{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:51:46Z","timestamp":1775868706085,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>FTO<\/jats:italic>\n                      rs9939609 variant is a major common genetic risk factor of adult obesity. We hypothesized that the rs9939609 variant of the fetus alters the plasma glucose (PG) levels during oral glucose tolerance test (OGTT) routinely performed between the 24\u201328th gestational week.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed the data of mother-neonate pairs from our prior gestational diabetes mellitus (GDM) case-control study (Hungarian-Austrian set,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009858) and the HAPO study European ancestry subset (HAPO-EUR,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091374) using pre-pregnancy body mass index (BMI) and maternal age as covariates. The rs8050136 (complete LD with rs9939609) was used in the HAPO-EUR data set.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fetal\n                      <jats:italic>FTO<\/jats:italic>\n                      variants were associated (dominant genetic model) with decreased maternal 60\u2019min PG values (\u00df\n                      <jats:sub>Hungarian-Austrian<\/jats:sub>\n                      \u2009=\u2009\u22121.39\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.97*10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ; \u00df\n                      <jats:sub>HAPO-EUR<\/jats:sub>\n                      \u2009=\u2009\u22120.18\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20094.36*10\n                      <jats:sup>\u22122<\/jats:sup>\n                      ; \u00df\n                      <jats:sub>combined<\/jats:sub>\n                      \u2009=\u2009\u22120.33\u2009mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.11*10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ) and with reduced incremental area under glucose curve at OGTT (\u00df\n                      <jats:sub>Hungarian-Austrian<\/jats:sub>\n                      =\u22121.70\u2009mmol*h\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20093.83*10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ; \u00df\n                      <jats:sub>HAPO-EUR<\/jats:sub>\n                      \u2009=\u2009\u22120.23\u2009mmol*h\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.91*10\n                      <jats:sup>\u22122<\/jats:sup>\n                      ; \u00df\n                      <jats:sub>combined<\/jats:sub>\n                      \u2009=\u2009\u22120.39\u2009mmol*h\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.61*10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>FTO<\/jats:italic>\n                      risk variants carried by the fetus may indirectly influence maternal metabolism and could be associated with a flatter OGTT curve driven by the reduced 1\u2009h postload PG levels in pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41366-025-01896-1","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:04:08Z","timestamp":1756379048000},"page":"2338-2345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of fetal FTO gene variants with maternal postload glucose levels in pregnancy"],"prefix":"10.1038","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-8131","authenticated-orcid":false,"given":"G\u00e1bor","family":"Firneisz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"N\u00e1dasdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8607-418X","authenticated-orcid":false,"given":"Botond A.","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-9032","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Rosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-9403","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Harreiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-4105","authenticated-orcid":false,"given":"Alexandra","family":"Kautzky-Willer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik\u00f3","family":"Somogyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-0359","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Beny\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"1896_CR1","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pgen.0030115","volume":"3","author":"A Scuteri","year":"2007","unstructured":"Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, et al. 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Hungarian and\/or Austrian authorities did not have jurisdiction to approve the HAPO study [\n                      \n                      ] and therefore no ethical approval was required to access the dbGaP database (HAPO-EUR dataset) after NIH had approved our request [#131484-1] and granted access.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}}]}}