{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:12:41Z","timestamp":1792793561869,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Oral Sci"],"DOI":"10.1038\/s41368-026-00427-6","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:13:46Z","timestamp":1773285226000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gli2 and Gli3 synergistically mediate HH-TGF-\u03b2 crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis"],"prefix":"10.1038","volume":"18","author":[{"given":"Tao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-8091","authenticated-orcid":false,"given":"Li","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2961-0086","authenticated-orcid":false,"given":"Hu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-8204","authenticated-orcid":false,"given":"Xianglong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8608-8316","authenticated-orcid":false,"given":"Junjun","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"427_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12105-021-01301-z","volume":"15","author":"DM Roth","year":"2021","unstructured":"Roth, D. M., Bayona, F., Baddam, P. & Graf, D. Craniofacial development: neural crest in molecular embryology. Head. Neck. Pathol. 15, 1\u201315 (2021).","journal-title":"Head. Neck. Pathol."},{"key":"427_CR2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nm1725","volume":"14","author":"NC Jones","year":"2008","unstructured":"Jones, N. C. et al. Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat. Med. 14, 125\u2013133 (2008).","journal-title":"Nat. Med."},{"key":"427_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/nyas.15183","volume":"1537","author":"X Niu","year":"2024","unstructured":"Niu, X., Zhang, F., Gu, W., Zhang, B. & Chen, X. FBLN2 is associated with Goldenhar syndrome and is essential for cranial neural crest cell development. Ann. N. Y. Acad. Sci. 1537, 113\u2013128 (2024).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"427_CR4","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202110","volume":"151","author":"RE Musa","year":"2024","unstructured":"Musa, R. E. et al. BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation. Development 151, dev202110 (2024).","journal-title":"Development"},{"key":"427_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/jdb4030024","volume":"4","author":"S Dworkin","year":"2016","unstructured":"Dworkin, S., Boglev, Y., Owens, H. & Goldie, S. J. The role of sonic hedgehog in craniofacial patterning, morphogenesis and cranial neural crest survival. J. Dev. Biol. 4, 24 (2016).","journal-title":"J. Dev. Biol."},{"key":"427_CR6","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1101\/gad.1190304","volume":"18","author":"J Jeong","year":"2004","unstructured":"Jeong, J., Mao, J., Tenzen, T., Kottmann, A. H. & McMahon, A. P. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes. Dev. 18, 937\u2013951 (2004).","journal-title":"Genes. Dev."},{"key":"427_CR7","doi-asserted-by":"publisher","first-page":"15814","DOI":"10.1074\/jbc.M117.777532","volume":"292","author":"J Li","year":"2017","unstructured":"Li, J. et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J. Biol. Chem. 292, 15814\u201315825 (2017).","journal-title":"J. Biol. Chem."},{"key":"427_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.714","volume":"7","author":"P Meng","year":"2019","unstructured":"Meng, P. et al. Three GLI2 mutations combined potentially underlie non-syndromic cleft lip with or without cleft palate in a Chinese pedigree. Mol. Genet. Genom. Med. 7, e714 (2019).","journal-title":"Mol. Genet. Genom. Med."},{"key":"427_CR9","doi-asserted-by":"publisher","first-page":"e1006351","DOI":"10.1371\/journal.pgen.1006351","volume":"12","author":"CF Chang","year":"2016","unstructured":"Chang, C. F., Chang, Y. T., Millington, G. & Brugmann, S. A. Craniofacial ciliopathies reveal specific requirements for GLI proteins during development of the facial midline. PLoS. Genet. 12, e1006351 (2016).","journal-title":"PLoS. Genet."},{"key":"427_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/352539a0","volume":"352","author":"A Vortkamp","year":"1991","unstructured":"Vortkamp, A., Gessler, M. & Grzeschik, K. H. GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352, 539\u2013540 (1991).","journal-title":"Nature"},{"key":"427_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1242\/dev.124.1.113","volume":"124","author":"R Mo","year":"1997","unstructured":"Mo, R. et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124, 113\u2013123 (1997).","journal-title":"Development"},{"key":"427_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.7554\/eLife.56450","volume":"9","author":"KH Elliott","year":"2020","unstructured":"Elliott, K. H. et al. Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks. Elife 9, 24 (2020).","journal-title":"Elife"},{"key":"427_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0003-9969(02)00208-X","volume":"48","author":"MT Cobourne","year":"2003","unstructured":"Cobourne, M. T. & Sharpe, P. T. Tooth and jaw: molecular mechanisms of patterning in the first branchial arch. Arch. Oral. Biol. 48, 1\u201314 (2003).","journal-title":"Arch. Oral. Biol."},{"key":"427_CR14","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1242\/dev.137216","volume":"144","author":"J Li","year":"2017","unstructured":"Li, J., Parada, C. & Chai, Y. Cellular and molecular mechanisms of tooth root development. Development 144, 374\u2013384 (2017).","journal-title":"Development"},{"key":"427_CR15","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.3390\/ijms21051587","volume":"21","author":"A Hosoya","year":"2020","unstructured":"Hosoya, A., Shalehin, N., Takebe, H., Shimo, T. & Irie, K. Sonic Hedgehog signaling and tooth development. Int. J. Mol. Sci. 21, 1587 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"427_CR16","first-page":"3374","volume":"142","author":"Y Liu","year":"2015","unstructured":"Liu, Y. et al. An Nfic-hedgehog signaling cascade regulates tooth root development. Development 142, 3374\u20133382 (2015).","journal-title":"Development"},{"key":"427_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1177\/154405910608500506","volume":"85","author":"M Nakatomi","year":"2006","unstructured":"Nakatomi, M., Morita, I., Eto, K. & Ota, M. S. Sonic hedgehog signaling is important in tooth root development. J. Dent. Res. 85, 427\u2013431 (2006).","journal-title":"J. Dent. Res."},{"key":"427_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32490-y","volume":"13","author":"J Jing","year":"2022","unstructured":"Jing, J. et al. Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat. Commun. 13, 4803 (2022).","journal-title":"Nat. Commun."},{"key":"427_CR19","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1242\/dev.150136","volume":"144","author":"J Feng","year":"2017","unstructured":"Feng, J. et al. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development 144, 2560\u20132569 (2017).","journal-title":"Development"},{"key":"427_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ydbio.2013.08.003","volume":"382","author":"Y Wang","year":"2013","unstructured":"Wang, Y., Cox, M. K., Coricor, G., MacDougall, M. & Serra, R. Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation. Dev. Biol. 382, 27\u201337 (2013).","journal-title":"Dev. Biol."},{"key":"427_CR21","doi-asserted-by":"publisher","first-page":"687099","DOI":"10.3389\/fcell.2021.687099","volume":"9","author":"R Zhang","year":"2021","unstructured":"Zhang, R. et al. Transforming growth factor-\u03b2 signaling regulates tooth root dentinogenesis by cooperation with Wnt signaling. Front. Cell. Dev. Biol. 9, 687099 (2021).","journal-title":"Front. Cell. Dev. Biol."},{"key":"427_CR22","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.1074\/jbc.M109.035105","volume":"285","author":"J Iwata","year":"2010","unstructured":"Iwata, J. et al. Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J. Biol. Chem. 285, 4975\u20134982 (2010).","journal-title":"J. Biol. Chem."},{"key":"427_CR23","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1242\/dev.128.22.4605","volume":"128","author":"CA Ferguson","year":"2001","unstructured":"Ferguson, C. A. et al. The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development 128, 4605\u20134613 (2001).","journal-title":"Development"},{"key":"427_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154626","volume":"110","author":"C Chen","year":"2023","unstructured":"Chen, C. et al. Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-\u03b2\/Smad signaling. Phytomedicine 110, 154626 (2023).","journal-title":"Phytomedicine"},{"key":"427_CR25","doi-asserted-by":"publisher","DOI":"10.1242\/dev.180075","volume":"146","author":"S Okuhara","year":"2019","unstructured":"Okuhara, S. et al. Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development 146, dev180075 (2019).","journal-title":"Development"},{"key":"427_CR26","doi-asserted-by":"publisher","first-page":"590539","DOI":"10.3389\/fcell.2020.590539","volume":"8","author":"MR Sun","year":"2020","unstructured":"Sun, M. R. et al. Sonic hedgehog signaling in cranial neural crest cells regulates microvascular morphogenesis in facial development. Front. Cell. Dev. Biol. 8, 590539 (2020).","journal-title":"Front. Cell. Dev. Biol."},{"key":"427_CR27","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1177\/00220345221075215","volume":"101","author":"R Xu","year":"2022","unstructured":"Xu, R. et al. Gnas loss causes chondrocyte fate conversion in cranial suture formation. J. Dent. Res. 101, 931\u2013941 (2022).","journal-title":"J. Dent. Res."},{"key":"427_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.devcel.2015.02.021","volume":"33","author":"J Li","year":"2015","unstructured":"Li, J. et al. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev. Cell. 33, 125\u2013135 (2015).","journal-title":"Dev. Cell."},{"key":"427_CR29","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202043","volume":"151","author":"F Pei","year":"2024","unstructured":"Pei, F. et al. Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis. Development 151, dev202043 (2024).","journal-title":"Development"},{"key":"427_CR30","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.devcel.2015.11.025","volume":"35","author":"J Prochazka","year":"2015","unstructured":"Prochazka, J. et al. Migration of founder epithelial cells drives proper molar tooth positioning and morphogenesis. Dev. Cell. 35, 713\u2013724 (2015).","journal-title":"Dev. Cell."},{"key":"427_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61050-3","volume":"16","author":"M Nagata","year":"2025","unstructured":"Nagata, M. et al. A Hedgehog-Foxf axis coordinates dental follicle-derived alveolar bone formation. Nat. Commun. 16, 6061 (2025).","journal-title":"Nat. Commun."},{"key":"427_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1011028","volume":"19","author":"SH Hwang","year":"2023","unstructured":"Hwang, S. H., White, K. A., Somatilaka, B. N., Wang, B. & Mukhopadhyay, S. Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis. PLoS. Genet 19, e1011028 (2023).","journal-title":"PLoS. Genet"},{"key":"427_CR33","doi-asserted-by":"publisher","first-page":"jcs263556","DOI":"10.1242\/jcs.263556","volume":"138","author":"Y Takahashi","year":"2025","unstructured":"Takahashi, Y. et al. Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression. J. Cell. Sci. 138, jcs263556 (2025).","journal-title":"J. Cell. Sci."},{"key":"427_CR34","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.devcel.2012.01.006","volume":"22","author":"J Lopez-Rios","year":"2012","unstructured":"Lopez-Rios, J. et al. GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev. Cell. 22, 837\u2013848 (2012).","journal-title":"Dev. Cell."},{"key":"427_CR35","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fphys.2012.00121","volume":"3","author":"L Veistinen","year":"2012","unstructured":"Veistinen, L. et al. Loss-of-function of Gli3 in mice causes abnormal frontal bone morphology and premature synostosis of the interfrontal suture. Front. Physiol. 3, 121 (2012).","journal-title":"Front. Physiol."},{"key":"427_CR36","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1242\/dev.01230","volume":"131","author":"Q Lei","year":"2004","unstructured":"Lei, Q., Zelman, A. K., Kuang, E., Li, S. & Matise, M. P. Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131, 3593\u20133604 (2004).","journal-title":"Development"},{"key":"427_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/1711","volume":"20","author":"J Motoyama","year":"1998","unstructured":"Motoyama, J. et al. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20, 54\u201357 (1998).","journal-title":"Nat. Genet."},{"key":"427_CR38","doi-asserted-by":"publisher","first-page":"6233","DOI":"10.1242\/dev.00851","volume":"130","author":"L Buttitta","year":"2003","unstructured":"Buttitta, L., Mo, R., Hui, C. C. & Fan, C. M. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130, 6233\u20136243 (2003).","journal-title":"Development"},{"key":"427_CR39","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1242\/dev.126.17.3915","volume":"126","author":"H Sasaki","year":"1999","unstructured":"Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. & Kondoh, H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915\u20133924 (1999).","journal-title":"Development"},{"key":"427_CR40","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1242\/dev.126.14.3205","volume":"126","author":"I Ruiz","year":"1999","unstructured":"Ruiz, I. & Altaba, A. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205\u20133216 (1999).","journal-title":"Development"},{"key":"427_CR41","doi-asserted-by":"crossref","unstructured":"Gozum, G. et al. Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development. Embo. J. (2025).","DOI":"10.1101\/2025.01.14.632991"},{"key":"427_CR42","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1534-5807(03)00394-0","volume":"6","author":"CB Bai","year":"2004","unstructured":"Bai, C. B., Stephen, D. & Joyner, A. L. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell. 6, 103\u2013115 (2004).","journal-title":"Dev. Cell."},{"key":"427_CR43","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.3390\/ijms20205002","volume":"20","author":"K Tominaga","year":"2019","unstructured":"Tominaga, K. & Suzuki, H. I. TGF-\u03b2 signaling in cellular senescence and aging-related pathology. Int. J. Mol. Sci. 20, 5002 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"427_CR44","doi-asserted-by":"publisher","first-page":"a022186","DOI":"10.1101\/cshperspect.a022186","volume":"9","author":"AC Mullen","year":"2017","unstructured":"Mullen, A. C. & Wrana, J. L. TGF-\u03b2 family signaling in embryonic and somatic stem-cell renewal and differentiation. Cold. Spring Harb. Perspect. Biol. 9, a022186 (2017).","journal-title":"Cold. Spring Harb. Perspect. Biol."},{"key":"427_CR45","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.devcel.2025.01.018","volume":"60","author":"M Rothstein","year":"2025","unstructured":"Rothstein, M., Azambuja, A. P., Kanno, T. Y., Breen, C. & Simoes-Costa, M. TGF-\u03b2 signaling controls neural crest developmental plasticity via SMAD2\/3. Dev. Cell. 60, 1686\u20131701.e1687 (2025).","journal-title":"Dev. Cell."},{"key":"427_CR46","doi-asserted-by":"crossref","unstructured":"Rowan, C. J. et al. Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGF\u03b2 signaling. Development 145, dev159947, (2018).","DOI":"10.1242\/dev.159947"},{"key":"427_CR47","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.devcel.2022.06.005","volume":"57","author":"Y Liu","year":"2022","unstructured":"Liu, Y. et al. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state. Dev. Cell. 57, 1758\u20131775.e1757 (2022).","journal-title":"Dev. Cell."},{"key":"427_CR48","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba8196","volume":"6","author":"JM Dias","year":"2020","unstructured":"Dias, J. M. et al. A Shh\/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells. Sci. Adv. 6, eaba8196 (2020).","journal-title":"Sci. Adv."},{"key":"427_CR49","doi-asserted-by":"publisher","first-page":"10547","DOI":"10.1074\/jbc.RA118.003255","volume":"293","author":"Q Li","year":"2018","unstructured":"Li, Q. et al. Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells. J. Biol. Chem. 293, 10547\u201310560 (2018).","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00427-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00427-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00427-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:02:45Z","timestamp":1773291765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00427-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["427"],"URL":"https:\/\/doi.org\/10.1038\/s41368-026-00427-6","relation":{},"ISSN":["2049-3169"],"issn-type":[{"value":"2049-3169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30"}}