{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:53:01Z","timestamp":1790977981086,"version":"4.1.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301115"],"award-info":[{"award-number":["82301115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC1584"],"award-info":[{"award-number":["2025ZNSFSC1584"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M742459"],"award-info":[{"award-number":["2023M742459"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Oral Sci"],"DOI":"10.1038\/s41368-026-00465-0","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:27:51Z","timestamp":1790929671000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H3K18la in periodontal ligament fibroblasts regulates immune niches and alveolar bone remodeling under mechanical loads"],"prefix":"10.1038","volume":"18","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yige","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2955-1706","authenticated-orcid":false,"given":"Zhihe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"465_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s007740070001","volume":"18","author":"HM Frost","year":"2000","unstructured":"Frost, H. M. The Utah paradigm of skeletal physiology: an overview of its insights for bone, cartilage and collagenous tissue organs. J. Bone Miner. Metab. 18, 305\u2013316 (2000).","journal-title":"J. Bone Miner. Metab."},{"key":"465_CR2","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1359\/JBMR.040307","volume":"19","author":"T Lang","year":"2004","unstructured":"Lang, T. et al. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J. Bone Miner. Res. 19, 1006\u20131012 (2004).","journal-title":"J. Bone Miner. Res."},{"key":"465_CR3","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(00)02217-0","volume":"355","author":"L Vico","year":"2000","unstructured":"Vico, L. et al. Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355, 1607\u20131611 (2000).","journal-title":"Lancet"},{"key":"465_CR4","doi-asserted-by":"crossref","unstructured":"Hathaway-Schrader, J. D. & Novince, C. M. Maintaining homeostatic control of periodontal bone tissue. Periodontol. 2000 86, 157\u2013187 (2021).","DOI":"10.1111\/prd.12368"},{"key":"465_CR5","doi-asserted-by":"crossref","unstructured":"Mei, H. et al. Sema3a secreted by sensory nerve induces bone formation under mechanical loads. Int. J. Oral Sci. 16, 5 (2024).","DOI":"10.1038\/s41368-023-00269-6"},{"key":"465_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/00220345211016285","volume":"101","author":"S Chaushu","year":"2022","unstructured":"Chaushu, S., Klein, Y., Mandelboim, O., Barenholz, Y. & Fleissig, O. Immune changes induced by orthodontic forces: a critical review. J. Dent. Res. 101, 11\u201320 (2022).","journal-title":"J. Dent. Res."},{"key":"465_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s11914-023-00774-x","volume":"21","author":"B Alghamdi","year":"2023","unstructured":"Alghamdi, B. et al. Osteoimmunology in periodontitis and orthodontic tooth movement. Curr. Osteoporos. Rep. 21, 128\u2013146 (2023).","journal-title":"Curr. Osteoporos. Rep."},{"key":"465_CR8","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.joen.2021.06.015","volume":"47","author":"C Le Fournis","year":"2021","unstructured":"Le Fournis, C. et al. Fibroblasts control macrophage differentiation during pulp inflammation. J. Endod. 47, 1427\u20131434 (2021).","journal-title":"J. Endod."},{"key":"465_CR9","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1177\/00220345221092752","volume":"101","author":"Q Wang","year":"2022","unstructured":"Wang, Q. et al. Single-cell transcriptomic atlas of gingival mucosa in type 2 diabetes. J. Dent. Res. 101, 1654\u20131664 (2022).","journal-title":"J. Dent. Res."},{"key":"465_CR10","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.7150\/thno.65694","volume":"12","author":"Y Chen","year":"2022","unstructured":"Chen, Y. et al. Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis. Theranostics 12, 1074\u20131096 (2022).","journal-title":"Theranostics"},{"key":"465_CR11","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1177\/00220345231151921","volume":"102","author":"A Wielento","year":"2023","unstructured":"Wielento, A., Lagosz-Cwik, K. B., Potempa, J. & Grabiec, A. M. The role of gingival fibroblasts in the pathogenesis of periodontitis. J. Dent. Res. 102, 489\u2013496 (2023).","journal-title":"J. Dent. Res."},{"key":"465_CR12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1177\/0022034509338914","volume":"88","author":"V Krishnan","year":"2009","unstructured":"Krishnan, V. & Davidovitch, Z. On a path to unfolding the biological mechanisms of orthodontic tooth movement. J. Dent. Res. 88, 597\u2013608 (2009).","journal-title":"J. Dent. Res."},{"key":"465_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41580-020-00306-w","volume":"22","author":"P Romani","year":"2021","unstructured":"Romani, P., Valcarcel-Jimenez, L., Frezza, C. & Dupont, S. Crosstalk between mechanotransduction and metabolism. Nat. Rev. Mol. Cell Biol. 22, 22\u201338 (2021).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"465_CR14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41586-020-1998-1","volume":"578","author":"JS Park","year":"2020","unstructured":"Park, J. S. et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature 578, 621\u2013626 (2020).","journal-title":"Nature"},{"key":"465_CR15","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jhep.2022.03.029","volume":"77","author":"T Greuter","year":"2022","unstructured":"Greuter, T. et al. Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. J. Hepatol. 77, 723\u2013734 (2022).","journal-title":"J. Hepatol."},{"key":"465_CR16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s42003-019-0553-9","volume":"2","author":"BG Kim","year":"2019","unstructured":"Kim, B. G. et al. Compression-induced expression of glycolysis genes in CAFs correlates with EMT and angiogenesis gene expression in breast cancer. Commun. Biol. 2, 313 (2019).","journal-title":"Commun. Biol."},{"key":"465_CR17","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang, D. et al. Metabolic regulation of gene expression by histone lactylation. Nature 574, 575\u2013580 (2019).","journal-title":"Nature"},{"key":"465_CR18","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1038\/s41590-024-01985-9","volume":"25","author":"D Raychaudhuri","year":"2024","unstructured":"Raychaudhuri, D. et al. Histone lactylation drives CD8(+) T cell metabolism and function. Nat. Immunol. 25, 2140\u20132151 (2024).","journal-title":"Nat. Immunol."},{"key":"465_CR19","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.immuni.2025.02.008","volume":"58","author":"A Llibre","year":"2025","unstructured":"Llibre, A., Kucuk, S., Gope, A., Certo, M. & Mauro, C. Lactate: a key regulator of the immune response. Immunity 58, 535\u2013554 (2025).","journal-title":"Immunity"},{"key":"465_CR20","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1177\/00220345251334583","volume":"104","author":"J Wang","year":"2025","unstructured":"Wang, J. et al. Single-cell atlas of immune microenvironment in orthodontic tooth movement. J. Dent. Res. 104, 1361\u20131372 (2025).","journal-title":"J. Dent. Res."},{"key":"465_CR21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1177\/0022034518805984","volume":"98","author":"Z Zhuang","year":"2019","unstructured":"Zhuang, Z. et al. Induction of M2 macrophages prevents bone loss in murine periodontitis models. J. Dent. Res. 98, 200\u2013208 (2019).","journal-title":"J. Dent. Res."},{"key":"465_CR22","doi-asserted-by":"publisher","first-page":"102438","DOI":"10.1016\/j.redox.2022.102438","volume":"56","author":"S Wang","year":"2022","unstructured":"Wang, S. et al. CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration. Redox Biol. 56, 102438 (2022).","journal-title":"Redox Biol."},{"key":"465_CR23","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1093\/eurheartj\/ehy085","volume":"39","author":"L Wang","year":"2018","unstructured":"Wang, L. et al. CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. Eur. Heart J. 39, 1818\u20131831 (2018).","journal-title":"Eur. Heart J."},{"key":"465_CR24","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ni.3796","volume":"18","author":"PS Liu","year":"2017","unstructured":"Liu, P. S. et al. -ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat. Immunol. 18, 985\u2013994 (2017).","journal-title":"Nat. Immunol."},{"key":"465_CR25","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1172\/JCI86387","volume":"126","author":"T Bertero","year":"2016","unstructured":"Bertero, T. et al. Vascular stiffness mechanoactivates YAP\/TAZ-dependent glutaminolysis to drive pulmonary hypertension. J. Clin. Investig. 126, 3313\u20133335 (2016).","journal-title":"J. Clin. Investig."},{"key":"465_CR26","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.cmet.2018.07.010","volume":"28","author":"JH Koo","year":"2018","unstructured":"Koo, J. H. & Guan, K. L. Interplay between YAP\/TAZ and metabolism. Cell. Metab. 28, 196\u2013206 (2018).","journal-title":"Cell. Metab."},{"key":"465_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01497-x","volume":"22","author":"F Shan","year":"2024","unstructured":"Shan, F. et al. Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells. Cell. Commun. Signal. 22, 93 (2024).","journal-title":"Cell. Commun. Signal."},{"key":"465_CR28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402944R","volume":"39","author":"Y Liu","year":"2025","unstructured":"Liu, Y. et al. In vitro stretch modulates mitochondrial dynamics and energy metabolism to induce smooth muscle differentiation in mesenchymal stem cells. FASEB J. 39, e70354 (2025).","journal-title":"FASEB J."},{"key":"465_CR29","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/s42255-020-0267-9","volume":"2","author":"L Li","year":"2020","unstructured":"Li, L. et al. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Nat. Metab. 2, 882\u2013892 (2020).","journal-title":"Nat. Metab."},{"key":"465_CR30","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","volume":"35","author":"H Rho","year":"2023","unstructured":"Rho, H., Terry, A. R., Chronis, C. & Hay, N. Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis. Cell. Metab. 35, 1406\u20131423.e1408 (2023).","journal-title":"Cell. Metab."},{"key":"465_CR31","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","volume":"131","author":"N Wang","year":"2022","unstructured":"Wang, N. et al. Histone lactylation boosts reparative gene activation post-myocardial infarction. Circ. Res. 131, 893\u2013908 (2022).","journal-title":"Circ. Res."},{"key":"465_CR32","doi-asserted-by":"publisher","first-page":"E131","DOI":"10.1152\/ajpendo.00347.2013","volume":"306","author":"SJ Burke","year":"2014","unstructured":"Burke, S. J. et al. NF-\u03baB and STAT1 control CXCL1 and CXCL2 gene transcription. Am. J. Physiol. Endocrinol. Metab. 306, E131\u2013E149 (2014).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"465_CR33","doi-asserted-by":"publisher","first-page":"101050","DOI":"10.1016\/j.mtbio.2024.101050","volume":"26","author":"HJ Bae","year":"2024","unstructured":"Bae, H. J. et al. Cyclic stretch induced epigenetic activation of periodontal ligament cells. Mater. Today Bio. 26, 101050 (2024).","journal-title":"Mater. Today Bio."},{"key":"465_CR34","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk0639","volume":"10","author":"Y Song","year":"2024","unstructured":"Song, Y. et al. Biphasic regulation of epigenetic state by matrix stiffness during cell reprogramming. Sci. Adv. 10, eadk0639 (2024).","journal-title":"Sci. Adv."},{"key":"465_CR35","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70035","volume":"24","author":"H Liu","year":"2025","unstructured":"Liu, H., Yuan, L., Baldi, L., Sornapudi, T. R. & Shivashankar, G. V. Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signaling pathway. Aging Cell 24, e70035 (2025).","journal-title":"Aging Cell"},{"key":"465_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.292","volume":"4","author":"R Liu","year":"2023","unstructured":"Liu, R. et al. Post-translational modifications of histones: mechanisms, biological functions, and therapeutic targets. MedComm 4, e292 (2023).","journal-title":"MedComm"},{"key":"465_CR37","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1093\/jimmun\/vkaf136","volume":"214","author":"B Zhang","year":"2025","unstructured":"Zhang, B. et al. Stromal cell-derived chemokines modulate immune cells in inflammation: new findings and future perspectives. J. Immunol. 214, 2822\u20132835 (2025).","journal-title":"J. Immunol."},{"key":"465_CR38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.molimm.2024.03.006","volume":"169","author":"S Jiang","year":"2024","unstructured":"Jiang, S. et al. CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration. Mol. Immunol. 169, 50\u201365 (2024).","journal-title":"Mol. Immunol."},{"key":"465_CR39","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1089\/dna.2022.0509","volume":"42","author":"X Li","year":"2023","unstructured":"Li, X. et al. A single-cell rna-sequencing analysis of distinct subsets of synovial macrophages in rheumatoid arthritis. DNA Cell Biol. 42, 212\u2013222 (2023).","journal-title":"DNA Cell Biol."},{"key":"465_CR40","doi-asserted-by":"crossref","unstructured":"Chen, L. et al. SCCA1\/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production. J. Clin. Investig. 133, e163841 (2023).","DOI":"10.1172\/JCI163841"},{"key":"465_CR41","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.62347\/UAIS7070","volume":"14","author":"Y Ou","year":"2024","unstructured":"Ou, Y. et al. The Zeb1-Cxcl1 axis impairs the antitumor immune response by inducing M2 macrophage polarization in breast cancer. Am. J. Cancer Res. 14, 4378\u20134397 (2024).","journal-title":"Am. J. Cancer Res."},{"key":"465_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156039","volume":"135","author":"S Wang","year":"2024","unstructured":"Wang, S. et al. Xiaopi formula inhibits chemoresistance and metastasis of triple-negative breast cancer by suppressing extracellular vesicle\/CXCL1-induced TAM\/PD-L1 signaling. Phytomedicine 135, 156039 (2024).","journal-title":"Phytomedicine"},{"key":"465_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2024.101103","volume":"60","author":"R Nakagawa","year":"2025","unstructured":"Nakagawa, R. et al. Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis. Neoplasia 60, 101103 (2025).","journal-title":"Neoplasia"},{"key":"465_CR44","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1177\/0022034514553817","volume":"94","author":"D He","year":"2015","unstructured":"He, D. et al. Enhanced M1\/M2 macrophage ratio promotes orthodontic root resorption. J. Dent. Res. 94, 129\u2013139 (2015).","journal-title":"J. Dent. Res."},{"key":"465_CR45","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.2147\/JIR.S423819","volume":"16","author":"K Hu","year":"2023","unstructured":"Hu, K., Shang, Z., Yang, X., Zhang, Y. & Cao, L. Macrophage polarization and the regulation of bone immunity in bone homeostasis. J. Inflamm. Res. 16, 3563\u20133580 (2023).","journal-title":"J. Inflamm. Res."},{"key":"465_CR46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.biomaterials.2017.12.025","volume":"196","author":"J Pajarinen","year":"2019","unstructured":"Pajarinen, J. et al. Mesenchymal stem cell-macrophage crosstalk and bone healing. Biomaterials 196, 80\u201389 (2019).","journal-title":"Biomaterials"},{"key":"465_CR47","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41413-024-00374-0","volume":"12","author":"JC Bertels","year":"2024","unstructured":"Bertels, J. C., He, G. & Long, F. Metabolic reprogramming in skeletal cell differentiation. Bone Res. 12, 57 (2024).","journal-title":"Bone Res."},{"key":"465_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301300","volume":"10","author":"J Wu","year":"2023","unstructured":"Wu, J. et al. Endothelial cell-derived lactate triggers bone mesenchymal stem cell histone lactylation to attenuate osteoporosis. Adv. Sci. 10, e2301300 (2023).","journal-title":"Adv. Sci."},{"key":"465_CR49","doi-asserted-by":"publisher","first-page":"102101","DOI":"10.1016\/j.mtbio.2025.102101","volume":"33","author":"M Zeng","year":"2025","unstructured":"Zeng, M. et al. Lactate-functionalized 3D-printed PCL\/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk. Mater. Today Bio. 33, 102101 (2025).","journal-title":"Mater. Today Bio."},{"key":"465_CR50","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.chembiol.2023.07.003","volume":"30","author":"X Ji","year":"2023","unstructured":"Ji, X. et al. Genetic activation of glycolysis in osteoblasts preserves bone mass in type I diabetes. Cell. Chem. Biol. 30, 1053\u20131063.e1055 (2023).","journal-title":"Cell. Chem. Biol."},{"key":"465_CR51","doi-asserted-by":"publisher","first-page":"11058","DOI":"10.1096\/fj.202000771R","volume":"34","author":"B Li","year":"2020","unstructured":"Li, B. et al. Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation. FASEB J. 34, 11058\u201311067 (2020).","journal-title":"FASEB J."},{"key":"465_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403177","volume":"11","author":"W Chu","year":"2024","unstructured":"Chu, W. et al. Prmt6 epigenetically drives metabolic switch from fatty acid oxidation toward glycolysis and promotes osteoclast differentiation during osteoporosis. Adv. Sci. 11, e2403177 (2024).","journal-title":"Adv. Sci."},{"key":"465_CR53","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1111\/febs.15327","volume":"287","author":"G Soto-Heredero","year":"2020","unstructured":"Soto-Heredero, G., G\u00f3mez de Las Heras, M. M., Gaband\u00e9-Rodr\u00edguez, E., Oller, J. & Mittelbrunn, M. Glycolysis - a key player in the inflammatory response. FEBS J. 287, 3350\u20133369 (2020).","journal-title":"FEBS J."},{"key":"465_CR54","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.120.046464","volume":"144","author":"L Edgar","year":"2021","unstructured":"Edgar, L. et al. Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis. Circulation 144, 961\u2013982 (2021).","journal-title":"Circulation"},{"key":"465_CR55","doi-asserted-by":"publisher","first-page":"115350","DOI":"10.1016\/j.celrep.2025.115350","volume":"44","author":"J Li","year":"2025","unstructured":"Li, J. et al. Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD. Cell. Rep. 44, 115350 (2025).","journal-title":"Cell. Rep."},{"key":"465_CR56","doi-asserted-by":"publisher","first-page":"139286","DOI":"10.1016\/j.jhazmat.2025.139286","volume":"496","author":"L Shi","year":"2025","unstructured":"Shi, L. et al. H3K18 lactylation drives the progression of silica nanoparticles-induced pulmonary fibrosis via promoting M1 macrophage polarization. J. Hazard. Mater. 496, 139286 (2025).","journal-title":"J. Hazard. Mater."},{"key":"465_CR57","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1136\/gutjnl-2022-329349","volume":"72","author":"X Liu","year":"2023","unstructured":"Liu, X. et al. CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-\u03baB\/p65 nuclear translocation in pancreatic ductal adenocarcinoma. Gut 72, 2329\u20132343 (2023).","journal-title":"Gut"},{"key":"465_CR58","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1177\/00220345241262706","volume":"103","author":"H Liu","year":"2024","unstructured":"Liu, H. et al. Periodontal ligament cell apoptosis activates Lepr+ osteoprogenitors in orthodontics. J. Dent. Res. 103, 937\u2013947 (2024).","journal-title":"J. Dent. Res."},{"key":"465_CR59","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"465_CR60","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS McGinnis","year":"2019","unstructured":"McGinnis, C. S., Murrow, L. M. & Gartner, Z. J. Doubletfinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell. Syst. 8, 329\u2013337.e324 (2019).","journal-title":"Cell. Syst."},{"key":"465_CR61","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nbt.4091","volume":"36","author":"L Haghverdi","year":"2018","unstructured":"Haghverdi, L., Lun, A. T. L., Morgan, M. D. & Marioni, J. C. Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors. Nat. Biotechnol. 36, 421\u2013427 (2018).","journal-title":"Nat. Biotechnol."},{"key":"465_CR62","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1111\/iej.70016","volume":"58","author":"Y Zhao","year":"2025","unstructured":"Zhao, Y. et al. Pfkfb3-inhibitor 3PO-mediated glycolytic reprogramming promotes inflammatory dental pulp repair: an in vitro and in vivo study. Int. Endod. J. 58, 1872\u20131889 (2025).","journal-title":"Int. Endod. J."},{"key":"465_CR63","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/jbmr.4744","volume":"38","author":"X Gong","year":"2023","unstructured":"Gong, X. et al. Osteoblastic STAT3 is crucial for orthodontic force driving alveolar bone remodeling and tooth movement. J. Bone Miner. Res. 38, 214\u2013227 (2023).","journal-title":"J. Bone Miner. Res."},{"key":"465_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09982-5","volume":"10","author":"HS Kaya-Okur","year":"2019","unstructured":"Kaya-Okur, H. S. et al. Cut&tag for efficient epigenomic profiling of small samples and single cells. Nat. Commun. 10, 1930 (2019).","journal-title":"Nat. Commun."},{"key":"465_CR65","doi-asserted-by":"publisher","first-page":"e4120","DOI":"10.21769\/BioProtoc.4120","volume":"11","author":"J Zhao","year":"2021","unstructured":"Zhao, J. & Sharpe, P. Isolation of single cells from mouse periodontal ligament. Bio Protoc. 11, e4120 (2021).","journal-title":"Bio Protoc."},{"key":"465_CR66","doi-asserted-by":"publisher","first-page":"110535","DOI":"10.1016\/j.exer.2025.110535","volume":"259","author":"D Hughes","year":"2025","unstructured":"Hughes, D. et al. Inhibition of glycolysis modulates retinal endothelial cell function and pathological neovascularization. Exp. Eye Res. 259, 110535 (2025).","journal-title":"Exp. Eye Res."}],"container-title":["International Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00465-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00465-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00465-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:02:42Z","timestamp":1790974962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41368-026-00465-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["465"],"URL":"https:\/\/doi.org\/10.1038\/s41368-026-00465-0","relation":{},"ISSN":["2049-3169"],"issn-type":[{"value":"2049-3169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"7 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"66"}}