{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:12:35Z","timestamp":1793916755205,"version":"4.8.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000072","name":"U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R56DE033913"],"award-info":[{"award-number":["R56DE033913"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03 DE027492"],"award-info":[{"award-number":["R03 DE027492"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Oral Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dental implants have restored masticatory function to over 100 000 000 individuals, yet almost 1 000 000 implants fail each year due to peri-implantitis, a disease triggered by peri-implant microbial dysbiosis. Our ability to prevent and treat peri-implantitis is hampered by a paucity of knowledge of how these biomes are acquired and the factors that engender normobiosis. Therefore, we combined a 3-month interventional study of 15 systemically and periodontally healthy adults with whole genome sequencing, fine-scale enumeration and graph theoretics to interrogate colonization dynamics in the pristine peri-implant sulcus. We discovered that colonization trajectories of implants differ substantially from adjoining teeth in acquisition of new members and development of functional synergies. Source-tracking algorithms revealed that this niche is initially seeded by bacteria trapped within the coverscrew chamber during implant placement. These pioneer species stably colonize the microbiome and exert a sustained influence on the ecosystem by serving as anchors of influential hubs and by providing functions that enable cell replication and biofilm maturation. Unlike the periodontal microbiome, recruitment of new members to the peri-implant community occurs on nepotistic principles. Maturation is accompanied by a progressive increase in anaerobiosis, however, the predominant functionalities are oxygen-dependent over the 12-weeks. The peri-implant community is easily perturbed following crown placement, but demonstrates remarkable resilience; returning to pre-perturbation states within three weeks. This study highlights important differences in the development of the periodontal and peri-implant ecosystems, and signposts the importance of placing implants in periodontally healthy individuals or following the successful resolution of periodontal disease.<\/jats:p>","DOI":"10.1038\/s41368-025-00367-7","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T06:39:44Z","timestamp":1745908784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Community dynamics during de novo colonization of the nascent peri-implant sulcus"],"prefix":"10.1038","volume":"17","author":[{"given":"Tamires Pereira","family":"Dutra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Robitaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Altabtbaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shareef M.","family":"Dabdoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-1341","authenticated-orcid":false,"given":"Purnima S.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"367_CR1","unstructured":"NIDCR. Tooth Loss Among Adults 20\u221264. http:\/\/www.nidcr.nih.gov\/DataStatistics\/FindDataByTopic\/ToothLoss\/ToothLossAdults20to64.htm (2014)."},{"key":"367_CR2","doi-asserted-by":"crossref","unstructured":"Emami, E., De Souza, R. F., Kabawat M. & Feine J. S. The impact of edentulism on oral and general health. Int. J. Dentistry. 2013, 1\u22127 (2013).","DOI":"10.1155\/2013\/498305"},{"key":"367_CR3","doi-asserted-by":"crossref","unstructured":"Jain, N., Dutt, U., Radenkov, I. & Jain S. WHO\u2019s global oral health status report 2022: Actions, discussion and implementation. Oral Dis. 30, 73\u201379 (2023).","DOI":"10.1111\/odi.14516"},{"key":"367_CR4","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0022-3913(83)80101-2","volume":"50","author":"PI Br\u00e5nemark","year":"1983","unstructured":"Br\u00e5nemark, P. I. Osseointegration and its experimental background. J. Prosthet. Dent. 50, 399\u2013410 (1983).","journal-title":"J. Prosthet. Dent."},{"key":"367_CR5","first-page":"31","volume":"5","author":"W Becker","year":"1990","unstructured":"Becker, W., Becker, B. E., Newman, M. G. & Nyman, S. Clinical and microbiologic findings that may contribute to dental implant failure. Int J. Oral. Maxillofac. Implants 5, 31\u201338 (1990).","journal-title":"Int J. Oral. Maxillofac. Implants"},{"key":"367_CR6","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/jre.12562","volume":"53","author":"H Dreyer","year":"2018","unstructured":"Dreyer, H. et al. Epidemiology and risk factors of peri-implantitis: A systematic review. J. Periodontal Res. 53, 657\u2013681 (2018).","journal-title":"J. Periodontal Res."},{"key":"367_CR7","first-page":"CD004970","volume":"1","author":"M Esposito","year":"2012","unstructured":"Esposito, M., Grusovin, M. G. & Worthington, H. V. Interventions for replacing missing teeth: treatment of peri-implantitis. Cochrane Database Syst. Rev. 1, CD004970 (2012).","journal-title":"Cochrane Database Syst. Rev."},{"key":"367_CR8","doi-asserted-by":"publisher","first-page":"S286","DOI":"10.1111\/jcpe.12957","volume":"45","author":"T Berglundh","year":"2018","unstructured":"Berglundh, T. et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 45, S286\u2013S291 (2018).","journal-title":"J. Clin. Periodontol."},{"key":"367_CR9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/clr.13684","volume":"32","author":"M Romandini","year":"2021","unstructured":"Romandini, M. et al. Prevalence and risk\/protective indicators of peri-implant diseases: A university-representative cross-sectional study. Clin. Oral. Implants Res. 32, 112\u2013122 (2021).","journal-title":"Clin. Oral. Implants Res."},{"key":"367_CR10","doi-asserted-by":"crossref","unstructured":"Belibasakis, G. N. & Manoil, D. Microbial community-driven etiopathogenesis of peri-implantitis. J. Dental Res. 100, 21\u201328 (2021).","DOI":"10.1177\/0022034520949851"},{"key":"367_CR11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/JPER.21-0423","volume":"93","author":"SM Ganesan","year":"2022","unstructured":"Ganesan, S. M. et al. Biome-microbiome interactions in peri-implantitis: A pilot investigation. J. Periodontol. 93, 814\u2013823 (2022).","journal-title":"J. Periodontol."},{"key":"367_CR12","doi-asserted-by":"crossref","unstructured":"Dabdoub, S. M., Tsigarida, A. A. & Kumar P. S. Patient-specific analysis of periodontal and peri-implant microbiomes. J. Dent. Res. 92, 168S\u201375S (2013).","DOI":"10.1177\/0022034513504950"},{"key":"367_CR13","doi-asserted-by":"crossref","unstructured":"Sinjab, K. et al. Impact of surface characteristics on the peri-implant microbiome in health and disease. J. Periodontol. 95, 244\u2212255 (2024).","DOI":"10.1002\/JPER.23-0205"},{"key":"367_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1600-0501.2005.01194.x","volume":"17","author":"M Quirynen","year":"2006","unstructured":"Quirynen, M. et al. Dynamics of initial subgingival colonization of \u2018pristine\u2019 peri-implant pockets. Clin. Oral. Implants Res. 17, 25\u201337 (2006).","journal-title":"Clin. Oral. Implants Res."},{"key":"367_CR15","doi-asserted-by":"crossref","unstructured":"Quirynen, M. et al. Initial subgingival colonization of \u2018pristine\u2019 pockets. 2005.","DOI":"10.1177\/154405910508400409"},{"key":"367_CR16","doi-asserted-by":"crossref","unstructured":"Payne, J. B. et al. Subgingival microbiome colonization and cytokine production during early dental implant healing. mSphere. 2, e00527\u221217 (2017).","DOI":"10.1128\/mSphereDirect.00527-17"},{"key":"367_CR17","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1034\/j.1600-0501.2000.011006511.x","volume":"11","author":"AJ Van Winkelhoff","year":"2000","unstructured":"Van Winkelhoff, A. J., Goen\u00e9, R. J., Benschop, C. & Folmer, T. Early colonization of dental implants by putative periodontal pathogens in partially edentulous patients. Clin. Oral. Implants Res. 11, 511\u2013520 (2000).","journal-title":"Clin. Oral. Implants Res."},{"key":"367_CR18","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1007\/s00784-018-2334-0","volume":"22","author":"AR de Freitas","year":"2018","unstructured":"de Freitas, A. R. et al. Oral bacterial colonization on dental implants restored with titanium or zirconia abutments: 6-month follow-up. Clin. Oral. Investig. 22, 2335\u20132343 (2018).","journal-title":"Clin. Oral. Investig."},{"key":"367_CR19","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1600-0501.2007.01381.x","volume":"18","author":"MM F\u00fcrst","year":"2007","unstructured":"F\u00fcrst, M. M., Salvi, G. E., Lang, N. P. & Persson, G. R. Bacterial colonization immediately after installation on oral titanium implants. Clin. Oral. Implants Res. 18, 501\u2013508 (2007).","journal-title":"Clin. Oral. Implants Res."},{"key":"367_CR20","doi-asserted-by":"crossref","unstructured":"Silva-Boghossian, C. M., Duarte, P. T., Silva DG, da, Louren\u00e7o, T. G. B. & Colombo, A. P. V. Colonization dynamics of subgingival microbiota in recently installed dental implants compared to healthy teeth in the same individual: a 6-month prospective observational study. J. Appl. Oral Sci. 31, 1\u221210 (2023).","DOI":"10.1590\/1678-7757-2023-0134"},{"key":"367_CR21","doi-asserted-by":"crossref","unstructured":"Avila, M., Ojcius, D. M. & Zlem, Y. \u00d6. The oral microbiota: living with a permanent guest. DNA Cell Biol. 28, 405\u2013411 (2009).","DOI":"10.1089\/dna.2009.0874"},{"key":"367_CR22","doi-asserted-by":"crossref","unstructured":"De Wit, R. & Bouvier, T. \u2018Everything is everywhere, but, the environment selects\u2019; what did Baas Becking and Beijerinck really say? Environ. Microbiol. 8, 755\u2013758 (2006).","DOI":"10.1111\/j.1462-2920.2006.01017.x"},{"key":"367_CR23","unstructured":"Holmberg, T. J. BIOL 1213. LibreTexts; Northwestern Connecticut Community College https:\/\/bio.libretexts.org\/@go\/page\/79240 (2022). Retrieved from https:\/\/bio.libretexts.org\/Sandboxes\/tholmberg_at_nwcc.edu\/BIOL_1213"},{"key":"367_CR24","unstructured":"Clark, M. A., Douglas, M. & Choi, J. Biology 2e. 2nd edn. Vol. 1. (OpenStax; 2018)."},{"key":"367_CR25","unstructured":"Sottosanti, K. \u2018pioneer species\u2019. In: Encyclopedia Britannica. https:\/\/www.britannica.com\/science\/pioneer-species (2023)."},{"key":"367_CR26","unstructured":"Darwin, C. On the Origin of Species (Murray, 1859)."},{"key":"367_CR27","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/s41396-020-0613-7","volume":"14","author":"JL Darcy","year":"2020","unstructured":"Darcy, J. L. et al. A phylogenetic model for the recruitment of species into microbial communities and application to studies of the human microbiome. ISME J. 14, 1359\u20131368 (2020).","journal-title":"ISME J."},{"key":"367_CR28","unstructured":"Sumida, S., Kazuyuki, I., Kishi, M. & Okuda, K. Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant Regions. 17, 696\u2013702 (2002)."},{"key":"367_CR29","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1098\/rspb.2011.2268","volume":"279","author":"M Verd\u00fa","year":"2012","unstructured":"Verd\u00fa, M., G\u00f3mez-Aparicio, L. & Valiente-Banuet, A. Phylogenetic relatedness as a tool in restoration ecology: A meta-analysis. Proc. R. Soc. B: Biol. Sci. 279, 1761\u20131767 (2012).","journal-title":"Proc. R. Soc. B: Biol. Sci."},{"key":"367_CR30","doi-asserted-by":"crossref","unstructured":"Connell, J. H. & Slatyer, R. O. Mechanisms of succession in natural communities and their role in community stability and organization. American Naturalist. 111, 1119\u22121144 (1977).","DOI":"10.1086\/283241"},{"key":"367_CR31","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1890\/10-0720.1","volume":"91","author":"JP Castillo","year":"2010","unstructured":"Castillo, J. P., Verd\u00fa, M. & Valiente-Banuet, A. Neighborhood phylodiversity affects plant performance. Ecology 91, 3656\u20133663 (2010).","journal-title":"Ecology"},{"key":"367_CR32","first-page":"E791","volume":"113","author":"JLM Welch","year":"2016","unstructured":"Welch, J. L. M., Rossetti, B. J., Rieken, C. W., Dewhirst, F. E. & Borisy, G. G. Biogeography of a human oral microbiome at the micron scale. Proc. Natl Acad. Sci. USA. 113, E791\u2013E800 (2016).","journal-title":"Proc. Natl Acad. Sci. USA."},{"key":"367_CR33","first-page":"E9105","volume":"114","author":"JLM Welch","year":"2017","unstructured":"Welch, J. L. M., Hasegawa, Y., McNulty, N. P., Gordon, J. I. & Borisy, G. G. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice. Proc. Natl Acad. Sci. USA. 114, E9105\u2013E9114 (2017).","journal-title":"Proc. Natl Acad. Sci. USA."},{"key":"367_CR34","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1600-051X.2012.01856.x","volume":"39","author":"PS Kumar","year":"2012","unstructured":"Kumar, P. S., Mason, M. R., Brooker, M. R. & O\u2019Brien, K. Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants. J. Clin. Periodontol. 39, 425\u2013433 (2012).","journal-title":"J. Clin. Periodontol."},{"key":"367_CR35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1902\/jop.2012.110662","volume":"84","author":"CR Matthews","year":"2013","unstructured":"Matthews, C. R., Joshi, V., de Jager, M., Aspiras, M. & Kumar, P. S. Host-bacterial interactions during induction and resolution of experimental gingivitis in current smokers. J. Periodontol. 84, 32\u201340 (2013).","journal-title":"J. Periodontol."},{"key":"367_CR36","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1111\/jcpe.12300","volume":"41","author":"V Joshi","year":"2014","unstructured":"Joshi, V. et al. Smoking decreases structural and functional resilience in the subgingival ecosystem. J. Clin. Periodontol. 41, 1037\u20131047 (2014).","journal-title":"J. Clin. Periodontol."},{"key":"367_CR37","doi-asserted-by":"crossref","unstructured":"Duran-Pinedo, A. et al. Long-term dynamics of the human oral microbiome during clinical disease progression. BMC Biol. 19, 2\u221217 (2021).","DOI":"10.1186\/s12915-021-01169-z"},{"key":"367_CR38","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3109\/00016356309011240","volume":"21","author":"H Loe","year":"1963","unstructured":"Loe, H. & Silness, J. Periodontal disease in pregnancy.I. Prevalence and severity. Acta Odontol. Scand. 21, 533\u2013551 (1963).","journal-title":"Acta Odontol. Scand."},{"key":"367_CR39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3109\/00016356408993968","volume":"22","author":"J Silness","year":"1964","unstructured":"Silness, J. & Loe, H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol. Scand. 22, 121\u2013135 (1964).","journal-title":"Acta Odontol. Scand."},{"key":"367_CR40","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357\u2013359 (2012).","journal-title":"Nat. Methods"},{"key":"367_CR41","doi-asserted-by":"crossref","unstructured":"Escapa, I. F. et al. New Insights into Human Nostril Microbiome from the Expanded Human Oral Microbiome Database (eHOMD): a Resource for the Microbiome of the Human Aerodigestive Tract. mSystems. 3, 1\u221220 (2018).","DOI":"10.1128\/msystems.00187-18"},{"key":"367_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nmeth.3176","volume":"12","author":"B Buchfink","year":"2015","unstructured":"Buchfink, B., Xie, C. & Huson, D. H. Fast and sensitive protein alignment using DIAMOND. Nat. Methods 12, 59\u201360 (2015).","journal-title":"Nat. Methods"},{"key":"367_CR43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"367_CR44","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1101\/gr.5969107","volume":"17","author":"DH Huson","year":"2007","unstructured":"Huson, D. H., Auch, A. F., Qi, J. & Schuster, S. C. MEGAN analysis of metagenomic data. Genome Res. 17, 377\u2013386 (2007).","journal-title":"Genome Res."},{"key":"367_CR45","unstructured":"Bolyen, E. et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37, 852\u2013857 (2019)."},{"key":"367_CR46","doi-asserted-by":"crossref","unstructured":"Dabdoub, S. M. et al. PhyloToAST: Bioinformatics tools for species-level analysis and visualization of complex microbial datasets. Sci. Rep. 6, 1\u22129 (2016).","DOI":"10.1038\/srep29123"},{"key":"367_CR47","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1046\/j.1466-822X.2003.00015.x","volume":"12","author":"IF Spellerberg","year":"2003","unstructured":"Spellerberg, I. F. & Fedor, P. J. A tribute to Claude Shannon (1916\u20132001) and a plea for more rigorous use of species richness, species diversity and the \u2018Shannon\u2013Wiener\u2019 Index. Glob. Ecol. Biogeogr. 12, 177\u2013179 (2003).","journal-title":"Glob. Ecol. Biogeogr."},{"key":"367_CR48","doi-asserted-by":"crossref","unstructured":"Han, R., Shi, P. & Zhang, A. R. Guaranteed functional tensor singular value decomposition. J. Am. Stat. Assoc. 119, 995\u20131007 (2023).","DOI":"10.1080\/01621459.2022.2153689"},{"key":"367_CR49","doi-asserted-by":"crossref","unstructured":"Shi, P., Martino, C., Han, R. et al. TEMPTED: time-informed dimensionality reduction for longitudinal microbiome studies. Genome. Biol. 25, 317 (2024).","DOI":"10.1186\/s13059-024-03453-x"},{"key":"367_CR50","doi-asserted-by":"crossref","unstructured":"McGhee, J. J. et al. Meta-SourceTracker: Application of Bayesian source tracking to shotgun metagenomics. PeerJ. 8, 2\u221218 (2020).","DOI":"10.7717\/peerj.8783"},{"key":"367_CR51","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/1755-0998.13704","volume":"23","author":"M Shaffer","year":"2023","unstructured":"Shaffer, M., Thurimella, K., Sterrett, J. D. & Lozupone, C. A. SCNIC: Sparse correlation network investigation for compositional data. Mol. Ecol. Resour. 23, 312\u2013325 (2023).","journal-title":"Mol. Ecol. Resour."},{"key":"367_CR52","doi-asserted-by":"publisher","unstructured":"Bastian, M., Heymann, S., & Jacomy, M. (2009). Gephi: an open source software for exploring and manipulating networks. In Proc. International AAAI Conference on Web and Social Media, 3(1), 361\u2212362. https:\/\/doi.org\/10.1609\/icwsm.v3i1.13937.","DOI":"10.1609\/icwsm.v3i1.13937"},{"key":"367_CR53","doi-asserted-by":"crossref","unstructured":"Xia, L. C. et al. Extended local similarity analysis (eLSA) of microbial community and other time series data with replicates. BMC Syst. Biol. 5, 1\u221212 (2011).","DOI":"10.1186\/1752-0509-5-S2-S15"},{"key":"367_CR54","doi-asserted-by":"publisher","first-page":"W510","DOI":"10.1093\/nar\/gky299","volume":"46","author":"Y Darzi","year":"2018","unstructured":"Darzi, Y., Letunic, I., Bork, P. & Yamada, T. iPath3.0: interactive pathways explorer v3. Nucleic Acids Res. 46, W510\u2013W513 (2018).","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00367-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00367-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00367-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T06:39:59Z","timestamp":1745908799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00367-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["367"],"URL":"https:\/\/doi.org\/10.1038\/s41368-025-00367-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5390824\/v1","asserted-by":"object"}]},"ISSN":["2049-3169"],"issn-type":[{"value":"2049-3169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"4 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None of the authors have any competing interests to declare. This study was supported by National Institutes of Health award R03DE027492 to Shareef Dabdoub. Tamires Pereira Dutra is supported by R01DE027857-06 from the National Institutes of Health. The sequencing and data analysis was supported by National Institutes of Health R56DE033913 awarded to Purnima Kumar","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"37"}}