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Multiple linear regression and mediation analysis were conducted to determine the relationship between maternal characteristics and infant anthropometric measurements or salivary cortisol concentration and whether they were mediated by milk cortisol.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Plasma and milk cortisol concentrations were inversely associated with gestational weight gain and postpartum weight retention at 10 days postpartum. Maternal plasma and milk cortisol concentrations were directly with infant salivary cortisol concentration [Beta (95% CI): 0.05 (0.00, 0.09), <jats:italic>p<\/jats:italic>\u2009=\u20090.038; 0.95 (0.51, 1.39), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001], and inversely associated with infant BMI <jats:italic>z<\/jats:italic>-score [Beta (95% CI): \u22120.11 (\u22120.17, \u22120.04), <jats:italic>p<\/jats:italic>\u2009=\u20090.004; \u22121.04 (\u22121.69, \u22120.39), <jats:italic>p<\/jats:italic>\u2009=\u20090.003] at 3 months of lactation, the former mediated by milk cortisol (<jats:italic>p<\/jats:italic>\u2009=\u20090.039). Infant salivary cortisol was not associated with body weight and adiposity at 3 months of lactation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our study shows that in exclusively breastfed infants, milk cortisol is inversely associated with BMI <jats:italic>z<\/jats:italic>-score and influences salivary cortisol at 3 months postpartum. Further research is warranted to explore the mechanisms involved and how these interactions evolve across different stages of lactation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>This study was registered at clinicaltrials.gov as NCT05798676.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41366-025-01815-4","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T14:30:56Z","timestamp":1748701856000},"page":"1632-1641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations"],"prefix":"10.1038","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-0342","authenticated-orcid":false,"given":"Ana Luz","family":"Kruger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Malpeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrecia","family":"Fotia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-9473","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Fasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8987-6348","authenticated-orcid":false,"given":"Mar\u00eda F.","family":"Andreoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"1815_CR1","doi-asserted-by":"crossref","unstructured":"Donato J, Jr. Programming of metabolism by adipokines during development. 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