{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:26:14Z","timestamp":1789133174446,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Oral Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigates the role of Interleukin 17 (IL-17) in exacerbating periapical lesions caused by\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    (\n                    <jats:italic>Pg<\/jats:italic>\n                    ) lipopolysaccharides (LPS) in the context of metabolic disease and its potential impact on glucose tolerance. Researchers developed a unique mouse model where mice were monocolonized with\n                    <jats:italic>Pg<\/jats:italic>\n                    to induce periapical lesions. After 1 month, they were fed a high-fat diet (HFD) for 2 months to simulate metabolic disease and oral microbiota dysbiosis. To explore the role of LPS from\n                    <jats:italic>Pg<\/jats:italic>\n                    , wild-type (WT) mice were challenged with purified LPS from\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , as well as with LPS-depleted and non-depleted\n                    <jats:italic>Pg<\/jats:italic>\n                    bacteria; IL-17 knockout (KO) mice were also included to assess the role of IL-17 signaling. The impact on bone lysis, periapical injury, glucose intolerance, and immune response was assessed. Results showed that in WT mice, the presence of LPS significantly worsened bone lysis, Th17 cell recruitment, and periapical injury. IL-17 KO mice exhibited reduced bone loss, glucose intolerance, and immune cell infiltration. Additionally, inflammatory markers in adipose tissue were lower in IL-17 KO mice, despite increased dysbiosis. The findings suggest that IL-17 plays a critical role in amplifying\n                    <jats:italic>Pg<\/jats:italic>\n                    -induced periapical lesions and systemic metabolic disturbances. Targeting IL-17 recruitment could offer a novel approach to improving glycemic control and reducing type 2 diabetes (T2D) risk in individuals with periapical disease.\n                  <\/jats:p>","DOI":"10.1038\/s41368-025-00403-6","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:22:41Z","timestamp":1763014961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response"],"prefix":"10.1038","volume":"17","author":[{"given":"Sylvie","family":"L\u00ea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Sturaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Canceill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Ekambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawel","family":"Fellouah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Knauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Abot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tenailleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Duployer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Loubieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Prosper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swann","family":"Diemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Burcelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Diemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Minty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-8980","authenticated-orcid":false,"given":"Vincent","family":"Blasco-Baque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"403_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature05485","volume":"444","author":"GS Hotamisligil","year":"2006","unstructured":"Hotamisligil, G. S. Inflammation and metabolic disorders. Nature 444, 860\u2013867 (2006).","journal-title":"Nature"},{"key":"403_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","volume":"582","author":"C de Luca","year":"2008","unstructured":"de Luca, C. & Olefsky, J. M. Inflammation and insulin resistance. FEBS Lett. 582, 97\u2013105 (2008).","journal-title":"FEBS Lett."},{"key":"403_CR3","doi-asserted-by":"publisher","first-page":"2439105","DOI":"10.1080\/19490976.2024.2439105","volume":"17","author":"M Minty","year":"2025","unstructured":"Minty, M. et al. Identifying the location-dependent adipose tissue bacterial DNA signatures in obese patients that predict body weight loss. Gut Microbes 17, 2439105 (2025).","journal-title":"Gut Microbes"},{"key":"403_CR4","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/iej.13467","volume":"54","author":"CS Tib\u00farcio-Machado","year":"2021","unstructured":"Tib\u00farcio-Machado, C. S. et al. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int. Endod. J. 54, 712\u2013735 (2021).","journal-title":"Int. Endod. J."},{"key":"403_CR5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/iej.13253","volume":"53","author":"V Nagendrababu","year":"2020","unstructured":"Nagendrababu, V., Segura-Egea, J. J., Fouad, A. F., Pulikkotil, S. J. & Dummer, P. M. H. Association between diabetes and the outcome of root canal treatment in adults: an umbrella review. Int. Endod. J. 53, 455\u2013466 (2020).","journal-title":"Int. Endod. J."},{"key":"403_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4067\/S0716-97602007000200001","volume":"40","author":"SA Arancibia","year":"2007","unstructured":"Arancibia, S. A. et al. Toll-like receptors are key participants in innate immune responses. Biol. Res. 40, 97\u2013112 (2007).","journal-title":"Biol. Res."},{"key":"403_CR7","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1902\/jop.2014.140087","volume":"85","author":"X Yang","year":"2014","unstructured":"Yang, X. et al. Toll-like receptor 4-mediated hyper-responsiveness of gingival epithelial cells to lipopolysaccharide in high-glucose environments. J. Periodontol. 85, 1620\u20131628 (2014).","journal-title":"J. Periodontol."},{"key":"403_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nrd3794","volume":"11","author":"P Miossec","year":"2012","unstructured":"Miossec, P. & Kolls, J. K. Targeting IL-17 and TH17 cells in chronic inflammation. Nat. Rev. Drug Discov. 11, 763\u2013776 (2012).","journal-title":"Nat. Rev. Drug Discov."},{"key":"403_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s12016-022-08928-y","volume":"64","author":"JM Mannion","year":"2023","unstructured":"Mannion, J. M., McLoughlin, R. M. & Lalor, S. J. The airway microbiome-IL-17 axis: a critical regulator of chronic inflammatory disease. Clin. Rev. Allerg. Immunol. 64, 161\u2013178 (2023).","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"403_CR10","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1348-0421.2009.00123.x","volume":"53","author":"F Oseko","year":"2009","unstructured":"Oseko, F. et al. IL-17 is involved in bone resorption in mouse periapical lesions. Microbiol. Immunol. 53, 287\u2013294 (2009).","journal-title":"Microbiol. Immunol."},{"key":"403_CR11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","volume":"4","author":"II Ivanov","year":"2008","unstructured":"Ivanov, I. I. et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 4, 337\u2013349 (2008).","journal-title":"Cell Host Microbe."},{"key":"403_CR12","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cmet.2015.06.001","volume":"22","author":"L Garidou","year":"2015","unstructured":"Garidou, L. et al. The gut microbiota regulates intestinal CD4 T cells expressing ROR\u03b3t and controls metabolic disease. Cell Metab. 22, 100\u2013112 (2015).","journal-title":"Cell Metab."},{"key":"403_CR13","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1136\/gutjnl-2019-320118","volume":"69","author":"L Massier","year":"2020","unstructured":"Massier, L. et al. Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes. Gut 69, 1796\u20131806 (2020).","journal-title":"Gut"},{"key":"403_CR14","doi-asserted-by":"publisher","DOI":"10.1177\/24705470221076390","volume":"6","author":"MJ Page","year":"2022","unstructured":"Page, M. J., Kell, D. B. & Pretorius, E. The role of lipopolysaccharide-induced cell signalling in chronic inflammation. Chronic Stress 6, 24705470221076390 (2022).","journal-title":"Chronic Stress"},{"key":"403_CR15","doi-asserted-by":"crossref","unstructured":"Mohammad, S. & Thiemermann, C. Role of metabolic endotoxemia in systemic inflammation and potential interventions. Front. Immunol. 11. Disponible sur: https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2020.594150\/full (2021).","DOI":"10.3389\/fimmu.2020.594150"},{"key":"403_CR16","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.3390\/ijms24021589","volume":"24","author":"M Minty","year":"2023","unstructured":"Minty, M. et al. Low-diversity microbiota in apical periodontitis and high blood pressure are signatures of the severity of apical lesions in humans. Int. J. Mol. Sci. 24, 1589 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"403_CR17","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1902\/jop.2011.110063","volume":"82","author":"CV Pereira","year":"2011","unstructured":"Pereira, C. V., Stipp, R. N., Fonseca, D. C., Pereira, L. J. & H\u00f6fling, J. F. Detection and clonal analysis of anaerobic bacteria associated to endodontic-periodontal lesions. J. Periodontol. 82, 1767\u20131775 (2011).","journal-title":"J. Periodontol."},{"key":"403_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1365-2591.2012.02035.x","volume":"45","author":"H Cao","year":"2012","unstructured":"Cao, H. et al. Detection of Porphyromonas endodontalis, Porphyromonas gingivalis and Prevotella intermedia in primary endodontic infections in a Chinese population. Int Endod. J. 45, 773\u2013781 (2012).","journal-title":"Int Endod. J."},{"key":"403_CR19","doi-asserted-by":"crossref","unstructured":"Jia, L. et al. Pathogenesis of important virulence factors of porphyromonas gingivalis via toll-like receptors. Front. Cell Infect. Microbiol. Disponible sur: https:\/\/www.frontiersin.org\/journals\/cellular-and-infection-microbiology\/articles\/10.3389\/fcimb.2019.00262\/full (2019).","DOI":"10.3389\/fcimb.2019.00262"},{"key":"403_CR20","doi-asserted-by":"publisher","first-page":"114002","DOI":"10.1016\/j.intimp.2024.114002","volume":"147","author":"J Zhang","year":"2025","unstructured":"Zhang, J., Chen, X., Huang, D. & Tan, X. Impact of p. Gingivalis-induced chronic apical periodontitis on systemic iron homeostasis via the hepatic IL-6\/STAT3\/Hepcidin signaling pathway. Int. Immunopharmacol. 147, 114002 (2025).","journal-title":"Int. Immunopharmacol."},{"key":"403_CR21","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1136\/gutjnl-2015-309897","volume":"66","author":"V Blasco-Baque","year":"2017","unstructured":"Blasco-Baque, V. et al. Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut 66, 872\u2013885 (2017).","journal-title":"Gut"},{"key":"403_CR22","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/biom12030378","volume":"12","author":"K Thouvenot","year":"2022","unstructured":"Thouvenot, K. et al. Links between insulin resistance and periodontal bacteria: insights on molecular players and therapeutic potential of polyphenols. Biomolecules 12, 378 (2022).","journal-title":"Biomolecules"},{"key":"403_CR23","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.2337\/dc12-0072","volume":"35","author":"RT Demmer","year":"2012","unstructured":"Demmer, R. T. et al. Periodontal infection, systemic inflammation, and insulin resistance: results from the continuous national health and nutrition examination survey (NHANES) 1999\u20132004. Diabetes Care 35, 2235\u20132242 (2012).","journal-title":"Diabetes Care"},{"key":"403_CR24","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3390\/jcm9020540","volume":"9","author":"F P\u00e9rez-Losada","year":"2020","unstructured":"P\u00e9rez-Losada, F. et al. Apical periodontitis and diabetes mellitus type 2: a systematic review and meta-analysis. J. Clin. Med. 9, 540 (2020).","journal-title":"J. Clin. Med."},{"key":"403_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.joen.2024.11.008","volume":"51","author":"R Dhamija","year":"2025","unstructured":"Dhamija, R. et al. Association of apical periodontitis with glycated hemoglobin levels and systemic inflammatory markers in patients with type 2 diabetes: a cross-sectional study. J. Endod. 51, 124\u2013131 (2025).","journal-title":"J. Endod."},{"key":"403_CR26","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","volume":"78","author":"A Ciesielska","year":"2021","unstructured":"Ciesielska, A., Matyjek, M. & Kwiatkowska, K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell. Mol. Life Sci. 78, 1233\u20131261 (2021).","journal-title":"Cell. Mol. Life Sci."},{"key":"403_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijmm.2023.5263","volume":"52","author":"L Ye","year":"2023","unstructured":"Ye, L. et al. Interaction between apical periodontitis and systemic disease (Review). Int. J. Mol. Med. 52, 1\u201319 (2023).","journal-title":"Int. J. Mol. Med."},{"key":"403_CR28","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.2174\/1381612822666160216145107","volume":"22","author":"H Sasaki","year":"2016","unstructured":"Sasaki, H. et al. Interrelationship between periapical lesion and systemic metabolic disorders. Curr. Pharm. Des. 22, 2204 (2016).","journal-title":"Curr. Pharm. Des."},{"key":"403_CR29","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.joen.2014.03.024","volume":"40","author":"NC Ajuz","year":"2014","unstructured":"Ajuz, N. C. et al. Immunoexpression of interleukin 17 in apical periodontitis lesions. J. Endod. 40, 1400\u20131403 (2014).","journal-title":"J. Endod."},{"key":"403_CR30","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.4049\/jimmunol.2000986","volume":"207","author":"SJ Gaudino","year":"2021","unstructured":"Gaudino, S. J. et al. Cutting edge: intestinal IL-17A receptor signaling specifically regulates high-fat diet\u2013mediated, microbiota-driven metabolic disorders. J. Immunol. 207, 1959\u20131963 (2021).","journal-title":"J. Immunol."},{"key":"403_CR31","doi-asserted-by":"publisher","first-page":"6947","DOI":"10.4049\/jimmunol.1001269","volume":"185","author":"LA Z\u00fa\u00f1iga","year":"2010","unstructured":"Z\u00fa\u00f1iga, L. A. et al. IL-17 Regulates adipogenesis, glucose homeostasis, and obesity. J. Immunol. 185, 6947\u20136959 (2010).","journal-title":"J. Immunol."},{"key":"403_CR32","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.4049\/jimmunol.0903664","volume":"185","author":"H Tang","year":"2010","unstructured":"Tang, H. et al. TLR4 activation is required for IL-17\u2013induced multiple tissue inflammation and wasting in mice. J. Immunol. 185, 2563\u20132569 (2010).","journal-title":"J. Immunol."},{"key":"403_CR33","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/pathogens11101173","volume":"11","author":"LH Aleksijevi\u0107","year":"2022","unstructured":"Aleksijevi\u0107, L. H. et al. Porphyromonas gingivalis virulence factors and clinical significance in periodontal disease and coronary artery diseases. Pathogens 11, 1173 (2022).","journal-title":"Pathogens"},{"key":"403_CR34","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.3390\/ijms25073611","volume":"25","author":"L Y\u00e1\u00f1ez","year":"2024","unstructured":"Y\u00e1\u00f1ez, L. et al. Co-culture of P. gingivalis and F. nucleatum synergistically elevates IL-6 expression via TLR4 signaling in oral keratinocytes. Int. J. Mol. Sci. 25, 3611 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"403_CR35","doi-asserted-by":"publisher","first-page":"e71727","DOI":"10.1371\/journal.pone.0071727","volume":"8","author":"Y Zhu","year":"2013","unstructured":"Zhu, Y. et al. Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development. PLoS ONE 8, e71727 (2013).","journal-title":"PLoS ONE"},{"key":"403_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/j.2040-4603.2019.tb00055.x","volume":"9","author":"MS Burhans","year":"2018","unstructured":"Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A. & Kratz, M. Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus. Compr. Physiol. 9, 1\u201358 (2018).","journal-title":"Compr. Physiol."},{"key":"403_CR37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","volume":"19","author":"F Di Vincenzo","year":"2024","unstructured":"Di Vincenzo, F., Del Gaudio, A., Petito, V., Lopetuso, L. R. & Scaldaferri, F. Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Intern Emerg. Med 19, 275\u2013293 (2024).","journal-title":"Intern Emerg. Med"},{"key":"403_CR38","doi-asserted-by":"publisher","first-page":"703310","DOI":"10.3389\/fcell.2021.703310","volume":"9","author":"R Linares","year":"2021","unstructured":"Linares, R., Franc\u00e9s, R., Guti\u00e9rrez, A. & Juanola, O. Bacterial translocation as inflammatory driver in Crohn\u2019s disease. Front Cell Dev. Biol. 9, 703310 (2021).","journal-title":"Front Cell Dev. Biol."},{"key":"403_CR39","doi-asserted-by":"publisher","first-page":"e85461","DOI":"10.1371\/journal.pone.0085461","volume":"9","author":"S Ge","year":"2014","unstructured":"Ge, S. et al. Interleukin 17 receptor A modulates monocyte subsets and macrophage generation in vivo. PLoS ONE 9, e85461 (2014).","journal-title":"PLoS ONE"},{"key":"403_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10753-010-9201-8","volume":"34","author":"E Silverpil","year":"2011","unstructured":"Silverpil, E., Glader, P., Hansson, M. & Lind\u00e9n, A. Impact of interleukin-17 on macrophage phagocytosis of apoptotic neutrophils and particles. Inflammation 34, 1\u20139 (2011).","journal-title":"Inflammation"},{"key":"403_CR41","doi-asserted-by":"crossref","unstructured":"Takeuchi, H., Nakamura, E., Yamaga, S. & Amano, A. Porphyromonas gingivalis Infection Induces Lipopolysaccharide and Peptidoglycan Penetration Through Gingival Epithelium. Front. Oral Health 3. Disponible sur: https:\/\/www.frontiersin.org\/journals\/oral-health\/articles\/10.3389\/froh.2022.845002\/full (2022).","DOI":"10.3389\/froh.2022.845002"},{"key":"403_CR42","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1128\/IAI.68.3.1441-1449.2000","volume":"68","author":"J Katz","year":"2000","unstructured":"Katz, J., Sambandam, V., Wu, J. H., Michalek, S. M. & Balkovetz, D. F. Characterization of porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes. Infect. Immun. 68, 1441 (2000).","journal-title":"Infect. Immun."},{"key":"403_CR43","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1128\/IAI.73.3.1543-1552.2005","volume":"73","author":"SM Sheets","year":"2005","unstructured":"Sheets, S. M., Potempa, J., Travis, J., Casiano, C. A. & Fletcher, H. M. Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells. Infect. Immun. 73, 1543 (2005).","journal-title":"Infect. Immun."},{"key":"403_CR44","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/pathogens9110944","volume":"9","author":"F Mei","year":"2020","unstructured":"Mei, F. et al. Porphyromonas gingivalis and its systemic impact: current status. Pathogens 9, 944 (2020).","journal-title":"Pathogens"},{"key":"403_CR45","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","volume":"55","author":"PM Preshaw","year":"2012","unstructured":"Preshaw, P. M. et al. Periodontitis and diabetes: a two-way relationship. Diabetologia 55, 21\u201331 (2012).","journal-title":"Diabetologia"},{"key":"403_CR46","doi-asserted-by":"crossref","unstructured":"Shoji, M., Sato, K., Yukitake, H., Naito, M. & Nakayama, K. Involvement of the Wbp pathway in the biosynthesis of Porphyromonas gingivalis lipopolysaccharide with anionic polysaccharide. Sci. Rep. 4. Disponible sur: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4031482\/ (2014).","DOI":"10.1038\/srep05056"}],"container-title":["International Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00403-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00403-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00403-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T08:03:32Z","timestamp":1763021012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41368-025-00403-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["403"],"URL":"https:\/\/doi.org\/10.1038\/s41368-025-00403-6","relation":{},"ISSN":["2049-3169"],"issn-type":[{"value":"2049-3169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]},"assertion":[{"value":"20 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.A. is employed by Enterosys SAS (Lab\u00e8ge, France) and C.K. is co-founder of Enterosys (add in the manuscript). The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}