ Mutagen"},{"key":"879_CR46","unstructured":"Royal College of Paediatrics and Child Health. Body mass index UK 2\u201320 years. 2013;2. https:\/\/www.rcpch.ac.uk\/sites\/default\/files\/2018-03\/boys_and_girls_bmi_chart.pdf"},{"key":"879_CR47","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/nprot.2009.53","volume":"4","author":"P Thomas","year":"2009","unstructured":"Thomas P, Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, Zeiger E, et al. Buccal micronucleus cytome assay. Nat Protoc. 2009;4:825\u201337.","journal-title":"Nat Protoc"},{"key":"879_CR48","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1758-5996-4-26","volume":"4","author":"JI Cohen","year":"2012","unstructured":"Cohen JI, Maayan L, Convit A. Preliminary evidence for obesity-associated insulin resistance in adolescents without elevations of inflammatory cytokines. Diabetol Metab Syndr. 2012;4:26.","journal-title":"Diabetol Metab Syndr"},{"key":"879_CR49","doi-asserted-by":"publisher","first-page":"501","DOI":"10.5830\/CVJA-2012-058","volume":"23","author":"T Naidoo","year":"2012","unstructured":"Naidoo T, Konkol K, Biccard B, Dudose K, McKune AJ. Elevated salivary C-reactive protein predicted by low cardio-respiratory fitness and being overweight in African children. Cardiovasc J Afr. 2012;23:501\u20136.","journal-title":"Cardiovasc J Afr"},{"key":"879_CR50","doi-asserted-by":"publisher","first-page":"e98799","DOI":"10.1371\/journal.pone.0098799","volume":"9","author":"JM Goodson","year":"2014","unstructured":"Goodson JM, Kantarci A, Hartman M-L, Denis GV, Stephens D, Hasturk H, et al. Metabolic disease risk in children by salivary biomarker analysis. PLoS ONE. 2014;9:e98799.","journal-title":"PLoS ONE"},{"key":"879_CR51","doi-asserted-by":"crossref","unstructured":"Janem WF, Scannapieco FA, Sabharwal A, Tsompana M, Berman HA, Haase EM, et al. Salivary inflammatory markers and microbiome in normoglycemic lean and obese children compared to obese children with type 2 diabetes. PLoS ONE. 2017;12:e0172647.","DOI":"10.1371\/journal.pone.0172647"},{"key":"879_CR52","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbi.2013.08.010","volume":"34","author":"ML Byrne","year":"2013","unstructured":"Byrne ML, O\u2019Brien-Simpson NM, Reynolds EC, Walsh KA, Laughton K, Waloszek JM, et al. Acute phase protein and cytokine levels in serum and saliva: a comparison of detectable levels and correlations in a depressed and healthy adolescent sample. Brain Behav Immunol. 2013;34:164\u201375.","journal-title":"Brain Behav Immunol"},{"key":"879_CR53","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/ijc.29868","volume":"138","author":"M Izano","year":"2016","unstructured":"Izano M, Wei EK, Tai C, Swede H, Gregorich S, Harris TB, et al. Chronic inflammation and risk of colorectal and other obesity\u2010related cancers: the health, aging and body composition study. Int J Cancer. 2016;138:1118\u201328.","journal-title":"Int J Cancer"},{"key":"879_CR54","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1021\/tx9600311","volume":"9","author":"S Tamir","year":"1996","unstructured":"Tamir S, Burney S, Tannenbaum SR. DNA damage by nitric oxide. Chem Res Toxicol. 1996;9:821\u20137.","journal-title":"Chem Res Toxicol"},{"key":"879_CR55","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1172\/JCI19757","volume":"112","author":"LJ Hofseth","year":"2003","unstructured":"Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, et al. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Investig. 2003;112:1887\u201394.","journal-title":"J Clin Investig"},{"key":"879_CR56","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0302-2838(02)00548-1","volume":"43","author":"F Di Silverio","year":"2003","unstructured":"Di Silverio F, Gentile V, De Matteis A, Mariotti G, Giuseppe V, Luigi PA, et al. Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: a retrospective analysis. Eur Urol. 2003;43:164\u201375.","journal-title":"Eur Urol"},{"key":"879_CR57","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1023\/B:APPT.0000018794.26438.22","volume":"9","author":"CJ van der Woude","year":"2004","unstructured":"van der Woude CJ, Kleibeuker JH, Jansen PLM, Moshage H. Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract. Apoptosis. 2004;9:123\u201330.","journal-title":"Apoptosis"},{"key":"879_CR58","doi-asserted-by":"crossref","unstructured":"Woodford D, Johnson SD, De Costa A-MA, Young MRI. An inflammatory cytokine milieu is prominent in premalignant oral lesions, but subsides when lesions progress to squamous cell carcinoma. J Clin Cell Immunol. 2014;5:230.","DOI":"10.4172\/2155-9899.1000230"},{"key":"879_CR59","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1902\/jop.2005.76.3.406","volume":"76","author":"M Tezal","year":"2005","unstructured":"Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol. 2005;76:406\u201310.","journal-title":"J Periodontol"},{"key":"879_CR60","first-page":"8670","volume":"63","author":"CS Cobbs","year":"2003","unstructured":"Cobbs CS, Whisenhunt TR, Wesemann DR, Harkins LE, Van Meir EG, Samanta M. Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res. 2003;63:8670\u20133.","journal-title":"Cancer Res"},{"key":"879_CR61","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1093\/carcin\/bgp127","volume":"30","author":"F Colotta","year":"2009","unstructured":"Colotta F, Garlanda C, Allavena P, Sica A, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis. 2009;30:1073\u201381.","journal-title":"Carcinogenesis"},{"key":"879_CR62","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.gde.2009.11.004","volume":"20","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov SI, Karin M. Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev. 2010;20:65\u201371.","journal-title":"Curr Opin Genet Dev"},{"key":"879_CR63","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.steroids.2013.05.010","volume":"78","author":"T Higashi","year":"2013","unstructured":"Higashi T, Hijikuro M, Yamagata K, Ogawa S. Overestimation of salivary 25-hydroxyvitamin D3 level when using stimulated saliva with gum-chewing. Steroids. 2013;78:884\u20137.","journal-title":"Steroids"},{"key":"879_CR64","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00216-007-1780-3","volume":"391","author":"T Higashi","year":"2008","unstructured":"Higashi T, Shibayama Y, Fuji M, Shimada K. Liquid chromatography\u2013tandem mass spectrometric method for the determination of salivary 25-hydroxyvitamin D3: a noninvasive tool for the assessment of vitamin D status. Anal Bioanal Chem. 2008;391:229\u201338.","journal-title":"Anal Bioanal Chem"},{"key":"879_CR65","doi-asserted-by":"crossref","unstructured":"Merino O, S\u00e1nchez R, Gregorio BM, Sampaio FJ, Risopatr\u00f3n J. Effects of diet-induced obesity and deficient in vitamin D on spermatozoa function and DNA integrity in Sprague-Dawley rats. Biomed Res Int. 2018;2018:5479057.","DOI":"10.1155\/2018\/5479057"},{"key":"879_CR66","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/mutage\/ges026","volume":"27","author":"BK Armstrong","year":"2012","unstructured":"Armstrong BK, Nair-Shalliker V, Fenech M, Forder PM, Clements MS. Sunlight and vitamin D affect DNA damage, cell division and cell death in human lymphocytes: a cross-sectional study in South Australia. Mutagenesis. 2012;27:609\u201314.","journal-title":"Mutagenesis"},{"key":"879_CR67","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0027-5107(01)00080-X","volume":"475","author":"M Chatterjee","year":"2001","unstructured":"Chatterjee M. Vitamin D and genomic stability. Mutat Res Mol Mech Mutagen. 2001;475:69\u201387.","journal-title":"Mutat Res Mol Mech Mutagen"},{"key":"879_CR68","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.jsbmb.2004.03.072","volume":"89\u201390","author":"G Wong","year":"2004","unstructured":"Wong G, Gupta R, Dixon KM, Deo SS, Choong SM, Halliday GM, et al. 1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway. J Steroid Biochem Mol Biol. 2004;89\u201390:567\u201370.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"879_CR69","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1158\/1055-9965.EPI-09-0448","volume":"19","author":"V Fedirko","year":"2010","unstructured":"Fedirko V, Bostick RM, Long Q, Flanders WD, McCullough ML, Sidelnikov E, et al. Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Prev Biomark. 2010;19:280\u201391.","journal-title":"Cancer Epidemiol Prev Biomark"},{"key":"879_CR70","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.mrfmmm.2012.02.005","volume":"733","author":"V Nair-Shalliker","year":"2012","unstructured":"Nair-Shalliker V, Armstrong BK, Fenech M. Does vitamin D protect against DNA damage? Mutat Res Mol Mech Mutagen. 2012;733:50\u20137.","journal-title":"Mutat Res Mol Mech Mutagen"},{"key":"879_CR71","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.jsbmb.2016.08.004","volume":"165","author":"MA Abbas","year":"2017","unstructured":"Abbas MA. Physiological functions of Vitamin D in adipose tissue. J Steroid Biochem Mol Biol. 2017;165:369\u201381.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"879_CR72","doi-asserted-by":"publisher","first-page":"e61707","DOI":"10.1371\/journal.pone.0061707","volume":"8","author":"C Ding","year":"2013","unstructured":"Ding C, Wilding JPH, Bing C. 1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NFkappaB and MAPK signalling and chemokine release in human adipocytes. PLoS ONE. 2013;8:e61707.","journal-title":"PLoS ONE"},{"key":"879_CR73","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/15592294.2016.1276681","volume":"13","author":"E Karkeni","year":"2018","unstructured":"Karkeni E, Bonnet L, Marcotorchino J, Tourniaire F, Astier J, Ye J, et al. Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: a new mechanism for the regulation of inflammation by vitamin D. Epigenetics. 2018;13:156\u201362.","journal-title":"Epigenetics"},{"key":"879_CR74","doi-asserted-by":"crossref","unstructured":"Chang E, Kim Y Vitamin D. Insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK\/SIRT1 activity in obese rats. Nutrients. 2017;9:338.","DOI":"10.3390\/nu9040338"},{"key":"879_CR75","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1210\/en.2014-1647","volume":"156","author":"E Karkeni","year":"2015","unstructured":"Karkeni E, Marcotorchino J, Tourniaire F, Astier J, Peiretti F, Darmon P, et al. Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice. Endocrinology. 2015;156:1782\u201393.","journal-title":"Endocrinology."},{"key":"879_CR76","doi-asserted-by":"publisher","first-page":"e1000951","DOI":"10.1371\/journal.pgen.1000951","volume":"6","author":"Z Wang","year":"2010","unstructured":"Wang Z, Rhee DB, Lu J, Bohr CT, Zhou F, Vallabhaneni H, et al. Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet. 2010;6:e1000951.","journal-title":"PLoS Genet"},{"key":"879_CR77","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mad.2018.03.013","volume":"177","author":"RP Barnes","year":"2019","unstructured":"Barnes RP, Fouquerel E, Opresko PL. The impact of oxidative DNA damage and stress on telomere homeostasis. Mech Ageing Dev. 2019;177:37\u201345.","journal-title":"Mech Ageing Dev"},{"key":"879_CR78","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1210\/jc.2010-2924","volume":"96","author":"JL Buxton","year":"2011","unstructured":"Buxton JL, Walters RG, Visvikis-Siest S, Meyre D, Froguel P, Blakemore AIF. Childhood obesity is associated with shorter leukocyte telomere length. J Clin Endocrinol Metab. 2011;96:1500\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"879_CR79","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.mrfmmm.2009.10.001","volume":"683","author":"J Pampalona","year":"2010","unstructured":"Pampalona J, Soler D, Genesc\u00e0 A, Tusell L. Telomere dysfunction and chromosome structure modulate the contribution of individual chromosomes in abnormal nuclear morphologies. Mutat Res. 2010;683:16\u201322.","journal-title":"Mutat Res"},{"key":"879_CR80","doi-asserted-by":"publisher","first-page":"12922","DOI":"10.1007\/s11356-014-3200-5","volume":"21","author":"M Feki-Tounsi","year":"2014","unstructured":"Feki-Tounsi M, Khlifi R, Mhiri M-N, Rebai A, Hamza-Chaffai A. Cytogenetic damage in the oral mucosa cells of bladder cancer patients exposed to tobacco in Southern Tunisia. Environ Sci Pollut Res. 2014;21:12922\u20137.","journal-title":"Environ Sci Pollut Res"},{"key":"879_CR81","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/ijc.2910390405","volume":"39","author":"AM Mandard","year":"1987","unstructured":"Mandard AM, Duigou F, Marnay J, Barrellier P, Lebigot G. Analysis of the results of the micronucleus test in patients presenting upper digestive tract cancers and in non\u2010cancerous subjects. Int J Cancer. 1987;39:442\u20134.","journal-title":"Int J Cancer"},{"key":"879_CR82","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/S1368-8375(00)00051-8","volume":"36","author":"M Bloching","year":"2000","unstructured":"Bloching M, Hofmann A, Lautenschl\u00e4ger C, Berghaus A, Grummt T. Exfoliative cytology of normal buccal mucosa to predict the relative risk of cancer in the upper aerodigestive tract using the MN-assay. Oral Oncol. 2000;36:550\u20135.","journal-title":"Oral Oncol"},{"key":"879_CR83","first-page":"246","volume":"1","author":"A Ramirez","year":"2002","unstructured":"Ramirez A, Saldanha PH. Micronucleus investigation of alcoholic patients with oral carcinomas. Genet Mol Res. 2002;1:246\u201360.","journal-title":"Genet Mol Res"},{"key":"879_CR84","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.oraloncology.2007.05.002","volume":"44","author":"R Saran","year":"2008","unstructured":"Saran R, Tiwari RK, Reddy PP, Ahuja YR. Risk assessment of oral cancer in patients with pre-cancerous states of the oral cavity using micronucleus test and challenge assay. Oral Oncol. 2008;44:354\u201360.","journal-title":"Oral Oncol"},{"key":"879_CR85","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0304-3835(96)04390-X","volume":"109","author":"SS Desai","year":"1996","unstructured":"Desai SS, Ghaisas SD, Jakhi SD, Bhide SV. Cytogenetic damage in exfoliated oral mucosal cells and circulating lymphocytes of patients suffering from precancerous oral lesions. Cancer Lett. 1996;109:9\u201314.","journal-title":"Cancer Lett"},{"key":"879_CR86","first-page":"895","volume":"19","author":"A Flores-Garc\u00eda","year":"2014","unstructured":"Flores-Garc\u00eda A, Torres-Bugar\u00edn O, Velarde-F\u00e9lix JS, Rangel-Villalobos H, Zepeda-Carrillo EA, Rodr\u00edguez-Trejo A, et al. Micronuclei and other nuclear anomalies in exfoliated buccal mucosa cells of Mexican women with breast cancer. J BUON. 2014;19:895\u20139.","journal-title":"J BUON"},{"key":"879_CR87","first-page":"69","volume":"38","author":"AK Nersesyan","year":"2004","unstructured":"Nersesyan AK, Adamyan RT. Micronuclei level in exfoliated buccal mucosa cells of patients with benign and malignant tumors of female reproductive organs and breasts. Cytol Genet. 2004;38:69.","journal-title":"Cytol Genet"},{"key":"879_CR88","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1134\/S1022795406050152","volume":"42","author":"IH Yildirim","year":"2006","unstructured":"Yildirim IH, Yesilada E, Yologlu S. Micronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients. Russ J Genet. 2006;42:573\u20137.","journal-title":"Russ J Genet"},{"key":"879_CR89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35903-5","volume":"8","author":"A Podrimaj-Bytyqi","year":"2018","unstructured":"Podrimaj-Bytyqi A, Borove\u010dki A, Selimi Q, Manxhuka-Kerliu S, Gashi G, Elezaj IR. The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma. Sci Rep. 2018;8:17873.","journal-title":"Sci Rep"},{"key":"879_CR90","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/mutage\/geq053","volume":"26","author":"N Shimizu","year":"2011","unstructured":"Shimizu N. Molecular mechanisms of the origin of micronuclei from extrachromosomal elements. Mutagenesis. 2011;26:119\u201323.","journal-title":"Mutagenesis."},{"key":"879_CR91","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature14493","volume":"522","author":"C-Z Zhang","year":"2015","unstructured":"Zhang C-Z, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, et al. Chromothripsis from DNA damage in micronuclei. Nature. 2015;522:179\u201384.","journal-title":"Nature"},{"key":"879_CR92","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cell.2013.06.007","volume":"154","author":"EM Hatch","year":"2013","unstructured":"Hatch EM, Fischer AH, Deerinck TJ, Hetzer MW. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 2013;154:47\u201360.","journal-title":"Cell"},{"key":"879_CR93","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature23449","volume":"548","author":"KJ Mackenzie","year":"2017","unstructured":"Mackenzie KJ, Carroll P, Martin C-A, Murina O, Fluteau A, Simpson DJ, et al. cGAS surveillance of micronuclei links genome instability to innate immunity. Nature. 2017;548:461\u20135.","journal-title":"Nature"},{"key":"879_CR94","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1073\/pnas.1220977110","volume":"110","author":"S Zakov","year":"2013","unstructured":"Zakov S, Kinsella M, Bafna V. An algorithmic approach for breakage-fusion-bridge detection in tumor genomes. Proc Natl Acad Sci USA. 2013;110:5546\u201351.","journal-title":"Proc Natl Acad Sci USA"},{"key":"879_CR95","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/S1359-6446(02)02502-3","volume":"7","author":"M Fenech","year":"2002","unstructured":"Fenech M. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov Today. 2002;7:1128\u201337.","journal-title":"Drug Discov Today"},{"key":"879_CR96","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s10616-015-9869-6","volume":"68","author":"K Nishimura","year":"2016","unstructured":"Nishimura K, Watanabe S, Hayashida R, Sugishima S, Iwasaka T, Kaku T. Binucleated HeLa cells are formed by cytokinesis failure in starvation and keep the potential of proliferation. Cytotechnology. 2016;68:1123\u201330.","journal-title":"Cytotechnology"},{"key":"879_CR97","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41568-018-0084-6","volume":"19","author":"SMA Lens","year":"2019","unstructured":"Lens SMA, Medema RH. Cytokinesis defects and cancer. Nat Rev Cancer. 2019;19:32\u201345.","journal-title":"Nat Rev Cancer"},{"key":"879_CR98","doi-asserted-by":"crossref","unstructured":"Paz MFCJ, Sobral ALP, Picada JN, Grivicich I, J\u00fanior ALG, da Mata AMOF, et al. Persistent increased frequency of genomic instability in women diagnosed with breast cancer: before, during, and after treatments. Oxid Med Cell Longev. 2018;2018:2846819.","DOI":"10.1155\/2018\/2846819"},{"key":"879_CR99","doi-asserted-by":"crossref","unstructured":"Khlifi R, Trabelsi-Ksibi F, Chakroun A, Rebai A, Hamza-Chaffai. A cytogenetic abnormality in exfoliated cells of buccal mucosa in head and neck cancer patients in the Tunisian population: impact of different exposure sources. Biomed Res Int. 2013;2013:905252.","DOI":"10.1155\/2013\/905252"},{"key":"879_CR100","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1002\/dc.21128","volume":"37","author":"N Kimura","year":"2009","unstructured":"Kimura N, Dota K, Araya Y, Ishidate T, Ishizaka M. Scoring system for differential diagnosis of malignant mesothelioma and reactive mesothelial cells on cytology specimens. Diagn Cytopathol. 2009;37:885\u201390.","journal-title":"Diagn Cytopathol"},{"key":"879_CR101","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1016\/j.febslet.2010.03.044","volume":"584","author":"AP Sagona","year":"2010","unstructured":"Sagona AP, Stenmark H. Cytokinesis and cancer. FEBS Lett. 2010;584:2652\u201361.","journal-title":"FEBS Lett"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41366-021-00879-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41366-021-00879-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41366-021-00879-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T23:07:23Z","timestamp":1629673643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41366-021-00879-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":101,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["879"],"URL":"https:\/\/doi.org\/10.1038\/s41366-021-00879-2","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"6 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}