{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:55:31Z","timestamp":1776210931896,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1038\/s41366-024-01683-4","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T04:52:48Z","timestamp":1731991968000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity"],"prefix":"10.1038","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-4990","authenticated-orcid":false,"given":"Carmen","family":"Lambert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Morales-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Victoria","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-8985","authenticated-orcid":false,"given":"Elsa","family":"Villa-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e8ssica","family":"Latorre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Garc\u00eda-Villarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-2606","authenticated-orcid":false,"given":"Estrella Olga","family":"Turienzo Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Su\u00e1rez-Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7932-3475","authenticated-orcid":false,"given":"Raquel Rodr\u00edguez","family":"Ur\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0722-5283","authenticated-orcid":false,"given":"Sandra Sanz","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Ares-Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-0690","authenticated-orcid":false,"given":"Pedro","family":"Pujante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-0899","authenticated-orcid":false,"given":"Lourdes Mar\u00eda","family":"Sanz \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edelmiro","family":"Men\u00e9ndez-Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-9874","authenticated-orcid":false,"given":"Mar\u00eda","family":"Moreno Gij\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-9323","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Fernandez-Real","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-9712","authenticated-orcid":false,"given":"El\u00edas","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"1683_CR1","unstructured":"WHO. Obesity and overweight. 2017. http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/."},{"key":"1683_CR2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1210\/er.2017-00111","volume":"38","author":"MW Schwartz","year":"2017","unstructured":"Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM, et al. Obesity pathogenesis: an Endocrine Society scientific statement. Endocr Rev. 2017;38:267\u201396.","journal-title":"Endocr Rev"},{"key":"1683_CR3","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3945\/an.115.010207","volume":"7","author":"CJ Andersen","year":"2016","unstructured":"Andersen CJ, Murphy KE, Fernandez ML. Impact of obesity and metabolic syndrome on immunity. Adv Nutr. 2016;7:66\u201375.","journal-title":"Adv Nutr"},{"key":"1683_CR4","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1093\/eurheartj\/ehy066","volume":"39","author":"B Rocca","year":"2018","unstructured":"Rocca B, Fox KAA, Ajjan RA, Andreotti F, Baigent C, Collet JP, et al. Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis. Eur Heart J. 2018;39:1672\u201386.","journal-title":"Eur Heart J"},{"key":"1683_CR5","doi-asserted-by":"publisher","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","volume":"320","author":"T Kawai","year":"2021","unstructured":"Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320:C375\u201391.","journal-title":"Am J Physiol Cell Physiol"},{"key":"1683_CR6","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrd.2016.75","volume":"15","author":"CM Kusminski","year":"2016","unstructured":"Kusminski CM, Bickel PE, Scherer PE. Targeting adipose tissue in the treatment of obesity-associated diabetes. Nat Rev Drug Discov. 2016;15:639\u201360.","journal-title":"Nat Rev Drug Discov"},{"key":"1683_CR7","doi-asserted-by":"publisher","unstructured":"Kurylowicz A. microRNAs in human adipose tissue physiology and dysfunction. Cells. 2021;10. https:\/\/doi.org\/10.3390\/CELLS10123342.","DOI":"10.3390\/CELLS10123342"},{"key":"1683_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.trsl.2018.07.011","volume":"202","author":"CE Fealy","year":"2018","unstructured":"Fealy CE, Mulya A, Axelrod CL, Kirwan JP. Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes. Transl Res. 2018;202:69\u201382.","journal-title":"Transl Res"},{"key":"1683_CR9","doi-asserted-by":"publisher","unstructured":"Dilworth L, Facey A, Omoruyi F. Diabetes mellitus and its metabolic complications: the role of adipose tissues. Int J Mol Sci. 2021;22. https:\/\/doi.org\/10.3390\/ijms22147644.","DOI":"10.3390\/ijms22147644"},{"key":"1683_CR10","doi-asserted-by":"publisher","unstructured":"Butz H, Kinga N, Racz K, Patocs A. Circulating miRNAs as biomarkers for endocrine disorders. J Endocrinol Invest. 2016. https:\/\/doi.org\/10.1007\/s40618-015-0316-5.","DOI":"10.1007\/s40618-015-0316-5"},{"key":"1683_CR11","unstructured":"Babraham Bioinformatics. FastQC a quality control tool for high throughput sequence data. 2020. https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"1683_CR12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","volume":"17","author":"M Martin","year":"2011","unstructured":"Martin M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 2011;17:10.","journal-title":"EMBnet J"},{"key":"1683_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/gkr688","volume":"40","author":"MR Friedl\u00e4nder","year":"2012","unstructured":"Friedl\u00e4nder MR, MacKowiak SD, Li N, Chen W, Rajewsky N. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res. 2012;40:37\u201352.","journal-title":"Nucleic Acids Res"},{"key":"1683_CR14","doi-asserted-by":"publisher","first-page":"D155","DOI":"10.1093\/nar\/gky1141","volume":"47","author":"A Kozomara","year":"2019","unstructured":"Kozomara A, Birgaoanu M, Griffiths-Jones S. miRBase: from microRNA sequences to function. Nucleic Acids Res. 2019;47:D155\u201362.","journal-title":"Nucleic Acids Res"},{"key":"1683_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340.","journal-title":"Bioinformatics"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Stat Methodol. 1995;57:289\u2013300.","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28:882\u20133.","journal-title":"Bioinformatics"},{"key":"1683_CR18","unstructured":"miRNet. https:\/\/www.mirnet.ca\/miRNet\/home.xhtml."},{"key":"1683_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 2000;28:27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"1683_CR20","doi-asserted-by":"crossref","unstructured":"Blanco JA, Lambert C, Fernandez-Sanjurjo M, Morales-Sanchez P, Pujante P, Pinto-Hern\u00e1ndez P, et al. miR-24-3p and body mass index as type 2 diabetes risk factors in Spanish women 15 years after gestational diabetes mellitus diagnosis. Int J Mol Sci. 2023;24:1152.","DOI":"10.3390\/ijms24021152"},{"key":"1683_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1159\/000511772","volume":"14","author":"L Wang","year":"2021","unstructured":"Wang L, Shang C, Pan H, Yang H, Zhu H, Gong F. MicroRNA expression profiles in the subcutaneous adipose tissues of morbidly obese Chinese women. Obes Facts. 2021;14:78.","journal-title":"Obes Facts"},{"key":"1683_CR22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S2213-8587(23)00058-X","volume":"11","author":"F Rubino","year":"2023","unstructured":"Rubino F, Batterham RL, Koch M, Mingrone G, le Roux CW, Farooqi IS, et al. Lancet Diabetes & Endocrinology Commission on the definition and diagnosis of clinical obesity. Lancet Diabetes Endocrinol. 2023;11:226\u20138.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1683_CR23","first-page":"1","volume":"2023","author":"L Salm\u00f3n-G\u00f3mez","year":"2023","unstructured":"Salm\u00f3n-G\u00f3mez L, Catal\u00e1n V, Fr\u00fchbeck G, G\u00f3mez-Ambrosi J. Relevance of body composition in phenotyping the obesities. Rev Endocr Metab Disord. 2023;2023:1\u201315.","journal-title":"Rev Endocr Metab Disord"},{"key":"1683_CR24","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","volume":"92","author":"YC Chooi","year":"2019","unstructured":"Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6\u201310.","journal-title":"Metabolism"},{"key":"1683_CR25","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1093\/cvr\/cvx106","volume":"113","author":"AS Antonopoulos","year":"2017","unstructured":"Antonopoulos AS, Tousoulis D. The molecular mechanisms of obesity paradox. Cardiovasc Res. 2017;113:1074\u201386.","journal-title":"Cardiovasc Res"},{"key":"1683_CR26","doi-asserted-by":"publisher","unstructured":"Schetz M, De Jong A, Deane AM, Druml W, Hemelaar P, Pelosi P, et al. Obesity in the critically ill: a narrative review. Intensive Care Med. 2019. https:\/\/doi.org\/10.1007\/s00134-019-05594-1.","DOI":"10.1007\/s00134-019-05594-1"},{"key":"1683_CR27","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","volume":"126","author":"ME Pich\u00e9","year":"2020","unstructured":"Pich\u00e9 ME, Tchernof A, Despr\u00e9s JP. Obesity phenotypes, diabetes, and cardiovascular diseases. Circ Res. 2020;126:1477\u2013500.","journal-title":"Circ Res"},{"key":"1683_CR28","doi-asserted-by":"publisher","unstructured":"Li K, Zhang Y, Zhang Y, Xi Q, Wang S-b, Li W, et al. Comparative analysis of microRNA expression profiles between skeletal muscle- and adipose-derived exosomes in pig. 2021. https:\/\/doi.org\/10.3389\/fgene.2021.631230.","DOI":"10.3389\/fgene.2021.631230"},{"key":"1683_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells9102235","volume":"9","author":"G Arderiu","year":"2020","unstructured":"Arderiu G, Lambert C, Ballesta C, Moscatiello F, Vilahur G, Badimon L. Cardiovascular risk factors and differential transcriptomic profile of the subcutaneous and visceral adipose tissue and their resident stem cells. Cells. 2020;9:1\u201320.","journal-title":"Cells"},{"key":"1683_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1089\/rej.2022.0004","volume":"25","author":"D Lacedonia","year":"2022","unstructured":"Lacedonia D, Tartaglia N, Scioscia G, Soccio P, Pavone G, Moriondo G, et al. Different expression of micro-RNA in the subcutaneous and visceral adipose tissue of obese subjects. Rejuvenation Res. 2022;25:89\u201394.","journal-title":"Rejuvenation Res"},{"key":"1683_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.gene.2017.04.013","volume":"618","author":"Q Wang","year":"2017","unstructured":"Wang Q, Qi R, Wang J, Huang W, Wu Y, Huang X, et al. Differential expression profile of miRNAs in porcine muscle and adipose tissue during development. Gene. 2017;618:49\u201356.","journal-title":"Gene"},{"key":"1683_CR32","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s13258-020-00988-8","volume":"42","author":"H Ji","year":"2020","unstructured":"Ji H, Wang H, Ji Q, Ji W, Luo X, Wang J, et al. Differential expression profile of microRNA in yak skeletal muscle and adipose tissue during development. Genes Genomics. 2020;42:1347\u201359.","journal-title":"Genes Genomics"},{"key":"1683_CR33","doi-asserted-by":"publisher","unstructured":"Safa A, Bahroudi Z, Shoorei H, Majidpoor J, Abak A, Taheri M, et al. miR-1: a comprehensive review of its role in normal development and diverse disorders. Biomed Pharmacother. 2020;132. https:\/\/doi.org\/10.1016\/J.BIOPHA.2020.110903.","DOI":"10.1016\/J.BIOPHA.2020.110903"},{"key":"1683_CR34","doi-asserted-by":"publisher","unstructured":"Morales-S\u00e1nchez P, Lambert C, Ares-Blanco J, Su\u00e1rez-Guti\u00e9rrez L, Villa-Fern\u00e1ndez E, Garcia AV, et al. Circulating miRNA expression in long-standing type 1 diabetes mellitus. Sci Rep. 2023;13. https:\/\/doi.org\/10.1038\/S41598-023-35836-8.","DOI":"10.1038\/S41598-023-35836-8"},{"key":"1683_CR35","doi-asserted-by":"publisher","first-page":"345","DOI":"10.7150\/ijbs.10921","volume":"11","author":"G Ma","year":"2015","unstructured":"Ma G, Wang Y, Li Y, Cui L, Zhao Y, Zhao B, et al. MiR-206, a key modulator of skeletal muscle development and disease. Int J Biol Sci. 2015;11:345\u201352.","journal-title":"Int J Biol Sci"},{"key":"1683_CR36","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1136\/gutjnl-2020-322526","volume":"70","author":"X Wang","year":"2021","unstructured":"Wang X, He Y, MacKowiak B, Gao B. MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases. Gut. 2021;70:784\u201395.","journal-title":"Gut"},{"key":"1683_CR37","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1530\/EJE-14-0867","volume":"172","author":"R Wang","year":"2015","unstructured":"Wang R, Hong J, Cao Y, Shi J, Gu W, Ning G, et al. Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults. Eur J Endocrinol. 2015;172:291\u2013300.","journal-title":"Eur J Endocrinol"},{"key":"1683_CR38","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/oby.22704","volume":"28","author":"AL Hess","year":"2020","unstructured":"Hess AL, Larsen LH, Udesen PB, Sanz Y, Larsen TM, Dalgaard LT. Levels of circulating miR-122 are associated with weight loss and metabolic syndrome. Obesity. 2020;28:493\u2013501.","journal-title":"Obesity"},{"key":"1683_CR39","doi-asserted-by":"publisher","unstructured":"Gharanei S, Shabir K, Brown JE, Weickert MO, Barber TM, Kyrou I, et al. Regulatory microRNAs in brown, brite and white adipose tissue. Cells. 2020;9. https:\/\/doi.org\/10.3390\/CELLS9112489.","DOI":"10.3390\/CELLS9112489"},{"key":"1683_CR40","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.biocel.2013.04.029","volume":"45","author":"Y Peng","year":"2013","unstructured":"Peng Y, Xiang H, Chen C, Zheng R, Chai J, Peng J, et al. MiR-224 impairs adipocyte early differentiation and regulates fatty acid metabolism. Int J Biochem Cell Biol. 2013;45:1585\u201393.","journal-title":"Int J Biochem Cell Biol"},{"key":"1683_CR41","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12013-013-9708-3","volume":"68","author":"L Zhu","year":"2014","unstructured":"Zhu L, Chen L, Shi CM, Xu GF, Xu LL, Zhu LL, et al. MiR-335, an adipogenesis-related microRNA, is involved in adipose tissue inflammation. Cell Biochem Biophys. 2014;68:283\u201390.","journal-title":"Cell Biochem Biophys"},{"key":"1683_CR42","doi-asserted-by":"publisher","first-page":"34872","DOI":"10.1371\/journal.pone.0034872","volume":"7","author":"DV Chartoumpekis","year":"2012","unstructured":"Chartoumpekis DV, Zaravinos A, Ziros PG, Iskrenova RP, Psyrogiannis AI, Kyriazopoulou VE, et al. Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. PLoS ONE. 2012;7:34872.","journal-title":"PLoS ONE"},{"key":"1683_CR43","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.bbrc.2009.05.058","volume":"385","author":"N Nakanishi","year":"2009","unstructured":"Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, et al. The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem Biophys Res Commun. 2009;385:492\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"1683_CR44","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/apha.12681","volume":"219","author":"S Vienberg","year":"2017","unstructured":"Vienberg S, Geiger J, Madsen S, Dalgaard LT. MicroRNAs in metabolism. Acta Physiol. 2017;219:346.","journal-title":"Acta Physiol"},{"key":"1683_CR45","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/nature05482","volume":"444","author":"SE Kahn","year":"2006","unstructured":"Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840\u20136.","journal-title":"Nature"},{"key":"1683_CR46","doi-asserted-by":"publisher","first-page":"773","DOI":"10.2337\/db09-9028","volume":"58","author":"RA Defronzo","year":"2009","unstructured":"Defronzo RA. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773\u201395.","journal-title":"Diabetes"},{"key":"1683_CR47","doi-asserted-by":"publisher","unstructured":"Arderiu G, Mendieta G, Gallinat A, Lambert C, D\u00edez-Caballero A, Ballesta C, et al. Type 2 diabetes in obesity: a systems biology study on serum and adipose tissue proteomic profiles. Int J Mol Sci. 2023;24. https:\/\/doi.org\/10.3390\/IJMS24010827.","DOI":"10.3390\/IJMS24010827"},{"key":"1683_CR48","first-page":"1905","volume":"13","author":"J Liu","year":"2021","unstructured":"Liu J, Yang D, Wang B, Zeng Y, Li W. The value of miRNAs in the prognosis of obese patients receiving bariatric surgery. Am J Transl Res. 2021;13:1905.","journal-title":"Am J Transl Res"},{"key":"1683_CR49","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/oby.22379","volume":"27","author":"YU Bae","year":"2019","unstructured":"Bae YU, Kim Y, Lee H, Kim H, Jeon JS, Noh H, et al. Bariatric surgery alters microRNA content of circulating exosomes in patients with obesity. Obesity. 2019;27:264\u201371.","journal-title":"Obesity"},{"key":"1683_CR50","doi-asserted-by":"publisher","unstructured":"Langi G, Szczerbinski L, Kretowski A. Meta-analysis of differential miRNA expression after bariatric surgery. J Clin Med. 2019;8. https:\/\/doi.org\/10.3390\/JCM8081220.","DOI":"10.3390\/JCM8081220"},{"key":"1683_CR51","doi-asserted-by":"publisher","unstructured":"He X, Kuang G, Wu Y, Ou C. Emerging roles of exosomal miRNAs in diabetes mellitus. Clin Transl Med. 2021;11. https:\/\/doi.org\/10.1002\/CTM2.468.","DOI":"10.1002\/CTM2.468"},{"key":"1683_CR52","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s11695-019-04190-y","volume":"30","author":"G Rega-Kaun","year":"2020","unstructured":"Rega-Kaun G, Kaun C, Jaegersberger G, Prager M, Hackl M, Demyanets S, et al. Roux-en-Y-Bariatric surgery reduces markers of metabolic syndrome in morbidly obese patients. Obes Surg. 2020;30:391\u2013400.","journal-title":"Obes Surg"},{"key":"1683_CR53","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/oby.21950","volume":"25","author":"A Jones","year":"2017","unstructured":"Jones A, Danielson KM, Benton MC, Ziegler O, Shah R, Stubbs RS, et al. miRNA signatures of insulin resistance in obesity. Obesity. 2017;25:1734\u201344.","journal-title":"Obesity"},{"key":"1683_CR54","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/oby.23342","volume":"30","author":"G Wojciechowska","year":"2022","unstructured":"Wojciechowska G, Szczerbinski L, Kretowski M, Niemira M, Hady HR, Kretowski A. Exploring microRNAs as predictive biomarkers for type 2 diabetes mellitus remission after sleeve gastrectomy: a pilot study. Obesity. 2022;30:435\u201346.","journal-title":"Obesity"},{"key":"1683_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.676265","volume":"12","author":"AC Rodrigues","year":"2021","unstructured":"Rodrigues AC, Spagnol AR, Frias F, de T, de Mendon\u00e7a M, Ara\u00fajo HN, et al. Intramuscular injection of miR-1 reduces insulin resistance in obese mice. Front Physiol. 2021;12:676265.","journal-title":"Front Physiol"},{"key":"1683_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/br.2021.1409","volume":"14","author":"G Al-Kafaji","year":"2021","unstructured":"Al-Kafaji G, Al-Muhtaresh HA, Salem AH. Expression and clinical significance of miR-1 and miR-133 in pre-diabetes. Biomed Rep. 2021;14:1\u20139.","journal-title":"Biomed Rep"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41366-024-01683-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41366-024-01683-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41366-024-01683-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T11:11:16Z","timestamp":1744715476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41366-024-01683-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1038\/s41366-024-01683-4","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"25 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}