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Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog, MAPK and WNT\/\u03b2-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. In this study, we used genetically modified mice to study the role of IKK\u03b2 (a fundamental regulator of NF-\u03baB activity and many other proteins) in oral epithelial cells and odontogenic tissues. Transgenic mice overexpressing IKK\u03b2 in oral epithelial cells show a significant increase in immune cells in both the oral epithelia and oral submucosa. They also show changes in the expression of several proteins and miRNAs that are important for cancer development. Interestingly, we found that overactivity of IKK\u03b2 in oral epithelia and odontogenic tissues, in conjunction with the loss of tumour suppressor proteins (p53, or p16 and p19), leads to the appearance of odontogenic tumours that can be classified as ameloblastic odontomas, sometimes accompanied by foci of secondary ameloblastic carcinomas. These tumours show NF-\u03baB activation and increased \u03b2-catenin activity. These findings may help to elucidate the molecular determinants of odontogenic tumourigenesis and the role of IKK\u03b2 in the homoeostasis and tumoural transformation of oral and odontogenic epithelia.<\/jats:p>","DOI":"10.1038\/s41368-019-0067-9","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T09:02:44Z","timestamp":1578042164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["IKK\u03b2 overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice"],"prefix":"10.1038","volume":"12","author":[{"given":"Angustias","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-8921","authenticated-orcid":false,"given":"Ana","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Suarez-Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-4687","authenticated-orcid":false,"given":"Raquel","family":"Sanchez-Baltasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Oteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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